CoChat
Sign Up
Cited by 112Mitochondrial Function and PathologyGenetics, Aging, and Longevity in Model OrganismsCell death mechanisms and regulation

The DOI matches its Crossref record; 52 of the 53 references it cites were found in a registry or an index.

Lifespan and mitochondrial control of neurodegeneration

Wright, Alan F, Jacobson, Samuel G, Cideciyan, Artur V, Roman, Alejandro J, Shu, Xinhua, Vlachantoni, Dafni, McInnes, Roderick R, Riemersma, Rudolph A·2004·Nature Genetics
DOI 10.1038/ng1448
Open this paper in CoChat — free account

Abstract

We examine the allometric (comparative scaling) relationships between rates of neurodegeneration resulting from equivalent mutations in a diverse group of genes from five mammalian species with different maximum lifespan potentials. In both retina and brain, rates of neurodegeneration vary by as much as two orders of magnitude and are strongly correlated with maximum lifespan potential and rates of formation of mitochondrial reactive oxygen and nitrogen species (RONS). Cell death in these disorders is directly or indirectly regulated by the intrinsic mitochondrial cell death pathway. Mitochondria are the main source of RONS production and integrate cellular stress signals to coordinate the intrinsic pathway. We propose that these two functions are intimately related and that steady-state RONS-mediated signaling or damage to the mitochondrial stress-integration machinery is the principal factor setting the probability of cell death in response to a diverse range of cellular stressors. This provides a new and unifying framework for investigating neurodegenerative disorders.

Overview

Integrity signals

Registry

Crossref · 10.1038/ng1448

Cites

52 of 52 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Flagged first, then by citations

1 of the 53 references couldn’t be matched to a known paper.

Research works printed but not linked: 1

  1. Shiva, S. et al. Redox signalling: from nitric oxide to oxidised lipids. in Free Radicals: Enzymology, Signalling and Disease (eds. Cooper, C.E., Wilson, M.T. & Darley-Usmar, V.M.) 107–120 (Portland, London, 2004).

Cited by

Sorted by citations

See all 112

Related

See all

Metadata

Authors
Wright, A. F., Jacobson, S. G., Cideciyan, A. V., Roman, A. J., Shu, X., Vlachantoni, D., McInnes, R. R., & Riemersma, R. A.
Affiliations
  • Western General Hospital (GB)
  • University of Pennsylvania (US)
  • University of Toronto (CA)
  • UiT The Arctic University of Norway (NO)
Corresponding author
Wright, Alan F
ORCID
Venue
Nature Genetics
Publisher
Springer Science and Business Media LLC
Published
2004-10-28
Volume
36
Issue
11
Pages
1153-1158
ISSN
  • 1061-4036 (ISSN-L)
  • 1546-1718
DOI
10.1038/ng1448
OpenAlex
W2050863429
Cited by
111
References
53
Citations by year
2026: 4 · 2025: 3 · 2024: 2 · 2023: 5 · 2022: 4 · 2021: 6 · 2020: 8 · 2019: 3 · 2018: 7 · 2017: 5 · 2016: 3 · 2015: 5 · 2014: 5 · 2013: 3 · 2012: 3
FWCI
0.46
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Nature Genetics (publishedVersion)
  • PubMed (publishedVersion)
  • ResearchOnline (Glasgow Caledonian University) (acceptedVersion)
Funders
  • Macula Vision Research Foundation
  • National Institutes of Health
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Keywords
neurodegeneration, lifespan, allometric scaling, retina, brain, mammalian species comparison, genetic mutations
MeSH terms
Animals, Brain, Humans, Life Expectancy, Mitochondria, Nerve Degeneration, Retina, Species Specificity, Cell Death, Reactive Oxygen Species, Oxidative Stress, Neurodegenerative Diseases, Reactive Nitrogen Species

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review