Potential therapeutic effects of the MTOR inhibitors for preventing ageing and progeria-related disorders

The Hallmarks of Aging

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mTOR Signaling in Growth Control and Disease

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Cellular senescence: when bad things happen to good cells

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Protein aggregation and neurodegenerative disease

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Everolimus for Advanced Pancreatic Neuroendocrine Tumors

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Prolonged Rapamycin Treatment Inhibits mTORC2 Assembly and Akt/PKB

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Diabetes and Cancer

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Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

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DNA damage, aging, and Cancer

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Autophagy and Aging

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Targets for Cell Cycle Arrest by the Immunosuppressant Rapamycin in Yeast

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ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase

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A unifying model for mTORC1-mediated regulation of mRNA translation

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Metformin improves healthspan and lifespan in mice

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Fasting: molecular mechanisms and clinical applications

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α-Synuclein Blocks ER-Golgi Traffic and Rab1 Rescues Neuron Loss in Parkinson's Models

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Loss of Huntingtin-Mediated BDNF Gene Transcription in Huntington's Disease

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Regulation of Yeast Replicative Life Span by TOR and Sch9 in Response to Nutrients

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Rapamycin: one drug, many effects

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Autophagy Genes Are Essential for Dauer Development and Life-Span Extension in <i>C. elegans</i>

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Atg8, a Ubiquitin-like Protein Required for Autophagosome Formation, Mediates Membrane Tethering and Hemifusion

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Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity

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Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules

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MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation

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Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span

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Efficacy and safety of sirolimus in lymphangioleiomyomatosis

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Influence of TOR kinase on lifespan in C. elegans

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Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila Melanogaster

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Making new contacts: the mTOR network in metabolism and signalling crosstalk

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Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease

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Everolimus for Subependymal Giant-Cell Astrocytomas in Tuberous Sclerosis

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New Users of Metformin Are at Low Risk of Incident Cancer

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Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans

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Rapamycin, But Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous Mice

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Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner

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Molecular Interplay between Mammalian Target of Rapamycin (mTOR), Amyloid-β, and Tau

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Regulation of innate immune cell function by mTOR

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Pathogenic Lysosomal Depletion in Parkinson's Disease

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Coronary-Artery Stents

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mTOR Regulation and Therapeutic Rejuvenation of Aging Hematopoietic Stem Cells

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Metformin Induces a Dietary Restriction-Like State and the Oxidative Stress Response to Extend C. elegans Healthspan via AMPK, LKB1 and SKN-1

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With TOR, Less Is More: A Key Role for the Conserved Nutrient-Sensing TOR Pathway in Aging

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Activation of mTORC2 by Association with the Ribosome

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Metformin, independent of AMPK, induces mTOR inhibition and cell-cycle arrest through REDD1

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A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma

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mTOR complex 2 signaling and functions

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SDZ RAD, A NEW RAPAMYCIN DERIVATIVE

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Yeast Life Span Extension by Depletion of 60S Ribosomal Subunits Is Mediated by Gcn4

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Picking the Point of Inhibition: A Comparative Review of PI3K/AKT/mTOR Pathway Inhibitors

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Rapamycin Protects against Neuron Death inIn VitroandIn VivoModels of Parkinson's Disease

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Life Span Extension by Calorie Restriction Depends on Rim15 and Transcription Factors Downstream of Ras/PKA, Tor, and Sch9

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mTOR and autophagy: a dynamic relationship governed by nutrients and energy.

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Understanding the benefit of metformin use in cancer treatment

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Inducing Autophagy by Rapamycin Before, but Not After, the Formation of Plaques and Tangles Ameliorates Cognitive Deficits

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Rapamycin decelerates cellular senescence

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Aβ inhibits the proteasome and enhances amyloid and tau accumulation

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Akt-dependent and -independent mechanisms of mTOR regulation in cancer

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Growth stimulation leads to cellular senescence when the cell cycle is blocked

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Rapamycin extends murine lifespan but has limited effects on aging

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RecQ helicases: suppressors of tumorigenesis and premature aging

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Rapamycin reverses cellular phenotypes and enhances mutant protein clearance in Hutchinson-Gilford progeria syndrome cells

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Metformin slows down aging and extends life span of female SHR mice

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Xeroderma pigmentosum

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Increased Mammalian Lifespan and a Segmental and Tissue-Specific Slowing of Aging after Genetic Reduction of mTOR Expression

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Resveratrol as a Therapeutic Agent for Neurodegenerative Diseases

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�씠吏��썝, �씠�뼢洹�, & 異붿긽�씗 (2011) · YUHSpace (Yonsei University Medical Library)