Genome-wide association identifies the first risk loci for psychosis in Alzheimer disease
Open accessPublished version of a preprint
Abstract
Psychotic symptoms, defined as the occurrence of delusions or hallucinations, are frequent in Alzheimer disease (AD with psychosis, AD + P). AD + P affects ~50% of individuals with AD, identifies a subgroup with poor outcomes, and is associated with a greater degree of cognitive impairment and depressive symptoms, compared to subjects without psychosis (AD - P). Although the estimated heritability of AD + P is 61%, genetic sources of risk are unknown. We report a genome-wide meta-analysis of 12,317 AD subjects, 5445 AD + P. Results showed common genetic variation accounted for a significant portion of heritability. Two loci, one in ENPP6 (rs9994623, O.R. (95%CI) 1.16 (1.10, 1.22), p = 1.26 × 10-8) and one spanning the 3'-UTR of an alternatively spliced transcript of SUMF1 (rs201109606, O.R. 0.65 (0.56-0.76), p = 3.24 × 10-8), had genome-wide significant associations with AD + P. Gene-based analysis identified a significant association with APOE, due to the APOE risk haplotype ε4. AD + P demonstrated negative genetic correlations with cognitive and educational attainment and positive genetic correlation with depressive symptoms. We previously observed a negative genetic correlation with schizophrenia; instead, we now found a stronger negative correlation with the related phenotype of bipolar disorder. Analysis of polygenic risk scores supported this genetic correlation and documented a positive genetic correlation with risk variation for AD, beyond the effect of ε4. We also document a small set of SNPs likely to affect risk for AD + P and AD or schizophrenia. These findings provide the first unbiased identification of the association of psychosis in AD with common genetic variation and provide insights into its genetic architecture.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282 · see citing works
PLINK: a tool set for whole-genome association and population-based linkage analyses.
Purcell, S., Neale, B., Todd-Brown, K., Thomas, L., Ferreira, M. A. R., Bender, D., Maller, J., Sklar, P., de Bakker, P. I. W., Daly, M. J., et al. (2007) · The American Journal of Human Genetics · doi:10.1086/519795 · Cited by 34,089 · see citing works
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984) · Neurology · doi:10.1212/wnl.34.7.939 · Cited by 27,915 · see citing works
Hirono, N., Mori, E., Ikejiri, Y., Imamura, T., Shimomura, T., Hashimoto, M., Yamashita, H., & Ikeda, M. (1997) · PubMed · Cited by 21,010 · see citing works
Kok, J. S., Berg, I. J., & Scherder, E. J. A. (2013) · Dementia and Geriatric Cognitive Disorders Extra · doi:10.1159/000353441 · Cited by 20,589 · see citing works
Older Adults' Reasons for Using Technology while Aging in Place
Peek, S. T. M., Luijkx, K. G., Rijnaard, M. D., Nieboer, M. E., van der Voort, C. S., Aarts, S., van Hoof, J., Vrijhoef, H. J., & Wouters, E. (2015) · Gerontology · doi:10.1159/000430949 · Cited by 19,803 · see citing works
Sensitivity and False Alarm Rate of a Fall Sensor in Long-Term Fall Detection in the Elderly
Kangas, M., Korpelainen, R., Vikman, I., Nyberg, L., & Jämsä, T. J. (2014) · Gerontology · doi:10.1159/000362720 · Cited by 19,003 · see citing works
A global reference for human genetic variation
The 1000 Genomes Project Consortium, authors, C., Auton, A., Abecasis, G. R., Steering committee, Altshuler, D. M., Durbin, R. M., Abecasis, G. R., Bentley, D. R., Chakravarti, A., et al. (2015) · Nature · doi:10.1038/nature15393 · Cited by 18,247 · see citing works
Second-generation PLINK: rising to the challenge of larger and richer datasets
Chang, C. C., Chow, C. C., Tellier, L. C., Vattikuti, S., Purcell, S. M., & Lee, J. J. (2015) · Gigascience · doi:10.1186/s13742-015-0047-8 · Cited by 12,709 · see citing works
The Brief Psychiatric Rating Scale.
Overall, J. E., & Gorham, D. R. (1962) · Psychological Reports · doi:10.2466/pr0.1962.10.3.799 · Cited by 11,090 · see citing works
GCTA: a tool for genome-wide complex trait analysis
Yang, J., Lee, S. H., Goddard, M. E., & Visscher, P. M. (2011) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2010.11.011 · Cited by 8,279 · see citing works
Biological insights from 108 schizophrenia-associated genetic loci
Schizophrenia Working Group of the Psychiatric Genomics Consortium (2014) · Nature · doi:10.1038/nature13595 · Cited by 7,577 · see citing works
Self-citationThe Neuropsychiatric Inventory: Comprehensive assessment of psychopathology in dementia
Cummings, J. L., Mega, M., Gray, K., Rosenberg-Thompson, S., Carusi, D. A., & Gornbein, J. (1994) · Neurology · doi:10.1212/wnl.44.12.2308 · Cited by 7,568 · cited 2× · see citing works
“Language Version [48] (ACE/GR@ACE), NPI [49]”
A New Clinical Scale for the Staging of Dementia
Hughes, C. P., Berg, L., Danziger, W., Coben, L. A., & Martin, R. L. (1982) · British Journal of Psychiatry · doi:10.1192/bjp.140.6.566 · Cited by 7,056 · see citing works
LD Score regression distinguishes confounding from polygenicity in genome-wide association studies
Schizophrenia Working Group of the Psychiatric Genomics Consortium, Bulik-Sullivan, B. K., Loh, P.-R., Finucane, H. K., Ripke, S., Yang, J., Patterson, N., Daly, M. J., Price, A. L., & Neale, B. M. (2015) · Nature Genetics · doi:10.1038/ng.3211 · Cited by 5,559 · see citing works
METAL: fast and efficient meta-analysis of genomewide association scans
Willer, C. J., Li, Y., & Abecasis, G. R. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btq340 · Cited by 5,205 · see citing works
Mirra, S. S., Heyman, A., McKeel, D., Sumi, S. M., Crain, B. J., Brownlee, L. M., Vogel, F. S., Hughes, J. P., Belle, G. V., Berg, L., et al. (1991) · Neurology · doi:10.1212/wnl.41.4.479 · Cited by 4,961 · see citing works
Zhang, Y., Chen, K., Sloan, S. A., Bennett, M. L., Scholze, A. R., O'Keeffe, S., Phatnani, H. P., Guarnieri, P., Caneda, C., Ruderisch, N., et al. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.1860-14.2014 · Cited by 4,875 · see citing works
Common polygenic variation contributes to risk of schizophrenia and bipolar disorder
The International Schizophrenia Consortium (2009) · Nature · doi:10.1038/nature08185 · Cited by 4,821 · see citing works
Self-citationMeta-Analysis of 74,046 Individuals Identifies 11 New Susceptibility Loci for Alzheimer’s Disease
(EADI), E. A. D. I., Lambert, J.-C., (GERAD), G. A. E. R. I. A. D., Alzheimer's Disease Genetic Consortium (ADGC), (CHARGE), C. F. H. A. A. R. I. G. E., Ibrahim-Verbaas, C. A., Harold, D., Naj, A. C., Sims, R., Bellenguez, C., et al. (2013) · Nature Genetics · doi:10.1038/ng.2802 · Cited by 4,336 · see citing works
Self-citationMAGMA: Generalized Gene-Set Analysis of GWAS Data
de Leeuw, C. A., Mooij, J. M., Heskes, T., & Posthuma, D. (2015) · PLOS Computational Biology · doi:10.1371/journal.pcbi.1004219 · Cited by 3,653 · see citing works
Cognitive reserve in ageing and Alzheimer's disease
Stern, Y. (2012) · The Lancet Neurology · doi:10.1016/s1474-4422(12)70191-6 · Cited by 3,557 · see citing works
Genomic Control for Association Studies
Devlin, B., & Roeder, K. (1999) · Biometrics · doi:10.1111/j.0006-341x.1999.00997.x · Cited by 3,162 · see citing works
Self-citationAlzheimer Disease Genetics Consortium (ADGC), Kunkle, B. W., The European Alzheimer’s Disease Initiative (EADI), Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (CHARGE), Genetic and Environmental Risk in AD/Defining Genetic, P. A. E. R. F. A. D. C. (., Grenier-Boley, B., Sims, R., Bis, J. C., Damotte, V., Naj, A. C., et al. (2019) · Nature Genetics · doi:10.1038/s41588-019-0358-2 · Cited by 2,946 · see citing works
Self-citationA reference panel of 64,976 haplotypes for genotype imputation
the Haplotype Reference Consortium (2016) · Nature Genetics · doi:10.1038/ng.3643 · Cited by 2,836 · see citing works
Appelhof, B., Bakker, C., den IJssel, J. C. L. V. D., Zwijsen, S. A., Smalbrugge, M., Verhey, F. R. J., de Vugt, M. E., Zuidema, S. U., & Koopmans, R. T. C. M. (2017) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000477087 · Cited by 2,773 · see citing works
Integrative approaches for large-scale transcriptome-wide association studies
Gusev, A., Ko, A., Shi, H., Bhatia, G., Chung, W., Penninx, B. W. J. H., Jansen, R., de Geus, E. J. C., Boomsma, D. I., Wright, F. A., et al. (2016) · Nature Genetics · doi:10.1038/ng.3506 · Cited by 2,479 · see citing works
Jansen, I. E., Savage, J. E., Watanabe, K., Bryois, J., Williams, D. M., Steinberg, S., Sealock, J., Karlsson, I. K., Hägg, S., Athanasiu, L., et al. (2019) · Nature Genetics · doi:10.1038/s41588-018-0311-9 · Cited by 2,277 · see citing works
Self-citationValidation of the NPI-Q, a Brief Clinical Form of the Neuropsychiatric Inventory
Kaufer, D., Cummings, J. L., Ketchel, P., Smith, V. M., MacMillan, A., Shelley, T., López, O. L., & DeKosky, S. T. (2000) · Journal of Neuropsychiatry · doi:10.1176/jnp.12.2.233 · Cited by 1,978 · see citing works
Reference-based phasing using the Haplotype Reference Consortium panel
Loh, P.-R., Danecek, P., Palamara, P. F., Fuchsberger, C., A Reshef, Y., K Finucane, H., Schoenherr, S., Forer, L., McCarthy, S., Abecasis, G. R., et al. (2016) · Nature Genetics · doi:10.1038/ng.3679 · Cited by 1,894 · see citing works
Phase 3 Trials of Solanezumab for Mild-to-Moderate Alzheimer's Disease
Doody, R. S., Thomas, R. G., Farlow, M., Iwatsubo, T., Vellas, B., Joffe, S., Kieburtz, K., Raman, R., Sun, X., Aisen, P. S., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1312889 · Cited by 1,668 · see citing works
GERAD1 Consortium, Pardiñas, A. F., CRESTAR Consortium, Holmans, P., Pocklington, A. J., Escott-Price, V., Ripke, S., Carrera, N., Legge, S. E., Bishop, S., et al. (2018) · Nature Genetics · doi:10.1038/s41588-018-0059-2 · Cited by 1,552 · see citing works
Self-citationGenome-wide association study identifies 30 loci associated with bipolar disorder
eQTLGen Consortium, Stahl, E. A., BIOS Consortium, the Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, Breen, G., Forstner, A. J., McQuillin, A., Ripke, S., Trubetskoy, V., Mattheisen, M., et al. (2019) · Nature Genetics · doi:10.1038/s41588-019-0397-8 · Cited by 1,519 · see citing works
Self-citationTranscriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder
Gandal, M. J., Zhang, P., Hadjimichael, E., Walker, R. L., Chen, C., Liu, S., Won, H., van Bakel, H., Varghese, M., Wang, Y., et al. (2018) · Science · doi:10.1126/science.aat8127 · Cited by 1,247 · see citing works
Genome-wide Analysis of Genetic Loci Associated With Alzheimer Disease
Seshadri, S. (2010) · JAMA · doi:10.1001/jama.2010.574 · Cited by 1,219 · see citing works
Rapid formation and selective stabilization of synapses for enduring motor memories
Xu, T., Yu, X., Perlik, A. J., Tobin, W. F., Zweig, J. A., Tennant, K., Jones, T., & Zuo, Y. (2009) · Nature · doi:10.1038/nature08389 · Cited by 1,193 · see citing works
Trial of Solanezumab for Mild Dementia Due to Alzheimer’s Disease
Honig, L. S., Vellas, B., Woodward, M., Boada, M., Bullock, R., Borrie, M., Hager, K., Andreasen, N., Scarpini, E., Liu-Seifert, H., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1705971 · Cited by 1,049 · cited 5× · see citing works
“Diagnoses were made based on diagnostic evaluations, cognitive testing, and in some cases neuropathologic assessment, conducted during subjects’ participation in the following eight source programs as previously described: the Fundació ACE Barcelona Alzheimer Treatment and Research Center (ACE/GR@ACE) [31–33], a Conso…”
MethodInfluentialSelf-citationA Comparison of Linkage Disequilibrium Measures for Fine-Scale Mapping
Devlin, B., & RISCH, N. J. (1995) · Genomics · doi:10.1006/geno.1995.9003 · Cited by 1,044 · see citing works
Self-citationZheng, J., Erzurumluoglu, A. M., Elsworth, B. L., Kemp, J. P., Howe, L., Haycock, P. C., Hemani, G., Tansey, K., Laurin, C., Early Genetics and Lifecourse Epidemiology (EAGLE) Eczema Consortium, et al. (2017) · Bioinformatics · doi:10.1093/bioinformatics/btw613 · Cited by 869 · see citing works
Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways
The Network and Pathway Analysis Subgroup of the Psychiatric Genomics Consortium (2015) · Nature Neuroscience · doi:10.1038/nn.3922 · Cited by 755 · see citing works
Self-citationThe Impact of Dementia on the Family
Rabins, P. V. (1982) · JAMA · doi:10.1001/jama.1982.03330030039022 · Cited by 739 · see citing works
Kaufer, D., Cummings, J. L., Christine, D., Bray, T., Castellon, S., Masterman, D. L., MacMillan, A., Ketchel, P., & DeKosky, S. T. (1998) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1998.tb02542.x · Cited by 607 · see citing works
Rapid production of new oligodendrocytes is required in the earliest stages of motor-skill learning
Xiao, L., Ohayon, D., McKenzie, I. A., Sinclair-Wilson, A., Wright, J. L., Fudge, A. D., Emery, B., Li, H., & Richardson, W. D. (2016) · Nature Neuroscience · doi:10.1038/nn.4351 · Cited by 507 · cited 1× · see citing works
“Recent data in mice have demonstrated that differentiation of oligodendrocytes from their precursors (as indicated by increased ENPP6 mRNA expression) is a necessary component of early [83], i.”
BackgroundRopacki, S., & Jeste, D. V. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.11.2022 · Cited by 432 · see citing works
Tariot, P. N., Mack, J. L., Patterson, M. B., Edland, S. D., Weiner, M., Fillenbaum, G. G., Blazina, L., Teri, L. L., Rubin, E. H., & Mortimer, J. A. (1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.9.1349 · Cited by 425 · see citing works
Dierks, T., Schmidt, B., Borissenko, L. V., Peng, J., Preusser-Kunze, A., Mariappan, M., & FIGURA, K. V. (2003) · Cell · doi:10.1016/s0092-8674(03)00347-7 · Cited by 384 · see citing works
Tushev, G., Glock, C., Heumüller, M., Biever, A., Jovanovic, M., & Schuman, E. M. (2018) · Neuron · doi:10.1016/j.neuron.2018.03.030 · Cited by 377 · see citing works
Exome sequencing and the genetic basis of complex traits
Kiezun, A., Garimella, K., Do, R., Stitziel, N. O., Neale, B. M., McLaren, P. J., Gupta, N., Sklar, P., Sullivan, P. F., Moran, J. L., et al. (2012) · Nature Genetics · doi:10.1038/ng.2303 · Cited by 372 · see citing works
Cosma, M. P., Pepe, S., Annunziata, I., Newbold, R. F., Grompe, M., Parenti, G., & Ballabio, A. (2003) · Cell · doi:10.1016/s0092-8674(03)00348-9 · Cited by 364 · see citing works
Pollock, B. G., Mulsant, B. H., Rosen, J., Sweet, R. A., Mazumdar, S., Bharucha, A. J., Marin, R. S., Jacob, N. J., Huber, K., Kastango, K. B., et al. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.3.460 · Cited by 329 · see citing works
Self-citationThe statistical properties of gene-set analysis
de Leeuw, C., Neale, B. M., Heskes, T., & Posthuma, D. (2016) · Nature Reviews Genetics · doi:10.1038/nrg.2016.29 · Cited by 286 · see citing works
Lyketsos, C. G., Sheppard, J. E., Steinberg, M., Tschanz, J. A. T., Norton, M. C., Steffens, D. C., & Breitner, J. C. S. (2001) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.448 · Cited by 275 · see citing works
The Genotype-Tissue Expression (GTEx) project
Lonsdale, J., Thomas, J., Salvatore, M., Phillips, R., Lo, E., Shad, S., Hasz, R., Walters, G., Garcia, F., Young, N., et al. (2013) · Nature Genetics · doi:10.1038/ng.2653 · Cited by 263 · see citing works
Pollock, B. G., Mulsant, B. H., Rosen, J., Mazumdar, S., Blakesley, R. E., Houck, P. R., & Huber, K. A. (2007) · The American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e3180cc1ff5 · Cited by 257 · see citing works
Zung, Beck and Hamilton Rating Scales as measures of treatment outcome: a meta-analytic comparison.
Lambert, M. J., Hatch, D. R., Kingston, M. D., & Edwards, B. C. (1986) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.54.1.54 · Cited by 232 · see citing works
Zung, Beck, and Hamilton Rating Scales as measures of treatment outcome: A meta-analytic comparison.
Lambert, M. J., Hatch, D. R., Kingston, M. D., & Edwards, B. C. (1986) · Journal of Consulting and Clinical Psychology · doi:10.1037//0022-006x.54.1.54 · Cited by 231 · see citing works
AddNeuroMed—The European Collaboration for the Discovery of Novel Biomarkers for Alzheimer's Disease
Lovestone, S., Francis, P. T., Kłoszewska, I., Mecocci, P., Simmons, A., Soininen, H. S., Spenger, C., Tsolaki, M., Vellas, B. J., Wahlund, L., et al. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05064.x · Cited by 211 · see citing works
Self-citationPsychosis in Alzheimer’s Disease
Murray, P. S., Kumar, S., DeMichele‐Sweet, M. A. A., & Sweet, R. A. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.08.020 · Cited by 198 · see citing works
Self-citationThe Role of APOE and TREM2 in Alzheimer′s Disease—Current Understanding and Perspectives
Wolfe, C. M., Fitz, N. F., Nam, K. N., Lefterov, I. M., & Koldamova, R. P. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms20010081 · Cited by 192 · see citing works
López, O. L., Wisniewski, S. R., Becker, J. T., Boller, F., & DeKosky, S. T. (1999) · Archives of Neurology · doi:10.1001/archneur.56.10.1266 · Cited by 183 · see citing works
Chun, J. J. M., & Brinkmann, V. (2011) · PubMed · Cited by 177 · see citing works
Dysregulation of autophagy as a common mechanism in lysosomal storage diseases
Seranova, E., Connolly, K. J., Zatyka, M., Rosenstock, T. R., Barrett, T. G., Tuxworth, R. I., & Sarkar, S. (2017) · Essays in Biochemistry · doi:10.1042/ebc20170055 · Cited by 176 · see citing works
Moreno–Grau, S., de Rojas, I., Hernández, I., Quintela, I., Montrreal, L., Alegret, M., Hernández‐Olasagarre, B., Madrid, L., González‐Pérez, A., Maroñas, O., et al. (2019) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2019.06.4950 · Cited by 156 · see citing works
Self-citationBoada, M., Cejudo, J. C., Tárraga, L., López, O. L., & Kaufer, D. (2002) · PubMed · Cited by 128 · see citing works
Self-citationPsychotic Symptoms and Physically Aggressive Behavior in Alzheimer's Disease
Gilley, D. W., Wilson, R. S., Beckett, L. A., & Evans, D. A. (1997) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1997.tb05969.x · Cited by 127 · see citing works
Genome-wide association study of Alzheimer's disease with psychotic symptoms
Hollingworth, P., Sweet, R. A., Sims, R., Harold, D. H., Russo, G., Abraham, R., Stretton, A., Jones, N., Gerrish, A., Chapman, J., et al. (2011) · Molecular Psychiatry · doi:10.1038/mp.2011.125 · Cited by 123 · see citing works
Self-citationAstrocyte dysfunction triggers neurodegeneration in a lysosomal storage disorder
Malta, C. D., Fryer, J. D., Settembre, C., & Ballabio, A. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1209577109 · Cited by 123 · see citing works
Sakagami, H., Aoki, J., Natori, Y., Nishikawa, K., Kakehi, Y., Natori, Y., & Arai, H. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m413438200 · Cited by 112 · see citing works
Hallucinations and associated factors in Alzheimer's disease
Gilley, D. W., Whalen, M. E., Wilson, R. S., & Bennett, D. A. (1991) · Journal of Neuropsychiatry · doi:10.1176/jnp.3.4.371 · Cited by 112 · see citing works
Discovering genetic ancestry using spectral graph theory
Lee, A. B., Luca, D., Klei, L., Devlin, B., & Roeder, K. (2010) · Genetic Epidemiology · doi:10.1002/gepi.20434 · Cited by 108 · cited 1× · see citing works
“We determined ancestry using GemTools analysis [59] of a subset of autosomal SNPs with non-call rate < 0.”
MethodSelf-citationSweet, R. A., Pollock, B. G., Sukonick, D. L., Rosen, J., Klunk, W. E., Kastango, K. B., Mulsant, B. H., DeKosky, S. T., & Ferrell, R. E. (2001) · International Psychogeriatrics · doi:10.1017/s1041610201007827 · Cited by 104 · see citing works
Self-citationPsychotic symptoms in Alzheimer disease: evidence for a distinct phenotype
Sweet, R. A., Nimgaonkar, V. L., Devlin, B., & Jeste, D. V. (2003) · Molecular Psychiatry · doi:10.1038/sj.mp.4001262 · Cited by 103 · see citing works
Self-citationIncreased familial risk of the psychotic phenotype of Alzheimer disease
Sweet, R. A., Nimgaonkar, V. L., Devlin, B., López, O. L., & DeKosky, S. T. (2002) · Neurology · doi:10.1212/wnl.58.6.907 · Cited by 91 · see citing works
Self-citationHeritability of Psychosis in Alzheimer Disease
Bacanu, S., Devlin, B., Chowdari, K. V., DeKosky, S. T., Nimgaonkar, V. L., & Sweet, R. A. (2005) · American Journal of Geriatric Psychiatry · doi:10.1097/00019442-200507000-00011 · Cited by 89 · see citing works
Self-citationZunzunegui, M. V., Cuadra, P. G., B�land, F., del Ser, T., & Wolfson, C. M. (2000) · International Journal of Geriatric Psychiatry · doi:10.1002/(sici)1099-1166(200002)15:2 · Cited by 85 · see citing works
Impact of psychiatric hospitalization on behavioral complications of Alzheimer's disease
Zubenko, G. S., Rosen, J., Sweet, R. A., Mulsant, B. H., & Rifai, A. H. (1992) · American Journal of Psychiatry · doi:10.1176/ajp.149.11.1484 · Cited by 81 · see citing works
Self-citationSweet, R. A., Bennett, D. A., Graff‐Radford, N. R., & Mayeux, R. P. (2010) · Brain · doi:10.1093/brain/awq001 · Cited by 74 · see citing works
Self-citationEmanuel, J. E., López, O. L., Houck, P. R., Becker, J. T., Weamer, E. A., DeMichele‐Sweet, M. A. A., Kuller, L. H., & Sweet, R. A. (2010) · American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e3181e446c8 · Cited by 73 · see citing works
Self-citationHallucinations, Cognitive Decline, and Death in Alzheimer’s Disease
Wilson, R. S., Tang, Y., Aggarwal, N. T., Gilley, D. W., McCann, J. J., Bienias, J. L., & Evans, D. A. (2006) · Neuroepidemiology · doi:10.1159/000090251 · Cited by 72 · see citing works
Røen, I., Selbæk, G., Kirkevold, Ø., Engedal, K., Testad, I., & Bergh, S. (2017) · BMC Health Services Research · doi:10.1186/s12913-017-2289-x · Cited by 70 · see citing works
Self-citationReconstitution of Formylglycine-generating Enzyme with Copper(II) for Aldehyde Tag Conversion
Holder, P. G., Jones, L. C., Drake, P. M., Barfield, R. M., Bañas, S., de Hart, G. W., Baker, J., & Rabuka, D. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.652669 · Cited by 69 · see citing works
Genetic risk for schizophrenia and psychosis in Alzheimer disease
DeMichele‐Sweet, M. A. A., Weamer, E. A., Klei, L., Vrana, D. T., Hollingshead, D. J., Seltman, H. J., Sims, R., Foroud, T., Hernández, I., Moreno–Grau, S., et al. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.81 · Cited by 68 · see citing works
Self-citationRisk of Mortality and Institutionalization in Demented Patients with Delusions
Magni, E., Binetti, G. G., Bianchetti, A., & Trabucchi, M. (1996) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/089198879600900303 · Cited by 67 · see citing works
Sweet, R. A., Seltman, H. J., Emanuel, J. E., López, O. L., Becker, J. T., Bis, J. C., Weamer, E. A., DeMichele‐Sweet, M. A. A., & Kuller, L. H. (2012) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2012.11121815 · Cited by 66 · see citing works
Self-citationKoppel, J., Sunday, S., Goldberg, T. E., Davies, P., Christen, E., & Greenwald, B. S. (2014) · The American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2012.10.028 · Cited by 65 · see citing works
Weamer, E. A., Emanuel, J. E., Varón, D., Miyahara, S., Wilkosz, P. A., López, O. L., DeKosky, S. T., & Sweet, R. A. (2008) · International Psychogeriatrics · doi:10.1017/s1041610208007734 · Cited by 60 · see citing works
Self-citationLinkage analysis of Alzheimer disease with psychosis
Bacanu, S., Devlin, B., Chowdari, K. V., DeKosky, S. T., Nimgaonkar, V. L., & Sweet, R. A. (2002) · Neurology · doi:10.1212/wnl.59.1.118 · Cited by 60 · see citing works
Self-citationProgression of Alzheimer’s Disease: A Longitudinal Study in Norwegian Memory Clinics
Eldholm, R. S., Barca, M. L., Persson, K., Knapskog, A., Kersten, H., Engedal, K., Selbæk, G., Brækhus, A., Skovlund, E., & Saltvedt, I. T. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-170436 · Cited by 59 · see citing works
Self-citationKoppel, J. L., Goldberg, T. E., Gordon, M. L., Huey, E. D., Davies, P., Keehlisen, L., Huet, S., Christen, E., & GREENWALD, B. S. (2011) · American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e3182358921 · Cited by 57 · see citing works
Wilkosz, P. A., Miyahara, S., López, O. L., DeKosky, S. T., & Sweet, R. A. (2006) · American Journal of Geriatric Psychiatry · doi:10.1097/01.jgp.0000192500.25940.1b · Cited by 55 · see citing works
Self-citationCreese, B., Vassos, E., Bergh, S., Athanasiu, L., Johar, I., Rongve, A., Medbøen, I. T., Silva, M. V. D., Aakhus, E., Andersen, F., et al. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0592-5 · Cited by 55 · see citing works
Self-citation[ECG examination of calves with nutritional muscular degeneration].
Nĕmecek, L., & Kursa, J. (1971) · PubMed · Cited by 52 · see citing works
Borroni, B., Bonvicini, C., Galimberti, D., Tremolizzo, L., Papetti, A., Archetti, S., Turla, M., Alberici, A., Agosti, C., Premi, E., et al. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.08.009 · Cited by 51 · see citing works
Self-citationNeuropsychiatric Syndromes in Neurodegenerative Disease: Frequency and Signficance.
Jl, C., Díaz, C., Levy, M. L., Binetti, G. G., & Litvan, I. (1996) · PubMed · doi:10.1053/scnp00100241 · Cited by 49 · see citing works
Heritability of Psychosis in Alzheimer Disease
Bacanu, S. (2005) · American Journal of Geriatric Psychiatry · doi:10.1176/appi.ajgp.13.7.624 · Cited by 44 · see citing works
Kim, H. J., & Kikuchi, G. (1972) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a129847 · Cited by 43 · see citing works
Increased familial risk and genomewide significant linkage for Alzheimer's disease with psychosis
Hollingworth, P., Hamshere, M. L., Holmans, P., O’Donovan, M. C., Sims, R., Powell, J. F., Lovestone, S., Myers, A., DeVriéze, F. W., Hardy, J., et al. (2007) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30515 · Cited by 43 · see citing works
Self-citationSweet, R. A., MacDonald, M. L., Kirkwood, C. M., Ding, Y., Schempf, T. A., Jones-Laughner, J., Kofler, J., Ikonomović, M. D., López, O. L., Garver, M. E., et al. (2016) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m115.056580 · Cited by 35 · see citing works
Self-citationLee, S. H., Nyholt, D. R., Macgregor, S., Henders, A. K., Zondervan, K. T., Montgomery, G. W., & Visscher, P. M. (2010) · Genetic Epidemiology · doi:10.1002/gepi.20541 · Cited by 33 · see citing works
AssocTests: An R Package for Genetic Association Studies
Wang, L., Zhang, W., & Li, Q. (2020) · Journal of Statistical Software · doi:10.18637/jss.v094.i05 · Cited by 33 · see citing works
Ito, M., Chiu, T. H., & Rosenberg, H. C. (1986) · Neurochemical Research · doi:10.1007/bf00965333 · Cited by 32 · see citing works
Synaptic Proteome Compensation and Resilience to Psychosis in Alzheimer’s Disease
Krivinko, J. M., Erickson, S. L., Ding, Y., Sun, Z., Penzes, P., MacDonald, M. L., Yates, N. A., Ikonomović, M. D., López, O. L., Sweet, R. A., et al. (2018) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2018.17080858 · Cited by 32 · see citing works
Self-citationWilkosz, P. A., Kodavali, C. V., Weamer, E. A., Miyahara, S., López, O. L., Nimgaonkar, V. L., DeKosky, S. T., & Sweet, R. A. (2007) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30549 · Cited by 30 · see citing works
Self-citationDeMichele‐Sweet, M. A. A., López, O. L., & Sweet, R. A. (2011) · International Journal of Alzheimer s Disease · doi:10.4061/2011/926597 · Cited by 29 · see citing works
Self-citationTime from Symptom Debut to Dementia Assessment by the Specialist Healthcare Service in Norway
Helvik, A., Engedal, K., Benth, J. Š., & Selbæk, G. (2018) · Dementia and Geriatric Cognitive Disorders Extra · doi:10.1159/000487233 · Cited by 28 · see citing works
Incident Psychosis in Subjects With Mild Cognitive Impairment or Alzheimer’s Disease
Weamer, E. A., DeMichele‐Sweet, M. A. A., Cloonan, Y. K., López, O. L., & Sweet, R. A. (2016) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.15m10617 · Cited by 26 · see citing works
Self-citationBergh, S., Holmen, J., Gabin, J. M., Stordal, E., Fikseaunet, A., Selbæk, G., Saltvedt, I. T., Langballe, E. M., & Tambs, K. (2014) · International Journal of Epidemiology · doi:10.1093/ije/dyu007 · Cited by 24 · see citing works
Self-citationNo association of psychosis in Alzheimer disease with neurodegenerative pathway genes
DeMichele‐Sweet, M. A. A., Klei, L., Devlin, B., Ferrell, R. E., Weamer, E. A., Emanuel, J. E., López, O. L., & Sweet, R. A. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.10.003 · Cited by 23 · see citing works
Self-citationCyclosporine A impairs wound healing of ureterocystoneostomy in rats
Recker, F., Marquardt, K., Redha, F., Uhlschmid, G. K., & Largiad�r, F. (1989) · Urological Research · doi:10.1007/bf00261043 · Cited by 22 · see citing works
A Bayesian model of psychosis symptom trajectory in Alzheimer's disease
Seltman, H. J., Mitchell, S., & Sweet, R. A. (2015) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.4326 · Cited by 19 · see citing works
Self-citationBarral, S., Vardarajan, B. N., Reyes‐Dumeyer, D., Faber, K. M., Bird, T. D., Tsuang, D. W., Bennett, D. A., Rosenberg, R. N., Boeve, B. F., Graff‐Radford, N. R., et al. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2015.08.006 · Cited by 16 · see citing works
Self-citationDarios, F. D., Jorgačevski, J., Flašker, A., Zorec, R., García-Martinez, V., Villanueva, J., Gutiérrez, L. M., Leese, C., Bal, M., Nosyreva, E. D., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-05948-z · Cited by 16 · see citing works
Chen, X., Chen, Y., Guo, X., Cao, B., Wei, Q., Ou, R., Zhao, B., Song, W., Wu, Y., & Shang, H. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2015.07.026 · Cited by 13 · see citing works
Greiner-Tollersrud, L., Berg, T., Stensland, H. M. F. R., Evjen, G., & Greiner-Tollersrud, O. K. (2012) · Neurochemical Research · doi:10.1007/s11064-012-0921-z · Cited by 13 · see citing works
Tariot, P. N., Mack, J. L., Patterson, M. B., Edland, S. D., Weiner, M., Fillenbaum, G. G., Blazina, L., Teri, L., Rubin, E., Mortimer, J. A., et al. (2022) · Columbia Academic Commons (Columbia University) · doi:10.7916/3mmh-3510 · Cited by 12 · see citing works
Fingolimod Treatment Rescues Psychosis-Associated Behavioral Aberrations in Appswe/Psen1de9 Mice
Krivinko, J. M., Erickson, S. L., MacDonald, M. L., Garver, M. E., & Sweet, R. A. (2018) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2018.01.175 · Cited by 1 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Dementia prevention, intervention, and care: 2024 report of the Lancet standing Commission
Livingston, G., Huntley, J., Liu, K. Y., Costafreda, S. G., Selbæk, G., Alladi, S., Ames, D., Banerjee, S., Burns, A., Brayne, C., et al. (2024) · The Lancet · doi:10.1016/s0140-6736(24)01296-0 · Cited by 3,860 · see citing works
Psychosis in Alzheimer disease—mechanisms, genetics and therapeutic opportunities
Ismail, Z., Creese, B., Aarsland, D., Kales, H. C., Lyketsos, C. G., Sweet, R. A., & Ballard, C. (2022) · Nature Reviews Neurology · doi:10.1038/s41582-021-00597-3 · Cited by 189 · see citing works
Self-citationA global view of the genetic basis of Alzheimer disease
Reitz, C., Pericak-Vance, M., Foroud, T., & Mayeux, R. (2023) · Nature Reviews Neurology · doi:10.1038/s41582-023-00789-z · Cited by 143 · see citing works
Self-citationGenomics and Functional Genomics of Alzheimer's Disease
Kamboh, M. I. (2022) · Neurotherapeutics · doi:10.1007/s13311-021-01152-0 · Cited by 73 · see citing works
Self-citationA review of brain imaging biomarker genomics in Alzheimer’s disease: implementation and perspectives
Li, L., Yu, X., Sheng, C., Jiang, X., Zhang, Q., Han, Y., & Jiang, J. (2022) · Translational Neurodegeneration · doi:10.1186/s40035-022-00315-z · Cited by 40 · see citing works
Psychosis as a Treatment Target in Dementia: A Roadmap for Designing Interventions
Agüera-Ortíz, L., Babulal, G. M., Bruneau, M., Creese, B., D’Antonio, F., Fischer, C. E., Gatchel, J. R., Ismail, Z., Kumar, S., McGeown, W. J., et al. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-215483 · Cited by 29 · see citing works
Self-citationDistinguishing features of depression in dementia from primary psychiatric disease
Fisher, D. W., Dunn, J. T., & Dong, H. (2024) · Discover Mental Health · doi:10.1007/s44192-023-00057-y · Cited by 30 · see citing works
Composite immune marker scores associated with severe mental disorders and illness course
Ormerod, M. B. E. G., Ueland, T., Werner, M. C. F., Hjell, G., Rødevand, L. N., Sæther, L. S., Lunding, S. H., Johansen, I. T., Ueland, T., Lagerberg, T. V., et al. (2022) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2022.100483 · Cited by 19 · see citing works
Self-citationLicinio, J., & Wong, M. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-01968-6 · Cited by 17 · see citing works
Emerging Pharmacological Approaches for Psychosis and Agitation in Alzheimer’s Disease
Imbimbo, C., Ramusino, M. C., Leone, S., Mazzacane, F., Franco, V. D., Gatti, A., Perini, G., & Costa, A. C. (2024) · CNS Drugs · doi:10.1007/s40263-024-01133-9 · Cited by 20 · see citing works
Mild Behavioral Impairment: An Early Sign and Predictor of Alzheimer's Disease Dementia
Jiang, F., Cheng, C., Huang, J., Chen, Q., & Le, W. (2022) · Current Alzheimer Research · doi:10.2174/1567205019666220805114528 · Cited by 16 · see citing works
Ruffini, N., Klingenberg, S., Heese, R., Schweiger, S., & Gerber, S. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.866886 · Cited by 14 · see citing works
Fan, P., Miranda, O., Qi, X., Kofler, J., Sweet, R. A., & Wang, L. (2023) · Pharmaceuticals · doi:10.3390/ph16070911 · Cited by 15 · see citing works
Self-citationAlmeida, F., Jesus, T., Coelho, A., Quintas-Neves, M., Gauthreaux, K. M., Teylan, M., Mock, C., Kukull, W. A., Crary, J. F., & Oliveira, T. G. (2024) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2024.02.013 · Cited by 14 · see citing works
Beyond memory impairment: the complex phenotypic landscape of Alzheimer’s disease
Argyriou, S., Fullard, J. F., Krivinko, J. M., Lee, D., Wingo, T. S., Wingo, A. P., Sweet, R. A., & Roussos, P. (2024) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2024.04.016 · Cited by 13 · see citing works
Self-citationDeChellis-Marks, M. R., Wei, Y., Ding, Y., Wolfe, C. M., Krivinko, J. M., MacDonald, M. L., López, O. L., Sweet, R. A., & Kofler, J. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.778419 · Cited by 13 · see citing works
Self-citationSaraceno, G. F., Abrego-Guandique, D. M., Cannataro, R., Caroleo, M. C., & Cione, E. (2024) · BioMedInformatics · doi:10.3390/biomedinformatics4010033 · Cited by 13 · see citing works
Fingolimod mitigates synaptic deficits and psychosis‐like behavior in APP/PSEN1 mice
Krivinko, J. M., Erickson, S. L., MacDonald, M. L., Garver, M. E., & Sweet, R. A. (2022) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1002/trc2.12324 · Cited by 13 · see citing works
Self-citationThe role of hand preference in cognition and neuropsychiatric symptoms in neurodegenerative diseases
Saari, T. T., & Vuoksimaa, E. (2023) · Brain Communications · doi:10.1093/braincomms/fcad137 · Cited by 12 · see citing works
Gilchrist, L., Spargo, T. P., Green, R., Coleman, J. R. I., Howard, D. M., Thorp, J. G., Adey, B. N., Lord, J., Davies, H. L., Mundy, J., et al. (2025) · Nature Mental Health · doi:10.1038/s44220-024-00369-0 · Cited by 12 · see citing works
Self-citationA data‐driven examination of apathy and depressive symptoms in dementia with independent replication
Silva, M. V. D., Meléndez‐Torres, G. J., Ismail, Z., Testad, I., Ballard, C. G., Creese, B., & Initiative, A. D. N. (2023) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1002/dad2.12398 · Cited by 11 · see citing works
Self-citationBenmelouka, A. Y., Ouerdane, Y., Outani, O., Alnasser, Y., Alghamdi, B. S. A., Perveen, A., Ashraf, G. M., & Ebada, M. A. (2022) · Current Alzheimer Research · doi:10.2174/1567205019666220418151914 · Cited by 11 · see citing works
Fisher, D. W., Dunn, J. T., Keszycki, R. M., Rodríguez, G., Bennett, D. A., Wilson, R. S., & Dong, H. (2024) · Translational Psychiatry · doi:10.1038/s41398-024-02878-z · Cited by 10 · see citing works
Shwab, E. K., Pathak, G. A., Harvey, J., Belloy, M. E., Fischer, C. E., Lutz, M. W., Scholz, S. W., Cook, N., Reid, D. M., Chen, J., et al. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70549 · Cited by 11 · see citing works
Self-citationTargeting the post-synaptic proteome has therapeutic potential for psychosis in Alzheimer Disease
Krivinko, J. M., DeChellis-Marks, M. R., Zeng, L., Fan, P., López, O. L., Ding, Y., Wang, L., Kofler, J., MacDonald, M. L., & Sweet, R. A. (2023) · Communications Biology · doi:10.1038/s42003-023-04961-5 · Cited by 10 · see citing works
Self-citationEmerging therapies for treatment of agitation, psychosis, or apathy in Alzheimer’s disease
Wang, H. J., Chinna‐Meyyappan, A., Feldman, O. J., & Lanctôt, K. L. (2024) · Expert Opinion on Emerging Drugs · doi:10.1080/14728214.2024.2363215 · Cited by 9 · see citing works
Briand‐Mésange, F., Gennero, I., Salles, J., Trudel, S., Dahan, L., Ausseil, J., Payrastre, B., Salles, J., & Chap, H. (2024) · Molecules · doi:10.3390/molecules29153694 · Cited by 9 · see citing works
Fan, P., Zeng, L., Ding, Y., Kofler, J., Silverstein, J. C., Krivinko, J. M., Sweet, R. A., & Wang, L. (2023) · CPT Pharmacometrics & Systems Pharmacology · doi:10.1002/psp4.12979 · Cited by 6 · see citing works
Self-citationGWAS links APOE to neuropsychiatric symptoms in mild cognitive impairment and dementia
Vattathil, S., Blostein, F., Miller‐Fleming, T. W., Davis, L. K., Initiative, A. D. N., Wingo, T. S., & Wingo, A. P. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70329 · Cited by 6 · see citing works
Sharma, B., Das, S., Mazumder, A., Rautela, D. S., Tyagi, P. K., & Khurana, N. (2024) · The Egyptian Journal of Neurology Psychiatry and Neurosurgery · doi:10.1186/s41983-024-00848-2 · Cited by 8 · see citing works
A brain DNA co‐methylation network analysis of psychosis in Alzheimer's disease
Kouhsar, M. P., Weymouth, L. S., Smith, A. R., Imm, J. L., Bredemeyer, C., Wedatilake, Y., Torkamani, A., Bergh, S., Selbæk, G., Mill, J. S., et al. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.14501 · Cited by 8 · see citing works
Self-citationNeuropsychiatric symptoms in AD: the search for mechanisms
Creese, B., & Lunnon, K. (2022) · Nature Reviews Neurology · doi:10.1038/s41582-022-00721-x · Cited by 6 · see citing works
Self-citationGenetic associations with psychosis and affective disturbance in Alzheimer's disease
Antonsdottir, I. M., Creese, B., Klei, L., DeMichele‐Sweet, M. A. A., Weamer, E. A., García‐González, P., Marquié, M., Boada, M., Alarcón‐Martín, E., Valero, S., et al. (2024) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1002/trc2.12472 · Cited by 5 · see citing works
Self-citationPsychosis associated with dementia: evaluation and management
Tampi, R. R., Joshi, P., & Jeste, D. V. (2025) · Schizophrenia Research · doi:10.1016/j.schres.2025.04.022 · Cited by 5 · see citing works
Molecular Psychiatry special issue: advances in Alzheimer’s disease
Licinio, J., & Wong, M. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01434-1 · Cited by 5 · see citing works
Neuropsychiatric Manifestations in Alzheimer’s Disease Patients: Genetics and Treatment Options
Singh, A. K., Malviya, R., Prakash, A., & Verma, S. (2023) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527322666230301111216 · Cited by 5 · see citing works
Annevelink, C. E., Westra, J., Sala‐Vila, A., Harris, W. S., Tintle, N., & Shearer, G. C. (2023) · Journal of Nutrition · doi:10.1016/j.tjnut.2023.12.035 · Cited by 5 · see citing works
Presenilin Gene Mutation-associated Psychosis
Colijn, M. A., & Ismail, Z. (2024) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0000000000000599 · Cited by 5 · see citing works
Fan, P., Kofler, J., Ding, Y., Marks, M., Sweet, R. A., & Wang, L. (2022) · Briefings in Bioinformatics · doi:10.1093/bib/bbac394 · Cited by 5 · see citing works
Self-citationNovel drug targets for delirium based on genetic causality
Zhu, S., Ding, X., Bo, J., Xia, T., & Gu, X. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.02.095 · Cited by 4 · see citing works
Namasivayam, A. A., Fischer, C. E., Abler, V., Creese, B., Gastiazoro, M. P., Hermida, A. P., Ikeda, M., Ismail, Z., Jeste, D. V., McDermid, J., et al. (2025) · International Psychogeriatrics · doi:10.1016/j.inpsyc.2025.100133 · Cited by 3 · see citing works
Self-citationThe role of the endocannabinoid system in managing neuropsychiatric symptoms in Alzheimer’s disease
Rao, J. S., Tangarife, M. A., Venegas, M., Forero, B., Tamayo, L. L. G., Escobar-Gallego, J. P., Rodríguez‐Soacha, D. A., Ferreirós, A., & Mukunda, R. (2026) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2025.1709266 · Cited by 4 · see citing works
Ray, N. R., Kumar, A., Zaman, A. F., del Rosario, P., Mena, P. R., Manoochehri, M., Stein, C. M., Vito, A. N. D., Sweet, R. A., Hohman, T. J., et al. (2024) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1002/dad2.70000 · Cited by 3 · see citing works
Self-citationChen, Y., Wang, Z., Liu, X., Xu, J., & Mao, Z. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1301854 · Cited by 3 · see citing works
Miranda, O., Jiang, C., Qi, X., Kofler, J., Sweet, R. A., & Wang, L. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26041617 · Cited by 3 · see citing works
Self-citationBabaiha, N. S., Geissler, S., Nibart, V., Ataş, H., Bharadhwaj, V. S., Kodamullil, A. T., Klein, J., Jacobs, M. D., & Hofmann‐Apitius, M. (2025) · Artificial Intelligence in the Life Sciences · doi:10.1016/j.ailsci.2025.100138 · Cited by 4 · see citing works
Genetic associations of plasma proteomics with dementia subtypes and neuroimaging markers
Salih, A. M., Salatzki, J., Wang, Y., Aklilu, T., Maldonado-Garcia, C., Masud Husain, B., Neubauer, S., Topiwala, A., Altmann, A., & Raisi‐Estabragh, Z. (2025) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1002/dad2.70202 · Cited by 2 · see citing works
Genetic and neurobiological aspects of psychosis in major neurocognitive disorder
Abarca, M., Pizarro, H., Bustamante, M. L., Rohde, G., & Marcelo Arancibia, M. (2025) · Medwave · doi:10.5867/medwave.2025.01.2994 · Cited by 1 · see citing works
Correlation of Alzheimer’s Disease and Other Psychological and Non-Psychological Conditions
Boiko, D. I., Zhyvotovska, L. V., Боднарь, Л. А., Rud, V. O., Vasylyeva, G. Y., & Skrypnikov, A. M. (2024) · Springer eBooks · doi:10.1007/978-981-96-0259-9_5 · Cited by 1 · see citing works
Neurobiology of Behavioral and Psychological Symptoms of Dementia
Tampi, R. R., Joshi, P., & Zdanys, K. F. (2025) · Advances in Psychiatry and Behavioral Health · doi:10.1016/j.ypsc.2025.01.002 · Cited by 1 · see citing works
Support vector machine-based classification of bulimia nervosa using diffusion tensor imaging
Zheng, L., Wang, Y., Ma, J., Wang, M., Liu, Y., Li, J., Li, T., & Zhang, L. (2025) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2025.1667996 · Cited by 1 · see citing works
Self-citationPlasma biomarkers in neuropsychiatric syndromes: A narrative review
Ismail, Z., Guan, D. X., Babulal, G. M., Bateman, J. R., Cantillon, M., Creese, B., D’Antonio, F., Fischer, C. E., Gatchel, J. R., Ghahremani, M., et al. (2025) · Journal of Alzheimer s Disease · doi:10.1177/13872877251392185 · Cited by 2 · see citing works
Self-citationRajkumar, G., Uthayakumar, H., Khoury, M. A., Valcic, M., Rashidi‐Ranjbar, N., Churchill, N. W., Fornazzari, L., Luca, V. D., Ismail, Z., Graham, S. J., et al. (2026) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2026.02.011 · Cited by 1 · see citing works
An artificial intelligence-derived metabolic network predicts psychosis in Alzheimer’s disease
Nguyen, N., Gomar, J. J., Truong, J. N., Barbero, J., Do, P. P., Rommal, A., Oh, A., Eidelberg, D., Koppel, J. L., & Vo, A. (2025) · Brain Communications · doi:10.1093/braincomms/fcaf159 · Cited by 1 · see citing works
Najar, J., de Rojas, I., Dalmasso, M. C., Fernandez, M., de Boer, S. D., Ramírez, A., Priller, J., Laske, C., Kleineidam, L., Schneider, A., et al. (2025) · International Review of Psychiatry · doi:10.1080/09540261.2025.2600619 · Cited by 1 · see citing works
Compensatory Plasticity Defines a Vulnerable Neuronal State in Alzheimer’s Disease with PsychosisPreprint
Victor, M. B., Sun, N., Galani, K., Leary, N., Tanigawa, Y., Scannail, A. N., Ho, L., Prosper, S., Liu, L., Kofler, J., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.04.30.651435 · Cited by 1 · see citing works
Self-citationGilchrist, L., Spargo, T. P., Green, R., Coleman, J. R. I., Howard, D. M., Thorp, J. G., Adey, B. N., Lord, J., Davies, H. L., Mundy, J., et al. (2023) · medRxiv · doi:10.1101/2023.06.05.23290588
Self-citationSönmez, D., & Hocaoğlu, Ç. (2024) · Anadolu Kliniği Tıp Bilimleri Dergisi · doi:10.21673/anadoluklin.1476946
Ku, T. S.-H., Mullett, S. J., Sui, Z., Zeng, L., Ding, Y., Yocum, A. K., MacDonald, M. L., Gelhaus, S. L., Kofler, J., & Sweet, R. A. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.11.26.690872
Self-citationLi, L., Yu, X., Sheng, C., Jiang, X., Zhang, Q., Han, Y., & Jiang, J. (2022) · Figshare · doi:10.6084/m9.figshare.21130048
Ihianle, I., Samarasekara, W., Brookes, K., & Machado, P. (2025) · BioData Mining · doi:10.1186/s13040-025-00506-0
Neuropsychiatric and behavioural correlates of sundowning in Alzheimer’s disease
Luca, A., Luca, M., Ferri, R., Lanza, G., & Serretti, A. (2026) · International Journal of Psychiatry in Clinical Practice · doi:10.1080/13651501.2026.2642681
Self-citationAlkaline phosphatase superfamily members: new pieces of the choline metabolism puzzle
Lecornu, F., Mulard, E. D., Bessueille, L., Gerardin, D., Rautureau, G. J. P., Ballut, L., & Magne, D. (2026) · Metabolism · doi:10.1016/j.metabol.2026.156625
Mekkes, N., Kumar, U., Hoekstra, E., Marmolejo-Garza, A., Dagkesamanskaia, E., Wever, D. D., de Groot, M., Kreft, K. L., Rajicic, A., Seelaar, H., et al. (2026) · medRxiv · doi:10.64898/2026.06.30.26356924 · Cited by 1 · see citing works
- Authors
- DeMichele-Sweet, M. A. A., Klei, L., Creese, B., Harwood, J. C., Weamer, E. A., McClain, L., Sims, R., Hernandez, I., Moreno-Grau, S., Tárraga, L., Boada, M., Alarcón-Martín, E., Valero, S., NIA-LOAD Family Based Study Consortium, A. D. G. C. (., Liu, Y., Hooli, B., Aarsland, D., Selbaek, G., Bergh, S., Rongve, A., Saltvedt, I., Skjellegrind, H. K., Engdahl, B., Stordal, E., Andreassen, O. A., Djurovic, S., Athanasiu, L., Seripa, D., Borroni, B., Albani, D., Forloni, G., Mecocci, P., Serretti, A., De Ronchi, D., Politis, A., Williams, J., Mayeux, R., Foroud, T., Ruiz, A., Ballard, C., Holmans, P., Lopez, O. L., Kamboh, M. I., Devlin, B., & Sweet, R. A.
- Affiliations
- University of Pittsburgh (US)
- University of Exeter (GB)
- Cardiff University (GB)
- Instituto de Salud Carlos III (ES)
- Eli Lilly (United States) (US)
- King's College London (GB)
- Innlandet Hospital Trust (NO)
- Fonna Hospital Trust (NO)
- Norwegian University of Science and Technology (NO)
- Norwegian Institute of Public Health (NO)
- Oslo University Hospital (NO)
- University of Oslo (NO)
- Ospedale Vito Fazzi (IT)
- University of Brescia (IT)
- Mario Negri Institute for Pharmacological Research (IT)
- University of Perugia (IT)
- University of Bologna (IT)
- National and Kapodistrian University of Athens (GR)
- UK Dementia Research Institute (GB)
- Columbia University (US)
- Indiana University School of Medicine (US)
- Corresponding author
- Sweet, Robert A.
- ORCID
- DeMichele-Sweet, Mary Ann A.
- Klei, Lambertus
- Creese, Byron
- Harwood, Janet C.
- Sims, Rebecca
- Tárraga, Lluís
- Boada, Mercè
- Valero, Sergi
- Liu, Yushi
- Hooli, Basavaraj
- Aarsland, Dag
- Selbaek, Geir
- Bergh, Sverre
- Rongve, Arvid
- Saltvedt, Ingvild
- Skjellegrind, Håvard K.
- Engdahl, Bo
- Stordal, Eystein
- Andreassen, Ole A.
- Djurovic, Srdjan
- Athanasiu, Lavinia
- Seripa, Davide
- Borroni, Barbara
- Albani, Diego
- Forloni, Gianluigi
- Mecocci, Patrizia
- Serretti, Alessandro
- Politis, Antonis
- Williams, Julie
- Mayeux, Richard
- Foroud, Tatiana
- Ruiz, Agustin
- Ballard, Clive
- Holmans, Peter
- Lopez, Oscar L.
- Kamboh, M. Ilyas
- Devlin, Bernie
- Sweet, Robert A.
- Venue
- Molecular Psychiatry
- Published
- 2021-06-10
- Volume
- 26
- Issue
- 10
- Pages
- 5797-5811
- ISSN
- 1359-4184 (ISSN-L)
- 1476-5578
- PMC
- PMC8660923
- OpenAlex
- W3169406292
- Cited by
- 64
- References
- 115
- Citations by year
- 2026: 5 · 2025: 19 · 2024: 16 · 2023: 10 · 2022: 12 · 2021: 2
- FWCI
- 7.18
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Licence
- Locations
- Molecular Psychiatry (publishedVersion)
- medRxiv (acceptedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- ORCA Online Research @Cardiff (Cardiff University) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Open Research Exeter (University of Exeter) (acceptedVersion)
- IUScholarWorks (Indiana University) (submittedVersion)
- Brunel University Research Archive (BURA) (Brunel University London) (submittedVersion)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion, other-oa)
- NORA - Norwegian Open Research Archives (submittedVersion, other-oa)
- Figshare (submittedVersion)
- Institutional Research Information System (Università degli Studi di Brescia) (submittedVersion)
- Funders
- U.S. Department of Health & Human Services | NIH | National Institute on Aging (AG027224, AG066468, AG030653)
- U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (MH116046, MH057881)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- psychosis, delusions, hallucinations, genetic susceptibility loci, SUMF1, APOE ε4, genetic correlation, bipolar disorder, schizophrenia, polygenic risk score, cognitive impairment, depressive symptoms, educational attainment, heritability
- MeSH terms
- Alzheimer Disease, Hallucinations, Humans, Psychotic Disorders, Schizophrenia, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Oxidoreductases Acting on Sulfur Group Donors, Genome-Wide Association Study
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
