The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Hypoxia-inducible factor–dependent induction of netrin-1 dampens inflammation caused by hypoxia
Open accessAbstract
Hypoxia incites inflammation, particularly at mucosal surfaces. Eltzschig and colleagues show that hypoxia also suppresses inflammation by inducing expression of the neuronal guidance molecule netrin-1, which inhibits the transepithelial migration of neutrophils. The neuronal guidance molecule netrin-1 is linked to the coordination of inflammatory responses. Given that mucosal surfaces are particularly prone to hypoxia-elicited inflammation, we sought to determine the function of netrin-1 in hypoxia-induced inflammation. We detected hypoxia-inducible factor 1α (HIF-1α)-dependent induction of expression of the gene encoding netrin-1 (Ntn1) in hypoxic epithelia. Neutrophil transepithelial migration studies showed that by engaging A2B adenosine receptor (A2BAR) on neutrophils, netrin-1 attenuated neutrophil transmigration. Exogenous netrin-1 suppressed hypoxia-elicited inflammation in wild-type but not in A2BAR-deficient mice, and inflammatory hypoxia was enhanced in Ntn1+/− mice relative to that in Ntn1+/+ mice. Our studies demonstrate that HIF-1α-dependent induction of netrin-1 attenuates hypoxia-elicited inflammation at mucosal surfaces.
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NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α
Rius, J., Guma, M., Schachtrup, C., Akassoglou, K., Zinkernagel, A. S., Nizet, V., Johnson, R. S., Haddad, G. G., & Karin, M. (2008) · Nature · doi:10.1038/nature06905 · Cited by 1,614
Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis
Karhausen, J., Furuta, G. T., Tomaszewski, J. E., Johnson, R. S., Colgan, S. P., & Haase, V. H. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200421086 · Cited by 655
Regulation of immune cells by local-tissue oxygen tension: HIF1α and adenosine receptors
Sitkovsky, M., & Lukashev, D. (2005) · Nature Reviews Immunology · doi:10.1038/nri1685 · Cited by 518
Coordinated Adenine Nucleotide Phosphohydrolysis and Nucleoside Signaling in Posthypoxic Endothelium
Eltzschig, H. K., Ibla, J. C., Furuta, G. T., Leonard, M. O., Jacobson, K. A., Enjyoji, K., Robson, S. C., & Colgan, S. P. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030891 · Cited by 499
Self-citationThe Hydroxylase Inhibitor Dimethyloxalylglycine Is Protective in a Murine Model of Colitis
Cummins, E. P., Seeballuck, F., Keely, S. J., Mangan, N. E., Callanan, J. J., Fallon, P. G., & Taylor, C. T. (2008) · Gastroenterology · doi:10.1053/j.gastro.2007.10.012 · Cited by 407 · cited 1×
“, and some data suggest an anti-inflammatory and tissue-protective function for HIF-1α signaling during acute inflammatio”
BackgroundMucosal Protection by Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibition
Robinson, A., Keely, S., Karhausen, J., Gerich, M. E., Furuta, G. T., & Colgan, S. P. (2008) · Gastroenterology · doi:10.1053/j.gastro.2007.09.033 · Cited by 368
Kojima, H., Gu, H., Nomura, S., Caldwell, C. C., Kobata, T., Carmeliet, P., Semenza, G. L., & Sitkovsky, M. V. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.052706699 · Cited by 224
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Eltzschig, H. K., & Carmeliet, P. (2011) · New England Journal of Medicine · doi:10.1056/nejmra0910283 · Cited by 2,061
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Borea, P. A., Gessi, S., Merighi, S., Vincenzi, F., & Varani, K. (2018) · Physiological Reviews · doi:10.1152/physrev.00049.2017 · Cited by 783
Clambey, E. T., McNamee, E. N., Westrich, J. A., Glover, L. E., Campbell, E. L., Jedlicka, P., de Zoeten, E. F., Cambier, J. C., Stenmark, K. R., Colgan, S. P., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1202366109 · Cited by 560
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Zhu, S., Zhu, J., Zhen, G., Hu, Y., An, S., Li, Y., Zheng, Q., Chen, Z., Yang, Y., Wan, M., et al. (2019) · Journal of Clinical Investigation · doi:10.1172/jci121561 · Cited by 456
Self-citationvan Gils, J. M., Derby, M. C., Fernandes, L. R., Ramkhelawon, B., Ray, T. D., Rayner, K. J., Parathath, S., Distel, E., Feig, J. L., Alvarez-Leite, J. I., et al. (2012) · Nature Immunology · doi:10.1038/ni.2205 · Cited by 365
Keeley, T. P., & Mann, G. E. (2019) · Physiological Reviews · doi:10.1152/physrev.00041.2017 · Cited by 329
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Bartels, K., Grenz, A., & Eltzschig, H. K. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1318345110 · Cited by 218
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Podjaski, C., Alvarez, J. I., Bourbonniere, L., Larouche, S., Terouz, S., Bin, J. M., Lécuyer, M.-A., Saint-Laurent, O., Larochelle, C., Darlington, P. J., et al. (2015) · Brain · doi:10.1093/brain/awv092 · Cited by 185
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Mirakaj, V., Dalli, J., Granja, T., Rosenberger, P., & Serhan, C. N. (2014) · Journal of Experimental Medicine · doi:10.1084/jem.20132103 · Cited by 176
Hypoxia‐inducible factors as neuroprotective agent in Alzheimer's disease
Ashok, B. S., Ajith, T. A., & Sivanesan, S. (2017) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.12717 · Cited by 150
Hindryckx, P., De Vos, M., Jacques, P., Ferdinande, L., Peeters, H., Olievier, K., Bogaert, S., Brinkman, B., Vandenabeele, P., Elewaut, D., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1002541 · Cited by 73
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Wang, B., Wan, J., Gong, X., Kuang, G., Cheng, X., & Min, S. (2015) · International Immunopharmacology · doi:10.1016/j.intimp.2014.11.011 · Cited by 32
Perez-Cornago, A., Mansego, M., Zulet, M., & Martinez, J. (2014) · Nutrients · doi:10.3390/nu6062387 · Cited by 28
Tada, Y., Ogawa, M., Watanabe, R., Zempo, H., Takamura, C., Suzuki, J.-I., Dan, T., Miyata, T., Isobe, M., & Komuro, I. (2014) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.2014.855196 · Cited by 9
Metadata
- Authors
- Rosenberger, P., Schwab, J. M., Mirakaj, V., Masekowsky, E., Mager, A., Morote-Garcia, J. C., Unertl, K., & Eltzschig, H. K.
- Venue
- Nature Immunology
- Published
- 2009-01-04
- Volume
- 10
- Issue
- 2
- Pages
- 195-202
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W2015111630
- Cited by
- 406
- References
- 7
- FWCI
- 17.01
- Type
- journal article
- Language
- en
- Open access
- hybrid
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