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Mechanisms of Disease: the role of intestinal barrier function in the pathogenesis of gastrointestinal autoimmune diseases

Fasano, Alessio, Shea-Donohue, Terez·2005·Nature Clinical Practice Gastroenterology & Hepatology
DOI 10.1038/ncpgasthep0259
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Abstract

The primary functions of the gastrointestinal tract have traditionally been perceived to be limited to the digestion and absorption of nutrients and electrolytes, and to water homeostasis. A more attentive analysis of the anatomic and functional arrangement of the gastrointestinal tract, however, suggests that another extremely important function of this organ is its ability to regulate the trafficking of macromolecules between the environment and the host through a barrier mechanism. Together with the gut-associated lymphoid tissue and the neuroendocrine network, the intestinal epithelial barrier, with its intercellular tight junctions, controls the equilibrium between tolerance and immunity to nonself-antigens. When the finely tuned trafficking of macromolecules is dysregulated in genetically susceptible individuals, both intestinal and extraintestinal autoimmune disorders can occur. This new paradigm subverts traditional theories underlying the development of autoimmunity, which are based on molecular mimicry and/or the bystander effect, and suggests that the autoimmune process can be arrested if the interplay between genes and environmental triggers is prevented by re-establishing intestinal barrier function. Understanding the role of the intestinal barrier in the pathogenesis of gastrointestinal disease is an area of translational research that encompasses many fields and is currently receiving a great deal of attention. This review is timely given the increased interest…

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Crossref · 10.1038/ncpgasthep0259

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2 of 2 references verified0 citation errors · 0 not checkable

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  • The luminal-mucosal interface is where the majority of host-microbe interaction occurs, and exchange of molecules through the mucous layer and epithelium facilitates communication between the gut and the immune system through recognition of self and non-self antigens.

    “This luminal-mucosal interface is where the majority of host-microbe interaction occurs, and the exchange of molecules through the mucous layer and epithelium serve to facilitate communication between the gut and the immune system through the recognition of self and non-self antigens (Fasano and Shea-Donohue, 2005)”

    From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Fasano and Shea-Donohue, 2005

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Authors
Fasano, A., & Shea-Donohue, T.
Venue
Nature Clinical Practice Gastroenterology & Hepatology
Publisher
Springer Science and Business Media LLC
Published
2005-09
Volume
2
Issue
9
Pages
416-422
ISSN
  • 1743-4378
  • 1743-4386
DOI
10.1038/ncpgasthep0259
Cited by
399
References
2
Language
en
Licence
www.springer.com/tdm (tdm)

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