Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease

Romeo, Stefano, Kozlitina, Julia, Xing, Chao, Pertsemlidis, Alexander, Cox, David, Pennacchio, Len A, Boerwinkle, Eric, Cohen, Jonathan C +1 more·2008·Nature Genetics
DOI 10.1038/ng.257

Cited by (143)

Items 101–143 of 143

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  2. Hepatocellular carcinoma in nonalcoholic fatty liver: role of environmental and genetic factors
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  5. Is moderate alcohol use in nonalcoholic fatty liver disease good or bad? A critical review
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  9. Spatial transcriptomics of healthy and fibrotic human liver at single-cell resolution
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  11. Hepatic Fat Accumulation Is Modulated by the Interaction between the rs738409 Variant in the PNPLA3 Gene and the Dietary Omega6/Omega3 PUFA Intake
    Santoro, Nicola, Savoye, Mary, Kim, Grace, Marotto, Katie, Shaw, Melissa M., Pierpont, Bridget, Caprio, Sonia · 2012 · PLoS ONE
  12. Three-Dimensional spatially resolved geometrical and functional models of human liver tissue reveal new aspects of NAFLD progression
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  13. Nonalcoholic fatty liver disease – current status and future directions
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  14. Circulating phospholipid patterns in NAFLD patients associated with a combination of metabolic risk factors
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  15. Genetic variation in the ABCA1 gene, HDL cholesterol, and risk of ischemic heart disease in the general population
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  16. Strain dependence of diet‐induced <scp>NASH</scp> and liver fibrosis in obese mice is linked to diabetes and inflammatory phenotype
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  17. Spectrum of alcoholic liver disease
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  18. Emerging role of genomic analysis in clinical evaluation of lean individuals with NAFLD
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  19. Hepatokines and non-alcoholic fatty liver disease
    Lebensztejn, Dariusz M., Flisiak-Jackiewicz, Marta, Białokoz-Kalinowska, Irena, Bobrus-Chociej, Anna, Kowalska, Irina · 2016 · Acta Biochimica Polonica
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  21. PNPLA3 expression and its impact on the liver: current perspectives
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  22. PNPLA3 as a therapeutic target for fatty liver disease: the evidence to date
    Cherubini, Alessandro, Casirati, Elia, Tomasi, Melissa, Valenti, Luca · 2021 · Expert Opinion on Therapeutic Targets
  23. Longer lactation duration is associated with decreased prevalence of non-alcoholic fatty liver disease in women
    Ajmera, Veeral H., Terrault, Norah A., VanWagner, Lisa B., Sarkar, Monika, Lewis, Cora E., Carr, John J., Gunderson, Erica P. · 2019 · Journal of Hepatology
  24. Positive selection of somatically mutated clones identifies adaptive pathways in metabolic liver disease
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  25. The immune landscape in nonalcoholic steatohepatitis
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  26. Familial coaggregation of MASLD with hepatocellular carcinoma and adverse liver outcomes: nationwide multigenerational cohort study
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  27. Hepatic deletion of Mboat7 (LPIAT1) causes activation of SREBP-1c and fatty liver
    Xia, Mingfeng, Chandrasekaran, Preethi, Rong, Shunxing, Fu, Xiaorong, Mitsche, Matthew A. · 2021 · Journal of Lipid Research
  28. Impact of PNPLA3 rs738409 polymorphism on the development of liver-related events in patients with nonalcoholic fatty liver disease
    Rosso, Chiara, Caviglia, Gian Paolo, Birolo, Giovanni, Armandi, Angelo, Pennisi, Grazia, Pelusi, Serena, Younes, Ramy, Liguori, Antonio, Perez-Diaz-del-Campo, Nuria, Nicolosi, Aurora et al. · 2023 · Clinical Gastroenterology and Hepatology
  29. A sequential algorithm combining ADAPT and liver stiffness can stage metabolic-associated fatty liver disease in hospital-based and primary care patients
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  30. Risk for hepatic and extra-hepatic outcomes in nonalcoholic fatty liver disease
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  31. Role of CC chemokine receptor 9 in the progression of murine and human non-alcoholic steatohepatitis
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  32. Genetic-related and carbohydrate-related factors affecting liver fat accumulation
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  33. Quantitative modeling of human liver reveals dysregulation of glycosphingolipid pathways in nonalcoholic fatty liver disease
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  34. Baseline Parameters in Clinical Trials for Nonalcoholic Steatohepatitis: Recommendations From the Liver Forum
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  35. Association of HSD17B13 and PNPLA3 With Liver Enzymes and Fibrosis in Hispanic/Latino Individuals of Diverse Genetic Ancestries
    Rutledge, Stephanie M., Soper, Emily R., Ma, Ning, Pejaver, Vikas, Friedman, Scott L., Branch, Andrea D., Kenny, Eimear E., Belbin, Gillian M., Abul-Husn, Noura S. · 2023 · Clinical Gastroenterology and Hepatology
  36. Targeting MASLD and MASH in the US Hispanic/Latino Population: A Review
    Cumpian, Nicholas A., Gutierrez, Julio A., Wu, William, Saab, Sammy · 2025 · JAMA Internal Medicine
  37. The PNPLA3 I148M variant is associated with transaminase elevations in type 2 diabetes patients treated with basal insulin peglispro
    Pillai, S, Duvvuru, S, Bhatnagar, P, Foster, W, Farmen, M, Shankar, S, Harris, C, Bastyr, E, Hoogwerf, B, Haupt, A · 2018 · The Pharmacogenomics Journal
  38. Increased genetic risk for β-cell failure is associated with β-cell function decline in people with prediabetes
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  39. PNPLA3 148M/M Is More Susceptible to Palmitic Acid-Induced Endoplasmic Reticulum Stress-Associated Apoptosis in HepG2 Cells
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  42. Mendelian Randomization Analysis Dissects the Relationship between NAFLD, T2D, and Obesity and Provides Implications to Precision Medicine
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