Microbiota, a key player in alcoholic liver disease
Open accessAbstract
Alcoholic liver disease (ALD) is a major cause of morbidity and mortality worldwide. Only 20% of heavy alcohol consumers develop alcoholic liver cirrhosis. The intestinal microbiota (IM) has been recently identified as a key player in the severity of liver injury in ALD. Common features of ALD include a decrease of gut epithelial tight junction protein expression, mucin production, and antimicrobial peptide levels. This disruption of the gut barrier, which is a prerequisite for ALD, leads to the passage of bacterial products into the blood stream (endotoxemia). Moreover, metabolites produced by bacteria, such as short chain fatty acids, volatile organic compounds (VOS), and bile acids (BA), are involved in ALD pathology. Probiotic treatment, IM transplantation, or the consumption of dietary fiber, such as pectin, which all alter the ratio of bacterial species, have been shown to improve liver injury in animal models of ALD and to be associated with an improvement in gut barrier function. Although the connections between the microbiota and the host in ALD are well established, the underlying mechanisms are still an active area of research. Targeting the microbiome through the use of prebiotic, probiotic, and postbiotic modalities could be an attractive new approach to manage ALD.
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Alcoholic liver disease is associated with gut microbial dysbiosis.
“Alcoholic liver disease (ALD) is associated with gut microbial dysbiosis,113, 114, 115”
From Regulation of Intestinal Barrier Function by Microbial Metabolites (2021) · cites this paper as [115]
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- Authors
- Cassard, A.-M., & Ciocan, D.
- Affiliations
- Inserm (FR)
- Corresponding author
- Cassard, Anne-Marie
- Venue
- Clinical and Molecular Hepatology
- Published
- 2018-06-25
- Volume
- 24
- Issue
- 2
- Pages
- 100-107
- ISSN
- 2287-2728 (ISSN-L)
- 2287-285X
- PMC
- PMC6038939
- OpenAlex
- W2780202366
- Cited by
- 100
- References
- 64
- Citations by year
- 2026: 7 · 2025: 8 · 2024: 14 · 2023: 9 · 2022: 10 · 2021: 20 · 2020: 10 · 2019: 14 · 2018: 8
- FWCI
- 0.82
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Clinical and Molecular Hepatology (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Agence Nationale de la Recherche (ANR-10-LABX-0033)
- Institut National de la Santé et de la Recherche Médicale
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Keywords
- alcoholic liver disease, gut microbiota, intestinal barrier dysfunction, tight junction proteins, mucin, antimicrobial peptides, endotoxemia, short-chain fatty acids, volatile organic compounds, bile acids, probiotics, prebiotics, postbiotics, microbiota transplantation, pectin, dietary fiber, alcoholic cirrhosis
- MeSH terms
- Gastrointestinal Microbiome, Fecal Microbiota Transplantation, Animals, Bacteria, Dietary Fiber, Fungi, Humans, Liver Diseases, Alcoholic, Severity of Illness Index, Probiotics
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