Genetic associations with human longevity at the APOE and ACE loci

Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families

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Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.

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Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction.

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Aging, natural death, and the compression of morbidity

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Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI.

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Apolipoprotein E polymorphism and atherosclerosis.

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Deletion polymorphism in the gene for angiotensin-converting enzyme is a potent risk factor for myocardial infarction

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PCR detection of the insertion/deletion polymorphism of the human angiotensin converting enzyme gene (DCP1) (dipeptidyl carboxypeptidase 1)

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Evidence, from combined segregation and linkage analysis, that a variant of the angiotensin I-converting enzyme (ACE) gene controls plasma ACE levels.

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Evolution of senescence: late survival sacrificed for reproduction

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A Population-Based Study of Dementia in 85-Year-Olds

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Longevity, senescence, and the genome

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Proposed nomenclature of apoE isoproteins, apoE genotypes, and phenotypes

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Angiotensin-converting enzyme: new concepts concerning its biological role.

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Absence of linkage between the angiotensin converting enzyme locus and human essential hypertension

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Deletion polymorphism in angiotensin-converting enzyme gene associated with parental history of myocardial infarction

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Apolipoprotein E isoform phenotyping methodology and population frequency with identification of apoE1 and apoE5 isoforms

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Apolipoprotein ∈4 homozygosity in young men with coronary heart disease

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INFLUENCE OF MAJOR HISTOCOMPATIBILITY COMPLEX REGION GENES ON HUMAN LONGEVITY AMONG OKINAWAN-JAPANESE CENTENARIANS AND NONAGENARIANS

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Expression of a membrane protease enhances presentation of endogenous antigens to MHC class I-restricted T lymphocytes

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Genetic control of human apolipoprotein E polymorphism: Comparison of one-and two-dimensional techniques of isoprotein analysis

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Apolipoprotein B gene polymorphisms, lipoproteins and coronary atherosclerosis: A study of young myocardial infarction survivors and healthy population-based individuals

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HLA and longevity

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Prospects for the genetics of human longevity

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Increased frequencies of apolipoprotein ε2 and ε4 alleles in patients with ischemic heart disease

Eto, M., Watanabe, K., & Makino, I. (1989) · Clinical Genetics · doi:10.1111/j.1399-0004.1989.tb03186.x · Cited by 83

PCR DETECTION OF THE INSERTION/ DELETION POLYMORPHISM OF THE HUMAN ANGIOTENSIN CONVERTING ENZYME GENE

Rigat, B. A., Hübert, C., Corvol, P. L., & Soubrier, F. (1992) · Cited by 75

The familial component in longevity. A study of offspring of nonagenarians. II. Preliminary analysis of the completed study.

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Rapid typing of apolipoprotein B DNA polymorphisms by DNA amplification association between Ag epitopes of human apolipoprotein B-100, a signal peptide insertion/deletion polymorphism, and a 3' flanking DNA variable number of tandem repeats polymorphism of the apolipoprotein B gene

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Direct Phenotyping of Human Apolipoprotein E in Plasma: Application to Population Frequency Distribution in Paris (France)

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The Angiotensin I–Converting Enzyme (Kininase II): Molecular Organization and Regulation of Its Expression in Humans

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Linkage relationships of the gene for apolipoprotein CII with loci on chromosome 19

Donald, J. A., Wallis, S. C., Kessling, A. M., Tippett, P., Robson, E. B., Ball, S., Davies, K. E., Scambler, P. J., Berg, K., Heiberg, A., et al. (1985) · Human Genetics · doi:10.1007/bf00295527 · Cited by 31

Nonrandom association between huntington disease and two loci separated by about 3 Mb on 4p16.3

Andrew, S. E., Theilmann, J., Hedrick, A., Mah, D. G., Weber, B. H. F., & Hayden, M. R. (1992) · Genomics · doi:10.1016/0888-7543(92)90246-o · Cited by 28

Angiotensin-Converting Enzyme in Cortical Tissue in Alzheimer's and Some Other Neurological Diseases

McGeer, E. G., & Singh, E. A. (1992) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000107029 · Cited by 20

Gender differences in a Type 2 (non-insulin-dependent) diabetic population with respect to apolipoprotein E phenotype frequencies

Boemi, M., James, R. W., Romagnoli, F., Gerber, P., Pometta, D., & Fumelli, P. (1993) · Diabetologia · doi:10.1007/bf00399955 · Cited by 18

GROWTH HORMONE THERAPY

Jørgensen, J. L., & Christiansen, J. (1993) · The Lancet · doi:10.1016/0140-6736(93)91150-k · Cited by 16

Genetic Dissection of Complex Traits

Lander, E. S., & Schork, N. J. (1994) · Science · doi:10.1126/science.8091226 · Cited by 3,425

Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans

Franceschi, C., Capri, M., Monti, D., Giunta, S., Olivieri, F., Sevini, F., Panourgia, M. P., Invidia, L., Celani, L., Scurti, M., et al. (2007) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2006.11.016 · Cited by 2,087

Distinct patterns of brain activity in young carriers of the APOE -ε4 allele

Filippini, N., MacIntosh, B. J., Hough, M. G., Goodwin, G. M., Frisoni, G. B., Smith, S. M., Matthews, P. M., Beckmann, C. F., & Mackay, C. E. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0811879106 · Cited by 1,613

Facing up to the global challenges of ageing

Partridge, L., Deelen, J., & Slagboom, P. E. (2018) · Nature · doi:10.1038/s41586-018-0457-8 · Cited by 1,475

Preclinical Evidence of Alzheimer's Disease in Persons Homozygous for the ε4 Allele for Apolipoprotein E

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Vascular genetic factors and human longevity

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Sex Differences in the Association of Apolipoprotein E and Angiotensin-Converting Enzyme Gene Polymorphisms With Healthy Aging and Longevity: A Population-Based Study From Southern Italy

Seripa, D., Franceschi, M., Matera, M. G., Panza, F., Kehoe, P. G., Gravina, C., Orsitto, G., Solfrizzi, V., Minno, G. D., Dallapiccola, B., et al. (2006) · The Journals of Gerontology Series A · doi:10.1093/gerona/61.9.918 · Cited by 78

APOE and longevity: study of a population of Sardinian Centenarians

Bellia, C., Sasso, B. L., Caruso, A., Liga, L., Raineri, R., Agnello, L., Bazza, F., & Ciaccio, M. (2011) · Nova Science Publishers (Nova Science Publishers, Inc.)

APOLIPOPROTEIN E, DEMENTIA, AND HUMAN LONGEVITY

Panza, F., Frisardi, V., Capurso, C. A., D’Introno, A., Colacicco, A. M., Seripa, D., Pilotto, A., Vendemiale, G., Capurso, A., & Solfrizzi, V. (2009) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2009.02211.x · Cited by 8

The ApoE Gene Is Related with Exceptional Longevity: A Systematic Review and Meta-Analysis

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