Weight loss and metabolic benefits with diets of varying fat and carbohydrate content: separating the wheat from the chaff

Brehm, Bonnie J; D'Alessio, David A

doi:10.1038/ncpendmet0730

Cited by 30Diet and metabolism studiesDietary Effects on HealthNutritional Studies and Diet

Weight loss and metabolic benefits with diets of varying fat and carbohydrate content: separating the wheat from the chaff

Brehm, Bonnie J, D'Alessio, David A·2008·Nature Clinical Practice Endocrinology & Metabolism

DOI 10.1038/ncpendmet0730

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Abstract

With the rising prevalence of both obesity and diabetes, the contributing role of diet to the prevention and treatment of these conditions has become a major focus of research, clinical practice, and public policy. There has been intense debate over which dietary regimens might be most effective for weight loss, with interest centered on the potential for specific dietary macronutrients to affect body composition, metabolism, and overall health. This Review addresses two regimens with distinct macronutrient prescriptions that have been widely touted as being beneficial for weight loss and/or metabolic profile: diets low in carbohydrate and diets high in monounsaturated fat. Although data from recent randomized, controlled trials suggest these popular diets may be useful for weight control, cardiovascular health, and glycemic control, longer studies of the efficacy and safety of varying macronutrient content are needed to strengthen the evidence base for nutritional recommendations. Until more support for specific macronutrient combinations is available, practitioners can recommend an array of diets with moderate amounts of macronutrients, tailored to individual needs and preferences.

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Authors: Brehm, B. J., & D'Alessio, D. A.
Affiliations: University of Cincinnati (US)
Corresponding author: Brehm, Bonnie J
ORCID: Brehm, Bonnie J
Venue: Nature Clinical Practice Endocrinology & Metabolism
Publisher: Springer Science and Business Media LLC
Published: 2008-01-29
Volume: 4
Issue: 3
Pages: 140-146
ISSN: 1745-8366 (ISSN-L)
1745-8374
DOI: 10.1038/ncpendmet0730
OpenAlex: W1980560276
Cited by: 30
References: 65
Citations by year: 2025: 1 · 2018: 1 · 2013: 4 · 2012: 4
FWCI: 0.72
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Clinical Practice Endocrinology & Metabolism (publishedVersion)
PubMed (publishedVersion)
Funders: American Heart Association
Topics: Health Sciences › Medicine › Physiology › Diet and metabolism studies
Health Sciences › Medicine › Physiology › Dietary Effects on Health
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Keywords: weight loss, macronutrient composition, low-carbohydrate diet, monounsaturated fatty acids, high-fat diet, obesity, diabetes mellitus, glycemic control, cardiovascular risk, body composition
MeSH terms: Dietary Carbohydrates, Dietary Fats, Humans, Weight Loss, Diet, Fat-Restricted, Diet, Carbohydrate-Restricted

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Weight loss and metabolic benefits with diets of varying fat and carbohydrate content: separating the wheat from the chaff

Abstract

Integrity signals

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