The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
The tumor suppressor Tsc1 enforces quiescence of naive T cells to promote immune homeostasis and function
Open accessAbstract
The mechanisms that regulate T cell quiescence are poorly understood. We report that tuberous sclerosis complex 1 (Tsc1) establishes a quiescence program in naive T cells by controlling cell size, cell cycle entry, and responses to T cell receptor stimulation. Loss of quiescence predisposed Tsc1-deficient T cells to apoptosis that resulted in loss of conventional T cells and invariant natural killer T cells. Loss of Tsc1 function dampened in vivo immune responses to bacterial infection. Tsc1-deficient T cells exhibited increased mTORC1 but diminished mTORC2 activities, with mTORC1 activation essential for the disruption of immune homeostasis. Therefore, Tsc1-dependent control of mTOR is crucial in establishing naive T cell quiescence to facilitate adaptive immune function.
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Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
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mTOR: from growth signal integration to cancer, diabetes and ageing
Zoncu, R., Efeyan, A., & Sabatini, D. M. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3025 · Cited by 3,941
TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival
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Mitochondria and cell death: outer membrane permeabilization and beyond
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Self-citationmTOR regulates memory CD8 T-cell differentiation
Araki, K., Turner, A. P., Shaffer, V. O., Gangappa, S., Keller, S. A., Bachmann, M. F., Larsen, C. P., & Ahmed, R. (2009) · Nature · doi:10.1038/nature08155 · Cited by 1,575
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The TSC-mTOR Signaling Pathway Regulates the Innate Inflammatory Response
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Self-citationPanwar, V., Singh, A., Bhatt, M., Tonk, R. K., Azizov, S., Raza, A. S., Sengupta, S., Kumar, D., & Garg, M. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01608-z · Cited by 967
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Zeng, H., Yang, K., Cloer, C., Neale, G., Vogel, P., & Chi, H. (2013) · Nature · doi:10.1038/nature12297 · Cited by 788
Self-citationPaths to stemness: building the ultimate antitumour T cell
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Metadata
- Authors
- Yang, K., Neale, G., Green, D. R., He, W., & Chi, H.
- Venue
- Nature Immunology
- Published
- 2011-07-17
- Volume
- 12
- Issue
- 9
- Pages
- 888-897
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W2004629226
- Cited by
- 293
- References
- 14
- FWCI
- 10.68
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
