The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
miR-142-5p and miR-130a-3p are regulated by IL-4 and IL-13 and control profibrogenic macrophage program
Open accessAbstract
Macrophages play a pivotal role in tissue fibrogenesis, which underlies the pathogenesis of many end-stage chronic inflammatory diseases. MicroRNAs are key regulators of immune cell functions, but their roles in macrophage’s fibrogenesis have not been characterized. Here we show that IL-4 and IL-13 induce miR-142-5p and downregulate miR-130a-3p in macrophages; these changes sustain the profibrogenic effect of macrophages. In vitro, miR-142-5p mimic prolongs STAT6 phosphorylation by targeting its negative regulator, SOCS1. Blocking miR-130a relieves its inhibition of PPARγ, which coordinates STAT6 signalling. In vivo, inhibiting miR-142-5p and increasing miR-130a-3p expression with locked nucleic acid-modified oligonucleotides inhibits CCL 4-induced liver fibrosis and bleomycin-induced lung fibrosis in mice. Furthermore, macrophages from the tissue samples of patients with liver cirrhosis and idiopathic pulmonary fibrosis display increased miR-142-5p and decreased miR-130a-3p expression. Therefore, miR-142-5p and miR-130a-3p regulate macrophage profibrogenic gene expression in chronic inflammation.
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Cites
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Novel regulators of hepatic macrophages in liver fibrosis
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Metadata
- Authors
- Su, S., Zhao, Q., He, C., Huang, D., Liu, J., Chen, F., Chen, J., Liao, J.-Y., Cui, X., Zeng, Y., Yao, H., Su, F., Liu, Q., Jiang, S., & Song, E.
- Venue
- Nature Communications
- Published
- 2015-10-05
- Volume
- 6
- Issue
- 1
- Pages
- 8523-8523
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2183645018
- Cited by
- 253
- References
- 14
- FWCI
- 6.18
- Type
- journal article
- Language
- en
- Open access
- gold
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