Altered intestinal permeability in patients with primary fibromyalgia and in patients with complex regional pain syndrome
Abstract
OBJECTIVES: The pain intensity of patients with FM has recently been reported to be correlated with the degree of small intestinal bacterial overgrowth (SIBO). SIBO is often associated with an increased intestinal permeability (IP). Increased IP, if shown in FM, may have pathogenetic relevance because it leads to the exposure of immune cells to luminal antigens and consequent immune modulation. It is currently unknown whether IP is altered in FM. We therefore examined the IP in a group of patients with primary FM and in two control groups, healthy volunteers and patients with an unrelated chronic pain syndrome, complex regional pain syndrome (CRPS). We hypothesized that patients with FM, but not volunteers or those patients with CRPS, would have altered IP. METHODS: Both gastroduodenal and small IP were assessed using an established three-sugar test, where urinary disaccharide excretion reflecting intestinal uptake was measured using HPLC. RESULTS: Forty patients with primary FM, 57 age- and sex-matched volunteers and 17 patients with CRPS were enrolled in this study. In the FM group, 13 patients had raised gastroduodenal permeability and 15 patients had raised small intestinal permeability, but only one volunteer had increased gastroduodenal permeability (P < 0.0001, chi-square test for the three groups). The IP values were significantly increased in the patient groups (P < 0.0003 for all comparisons, one-way analysis of variance). CONCLUSIONS: The IPs in primary FM and, unexpectedly, CRPS are increased. This study should stimulate further research to determine the implication of altered IP in the disease pathophysiology of FM and CRPS.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Increased intestinal permeability has been described in patients with chronic fatigue syndrome, fibromyalgia, and complex regional pain syndrome.
“Increased intestinal permeability has also been described in patients with chronic fatigue syndrome (CFS),37 fibromyalgia, and complex regional pain syndrome.38”
From The Gut Microbiome and the Brain (2014) · cites this paper as [38]
Cites
The american college of rheumatology 1990 criteria for the classification of fibromyalgia
Wolfe, F., Smythe, H. A., Yunus, M. B., Bennett, R. M., Bombardier, C., Goldenberg, D. L., Tugwell, P., Campbell, S. M., Abeles, M., Clark, P., et al. (1990) · Arthritis & Rheumatism · doi:10.1002/art.1780330203 · Cited by 9,563 · see citing works
International Association for the Study of Pain
Breivik, H. (2002) · Journal of Pain and Symptom Management · doi:10.1016/s0885-3924(02)00465-7 · Cited by 1,222 · see citing works
Reflex sympathetic dystrophy: changing concepts and taxonomy
Stanton-Hicks, M. D., Jänig, W., Hassenbusch, S. J., Haddox, J. D., Boas, R. A., & Wilson, P. (1995) · Pain · doi:10.1016/0304-3959(95)00110-e · Cited by 1,102 · see citing works
Immunity, Inflammation, and Allergy in the Gut
MacDonald, T. T., & Monteleone, G. (2005) · Science · doi:10.1126/science.1106442 · Cited by 1,035 · see citing works
Intestinal permeability: an overview
Bjarnason, I., Macpherson, A., & Hollander, D. (1995) · Gastroenterology · doi:10.1016/0016-5085(95)90708-4 · Cited by 927 · see citing works
Eradication of Small Intestinal Bacterial Overgrowth Reduces Symptoms of Irritable Bowel Syndrome
Pimentel, M., Chow, E. J., & Lin, H. C. (2000) · American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2000.03368.x · Cited by 780 · see citing works
Intestinal permeability and the prediction of relapse in Crohn's disease
Wyatt, J., Vogelsang, H., Hübl, W., Waldhoer, T., & Lochs, H. (1993) · The Lancet · doi:10.1016/0140-6736(93)90882-h · Cited by 626 · see citing works
Self-citationBruehl, S. P., Harden, N. R., Galer, B. S., Saltz, S., Bertram, M., Bačkonja, M., Gayles, R., Rudin, N. J., Bhugra, M. K., & Stanton-Hicks, M. D. (1999) · Pain · doi:10.1016/s0304-3959(99)00011-1 · Cited by 621 · see citing works
Clayburgh, D. R. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24970 · Cited by 419 · see citing works
Fasano, A., & Shea-Donohue, T. (2005) · Nature Clinical Practice Gastroenterology & Hepatology · doi:10.1038/ncpgasthep0259 · Cited by 399 · see citing works
Small Intestinal Bacterial Overgrowth: A Framework for Understanding Irritable Bowel Syndrome
Lin, H. C. (2004) · JAMA · doi:10.1001/jama.292.7.852 · Cited by 396 · see citing works
Bühner, S., Büning, C., Genschel, J., Kling, K., Herrmann, D., Dignass, A., Kuechler, I., Krueger, S., Schmidt, H. H.-J., & Lochs, H. (2005) · Gut · doi:10.1136/gut.2005.065557 · Cited by 366 · see citing works
Self-citationDifferential expression patterns of cytokines in complex regional pain syndrome
Üçeyler, N., Eberle, T., Rolke, R., Birklein, F., & Sommer, C. (2007) · Pain · doi:10.1016/j.pain.2007.07.031 · Cited by 350 · see citing works
Cytokines play an aetiopathogenetic role in fibromyalgia: a hypothesis and pilot study
Wallace, D. J., Linker‐Israeli, M., Hallegua, D. S., Silverman, S. L., Silver, D., & Weisman, M. H. (2001) · Lara D. Veeken · doi:10.1093/rheumatology/40.7.743 · Cited by 334 · see citing works
Rosenfeldt, V., Benfeldt, E., Valerius, N. H., Pærregaard, A., & Michaelsen, K. F. (2004) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2004.06.068 · Cited by 326 · see citing works
Watts, T. L., Berti, I., Sapone, A., Gerarduzzi, T., Not, T., Zielke, R. H., & Fasano, A. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500178102 · Cited by 313 · see citing works
Marshall, J. K., Thabane, M., Garg, A. X., Clark, W., Meddings, J., Collins, S. M., & for the WEL Investigators (2004) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2004.02284.x · Cited by 292 · see citing works
Wallon, C., Yang, P.-C., Keita, Å. V., Ericson, A.-C., McKay, D. M., Sherman, P. M., Perdue, M. H., & Söderholm, J. D. (2007) · Gut · doi:10.1136/gut.2006.117549 · Cited by 267 · see citing works
Reduced levels of antiinflammatory cytokines in patients with chronic widespread pain
Üçeyler, N., Valenza, R., Stock, M., Schedel, R., Sprotte, G., & Sommer, C. (2006) · Arthritis & Rheumatism · doi:10.1002/art.22026 · Cited by 251 · see citing works
Self-citationEdwin, A. D. (2006) · Frontiers in bioscience · doi:10.2741/1816 · Cited by 242 · see citing works
Maes, M., Mihaylova, I., & Leunis, J.-C. (2007) · Journal of Affective Disorders · doi:10.1016/j.jad.2006.08.021 · Cited by 197 · see citing works
Intestinal permeability and inflammation in patients on NSAIDs
Sigthorsson, G., Tibble, J. A., Hayllar, J. S., Menzies, I. S., Macpherson, A. J., Moots, R. J., Scott, D. L., Gumpel, M., & Bjarnason, I. (1998) · Gut · doi:10.1136/gut.43.4.506 · Cited by 190 · see citing works
Sucrose: A novel permeability marker for gastroduodenal disease
Meddings, J. B., Sutherland, L. R., Byles, N. I. A., & Wallace, J. L. (1993) · Gastroenterology · doi:10.1016/0016-5085(93)90637-r · Cited by 179 · see citing works
Ait-Belgnaoui, A., Bradesi, S., Fioramonti, J., Theodorou, V., & Bueno, L. (2005) · Pain · doi:10.1016/j.pain.2004.10.002 · Cited by 171 · see citing works
Enders, U., Karch, H., Toyka, K. V., MICHELS, M., Zielasek, J., Pette, M., Heesemann, J., & Hartung, H. (1993) · Annals of Neurology · doi:10.1002/ana.410340208 · Cited by 171 · see citing works
Cognitive impairment in patients with chronic pain: The significance of stress
Hart, R. P., Wade, J. B., & Martelli, M. F. (2003) · Current Pain and Headache Reports · doi:10.1007/s11916-003-0021-5 · Cited by 168 · see citing works
Nonsteroidal antiinflammatory drugs and the small intestine
Fortun, P., & Hawkey, C. J. (2005) · Current Opinion in Gastroenterology · doi:10.1097/01.mog.0000153314.51198.58 · Cited by 166 · see citing works
Pimentel, M., Wallace, D., Hallegua, D., Chow, E., Kong, Y., Park, S., & Lin, H. C. (2004) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2003.011502 · Cited by 147 · see citing works
Bowel dysfunction in fibromyalgia syndrome
Triadafilopoulos, G., Simms, R. W., & Goldenberg, D. L. (1991) · Digestive Diseases and Sciences · doi:10.1007/bf01300088 · Cited by 144 · see citing works
Özgöçmen, S., Özyurt, H., Söğüt, S., & Akyol, Ö. (2005) · Rheumatology International · doi:10.1007/s00296-005-0078-z · Cited by 121 · see citing works
INTESTINAL PERMEABILITY IN PATIENTS WITH ANKYLOSING SPONDYLITIS AND THEIR HEALTHY RELATIVES
MARTÍNEZ-GONZÁLEZ, O., Cantero-Hinojosa, J., PAULE-SASTRE, P., GÓMEZ-MAGÁN, J. C., & Ríos, D. S. (1994) · Lara D. Veeken · doi:10.1093/rheumatology/33.7.644 · Cited by 114 · see citing works
Luminal Bacteria and Small-Intestinal Permeability
Riordan, S. M., McIver, C. J., Thomas, D. H., Duncombe, V. M., Bolin, T. D., & Thomas, M. C. (1997) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365529709025099 · Cited by 95 · see citing works
Bühner, S., Reese, I., Kuehl, F., Lochs, H., & Zuberbier, T. (2004) · Allergy · doi:10.1111/j.1398-9995.2004.00631.x · Cited by 89 · see citing works
Self-citationHolden, W., Orchard, T., & Wordsworth, P. (2003) · Rheumatic Disease Clinics of North America · doi:10.1016/s0889-857x(03)00043-7 · Cited by 89 · see citing works
Nonsteroidal antiinflammatory drugs and the small intestine
Fortun, P., & Hawkey, C. J. (2007) · Current Opinion in Internal Medicine · doi:10.1097/mog.0b013e328020045a · Cited by 73 · see citing works
Reactive arthritis following an outbreak of Campylobacter jejuni infection.
Hannu, T. J., Kauppi, M. J., Tuomala, M., Laaksonen, I., Klemets, P., & Kuusi, M. (2004) · PubMed · Cited by 71 · see citing works
Uil, J. J., van Elburg, R. M., van Overbeek, F. M., Mulder, C. J. J., Henegouwen, G. P. V. B., & Heymans, H. S. A. (1997) · PubMed · Cited by 70 · see citing works
Is a leaky gut involved in the pathogenesis of intrahepatic cholestasis of pregnancy?†‡§
Reyes, H., Zapata, R., Hernández, I., Gotteland, M., Sandoval, L., Jirón, M. I., Palma, J., Almuna, R., V, & Silva, J. J. (2006) · Hepatology · doi:10.1002/hep.21099 · Cited by 65 · see citing works
Changes in Gastrointestinal Permeability in Celiac Disease
Vogelsang, H., Schwarzenhofer, M., & Oberhuber, G. (1998) · Digestive Diseases · doi:10.1159/000016886 · Cited by 62 · see citing works
Post-infectious irritable bowel syndrome
Rhodes, D. Y., & Wallace, M. R. (2006) · Current Gastroenterology Reports · doi:10.1007/s11894-006-0054-0 · Cited by 39 · see citing works
Th, S., Heesemann, J., Granfors, K., & Toivanen, A. (1989) · Annals of the Rheumatic Diseases · doi:10.1136/ard.48.7.577 · Cited by 35 · see citing works
Intestinal permeability in patients with yersinia triggered reactive arthritis.
Lahesmaa, R., Magnusson, K., Granfors, K., Leino, R., Sundqvist, T., & Toivanen, A. (1991) · Annals of the Rheumatic Diseases · doi:10.1136/ard.50.2.91 · Cited by 33 · see citing works
Liver Damage in Human Small Intestinal Bacterial Overgrowth
Riordan, S. M., Mclver, C. J., & Williams, R. L. (1998) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.1998.00234.x · Cited by 33 · see citing works
Deficiencies in Gut NK Cell Number and Function Precede Diabetes Onset in BB Rats
Todd, D. J., Forsberg, E. M., Greiner, D. L., Mordes, J. P., Rossini, A. A., & Bortell, R. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.9.5356 · Cited by 33 · see citing works
How Stress Induces Intestinal Hypersensitivity
Buret, A. G. (2006) · American Journal Of Pathology · doi:10.2353/ajpath.2006.050958 · Cited by 31 · see citing works
Karvar, Ş., Karch, H., Frosch, M., Burghardt, W., & Groß, U. (1997) · Journal of Clinical Microbiology · doi:10.1128/jcm.35.12.3058-3061.1997 · Cited by 25 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
The Gut Microbiome and the Brain
Galland, L. (2014) · Journal of Medicinal Food · doi:10.1089/jmf.2014.7000 · Cited by 648 · see citing works
Intestinal Permeability Defects: Is It Time to Treat?
Odenwald, M. A., & Turner, J. R. (2013) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2013.07.001 · Cited by 366 · see citing works
Acne vulgaris, probiotics and the gut-brain-skin axis - back to the future?
Bowe, W. P., & Logan, A. C. (2011) · Gut Pathogens · doi:10.1186/1757-4749-3-1 · Cited by 292 · see citing works
Fermented foods, microbiota, and mental health: ancient practice meets nutritional psychiatry
Selhub, E. M., Logan, A. C., & Bested, A. C. (2014) · Journal of Physiological Anthropology · doi:10.1186/1880-6805-33-2 · Cited by 280 · see citing works
Altered microbiome composition in individuals with fibromyalgia
Minerbi, A., Gonzalez, E., Brereton, N. J. B., Anjarkouchian, A., Dewar, K., Fitzcharles, M.-A., Chevalier, S., & Shir, Y. (2019) · Pain · doi:10.1097/j.pain.0000000000001640 · Cited by 220 · see citing works
Kohr, D., Singh, P., Tschernatsch, M., Kaps, M., Pouokam, E., Diener, M., Kummer, W., Birklein, F., Vincent, A. C., Göebel, A., et al. (2011) · Pain · doi:10.1016/j.pain.2011.06.012 · Cited by 191 · see citing works
Fibromyalgia: Recent Advances in Diagnosis, Classification, Pharmacotherapy and Alternative Remedies
Maffei, M. E. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21217877 · Cited by 150 · see citing works
Acne vulgaris, probiotics and the gut-brain-skin axis: from anecdote to translational medicine
Bowe, W. P., Patel, N., & Logan, A. C. (2013) · Beneficial Microbes · doi:10.3920/bm2012.0060 · Cited by 145 · see citing works
Bested, A. C., Logan, A. C., & Selhub, E. M. (2013) · Gut Pathogens · doi:10.1186/1757-4749-5-3 · Cited by 121 · see citing works
Martorell, P., Alvarez, B., Llopis, S., Navarro, V., Ortiz, P., González, N., Balaguer, F., Rojas, A., Chenoll, E., Ramón, D., et al. (2021) · Antioxidants · doi:10.3390/antiox10040536 · Cited by 116 · see citing works
Erdrich, S., Hawrelak, J. A., Myers, S. P., & Harnett, J. (2020) · BMC Musculoskeletal Disorders · doi:10.1186/s12891-020-03201-9 · Cited by 85 · see citing works
Risk factors associated with intestinal permeability in an adult population: A systematic review
Leech, B., McIntyre, E., Steel, A., & Sibbritt, D. W. (2019) · International Journal of Clinical Practice · doi:10.1111/ijcp.13385 · Cited by 72 · see citing works
Atopic dermatitis and the intestinal microbiota in humans and dogs
Craig, J. M. (2016) · Veterinary Medicine and Science · doi:10.1002/vms3.24 · Cited by 69 · see citing works
Anti-TNF-α antibodies improve intestinal barrier function in Crohn's disease
Noth, R., Stüber, E., Häsler, R., Nikolaus, S., Kühbacher, T., Hampe, J., Bewig, B., Schreiber, S., & Arlt, A. (2012) · Journal of Crohn s and Colitis · doi:10.1016/j.crohns.2011.10.004 · Cited by 68 · see citing works
Slim, M., Calandre, E. P., & Rico‐Villademoros, F. (2014) · Rheumatology International · doi:10.1007/s00296-014-3109-9 · Cited by 69 · see citing works
Clinical Evidence for the Microbiome in Inflammatory Diseases
Slingerland, A. E., Schwabkey, Z. I., Wiesnoski, D. H., & Jenq, R. R. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00400 · Cited by 64 · see citing works
Dworsky-Fried, Z., Kerr, B. J., & Taylor, A. M. W. (2020) · Neurobiology of Pain · doi:10.1016/j.ynpai.2020.100045 · Cited by 62 · see citing works
Intestinal Barrier Function and the Brain-Gut Axis
Alonso, C., Vicario, M., Pigrau, M., Lobo, B., & Santos, J. (2014) · Advances in experimental medicine and biology · doi:10.1007/978-1-4939-0897-4_4 · Cited by 57 · see citing works
The Microbiome and Mental Health: Looking Back, Moving Forward with Lessons from Allergic Diseases
Logan, A. C., Jacka, F. N., Craig, J. M., & Prescott, S. L. (2016) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2016.14.2.131 · Cited by 51 · see citing works
Detection of potential markers of primary fibromyalgia syndrome in human saliva
Bazzichi, L. M., Ciregia, F., Giusti, L., Baldini, C., Giannaccini, G., Giacomelli, C., Sernissi, F., Bombardieri, S., & Lucacchini, A. (2009) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.200900076 · Cited by 48 · see citing works
Penn, I., Chuang, E. Y.-Y., Chuang, T., Lin, C., & Kao, C. (2019) · BMJ Open · doi:10.1136/bmjopen-2018-026581 · Cited by 48 · see citing works
Prescott, S. L., Millstein, R. A., Katzman, M. A., & Logan, A. C. (2016) · International Journal of Biodiversity · doi:10.1155/2016/2718275 · Cited by 45 · see citing works
Zhou, Z., Hui, E. S. K., Kranz, G. S., Chang, J. R., de Luca, K. E., Pinto, S. M., Chan, W. W. Y., Yau, S., Chau, B. K. H., Samartzis, D., et al. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101767 · Cited by 46 · see citing works
Martı́n, F., Blanco-Suárez, M., Zambrano, P., Cáceres, O., Almirall, M., Alegre, J., Lobo, B., González-Castro, A. M., Santos, J., Domingo, J. C., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1253121 · Cited by 38 · see citing works
Fibromyalgia and its New Lessons for Neuropsychiatry
Duque, L., & Fricchione, G. L. (2019) · Medical science monitor basic research/Medical science monitor. Basic research · doi:10.12659/msmbr.915962 · Cited by 35 · see citing works
Autoimmunity in Complex‐Regional Pain Syndrome
Blaes, F., Tschernatsch, M., Bräu, M. E., Matz, O., SCHMITZ, K., Nascimento, D. S. M., Kaps, M., & Birklein, F. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1381.018 · Cited by 36 · see citing works
Food intolerance in dogs and cats
Craig, J. M. (2018) · Journal of Small Animal Practice · doi:10.1111/jsap.12959 · Cited by 35 · see citing works
Fang, H., Hou, Q., Zhang, W., Su, Z., Zhang, J., Li, J., Lin, J., Wang, Z., Yu, X., Yang, Y., et al. (2024) · The Journal of Pain · doi:10.1016/j.jpain.2024.104535 · Cited by 33 · see citing works
Silva, A. R., Bernardo, A., de Mesquita, M. F., Patto, J. V., Moreira, P. A. M., Silva, M. L., & Padrão, P. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.856216 · Cited by 25 · see citing works
Intestinal permeability measurements: general aspects and possible pitfalls.
Teixeira, T. F. S., Moreira, A. P. B., Souza, N. C., Frías, R., & Pelúzio, M. D. C. G. (2014) · PubMed · doi:10.3305/nh.2014.29.2.7076 · Cited by 21 · see citing works
Wang, J., Sung, F., Men, M., Wang, K. A., Lin, C., & Kao, C. (2017) · Pain · doi:10.1097/j.pain.0000000000000994 · Cited by 20 · see citing works
Small intestinal bacterial overgrowth
Parodi, A., Lauritano, E. C., Nardone, G., Fontana, L., Savarino, V., & Gasbarrini, A. (2009) · Digestive and Liver Disease Supplements · doi:10.1016/s1594-5804(09)60019-x · Cited by 18 · see citing works
Calandre, E. P., Hidalgo‐Tallon, J., Molina-Barea, R., Rico‐Villademoros, F., Molina‐Hidalgo, C., Garcia‐Leiva, J. M., Carrillo‐Izquierdo, M. D., & Slim, M. (2021) · Pharmaceuticals · doi:10.3390/ph14101063 · Cited by 18 · see citing works
Identification and Treatment of New Inflammatory Triggers for Complex Regional Pain Syndrome
Weinstock, L. B., Myers, T. L., Walters, A. S., Schwartz, O. A., Younger, J., Chopra, P. J., & Guarino, A. H. (2016) · A & A Case Reports · doi:10.1213/xaa.0000000000000292 · Cited by 16 · see citing works
Vilar, E. G., Oliva, S. L., Penadés, B. F., Niño, G. M. S., Lora, A. T., Rojo, S. S., & Martín, I. S. M. (2024) · Microorganisms · doi:10.3390/microorganisms12101969 · Cited by 15 · see citing works
Slim, M., Molina-Barea, R., Garcia‐Leiva, J. M., Rodriguez‐Lopez, C. M., Morillas-Arques, P., Rico‐Villademoros, F., & Calandre, E. P. (2014) · Contemporary Clinical Trials · doi:10.1016/j.cct.2014.11.019 · Cited by 15 · see citing works
Intestinal dysbiosis and hormonal neuroendocrine secretion in the fibromyalgic patient
Tomasello, G., Mazzola, M., Bosco, V., Tomasello, G., Damiani, P., Sinagra, E., & Carini, F. (2018) · Biomedical Papers · doi:10.5507/bp.2018.051 · Cited by 15 · see citing works
Neuroinflammation in fibromyalgia and CRPS is multifactorial
Vasquez, A. (2016) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2016.25 · Cited by 15 · see citing works
Microbiota-Accessible Boron-Containing Compounds in Complex Regional Pain Syndrome
Biță, C. E., Scorei, I. R., Vreju, F. A., Mușetescu, A. E., Mogoşanu, G. D., Biţă, A., Dinescu, V. C., Dinescu, Ș. C., Criveanu, C., Bărbulescu, A. L., et al. (2023) · Medicina · doi:10.3390/medicina59111965 · Cited by 14 · see citing works
Almirall, M., Casellas, F., Dot, J., de Torres, I. M., Segurola, H., & Marsal, S. (2022) · Rheumatology · doi:10.1093/rheumatology/keac434 · Cited by 13 · see citing works
Erdrich, S., Hawrelak, J. A., Myers, S. P., Vuyisich, M., & Harnett, J. (2023) · BMC Musculoskeletal Disorders · doi:10.1186/s12891-023-06259-3 · Cited by 10 · see citing works
Hydroxytyrosol as a Promising Ally in the Treatment of Fibromyalgia
Ramírez‐Tejero, J. A., Martínez‐Lara, E., Peinado, M. Á., del Moral, M. L., & Siles, E. (2020) · Nutrients · doi:10.3390/nu12082386 · Cited by 10 · see citing works
Silva, A. R., Bernardo, A., de Mesquita, M. F., Patto, J. V., Moreira, P. A. M., Silva, M. L., & Padrão, P. (2021) · Trials · doi:10.1186/s13063-021-05146-3 · Cited by 10 · see citing works
Association between fibromyalgia syndrome and peptic ulcer disease development
Wang, K. A., Wang, J., Lin, C., & Tseng, C. (2017) · PLoS ONE · doi:10.1371/journal.pone.0175370 · Cited by 9 · see citing works
Ruscio, M., Guard, G., Piedrahita, G., & D’Adamo, C. R. (2022) · Nutrients · doi:10.3390/nu14173572 · Cited by 10 · see citing works
Król, J., Brodziak, A., Litwińczuk, Z., & Barowsk, J. (2012) · InTech eBooks · doi:10.5772/46047 · Cited by 8 · see citing works
Restrictive Diets in Patients with Fibromyalgia: State of the Art
Almirall, M., Musté, M., Serrat, M., Touriño, R., Espartal, E., & Marsal, S. (2024) · Biomedicines · doi:10.3390/biomedicines12030629 · Cited by 6 · see citing works
Intestinal Permeability, Moderate Exercise, and Older Adult Health
Karper, W. B. (2011) · Holistic Nursing Practice · doi:10.1097/hnp.0b013e3181fe26ff · Cited by 6 · see citing works
Ievina, L., Fomins, N., Gudrā, D., Ķēniņa, V., Vilmane, A., Grāvelsiņa, S., Rasa, S., Murovska, M., Frīdmanis, D., & Nora-Krūkle, Z. (2024) · Biomolecules · doi:10.3390/biom14101291 · Cited by 6 · see citing works
Rodríguez-Bautista, J. C., López‐Lluch, G., Rodríguez-Torres, P., López-Moral, Á., Quijada-Carrera, J., Bueno‐Antequera, J., Blanco-Suárez, M., Cáceres-Calle, Ó., & Munguía‐Izquierdo, D. (2024) · Biomedicines · doi:10.3390/biomedicines12081895 · Cited by 5 · see citing works
Fibromyalgia diagnosis from a multi-omics approach: a gut feeling
Durán‐González, E., Ramírez‐Tejero, J. A., Pérez-Sánchez, M., Morales-Torres, C., Gómez-Morano, R., Díaz-López, C., Martínez‐Lara, A., & Cotán, D. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1641185 · Cited by 2 · see citing works
Does the levels of vitamin D correlate with the levels of vitamin B12 and ferritin in fibromyalgia?
Bakılan, F., Ortanca, B., Ekim, A. A., & Mutlu, F. (2023) · Journal of Surgery and Medicine · doi:10.28982/josam.7521 · Cited by 2 · see citing works
Pruebas de aliento basadas en hidrógeno
Maya, G. C. (2009) · Dialnet (Universidad de la Rioja) · Cited by 2 · see citing works
Minimally Invasive Image-Guided Gut Transport Function Measurement Probe
Otuya, D. O., Gavgiotaki, E., Carlson, C. J., Shi, S. Q. Z., Lee, A. J., Krall, A. A., Chung, A. S., Grant, C. N., Bhat, N. G. M., Choy, P., et al. (2021) · Frontiers in Physics · doi:10.3389/fphy.2021.735645 · Cited by 2 · see citing works
PSYCHO-EMOTIONAL STATE OF CHILDREN AND ADOLESCENTS WITH ACNE
Nosacheva, O. A., Karkashadze, G. A., & Namazov-Baranova, L. S. (2012) · Педиатрическая фармакология · doi:10.15690/pf.v9i4.389 · Cited by 2 · see citing works
Tungland, B. C. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-814649-1.00013-2 · Cited by 2 · see citing works
Regulatory roles of the microbiome in arthritis, fibromyalgia, and multiple sclerosis
Vázquez-Chinea, L. J., Johnson, S. N., & Lipski, E. A. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-822238-6.00028-5 · Cited by 1 · see citing works
Ding, X., Qiu, D., Li, X.-Y., Qiao, Y.-H., Hashimoto, K., Wang, X.-M., & Yang, J.-J. (2026) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2026.106949 · Cited by 1 · see citing works
ADVANCES IN TRANSLATIONAL SCIENCE
Sellin, J. H., Murthy, S. K., Goetz, M., Hoffman, A. W., & Kießlich, R. (2012) · Cited by 1 · see citing works
Unexplained Nausea and Weight Loss in Two Cases of Longstanding CRPS
Gupta, M., & Göebel, A. (2013) · Pain Medicine · doi:10.1111/pme.12190
A burning matter: Investigations into inflammation and central sensitization in CRPS
Fischer, S. G. L. (2014) · Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam)
Marum, A. P. (2016) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)
Bacterial Overgrowth of the Small Intestine Breath Test
James, M. (2013) · Elsevier eBooks · doi:10.1016/b978-1-4377-2333-5.00010-9
Bakılan, F., Uçan, A., & Ortanca, B. (2021) · OSMANGAZİ JOURNAL OF MEDICINE · doi:10.20515/otd.844052
Riché, D. (2017) · De Boeck Supérieur eBooks · doi:10.3917/dbu.riche.2017.02.0121
Análise molecular de DNA viral na parede de aneurismas intracranianos rotos e não rotos
Rabelo, N. N. (2021) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.5.2021.tde-11112021-140139
Bacterial Overgrowth of the Small Intestine Breath Test
James, M. (2020) · Elsevier eBooks · doi:10.1016/b978-0-323-43044-9.00009-1
SIBO, quand un mythe devient réalité
Escoda, T., Rétornaz, F., Plauzolles, A., & Halfon, P. (2024) · La Revue de Médecine Interne · doi:10.1016/j.revmed.2024.08.002
Jakobsson, J. E., Carlsson, H., Erngren, I., Menezes, J., Krock, E., Hunt, M. A., Sohlin, J. T., Al-Grety, A., Sándor, K., Kosek, E., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.10.17.618791
Silva, A. R., Bernardo, A., de Mesquita, M. F., Patto, J. V., Moreira, P., Silva, M. L., & Padrão, P. (2021) · Figshare · doi:10.6084/m9.figshare.14190359
Silva, A. R., Bernardo, A., de Mesquita, M. F., Patto, J. V., Moreira, P., Silva, M. L., & Padrão, P. (2021) · Figshare · doi:10.6084/m9.figshare.14190365
Silva, A. R., Bernardo, A., de Mesquita, M. F., Patto, J. V., Moreira, P., Silva, M. L., & Padrão, P. (2021) · Figshare · doi:10.6084/m9.figshare.14190362
Silva, A. R., Bernardo, A., de Mesquita, M. F., Patto, J. V., Moreira, P., Silva, M. L., & Padrão, P. (2021) · Figshare · doi:10.6084/m9.figshare.14190356
Jakobsson, J. E., Carlsson, H., Erngren, I., Menezes, J., Krock, E., Hunt, M. A., Sohlin, J. T., Al-Grety, A., Sándor, K., Kosek, E., et al. (2026) · Scientific Reports · doi:10.1038/s41598-026-40781-3 · Cited by 2 · see citing works
- Authors
- Goebel, A., Buhner, S., Schedel, R., Lochs, H., & Sprotte, G.
- Affiliations
- Universitätsklinikum Würzburg (DE)
- Venue
- Rheumatology
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-04-29
- Volume
- 47
- Issue
- 8
- Pages
- 1223-1227
- ISSN
- 1462-0324 (ISSN-L)
- 1462-0332
- OpenAlex
- W2140690831
- Cited by
- 76
- References
- 46
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 7 · 2023: 4 · 2022: 6 · 2021: 10 · 2020: 5 · 2019: 4 · 2018: 3 · 2017: 4 · 2016: 6 · 2014: 7 · 2013: 5 · 2012: 3
- FWCI
- 2.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Lara D. Veeken (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- intestinal permeability, primary fibromyalgia, complex regional pain syndrome, small intestinal bacterial overgrowth, chronic pain, immunomodulation
- MeSH terms
- Adult, Female, Fibromyalgia, Gastric Mucosa, Humans, Intestinal Absorption, Intestine, Small, Male, Middle Aged, Pain Measurement, Permeability, Complex Regional Pain Syndromes
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
