Cited by 142Liver Disease Diagnosis and TreatmentFatty Acid Research and HealthAlcohol Consumption and Health Effects

Omega-3 polyunsaturated fatty acids as a treatment strategy for nonalcoholic fatty liver disease

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Jump, Donald B., Lytle, Kelli A., Depner, Christopher M., Tripathy, Sasmita·2018·Pharmacology & Therapeutics

Abstract

Obese and type 2 diabetic (T2DM) patients have a high prevalence of nonalcoholic fatty liver disease (NAFLD). NAFLD is a continuum of chronic liver diseases ranging from benign hepatosteatosis to nonalcoholic steatohepatitis (NASH), cirrhosis and primary hepatocellular cancer (HCC). Because of its strong association with the obesity epidemic, NAFLD is rapidly becoming a major public health concern worldwide. Surprisingly, there are no FDA approved NAFLD therapies; and current therapies focus on the co-morbidities associated with NAFLD, namely, obesity, hyperglycemia, dyslipidemia, and hypertension. The goal of this review is to provide background on the disease process, discuss human studies and preclinical models that have examined treatment options. We also provide an in-depth rationale for the use of dietary ω3 polyunsaturated fatty acid (ω3 PUFA) supplements as a treatment option for NAFLD. This focus is based on recent studies indicating that NASH patients and preclinical mouse models of NASH have low levels of hepatic C 20-22 ω3 PUFA. This decline in hepatic PUFA may account for the major phenotypic features associated with NASH, including steatosis, inflammation and fibrosis. Finally, our discussion will address the strengths and limitations of ω3 PUFA supplements use in NAFLD therapy.

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  1. Brasaemle DL 2007 The perilipin family of structural lipid droplet proteins: stabilization of lipid droplets and control of lipolysis J Lipid Res 48 2547 2559 17878492
  2. Cordain L Eaton SB Sebastian A Mann N Lindeberg S Watkins BA O’Keefe JH Brand-Miller J 2005 Orgins and evolution of the western diet: health implications for the 21st century Am J Clin Nutr 81 341 354 15699220
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Authors
Jump, D. B., Lytle, K. A., Depner, C. M., & Tripathy, S.
Affiliations
Oregon State University (US)
Venue
Pharmacology & Therapeutics
Publisher
Elsevier BV
Published
2018-01
Volume
181
Pages
108-125
ISSN
0163-7258 (ISSN-L)
OpenAlex
W2735867008
Cited by
142
References
218
Citations by year
2026: 13 · 2025: 8 · 2024: 20 · 2023: 21 · 2022: 14 · 2021: 18 · 2020: 23 · 2019: 12 · 2018: 11 · 2017: 2
FWCI
1.74
Type
journal article
Language
en
Open access
Locations
  • Pharmacology & Therapeutics (acceptedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute of Food and Agriculture (2009-65200-05846)
  • National Institutes of Health (DK 094600)
Topics
  • Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
Keywords
omega-3 polyunsaturated fatty acids, non-alcoholic fatty liver disease, nonalcoholic steatohepatitis, dietary supplementation, hepatic steatosis, liver fibrosis, liver inflammation, obesity, type 2 diabetes
MeSH terms
Animals, Disease Models, Animal, Humans, Fatty Acids, Omega-3, Disease Progression, Non-alcoholic Fatty Liver Disease

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