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Widespread seasonal gene expression reveals annual differences in human immunity and physiology

Dopico, Xaquin Castro, Evangelou, Marina, Ferreira, Ricardo C., Guo, Hui, Pekalski, Marcin L., Smyth, Deborah J., Cooper, Nicholas, Burren, Oliver S., Fulford, Anthony J., Hennig, Branwen J., Prentice, Andrew M., Ziegler, Anette-G., Bonifacio, Ezio, Wallace, Chris, Todd, John A.·2015·Nature Communications
DOI 10.1038/ncomms8000PMC PMC4432600
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Abstract

Seasonal variations are rarely considered a contributing component to human tissue function or health, although many diseases and physiological process display annual periodicities. Here we find more than 4,000 protein-coding mRNAs in white blood cells and adipose tissue to have seasonal expression profiles, with inverted patterns observed between Europe and Oceania. We also find the cellular composition of blood to vary by season, and these changes, which differ between the United Kingdom and The Gambia, could explain the gene expression periodicity. With regards to tissue function, the immune system has a profound pro-inflammatory transcriptomic profile during European winter, with increased levels of soluble IL-6 receptor and C-reactive protein, risk biomarkers for cardiovascular, psychiatric and autoimmune diseases that have peak incidences in winter. Circannual rhythms thus require further exploration as contributors to various aspects of human physiology and disease.

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  • More than 4000 protein coding mRNAs within adipose tissue and white blood cells show seasonally derived expression profiles that differ between the Northern and Southern hemispheres, with implications for immunity and physiology.

    “more than 4000 protein coding mRNAs within adipose tissue and white blood cells show seasonally derived expression profiles that are different between the Northern and Southern hemisphere with implications for immunity and physiology”

    From The evolution of human skin pigmentation: A changing medley of vitamins, genetic variability, and UV radiation during human expansion (2023) · cites this paper as Dopico et al., 2015

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Metadata

Authors
Dopico, X. C., Evangelou, M., Ferreira, R. C., Guo, H., Pekalski, M. L., Smyth, D. J., Cooper, N., Burren, O. S., Fulford, A. J., Hennig, B. J., Prentice, A. M., Ziegler, A.-G., Bonifacio, E., Wallace, C., & Todd, J. A.
ORCID
Venue
Nature Communications
Publisher
Springer Science and Business Media LLC
Published
2015-05-12
Volume
6
Issue
1
ISSN
2041-1723
DOI
10.1038/ncomms8000
PMC
PMC4432600
Cited by
472
References
12
Language
en
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