Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization
Open accessAbstract
Allergen-specific immunoglobulin E (present in allergic sensitization) has a central role in the pathogenesis of allergic disease. We performed the first large-scale genome-wide association study (GWAS) of allergic sensitization in 5,789 affected individuals and 10,056 controls and followed up the top SNP at each of 26 loci in 6,114 affected individuals and 9,920 controls. We increased the number of susceptibility loci with genome-wide significant association with allergic sensitization from three to ten, including SNPs in or near TLR6, C11orf30, STAT6, SLC25A46, HLA-DQB1, IL1RL1, LPP, MYC, IL2 and HLA-B. All the top SNPs were associated with allergic symptoms in an independent study. Risk-associated variants at these ten loci were estimated to account for at least 25% of allergic sensitization and allergic rhinitis. Understanding the molecular mechanisms underlying these associations may provide new insights into the etiology of allergic disease.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
An accompanying GWAS on allergic sensitization showed strong overlap between top hits for sensitization and self-reported allergies.
“In an accompanying GWAS on allergic sensitization, there was strong overlap between top hits for sensitization and self-reported allergies.487,493”
From International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis (2018) · cites this paper as [493]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
LocusZoom: regional visualization of genome-wide association scan results
Pruim, R. J., Welch, R. P., Sanna, S., Teslovich, T. M., Chines, P. S., Gliedt, T. P., Boehnke, M., Abecasis, G. R., & Willer, C. J. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btq419 · Cited by 2,707 · see citing works
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis
The International Multiple Sclerosis Genetics Consortium & The Wellcome Trust Case Control Consortium 2 (2011) · Nature · doi:10.1038/nature10251 · Cited by 2,697 · see citing works
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease
the NIDDK IBD Genetics Consortium, Barrett, J. C., the Belgian-French IBD Consortium, the Wellcome Trust Case Control Consortium, Hansoul, S., Nicolae, D. L., Cho, J. H., Duerr, R. H., Rioux, J. D., Brant, S. R., et al. (2008) · Nature Genetics · doi:10.1038/ng.175 · Cited by 2,593 · see citing works
Franke, A., McGovern, D. P. B., Barrett, J. C., Wang, K., Radford-Smith, G. L., Ahmad, T., Lees, C. W., Balschun, T., Lee, J., Roberts, R., et al. (2010) · Nature Genetics · doi:10.1038/ng.717 · Cited by 2,520 · see citing works
Self-citationJohansson, S. G. O., Bieber, T., Dahl, R., Friedmann, P. S., Lanier, B. Q., Lockey, R. F., Motala, C., Ortega Martell, J. A., Platts-Mills, T. A. E., Ring, J., et al. (2004) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2003.12.591 · Cited by 2,391 · see citing works
lumi : a pipeline for processing Illumina microarray
Du, P., Kibbe, W. A., & Lin, S. M. (2008) · Bioinformatics · doi:10.1093/bioinformatics/btn224 · Cited by 2,028 · see citing works
A Large-Scale, Consortium-Based Genomewide Association Study of Asthma
Moffatt, M. F., Gut, I. G., Démenais, F., Strachan, D. P., Bouzigon, E., Heath, S. C., von Mutius, E., Farrall, M., Lathrop, M. G., & Cookson, W. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa0906312 · Cited by 2,003 · see citing works
Self-citationMatrix eQTL: ultra fast eQTL analysis via large matrix operations
Shabalin, A. A. (2012) · Bioinformatics · doi:10.1093/bioinformatics/bts163 · Cited by 1,694 · see citing works
Anderson, C. A., Boucher, G., Lees, C. W., Franke, A., D’Amato, M., Taylor, K. D., Lee, J. C., Goyette, P., Imielinski, M. B., Latiano, A., et al. (2011) · Nature Genetics · doi:10.1038/ng.764 · Cited by 1,312 · see citing works
Self-citationGenetics of gene expression and its effect on disease
Emilsson, V., Thorleifsson, G., Zhang, B., Leonardson, A. S., Zink, F., Zhu, J., Carlson, S., Helgason, A., Walters, G. B., Gunnarsdottir, S., et al. (2008) · Nature · doi:10.1038/nature06758 · Cited by 1,296 · see citing works
Transcriptional regulation and transformation by Myc proteins
Adhikary, S., & Eilers, M. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1703 · Cited by 1,122 · see citing works
Strange, A., Spencer, C. C. A., Band, G., Bellenguez, C., Freeman, C., Pirinen, M., Rautanen, A., Su, Z., Donnelly, P., Capon, F., et al. (2010) · Nature Genetics · doi:10.1038/ng.694 · Cited by 1,042 · see citing works
Self-citationEndotyping asthma: new insights into key pathogenic mechanisms in a complex, heterogeneous disease
Anderson, G. P. (2008) · The Lancet · doi:10.1016/s0140-6736(08)61452-x · Cited by 997 · see citing works
Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction
Gudbjartsson, D. F., Björnsdóttir, U. S., Halapi, E. C., Helgadóttir, A., Sulem, P., Jonsdottir, G. M., Þorleifsson, G., Helgadottir, H. T., Steinthórsdóttir, V., Stefánsson, H., et al. (2009) · Nature Genetics · doi:10.1038/ng.323 · Cited by 761 · see citing works
Self-citationDiscovering susceptibility genes for asthma and allergy
Vercelli, D. (2008) · Nature Reviews Immunology · doi:10.1038/nri2257 · Cited by 635 · see citing works
Genetics and Beyond – The Transcriptome of Human Monocytes and Disease Susceptibility
Zeller, T., Wild, P. S., Szymczak, S., Rotival, M., Schillert, A., Castagné, R., Maouche, S., Germain, M., Lackner, K. J., Rossmann, H., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010693 · Cited by 584 · see citing works
Fairfax, B. P., Makino, S., Radhakrishnan, J., Plant, K., Leslie, S., Dilthey, A., Ellis, P., Langford, C., Vannberg, F. O., & Knight, J. C. (2012) · Nature Genetics · doi:10.1038/ng.2205 · Cited by 486 · see citing works
Self-citationSegrè, A. V., DIAGRAM Consortium, MAGIC investigators, Groop, L., Mootha, V. K., Daly, M. J., & Altshuler, D. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1001058 · Cited by 463 · see citing works
Matrix eQTL: Ultra fast eQTL analysis via large matrix operationsPreprint
Shabalin, A. A. (2011) · arXiv (Cornell University) · doi:10.17615/g28n-r219 · Cited by 452 · see citing works
Martin, A. M., Nolan, D. A., Gaudieri, S., Almeida, C. A., Nolan, R., JAMES, I. R., Carvalho, F., Phillips, E. J., Christiansen, F., Purcell, A. W., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307067101 · Cited by 450 · see citing works
Raychaudhuri, S., Plenge, R. M., Rossin, E. J., Ng, A., Purcell, S., Sklar, P. B., Scolnick, E. M., Xavier, R. J., Altshuler, D., & Daly, M. J. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000534 · Cited by 422 · see citing works
Identification of IL6R and chromosome 11q13.5 as risk loci for asthma
Ferreira, M. A., Matheson, M. C., Duffy, D. L., Marks, G. B., Hui, J., Le Souëf, P., Danoy, P., Baltic, S., Nyholt, D. R., Jenkins, M., et al. (2011) · The Lancet · doi:10.1016/s0140-6736(11)60874-x · Cited by 381 · see citing works
Self-citationPaternoster, L., Standl, M., Chen, C., Ramasamy, A., Bønnelykke, K., Duijts, L., Ferreira, M. A. R., Alves, A. C., Thyssen, J. P., Albrecht, E., et al. (2011) · Nature Genetics · doi:10.1038/ng.1017 · Cited by 351 · see citing works
Self-citationA common variant on chromosome 11q13 is associated with atopic dermatitis
Esparza-Gordillo, J., Weidinger, S., Fölster-Holst, R., Bauerfeind, A., Ruschendorf, F., Patone, G., Rohde, K., Marenholz, I., Schulz, F., Kerscher, T., et al. (2009) · Nature Genetics · doi:10.1038/ng.347 · Cited by 317 · see citing works
Self-citationRole for Bcl-6 in the generation and maintenance of memory CD8+ T cells
Ichii, H., Sakamoto, A., Hatano, M., Okada, S., Toyama, H., Taki, S., Arima, M., 嘉和, 黒., & Tokuhisa, T. (2002) · Nature Immunology · doi:10.1038/ni802 · Cited by 258 · see citing works
Hinds, D. A., McMahon, G., Kiefer, A. K., Do, C. B., Eriksson, N., Evans, D. M., St Pourcain, B., Ring, S. M., Mountain, J. L., Francke, U., et al. (2013) · Nature Genetics · doi:10.1038/ng.2686 · Cited by 246 · see citing works
Self-citationRamasamy, A., Curjuric, I., Coin, L. J., Kumar, A., McArdle, W. L., Imboden, M., Leynaert, B., Kogevinas, M., Schmid-Grendelmeier, P., Pekkanen, J., et al. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.08.030 · Cited by 222 · see citing works
Self-citationRole for Bcl-6 in the generation and maintenance of memory CD8[+] T cells
市井, 啓. (2002) · Kobe University Repository Kernel (Kobe University) · Cited by 192 · see citing works
Rathmann, W., Straßburger, K., Heier, M., Holle, R., Thorand, B., Giani, G., & Meisinger, C. (2009) · Diabetic Medicine · doi:10.1111/j.1464-5491.2009.02863.x · Cited by 181 · see citing works
The Identification of MicroRNAs in a Genomically Unstable Region of Human Chromosome 8q24
Huppi, K. E., Volfovsky, N., Runfola, T., Jones, T. L., Mackiewicz, M., Martin, S. E., Mushinski, J. F., Stephens, R. M., & Caplen, N. J. (2008) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-07-0105 · Cited by 178 · see citing works
Toll-like receptor heterodimer variants protect from childhood asthma
Kormann, M., Depner, M., Hartl, D., Klopp, N., Illig, T., Adamski, J., Vogelberg, C., Weiland, S. K., von Mutius, E., & Kabesch, M. (2008) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2008.04.039 · Cited by 155 · see citing works
TOLL -like Receptor 10 Genetic Variation Is Associated with Asthma in Two Independent Samples
Lazarus, R. M., Raby, B. A., Lange, C., Silverman, E. K., Kwiatkowski, D. J., Vercelli, D., Klimecki, W. J., Martínez, F. D., & Weiss, S. T. (2004) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200404-491oc · Cited by 135 · see citing works
Current concepts of IgE regulation and impact of genetic determinants
Potaczek, D. P., & Kabesch, M. (2012) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2011.03953.x · Cited by 124 · see citing works
Rabin, R. L., & Levinson, A. I. (2008) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2008.03679.x · Cited by 119 · see citing works
Pvt1-encoded microRNAs in oncogenesis
Beck‐Engeser, G., Lum, A. M., Huppi, K. E., Caplen, N. J., Wang, B., & Wabl, M. R. (2008) · Retrovirology · doi:10.1186/1742-4690-5-4 · Cited by 115 · see citing works
Asthma Genetics and Intermediate Phenotypes: A Review From Twin Studies
Los, H., Postmus, P. E., & Boomsma, D. I. (2001) · Twin Research · doi:10.1375/1369052012191 · Cited by 97 · see citing works
Genetic variations in toll-like receptor pathway genes influence asthma and atopy
Tesse, R., Pandey, R. C., & Kabesch, M. (2010) · Allergy · doi:10.1111/j.1398-9995.2010.02489.x · Cited by 83 · see citing works
Savenije, O. E. M., Kerkhof, M., Reijmerink, N. E., Brunekreef, B., de Jongste, J. C., Smit, H. A., Wijga, A. H., Postma, D. S., & Koppelman, G. H. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.12.014 · Cited by 78 · see citing works
Self-citationFamily based association analysis of the IL2 and IL15 genes in allergic disorders
Christensen, U., Haagerup, A., Binderup, H. G., Vestbo, J., Kruse, T. A., & Børglum, A. D. (2005) · European Journal of Human Genetics · doi:10.1038/sj.ejhg.5201541 · Cited by 46 · see citing works
HLA genetics and allergic disease.
Howell, W. M., & Holgate, S. T. (1995) · Thorax · doi:10.1136/thx.50.8.815 · Cited by 44 · see citing works
Impact of common regulatory single-nucleotide variants on gene expression profiles in whole blood
Mehta, D., Heim, K., Herder, C., Carstensen, M., Eckstein, G., Schurmann, C., Homuth, G., Nauck, M. A., Völker, U., Roden, M., et al. (2012) · European Journal of Human Genetics · doi:10.1038/ejhg.2012.106 · Cited by 41 · see citing works
Self-citationMultivariate genetic analysis of atopy phenotypes in a selected sample of twins
Thomsen, S. F., Ulrik, C. S., Kyvik, K. O., Ferreira, M. A. R., & Backer, V. (2006) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2006.02512.x · Cited by 36 · see citing works
Self-citationA study of asthma severity in adult twins
Thomsen, S. F., van der Sluis, S., Kyvik, K. O., & Backer, V. (2011) · The Clinical Respiratory Journal · doi:10.1111/j.1752-699x.2011.00273.x · Cited by 26 · see citing works
Reijmerink, N. E., Kerkhof, M., Bottema, R. W. B., Gerritsen, J., Stelma, F. F., Thijs, C. T., van Schayck, O. C. P., Smit, H. A., Brunekreef, B., Postma, D. S., et al. (2011) · European Respiratory Journal · doi:10.1183/09031936.00099210 · Cited by 21 · see citing works
Self-citationVIZ-GRAIL: visualizing functional connections across disease loci
Raychaudhuri, S. (2011) · Bioinformatics · doi:10.1093/bioinformatics/btr185 · Cited by 13 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
The effect of host genetics on the gut microbiome
Bonder, M. J., Kurilshikov, A., Tigchelaar, E. F., Mujagic, Z., Imhann, F., Vila, A. V., Deelen, P., Vatanen, T., Schirmer, M., Smeekens, S. P., et al. (2016) · Nature Genetics · doi:10.1038/ng.3663 · Cited by 819 · see citing works
Revisiting IL-2: Biology and therapeutic prospects
Abbas, A. K., Trotta, E., Simeonov, D. R., Marson, A., & Bluestone, J. A. (2018) · Science Immunology · doi:10.1126/sciimmunol.aat1482 · Cited by 631 · see citing works
Paternoster, L., Kemp, J. P., Zheng, J., Smith, G. D., Relton, C. L., Evans, D. M., McArdle, W. L., Henderson, A. J., Standl, M., Tiesler, C. M. T., et al. (2015) · Nature Genetics · doi:10.1038/ng.3424 · Cited by 614 · see citing works
Self-citationInternational Consensus Statement on Allergy and Rhinology: Allergic Rhinitis
Wise, S. K., Lin, S. Y., Toskala, E., Orlandi, R. R., Akdis, C. A., Alt, J. A., Azar, A., Baroody, F. M., Bachert, C., Canonica, G. W., et al. (2018) · International Forum of Allergy & Rhinology · doi:10.1002/alr.22073 · Cited by 557 · see citing works
Schizophrenia Working Group of the Psychiatric Genomics Consortium, Loh, P.-R., Bhatia, G., Gusev, A., Finucane, H. K., Bulik-Sullivan, B. K., Pollack, S. J., de Candia, T. R., Lee, S. H., Wray, N. R., et al. (2015) · Nature Genetics · doi:10.1038/ng.3431 · Cited by 449 · see citing works
International consensus statement on allergy and rhinology: Allergic rhinitis – 2023
Wise, S. K., Damask, C. C., Roland, L. T., Ebert, C. S., Levy, J. M., Lin, S. Y., Luong, A., Rodriguez, K., Sedaghat, A. R., Toskala, E. M., et al. (2023) · International Forum of Allergy & Rhinology · doi:10.1002/alr.23090 · Cited by 554 · see citing works
Pathogenesis of allergic diseases and implications for therapeutic interventions
Wang, J., Zhou, Y., Zhang, H., Hu, L., Liu, J., Wang, L., Wang, T., Zhang, H., Cong, L., & Wang, Q. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01344-4 · Cited by 415 · see citing works
Kottyan, L. C., Davis, B. P., Sherrill, J. D., Liu, K., Rochman, M., Kaufman, K. M., Weirauch, M. T., Vaughn, S. E., Lázaro, S., Rupert, A., et al. (2014) · Nature Genetics · doi:10.1038/ng.3033 · Cited by 305 · see citing works
Deschamps, M., Laval, G., Fagny, M., Itan, Y., Abel, L., Casanova, J.-L., Patin, E., & Quintana-Murci, L. (2016) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2015.11.014 · Cited by 257 · see citing works
Cellular and molecular mechanisms of allergic asthma
Komlósi, Z. I., van de Veen, W., Kovács, N., Szűcs, G., Sokołowska, M., O’Mahony, L., Akdiş, M., & Akdiş, C. A. (2021) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2021.100995 · Cited by 260 · see citing works
Hinds, D. A., McMahon, G., Kiefer, A. K., Do, C. B., Eriksson, N., Evans, D. M., St Pourcain, B., Ring, S. M., Mountain, J. L., Francke, U., et al. (2013) · Nature Genetics · doi:10.1038/ng.2686 · Cited by 246 · see citing works
Self-citationEarly life microbial exposures and allergy risks: opportunities for prevention
Renz, H. E., & Skevaki, C. L. (2020) · Nature reviews. Immunology · doi:10.1038/s41577-020-00420-y · Cited by 261 · see citing works
Moderate-to-severe asthma in individuals of European ancestry: a genome-wide association study
Shrine, N. R. G., Portelli, M. A., John, C., Artigas, M. S., Bennett, N., Hall, R., Lewis, J., Henry, A. P., Billington, C. K., Ahmad, A., et al. (2018) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(18)30389-8 · Cited by 244 · see citing works
Self-citationHong, X., Hao, K., Ladd‐Acosta, C., Hansen, K. D., Tsai, H., Liu, X., Xu, X. P., Thornton, T. A., Caruso, D., Keet, C. A., et al. (2015) · Nature Communications · doi:10.1038/ncomms7304 · Cited by 247 · see citing works
Self-citationGWAS identifies four novel eosinophilic esophagitis loci
Abou‐Sleiman, P. M., Wang, M., Cianferoni, A., Aceves, S. S., Gonsalves, N. P., Nadeau, K. C., Bredenoord, A. J., Furuta, G. T., Spergel, J. M., & Hakonarson, H. H. (2014) · Nature Communications · doi:10.1038/ncomms6593 · Cited by 241 · see citing works
Ferreira, M. A. R., Matheson, M. C., Tang, C. S., Granell, R., Ang, W., Hui, J., Kiefer, A. K., Duffy, D. L., Baltic, S., Danoy, P., et al. (2014) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.10.030 · Cited by 216 · see citing works
Self-citationGenetic risk factors for the development of allergic disease identified by genome‐wide association
Portelli, M. A., Hodge, E., & Sayers, I. (2015) · Clinical & Experimental Allergy · doi:10.1111/cea.12327 · Cited by 206 · see citing works
PVT1: A Rising Star among Oncogenic Long Noncoding RNAs
Colombo, T., Farina, L., Macino, G., & Paci, P. (2015) · BioMed Research International · doi:10.1155/2015/304208 · Cited by 208 · see citing works
Yin, X., Low, H. Q., Wang, L., Li, Y., Ellinghaus, E., Han, J., Estivill, X., Sun, L., Zuo, X., Shen, C., et al. (2015) · Nature Communications · doi:10.1038/ncomms7916 · Cited by 200 · see citing works
Self-citationCockroach allergen exposure and risk of asthma
Do, D. C., Zhao, Y., & Gao, P. (2015) · Allergy · doi:10.1111/all.12827 · Cited by 194 · see citing works
A decade of research on the 17q12-21 asthma locus: Piecing together the puzzle
Stein, M. M., Thompson, E. E., Schoettler, N., Helling, B. A., Magnaye, K. M., Stanhope, C. T., Igartua, C., Morin, A., Washington, C., Nicolae, D. L., et al. (2018) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2017.12.974 · Cited by 181 · see citing works
Self-citationHpARI protein secreted by a helminth parasite suppresses interleukin-33
Osbourn, M., Soares, D. C., Vacca, F., Cohen, E. S., Scott, I. C., Gregory, W. F., Smyth, D. J., Toivakka, M., Kemter, A. M., le Bihan, T., et al. (2017) · Immunity · doi:10.1016/j.immuni.2017.09.015 · Cited by 178 · see citing works
Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles
Goldstein, J. I., Jarskog, L. F., Hilliard, C., Alfirevic, A., Duncan, L. E., Fourches, D., Huang, H., Lek, M., Neale, B. M., Ripke, S., et al. (2014) · Nature Communications · doi:10.1038/ncomms5757 · Cited by 178 · see citing works
Respiratory Syncytial Virus Disease Is Mediated by Age-Variable IL-33
Saravia, J., You, D., Shrestha, B., Jaligama, S., Siefker, D. T., Lee, G. I., Harding, J. N., Jones, T. L., Rovnaghi, C. R., Bagga, B., et al. (2015) · PLoS Pathogens · doi:10.1371/journal.ppat.1005217 · Cited by 170 · see citing works
The environment, epigenome, and asthma
Yang, I. V., Lozupone, C., & Schwartz, D. A. (2017) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2017.05.011 · Cited by 170 · see citing works
Waage, J., collaborators, A., Standl, M., Curtin, J. A., Jessen, L. E., Thorsen, J., Tian, C., Schoettler, N., Flores, C., Abdellaoui, A., et al. (2018) · Nature Genetics · doi:10.1038/s41588-018-0157-1 · Cited by 167 · see citing works
Self-citationAlves, A. C., Silva, N. M. G. D., Karhunen, V., Sovio, U., Das, S., Taal, H. R., Warrington, N. M., Lewin, A., Kaakinen, M., Cousminer, D. L., et al. (2019) · Science Advances · doi:10.1126/sciadv.aaw3095 · Cited by 153 · see citing works
Self-citationSystems biology of asthma and allergic diseases: A multiscale approach
Bunyavanich, S., & Schadt, E. E. (2014) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.10.015 · Cited by 147 · see citing works
ZNF341 controls STAT3 expression and thereby immunocompetence
Frey-Jakobs, S., Hartberger, J. M., Fliegauf, M., Bossen, C., Wehmeyer, M. L., Neubauer, J. C., Bulashevska, A., Proietti, M., Fröbel, P., Nöltner, C., et al. (2018) · Science Immunology · doi:10.1126/sciimmunol.aat4941 · Cited by 148 · see citing works
Self-citationDobbyn, A. L., Huckins, L. M., Boocock, J., Sloofman, L. G., Glicksberg, B. S., Giambartolomei, C., Hoffman, G. E., Perumal, T. M., Girdhar, K., Jiang, Y., et al. (2018) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2018.04.011 · Cited by 142 · see citing works
International consensus (ICON) on: clinical consequences of mite hypersensitivity, a global problem
Sánchez‐Borges, M., Fernández‐Caldas, E., Thomas, W. R., Chapman, M. D., Lee, B. W., Caraballo, L. R., Acevedo, N., Chew, F. T., Ansotegui, I. J., Behrooz, L., et al. (2017) · World Allergy Organization Journal · doi:10.1186/s40413-017-0145-4 · Cited by 136 · see citing works
Regulatory polymorphisms modulate the expression of HLA class II molecules and promote autoimmunity
Raj, P., Rai, E., Song, R., Khan, S., Wakeland, B., Viswanathan, K., Arana, C., Liang, C., Zhang, B., Dozmorov, I. M., et al. (2016) · eLife · doi:10.7554/elife.12089 · Cited by 131 · see citing works
Rhinitis associated with asthma is distinct from rhinitis alone: The ARIA‐MeDALL hypothesis
Bousquet, J., Melén, E., Haahtela, T., Koppelman, G. H., Togias, A. G., Valenta, R., Akdiş, C. A., Czarlewski, W., Rothenberg, M. E., Valiulis, A., et al. (2023) · Allergy · doi:10.1111/all.15679 · Cited by 135 · see citing works
Self-citationHuman germline heterozygous gain-of-function <i>STAT6</i> variants cause severe allergic disease
Sharma, M., Leung, D., Momenilandi, M., Jones, L. C. W., Pacillo, L., James, A. E., Murrell, J. R., Delafontaine, S., Maimaris, J., Vaseghi-Shanjani, M., et al. (2023) · Journal of Experimental Medicine · doi:10.1084/jem.20221755 · Cited by 125 · see citing works
Self-citationAsthma Genetics in the Post-GWAS Era
Ober, C. (2016) · Annals of the American Thoracic Society · doi:10.1513/annalsats.201507-459mg · Cited by 115 · see citing works
Immunoregulatory functions and the therapeutic implications of GARP-TGF-β in inflammation and cancer
Metelli, A., Salem, M. A., Wallace, C. H., Wu, B. X., Li, A., Li, X., & Li, Z. (2018) · Journal of Hematology & Oncology · doi:10.1186/s13045-018-0570-z · Cited by 114 · see citing works
Zhang, Y., Collier, F., Naselli, G., Saffery, R., Tang, M. L. K., Allen, K. J., Ponsonby, A., Harrison, L. C., Vuillermin, P., & on behalf of the BIS Investigator Group (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aad4322 · Cited by 111 · see citing works
Recent findings in the genetics and epigenetics of asthma and allergy
Kabesch, M., & Tost, J. (2020) · Seminars in Immunopathology · doi:10.1007/s00281-019-00777-w · Cited by 107 · see citing works
Lessons Learned From GWAS of Asthma
Kim, K. W., & Ober, C. (2019) · Allergy Asthma and Immunology Research · doi:10.4168/aair.2019.11.2.170 · Cited by 109 · see citing works
The role of environmental factors in allergy: A critical reappraisal
Gilles, S., Akdis, C., Lauener, R., Schmid‐Grendelmeier, P., Bieber, T., Schäppi, G., & Traidl‐Hoffmann, C. (2018) · Experimental Dermatology · doi:10.1111/exd.13769 · Cited by 97 · see citing works
Chronic Periodontitis Genome-wide Association Studies
Rhodin, K. E., Divaris, K., North, K. E., Barros, S. P., MOSS, K. L., Beck, J. D., & Offenbacher, S. (2014) · Journal of Dental Research · doi:10.1177/0022034514544506 · Cited by 97 · see citing works
Genetics and Epigenetics in Allergic Rhinitis
Choi, B. Y., Han, M. S., Kwak, J. W., & Kim, T. H. (2021) · Genes · doi:10.3390/genes12122004 · Cited by 101 · see citing works
Ballardini, N., Bergström, A., Wahlgren, C., van Hage, M., Hallner, E., Kull, I., Melén, E., Anto, J. M., Bousquet, J., & Wickman, M. C. (2015) · Allergy · doi:10.1111/all.12798 · Cited by 96 · see citing works
Genome‐wide association studies of atopic dermatitis
Tamari, M., & Hirota, T. (2014) · The Journal of Dermatology · doi:10.1111/1346-8138.12321 · Cited by 94 · see citing works
Identification of Four Novel Loci in Asthma in European American and African American Populations
Almoguera, B., Vazquez, L., Mentch, F. D., Connolly, J. J., Pacheco, J. A., Sundaresan, A. S., Peissig, P. L., Linneman, J. G., McCarty, C. A., Crosslin, D. R., et al. (2016) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201604-0861oc · Cited by 94 · see citing works
Melén, E., Bergström, A., Kull, I., Almqvist, C., Andersson, N., Asarnoj, A., Borres, M. P., Georgellis, A., Pershagen, G., Westman, M., et al. (2020) · Clinical and Translational Allergy · doi:10.1186/s13601-020-00319-w · Cited by 94 · see citing works
Molecular Biology of Atopic Dermatitis
Mu, Z., Zhao, Y. P., Liu, X., Chang, C. C.-C., & Zhang, J. (2014) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-014-8415-1 · Cited by 95 · see citing works
Genetics of allergy and allergic sensitization: common variants, rare mutations
Bønnelykke, K., Sparks, R., Waage, J., & Milner, J. D. (2015) · Current Opinion in Immunology · doi:10.1016/j.coi.2015.08.002 · Cited by 73 · see citing works
Self-citationVenturelli, N., Lexmond, W. S., Ohsaki, A., Nurko, S., Karasuyama, H., Fiebiger, E., & Oyoshi, M. K. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2016.02.034 · Cited by 75 · see citing works
Type 2 Inflammation in Eosinophilic Esophagitis: From Pathophysiology to Therapeutic Targets
Racca, F., Pellegatta, G., Cataldo, G., Vespa, E., Carlani, E., Pelaia, C., Paoletti, G., Messina, M., Nappi, E., Canonica, G. W., et al. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2021.815842 · Cited by 78 · see citing works
HLA and asthma phenotypes/endotypes: A review
Kontakioti, E., Domvri, K., Papakosta, D., & Daniilidis, M. (2014) · Human Immunology · doi:10.1016/j.humimm.2014.06.022 · Cited by 70 · see citing works
Li, J., Zhang, Y., & Zhang, L. (2014) · Current Opinion in Allergy and Clinical Immunology · doi:10.1097/aci.0000000000000124 · Cited by 70 · see citing works
Skin care interventions in infants for preventing eczema and food allergy
Kelleher, M. M., Phillips, R., Brown, S., Cro, S., Cornelius, V. R., Carlsen, K. C. L., Skjerven, H. O., Rehbinder, E. M., Lowe, A. J., Dissanayake, E., et al. (2022) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd013534.pub3 · Cited by 75 · see citing works
Self-citationBunyavanich, S., Schadt, E. E., Himes, B. E., Lasky-Su, J. A., Qiu, W., Lazarus, R. M., Ziniti, J. P., Cohain, A. T., Linderman, M. D., Torgerson, D. G., et al. (2014) · BMC Medical Genomics · doi:10.1186/1755-8794-7-48 · Cited by 69 · see citing works
Risk of Autoimmunity in EoE and Families: A Population-Based Cohort Study
Peterson, K. A., Firszt, R., Fang, J. C., Wong, J., Smith, K. R., & Allen‐Brady, K. (2016) · The American Journal of Gastroenterology · doi:10.1038/ajg.2016.185 · Cited by 67 · see citing works
Shared genetic variants suggest common pathways in allergy and autoimmune diseases
Kreiner‐Møller, E., Waage, J., Standl, M., Brix, S., Pers, T. H., Alves, A. C., Warrington, N. M., Tiesler, C. M. T., Fuertes, E., Franke, L., et al. (2017) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2016.10.055 · Cited by 66 · see citing works
Self-citationCohort Profile: The Tasmanian Longitudinal Health STUDY (TAHS)
Matheson, M. C., Abramson, M. J., Allen, K. J., Benke, G., Burgess, J. A., Dowty, J. G., Erbas, B., Feather, I. H., Frith, P. A., Giles, G. G., et al. (2016) · International Journal of Epidemiology · doi:10.1093/ije/dyw028 · Cited by 63 · see citing works
Self-citationGermline Features Associated with Immune Infiltration in Solid Tumors
Shahamatdar, S., He, M. X., Reyna, M. A., Gusev, A., AlDubayan, S. H., Allen, E. M. V., & Ramachandran, S. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.02.039 · Cited by 61 · see citing works
Molecular Mechanisms of Nasal Epithelium in Rhinitis and Rhinosinusitis
Toppila-Salmi, S., van Drunen, C. M., Fokkens, W. J., Golebski, K., Mattila, P., Joenvaara, S., Renkonen, J., & Renkonen, R. (2015) · Current Allergy and Asthma Reports · doi:10.1007/s11882-014-0495-8 · Cited by 57 · see citing works
Targeting alarmins in asthma: From bench to clinic
Akenroye, A. T., Boyce, J. A., & Kita, H. (2025) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2025.01.017 · Cited by 60 · see citing works
IL-33 and Thymic Stromal Lymphopoietin in mast cell functions
Saluja, R., Zoltowska, A., Ketelaar, M. E., & Nilsson, G. P. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.04.047 · Cited by 58 · see citing works
Genome-wide association study of recalcitrant atopic dermatitis in Korean children
Kim, K. W., Myers, R. A., Lee, J. H., Igartua, C., Lee, K. E., Kim, Y. H., Kim, E., Yoon, D., Lee, J.-S., Hirota, T., et al. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.03.030 · Cited by 56 · see citing works
Age-of-onset information helps identify 76 genetic variants associated with allergic disease
Ferreira, M. A. R., Vonk, J. M., Baurecht, H., Marenholz, I., Tian, C., Hoffman, J., Helmer, Q., Tillander, A., Ullemar, V., Lu, Y., et al. (2020) · PLoS Genetics · doi:10.1371/journal.pgen.1008725 · Cited by 53 · see citing works
Self-citationLu, C., Liu, Z., Liao, H., Yang, W., Li, Q., & Liu, Q. (2022) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2022.114076 · Cited by 52 · see citing works
Schoos, A. M., Chawes, B., Rasmussen, M. A., Bloch, J., Bønnelykke, K., & Bisgaard, H. F. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.10.004 · Cited by 50 · see citing works
Self-citationB lymphocytes confer immune tolerance via cell surface GARP-TGF-β complex
Wallace, C. H., Wu, B. X., Salem, M. A., Ansa-Addo, E. A., Metelli, A., Sun, S., Gilkeson, G. S., Shlomchik, M. J., Liu, B., & Li, Z. (2018) · JCI Insight · doi:10.1172/jci.insight.99863 · Cited by 50 · see citing works
Influences of Maternal Factors Over Offspring Allergies and the Application for Food Allergy
Fujimura, T., Lum, S. Z. C., Nagata, Y., Kawamoto, S., & Oyoshi, M. K. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01933 · Cited by 52 · see citing works
Computational analysis of multimorbidity between asthma, eczema and rhinitis
Aguilar, D., Pinart, M., Koppelman, G. H., Saeys, Y., Nawijn, M. C., Postma, D. S., Akdiş, M., Auffray, C., Ballereau, S. J., Benet, M., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0179125 · Cited by 48 · see citing works
Self-citationNasal DNA methylation at three CpG sites predicts childhood allergic disease
van Breugel, M., Qi, C., Xu, Z., Pedersen, C. T., Petoukhov, I., Vonk, J. M., Gehring, U., Berg, M., Bügel, M., Carpaij, O. A., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-35088-6 · Cited by 49 · see citing works
Self-citationMiddeldorp, C. M., Felix, J. F., Mahajan, A., & McCarthy, M. I. (2019) · European Journal of Epidemiology · doi:10.1007/s10654-019-00502-9 · Cited by 43 · see citing works
Circular PVT1: an oncogenic non-coding RNA with emerging clinical importance
Adhikary, J., Chakraborty, S., Dalal, S., Basu, S., Dey, A., & Ghosh, A. (2019) · Journal of Clinical Pathology · doi:10.1136/jclinpath-2019-205891 · Cited by 47 · see citing works
Yu, C.-H. A., Pal, L. R., & Moult, J. (2016) · OMICS A Journal of Integrative Biology · doi:10.1089/omi.2016.0063 · Cited by 43 · see citing works
The intersect of genetics, environment, and microbiota in asthma-perspectives and challenges
Tang, H. H. F., Teo, S. M., Sly, P. D., Holt, P. G., & Inouye, M. (2021) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2020.08.026 · Cited by 43 · see citing works
Self-citationHost genetics and parasitic infections
Mangano, V. D., & Modiano, D. (2014) · Clinical Microbiology and Infection · doi:10.1111/1469-0691.12793 · Cited by 44 · see citing works
Walker, M. M., Powell, N., & Talley, N. J. (2014) · Expert Review of Gastroenterology & Hepatology · doi:10.1586/17474124.2014.881716 · Cited by 43 · see citing works
Discovery of Genetic Variation on Chromosome 5q22 Associated with Mortality in Heart Failure
Smith, J. G., Felix, J. F., Morrison, A. C., Kalogeropoulos, A. P., Trompet, S., Wilk, J. B., Gidlöf, O., Wang, X., Morley, M. P., Mendelson, M., et al. (2016) · PLoS Genetics · doi:10.1371/journal.pgen.1006034 · Cited by 42 · see citing works
Højfeldt, S. G., Wolthers, B. O., Tulstrup, M., Abrahamsson, J., Gupta, R., Harila‐Saari, A. H., Heyman, M. M., Henriksen, L. T., Jónsson, Ó. G., Lähteenmäki, P. M., et al. (2018) · British Journal of Haematology · doi:10.1111/bjh.15660 · Cited by 43 · see citing works
Self-citationLau, M. Y. Z., Dharmage, S. C., Burgess, J. A., Win, A. K., Lowe, A. J., Lodge, C., Perret, J. L., Hui, J., Thomas, P. S., Morrison, S. C., et al. (2017) · Scientific Reports · doi:10.1038/srep43681 · Cited by 40 · see citing works
Self-citationMulti-omics in Allergic Rhinitis: Mechanism Dissection and Precision Medicine
Hao, Y., Yang, Y., Zhao, H., Chen, Y., Zuo, T., Zhang, Y., Yu, H., Cui, L., & Song, X. (2025) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-025-09028-3 · Cited by 37 · see citing works
Jones, A. V., Tilley, M. K., Gutteridge, A., Hyde, C. L., Nagle, M. W., Ziemek, D., Gorman, D. N., Fauman, E. B., Chen, X., Miller, M. R., et al. (2017) · Human Molecular Genetics · doi:10.1093/hmg/ddx036 · Cited by 37 · see citing works
Laulajainen‐Hongisto, A., Lyly, A., Hanif, T., Dhaygude, K., Kankainen, M., Renkonen, R., Donner, K. M., Mattila, P., Jartti, T. T., Bousquet, J., et al. (2020) · Clinical and Translational Allergy · doi:10.1186/s13601-020-00347-6 · Cited by 38 · see citing works
Role of epigenetics in the development of childhood asthma
Davidson, E., & Yang, I. V. (2018) · Current Opinion in Allergy and Clinical Immunology · doi:10.1097/aci.0000000000000429 · Cited by 36 · see citing works
Manz, J., Rodríguez, E., ElSharawy, A., Oesau, E.-M., Petersen, B., Baurecht, H., Gabriele Mayr, B., Weber, S., Harder, J., Reischl, E., et al. (2016) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2016.07.009 · Cited by 35 · see citing works
Self-citationMechanisms of gastrointestinal allergic disorders
Azouz, N. P., & Rothenberg, M. E. (2019) · Journal of Clinical Investigation · doi:10.1172/jci124604 · Cited by 35 · see citing works
Genetic regulation ofIL1RL1methylation and IL1RL1-a protein levels in asthma
Dijk, F. N., Xu, C., Melén, E., Carsin, A., Kumar, A., Nolte, I. M., Gruzieva, O., Pershagen, G., Grotenboer, N. S., Savenije, O. E. M., et al. (2018) · European Respiratory Journal · doi:10.1183/13993003.01377-2017 · Cited by 34 · see citing works
Self-citationBrandt, C., Bongcam‐Rudloff, E., & Müller, B. (2020) · Applied Sciences · doi:10.3390/app10217518 · Cited by 34 · see citing works
Schoos, A.-M. M., Chawes, B. L., Jelding-Dannemand, E., Elfman, L. B., & Bisgaard, H. (2016) · Allergy · doi:10.1111/all.12853 · Cited by 32 · see citing works
Self-citationFine mapping of the celiac disease-associated LPP locus reveals a potential functional variant
de Almeida, R. C., Ricaño-Ponce, I., Kumar, V., Deelen, P., Szperl, A., Trynka, G., Gutierrez‐Achury, J., Kanterakis, A., Westra, H.-J., Franke, L., et al. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt619 · Cited by 33 · see citing works
O’Neal, W. K., Gallins, P. J., Pace, R. G., Dang, H., Wolf, W., Jones, L. C., Guo, X., Zhou, Y., Madar, V., Huang, J., et al. (2015) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2014.12.022 · Cited by 32 · see citing works
Epigenomics and Allergic Disease
Lockett, G. A., Patil, V. K., Soto-Ramírez, N., Ziyab, A. H., Holloway, J. W., & Karmaus, W. (2013) · Epigenomics · doi:10.2217/epi.13.68 · Cited by 32 · see citing works
Replication of genomewide associations with allergic sensitization and allergic rhinitis
Nilsson, D., Henmyr, V., Halldén, C., Säll, T., Kull, I., Wickman, M. C., Melén, E., & Cardell, L. (2014) · Allergy · doi:10.1111/all.12495 · Cited by 31 · see citing works
Recent advances in the pathological understanding of eosinophilic esophagitis
Cianferoni, A., Spergel, J. M., & Muir, A. B. (2015) · Expert Review of Gastroenterology & Hepatology · doi:10.1586/17474124.2015.1094372 · Cited by 31 · see citing works
van Ginkel, C. D., Pettersson, M. E., Dubois, A. E. J., & Koppelman, G. H. (2018) · Allergy · doi:10.1111/all.13432 · Cited by 31 · see citing works
Self-citationAssociation between Irritable Bowel Syndrome and Allergic Diseases: To Make a Case for Aeroallergen
Loo, E. X. L., Wang, D. Y., & Siah, K. T. H. (2019) · International Archives of Allergy and Immunology · doi:10.1159/000503629 · Cited by 31 · see citing works
Decreased Histone Acetylation Levels at Th1 and Regulatory Loci after Induction of Food Allergy
Alhamwe, B. A., Meulenbroek, L. A. P. M., Veening-Griffioen, D. H., Wehkamp, T., Alhamdan, F., Miethe, S., Harb, H., Hogenkamp, A., Knippels, L. M. J., von Strandmann, E. P., et al. (2020) · Nutrients · doi:10.3390/nu12103193 · Cited by 31 · see citing works
Expression of Toll‐like receptors in nasal epithelium in allergic rhinitis
Renkonen, J., Toppila-Salmi, S., Joenväärä, S., Mattila, P., Parviainen, V. I., Hagström, J., Haglund, C., Lehtonen, M., & Renkonen, R. (2015) · Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS) · doi:10.1111/apm.12408 · Cited by 31 · see citing works
Radakovics, K., Battin, C., Leitner, J., Geiselhart, S., Paster, W., Stöckl, J., Hoffmann-Sommergruber, K., & Steinberger, P. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2021.817604 · Cited by 28 · see citing works
The Role of TLRs in Obesity and Its Related Metabolic Disorders
Campos-Bayardo, T. I., Román-Rojas, D., García-Sánchez, A., Cardona-Muñóz, E. G., Sánchez-Lozano, D. I., Totsuka-Sutto, S. E., Gómez-Hermosillo, L. F., Casillas-Moreno, J., Sierra, J. A., Pazarín–Villaseñor, L., et al. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26052229 · Cited by 33 · see citing works
Immune‐mediated diseases and microbial exposure in early life
Bisgaard, H. F., Bønnelykke, K., & Stokholm, J. (2014) · Clinical & Experimental Allergy · doi:10.1111/cea.12291 · Cited by 29 · see citing works
Self-citationRowe, R. K., & Gill, M. A. (2014) · Immunology and Allergy Clinics of North America · doi:10.1016/j.iac.2014.09.012 · Cited by 28 · see citing works
- Authors
- Australian Asthma Genetics Consortium (AAGC), Bønnelykke, K., the EArly Genetics and Lifecourse Epidemiology (EAGLE) Consortium, Matheson, M. C., Pers, T. H., Granell, R., Strachan, D. P., Alves, A. C., Linneberg, A., Curtin, J. A., Warrington, N. M., Standl, M., Kerkhof, M., Jonsdottir, I., Bukvic, B. K., Kaakinen, M., Sleimann, P., Thorleifsson, G., Thorsteinsdottir, U., Schramm, K., Baltic, S., Kreiner-Møller, E., Simpson, A., Pourcain, B. S., Coin, L., Hui, J., Walters, E. H., Tiesler, C. M. T., Duffy, D. L., Jones, G., Ring, S. M., McArdle, W. L., Price, L., Robertson, C. F., Pekkanen, J., Tang, C. S., Thiering, E., Montgomery, G. W., Hartikainen, A.-L., Dharmage, S. C., Husemoen, L. L., Herder, C., Kemp, J. P., Elliot, P., James, A., Waldenberger, M., Abramson, M. J., Fairfax, B. P., Knight, J. C., Gupta, R., Thompson, P. J., Holt, P., Sly, P., Hirschhorn, J. N., Blekic, M., Weidinger, S., Hakonarsson, H., Stefansson, K., Heinrich, J., Postma, D. S., Custovic, A., Pennell, C. E., Jarvelin, M.-R., Koppelman, G. H., Timpson, N., Ferreira, M. A., & Bisgaard, H.
- Affiliations
- University of Copenhagen (DK)
- The University of Melbourne (AU)
- Broad Institute (US)
- University of Bristol (GB)
- University of London (GB)
- Imperial College London (GB)
- Glostrup Hospital (DK)
- National Health Service (GB)
- The University of Western Australia (AU)
- Helmholtz Munich (DE)
- University Medical Center Groningen (NL)
- University of Oulu (FI)
- University of Tasmania (AU)
- QIMR Berghofer Medical Research Institute (AU)
- Western Sydney University (AU)
- Murdoch Children's Research Institute (AU)
- University of Eastern Finland (FI)
- Deutsches Diabetes-Zentrum e.V. (DE)
- Monash University (AU)
- Centre for Human Genetics (GB)
- Technical University of Denmark (DK)
- The Kids Research Institute Australia (AU)
- The University of Queensland (AU)
- University Hospital Schleswig-Holstein (DE)
- Corresponding author
- Bønnelykke, Klaus
- ORCID
- Bønnelykke, Klaus
- Matheson, Melanie C
- Pers, Tune H
- Granell, Raquel
- Strachan, David P
- Alves, Alexessander Couto
- Linneberg, Allan
- Curtin, John A
- Warrington, Nicole M
- Standl, Marie
- Kerkhof, Marjan
- Kaakinen, Marika
- Schramm, Katharina
- Baltic, Svetlana
- Simpson, Angela
- Coin, Lachlan
- Hui, Jennie
- Walters, Eugene H
- Duffy, David L
- Ring, Susan M
- McArdle, Wendy L
- Pekkanen, Juha
- Tang, Clara S
- Thiering, Elisabeth
- Montgomery, Grant W
- Dharmage, Shyamali C
- Husemoen, Lise L
- Herder, Christian
- Kemp, John P
- Abramson, Michael J
- Fairfax, Benjamin P
- Knight, Julian C
- Gupta, Ramneek
- Thompson, Philip J
- Holt, Patrick
- Sly, Peter
- Hirschhorn, Joel N
- Weidinger, Stephan
- Heinrich, Joachim
- Postma, Dirkje S
- Pennell, Craig E
- Koppelman, Gerard H
- Timpson, Nicholas
- Ferreira, Manuel A
- Bisgaard, Hans
- Venue
- Nature Genetics
- Published
- 2013-06-30
- Volume
- 45
- Issue
- 8
- Pages
- 902-906
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- PMC
- PMC4922420
- OpenAlex
- W2128738903
- Cited by
- 244
- References
- 45
- Citations by year
- 2026: 2 · 2025: 10 · 2024: 7 · 2023: 11 · 2022: 16 · 2021: 19 · 2020: 22 · 2019: 12 · 2018: 23 · 2017: 22 · 2016: 27 · 2015: 33 · 2014: 32 · 2013: 8
- FWCI
- 4.09
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Genetics (publishedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eCite Digital Repository (University of Tasmania) (submittedVersion)
- UWA Profiles and Research Repository (UWA) (submittedVersion)
- FedUni ResearchOnline (Federation University Australia) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
- Site cant be reached (submittedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Technical University of Denmark, DTU Orbit (Technical University of Denmark, DTU) (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
- Explore Bristol Research (submittedVersion)
- Bristol Research (University of Bristol) (submittedVersion)
- Hirsla (Landspítali University Hospital) (submittedVersion)
- STM:n Hallinnonalan avoin julkaisuarkisto (Julkari) (submittedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Funders
- Wellcome Trust (092731, 090532)
- National Institute for Health and Care Research (ACF-2008-13-017, CL-2012-13-004)
- Lundbeckfonden (R16-2007-1694)
- Medical Research Council (MR/K002449/1, MC_PC_15018)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Keywords
- allergen sensitization, genetic susceptibility loci, allergic rhinitis, atopic diseases, allergen-specific immunoglobulin E, TLR6, STAT6, HLA-DQB1, ST2, LPP, c-Myc, interleukin-2, HLA-B, SLC25A46, genetic risk variants
- MeSH terms
- Alleles, Humans, Hypersensitivity, Phenotype, Signal Transduction, Computational Biology, Polymorphism, Single Nucleotide, Genomics, Quantitative Trait Loci, Gene Regulatory Networks, Genome-Wide Association Study, Genetic Loci
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
