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Cited by 398

The DOI matches its Crossref record; 77 of the 77 references it cites were found in a registry or an index.

Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis

Open access
COPDGene Investigators, Hobbs, Brian D, ECLIPSE Investigators, LifeLines Investigators, SPIROMICS Research Group, International COPD Genetics Network Investigators, UK BiLEVE Investigators, International COPD Genetics Consortium, de Jong, Kim, Lamontagne, Maxime, Bossé, Yohan, Shrine, Nick, Artigas, María Soler, Wain, Louise V, Hall, Ian P, Jackson, Victoria E, Wyss, Annah B, London, Stephanie J, North, Kari E, Franceschini, Nora, Strachan, David P, Beaty, Terri H, Hokanson, John E, Crapo, James D, Castaldi, Peter J, Chase, Robert P, Bartz, Traci M, Heckbert, Susan R, Psaty, Bruce M, Gharib, Sina A, Zanen, Pieter, Lammers, Jan W, Oudkerk, Matthijs, Groen, H J, Locantore, Nicholas, Tal-Singer, Ruth, Rennard, Stephen I, Vestbo, Jørgen, Timens, Wim, Paré, Peter D, Latourelle, Jeanne C, Dupuis, Josée, O'Connor, George T, Wilk, Jemma B, Kim, Woo Jin, Lee, Mi Kyeong, Oh, Yeon-Mok, Vonk, Judith M, de Koning, Harry J, Leng, Shuguang, Belinsky, Steven A, Tesfaigzi, Yohannes, Manichaikul, Ani, Wang, Xin-Qun, Rich, Stephen S, Barr, R Graham, Sparrow, David, Litonjua, Augusto A, Bakke, Per, Gulsvik, Amund, Lahousse, Lies, Brusselle, Guy G, Stricker, Bruno H, Uitterlinden, André G, Ampleford, Elizabeth J, Bleecker, Eugene R, Woodruff, Prescott G, Meyers, Deborah A, Qiao, Dandi, Lomas, David A, Yim, Jae-Joon, Kim, Deog Kyeom, Hawrylkiewicz, Iwona, Sliwinski, Pawel, Hardin, Megan, Fingerlin, Tasha E, Schwartz, David A, Postma, Dirkje S, MacNee, William, Tobin, Martin D, Silverman, Edwin K, Boezen, H Marike, Cho, Michael H·2017·Nature Genetics
DOI 10.1038/ng.3752
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Abstract

Chronic obstructive pulmonary disease (COPD) is a leading cause of mortality worldwide. We performed a genetic association study in 15,256 cases and 47,936 controls, with replication of select top results (P < 5 × 10−6) in 9,498 cases and 9,748 controls. In the combined meta-analysis, we identified 22 loci associated at genome-wide significance, including 13 new associations with COPD. Nine of these 13 loci have been associated with lung function in general population samples, while 4 (EEFSEC, DSP, MTCL1, and SFTPD) are new. We noted two loci shared with pulmonary fibrosis (FAM13A and DSP) but that had opposite risk alleles for COPD. None of our loci overlapped with genome-wide associations for asthma, although one locus has been implicated in joint susceptibility to asthma and obesity. We also identified genetic correlation between COPD and asthma. Our findings highlight new loci associated with COPD, demonstrate the importance of specific loci associated with lung function to COPD, and identify potential regions of genetic overlap between COPD and other respiratory diseases.

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Metadata

Authors
COPDGene Investigators, Hobbs, B. D., ECLIPSE Investigators, LifeLines Investigators, SPIROMICS Research Group, International COPD Genetics Network Investigators, UK BiLEVE Investigators, International COPD Genetics Consortium, de Jong, K., Lamontagne, M., Bossé, Y., Shrine, N., Artigas, M. S., Wain, L. V., Hall, I. P., Jackson, V. E., Wyss, A. B., London, S. J., North, K. E., Franceschini, N., Strachan, D. P., Beaty, T. H., Hokanson, J. E., Crapo, J. D., Castaldi, P. J., Chase, R. P., Bartz, T. M., Heckbert, S. R., Psaty, B. M., Gharib, S. A., Zanen, P., Lammers, J. W., Oudkerk, M., Groen, H. J., Locantore, N., Tal-Singer, R., Rennard, S. I., Vestbo, J., Timens, W., Paré, P. D., Latourelle, J. C., Dupuis, J., O'Connor, G. T., Wilk, J. B., Kim, W. J., Lee, M. K., Oh, Y.-M., Vonk, J. M., de Koning, H. J., Leng, S., Belinsky, S. A., Tesfaigzi, Y., Manichaikul, A., Wang, X.-Q., Rich, S. S., Barr, R. G., Sparrow, D., Litonjua, A. A., Bakke, P., Gulsvik, A., Lahousse, L., Brusselle, G. G., Stricker, B. H., Uitterlinden, A. G., Ampleford, E. J., Bleecker, E. R., Woodruff, P. G., Meyers, D. A., Qiao, D., Lomas, D. A., Yim, J.-J., Kim, D. K., Hawrylkiewicz, I., Sliwinski, P., Hardin, M., Fingerlin, T. E., Schwartz, D. A., Postma, D. S., MacNee, W., Tobin, M. D., Silverman, E. K., Boezen, H. M., & Cho, M. H.
Venue
Nature Genetics
Publisher
Springer Science and Business Media LLC
Published
2017-02-06
Volume
49
Issue
3
Pages
426-432
ISSN
  • 1061-4036 (ISSN-L)
  • 1546-1718
DOI
10.1038/ng.3752
OpenAlex
W2558208069
Cited by
398
References
77
FWCI
36.04
Type
journal article
Language
en
Open access
bronze

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