Student or educator? Sign up with your school email and get 6 months of Pro free.
Cited by 529

The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.

The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1

Open access
Yan, Nan, Regalado-Magdos, Ashton D, Stiggelbout, Bart, Lee-Kirsch, Min Ae, Lieberman, Judy·2010·Nature Immunology

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1038/ni.1941

Cites

8 of 8 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 8 references

Research works printed but not linked: 42

  1. Bowerman, B., Brown, N., Bishop, K. & Varmus, H. A nucleoprotein complex mediates the integration of retroviral DNA. Genes Dev. 3, 469–478 (1989). · DOI · Paper page
  2. Yan, N., Cherepanov, P., Daigle, J.E., Engelman, A. & Lieberman, J. The SET complex acts as a barrier to autointegration of HIV-1. PLoS Pathog. 5, e1000327 (2009). · DOI
  3. Lee-Kirsch, M.A. et al. A mutation in TREX1 that impairs susceptibility to granzyme A-mediated cell death underlies familial chilblain lupus. J. Mol. Med. 85, 531–537 (2007). · DOI
  4. Crow, Y. et al. Mutations in the gene encoding the 3′-5′ DNA exonuclease TREX1 cause Aicardi-Goutieres syndrome at the AGS1 locus. Nat. Genet. 38, 917–920 (2006). · DOI · Paper page
  5. Stetson, D.B. & Medzhitov, R. Recognition of cytosolic DNA activates an IRF3-dependent innate immune response. Immunity 24, 93–103 (2006). · DOI · Paper page
  6. Stetson, D.B., Ko, J.S., Heidmann, T. & Medzhitov, R. Trex1 prevents cell-intrinsic initiation of autoimmunity. Cell 134, 587–598 (2008). · DOI · Paper page
  7. Yang, Y., Lindahl, T. & Barnes, D. Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune disease. Cell 131, 873–886 (2007). · DOI · Paper page
  8. Honda, K. et al. IRF-7 is the master regulator of type-I interferon-dependent immune responses. Nature 434, 772–777 (2005). · DOI · Paper page
  9. Kawai, T. et al. Interferon-α induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6. Nat. Immunol. 5, 1061–1068 (2004). · DOI · Paper page
  10. Agy, M.B., Acker, R.L., Sherbert, C.H. & Katze, M.G. Interferon treatment inhibits virus replication in HIV-1- and SIV-infected CD4+ T-cell lines by distinct mechanisms: evidence for decreased stability and aberrant processing of HIV-1 proteins. Virology 214, 379–386 (1995). · DOI
  11. Coccia, E.M., Krust, B. & Hovanessian, A.G. Specific inhibition of viral protein synthesis in HIV-infected cells in response to interferon treatment. J. Biol. Chem. 269, 23087–23094 (1994). · DOI
  12. Shirazi, Y. & Pitha, P.M. Alpha interferon inhibits early stages of the human immunodeficiency virus type 1 replication cycle. J. Virol. 66, 1321–1328 (1992). · DOI · Paper page
  13. Baca-Regen, L., Heinzinger, N., Stevenson, M. & Gendelman, H.E. Alpha interferon-induced antiretroviral activities: restriction of viral nucleic acid synthesis and progeny virion production in human immunodeficiency virus type 1-infected monocytes. J. Virol. 68, 7559–7565 (1994). · DOI
  14. Mazur, D. & Perrino, F. Identification and expression of the TREX1 and TREX2 cDNA sequences encoding mammalian 3′→5′ exonucleases. J. Biol. Chem. 274, 19655–19660 (1999). · DOI · Paper page
  15. Lehtinen, D.A., Harvey, S., Mulcahy, M.J., Hollis, T. & Perrino, F.W. The TREX1 double-stranded DNA degradation activity is defective in dominant mutations associated with autoimmune disease. J. Biol. Chem. 283, 31649–31656 (2008). · DOI
  16. Hornung, V. & Latz, E. Intracellular DNA recognition. Nat. Rev. Immunol. 10, 123–130 (2010). · DOI · Paper page
  17. Schroder, K., Muruve, D.A. & Tschopp, J. Innate immunity: cytoplasmic DNA sensing by the AIM2 inflammasome. Curr. Biol. 19, R262–R265 (2009). · DOI
  18. Yang, P. et al. The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a β-catenin-dependent pathway. Nat. Immunol. 11, 487–494 (2010). · DOI · Paper page
  19. Yanai, H. et al. HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses. Nature 462, 99–103 (2009). · DOI · Paper page
  20. Chiu, Y.-H., Macmillan, J.B. & Chen, Z.J. RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway. Cell 138, 576–591 (2009). · DOI · Paper page
  21. Ablasser, A. et al. RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate. Nat. Immunol. 10, 1065–1072 (2009). · DOI · Paper page
  22. Xu, L.-G. VISA is an adapter protein required for virus-triggered IFN-β signaling. Mol. Cell 19, 727–740 (2005). · DOI · Paper page
  23. Zhong, B. et al. The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation. Immunity 29, 538–550 (2008). · DOI · Paper page
  24. Sun, W. et al. ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization. Proc. Natl. Acad. Sci. USA 106, 8653–8658 (2009). · DOI · Paper page
  25. Fan, Z., Beresford, P., Zhang, D. & Lieberman, J. HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A. Mol. Cell. Biol. 22, 2810–2820 (2002). · DOI
  26. Lehming, N., Le Saux, A., Schüller, J. & Ptashne, M. Chromatin components as part of a putative transcriptional repressing complex. Proc. Natl. Acad. Sci. USA 95, 7322–7326 (1998). · DOI
  27. Gabellini, D., Green, M.R. & Tupler, R. Inappropriate gene activation in FSHD: a repressor complex binds a chromosomal repeat deleted in dystrophic muscle. Cell 110, 339–348 (2002). · DOI · Paper page
  28. El Gazzar, M. et al. Chromatin-specific remodeling by HMGB1 and linker histone H1 silences proinflammatory genes during endotoxin tolerance. Mol. Cell. Biol. 29, 1959–1971 (2009). · DOI
  29. Goldfeld, A.E., Birch-Limberger, K., Schooley, R.T. & Walker, B.D. HIV-1 infection does not induce tumor necrosis factor-α or interferon-β gene transcription. J. Acquir. Immune Defic. Syndr. 4, 41–47 (1991). · doi:10.1097/00126334-199101000-00006
  30. Haase, A.T. Targeting early infection to prevent HIV-1 mucosal transmission. Nature 464, 217–223 (2010). · DOI · Paper page
  31. Beignon, A.-S. et al. Endocytosis of HIV-1 activates plasmacytoid dendritic cells via Toll-like receptor-viral RNA interactions. J. Clin. Invest. 115, 3265–3275 (2005). · DOI · Paper page
  32. Takaoka, A. et al. DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response. Nature 448, 501–505 (2007). · DOI · Paper page
  33. Siva, A. & Bushman, F. Poly(ADP-ribose) polymerase 1 is not strictly required for infection of murine cells by retroviruses. J. Virol. 76, 11904–11910 (2002). · DOI
  34. Pagans, S. et al. SIRT1 regulates HIV transcription via Tat deacetylation. PLoS Biol. 3, e41 (2005). · DOI · Paper page
  35. Fan, Z., Beresford, P., Oh, D., Zhang, D. & Lieberman, J. Tumor suppressor NM23–H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor. Cell 112, 659–672 (2003). · DOI · Paper page
  36. Zandman-Goddard, G. & Shoenfeld, Y. HIV and autoimmunity. Autoimmun. Rev. 1, 329–337 (2002). · DOI · Paper page
  37. Morita, M. et al. Gene-targeted mice lacking the Trex1 (DNase III) 3′→5′ DNA exonuclease develop inflammatory myocarditis. Mol. Cell. Biol. 24, 6719–6727 (2004). · DOI · Paper page
  38. He, J. et al. CCR3 and CCR5 are co-receptors for HIV-1 infection of microglia. Nature 385, 645–649 (1997). · DOI · Paper page
  39. Shun, M.C., Daigle, J.E., Vandegraaff, N. & Engelman, A. Wild-type levels of human immunodeficiency virus type 1 infectivity in the absence of cellular emerin protein. J. Virol. 81, 166–172 (2007). · DOI
  40. Hirt, B. Selective extraction of polyoma DNA from infected mouse cell cultures. J. Mol. Biol. 26, 365–369 (1967). · DOI · Paper page
  41. Paz, S. et al. Ubiquitin-regulated recruitment of IκB kinase ɛ to the MAVS interferon signaling adapter. Mol. Cell. Biol. 29, 3401–3412 (2009). · DOI
  42. Uzri, D. & Gehrke, L. Nucleotide sequences and modifications that determine RIG-I/RNA binding and signaling activities. J. Virol. 83, 4174–4184 (2009). · DOI

Cited by

See all 529

Metadata

Authors
Yan, N., Regalado-Magdos, A. D., Stiggelbout, B., Lee-Kirsch, M. A., & Lieberman, J.
Venue
Nature Immunology
Published
2010-09-26
Volume
11
Issue
11
Pages
1005-1013
ISSN
  • 1529-2908 (ISSN-L)
  • 1529-2916
OpenAlex
W2111969980
Cited by
529
References
8
FWCI
19.32
Type
journal article
Language
en
Open access
green
Licence
www.springer.com/tdm (tdm)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1. https://app.cochat.ai/papers/10.1038/ni.1941
The paper
Yan, N., Regalado-Magdos, A. D., Stiggelbout, B., Lee-Kirsch, M. A., & Lieberman, J. (2010). The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1. Nature Immunology. https://doi.org/10.1038/ni.1941

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.