Cited by 552T-cell and B-cell ImmunologyCancer, Lipids, and MetabolismLipid metabolism and biosynthesis

The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.

Sterol regulatory element–binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity

Open access

Kidani, Yoko, Elsaesser, Heidi, Hock, M Benjamin, Vergnes, Laurent, Williams, Kevin J, Argus, Joseph P, Marbois, Beth N, Komisopoulou, Evangelia, Wilson, Elizabeth B, Osborne, Timothy F, Graeber, Thomas G, Reue, Karen, Brooks, David G, Bensinger, Steven J·2013·Nature Immunology

DOI 10.1038/ni.2570PMC PMC3652626

Open this paper in CoChat — free account

Abstract

Newly activated CD8(+) T cells reprogram their metabolism to meet the extraordinary biosynthetic demands of clonal expansion; however, the signals that mediate metabolic reprogramming remain poorly defined. Here we demonstrate an essential role for sterol regulatory element-binding proteins (SREBPs) in the acquisition of effector-cell metabolism. Without SREBP signaling, CD8(+) T cells were unable to blast, which resulted in attenuated clonal expansion during viral infection. Mechanistic studies indicated that SREBPs were essential for meeting the heightened lipid requirements of membrane synthesis during blastogenesis. SREBPs were dispensable for homeostatic proliferation, which indicated a context-specific requirement for SREBPs in effector responses. Our studies provide insights into the molecular signals that underlie the metabolic reprogramming of CD8(+) T cells during the transition from quiescence to activation.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/ni.2570

Cites

38 of 38 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
Huang, D. W., Sherman, B. T., & Lempicki, R. A. (2009) · Nature Protocols · doi:10.1038/nprot.2008.211 · Cited by 35,890
Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists
Huang, D. W., Sherman, B. T., & Lempicki, R. A. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkn923 · Cited by 14,108
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
Horton, J. D., Goldstein, J. L., & Brown, M. S. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15593 · Cited by 4,794
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
Horton, J. D., Goldstein, J. L., & Brown, M. S. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215593 · Cited by 4,092
The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation
Wang, R., Dillon, C. P., Shi, L. Z., Milasta, S., Carter, R., Finkelstein, D., McCormick, L. L., Fitzgerald, P., Chi, H., Munger, J., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.09.021 · Cited by 2,140
Activation of a metabolic gene regulatory network downstream of mTOR complex 1
Düvel, K., Yecies, J. L., Menon, S., Raman, P., Lipovsky, A. I., Souza, A. L., Triantafellow, E., Ma, Q., Gorski, R., Cleaver, S., et al. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.06.022 · Cited by 2,020
mTOR regulates memory CD8 T-cell differentiation
Araki, K., Turner, A. P., Shaffer, V. O., Gangappa, S., Keller, S. A., Bachmann, M. F., Larsen, C. P., & Ahmed, R. (2009) · Nature · doi:10.1038/nature08155 · Cited by 1,575
Enhancing CD8 T-cell memory by modulating fatty acid metabolism
Pearce, E. L., Walsh, M. C., Cejas, P. J., Harms, G. M., Shen, H., Wang, L.-S., Jones, R. G., & Choi, Y. (2009) · Nature · doi:10.1038/nature08097 · Cited by 1,559
Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development
van der Windt, G. J. W., Everts, B., Chang, C.-H., Curtis, J. D., Freitas, T. C., Amiel, E., Pearce, E. J., & Pearce, E. L. (2012) · Immunity · doi:10.1016/j.immuni.2011.12.007 · Cited by 1,540
Cancer's Molecular Sweet Tooth and the Warburg Effect
Kim, J., & Dang, C. V. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-1501 · Cited by 1,233

Show all 38 references

Sorted by citations

Items 201–300 of 544

MicroRNA regulation of cholesterol metabolism
Citrin, K. M., Fernandez-Hernando, C. F., & Suárez, Y. (2021) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14566 · Cited by 45
Cancer Immunotherapy: Whence and Whither
Stambrook, P. J., Maher, J. F., & Farzaneh, F. (2017) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-16-0427 · Cited by 43
Oncolytic adenovirus with MUC16-BiTE shows enhanced antitumor immune response by reversing the tumor microenvironment in PDX model of ovarian cancer
Wang, Q., Ma, X., Wu, H., Zhao, C., Chen, J., Li, R., Yan, S., Li, Y., Zhang, Q., Song, K., et al. (2022) · OncoImmunology · doi:10.1080/2162402x.2022.2096362 · Cited by 43
Metabolic rewiring and communication in cancer immunity
Chapman, N. M., & Chi, H. (2024) · Cell chemical biology · doi:10.1016/j.chembiol.2024.02.001 · Cited by 44
Dissecting Daily and Circadian Expression Rhythms of Clock-Controlled Genes in Human Blood
Lech, K., Ackermann, K., Revell, V. L., Lao, Ó., Skene, D. J., & Kayser, M. (2015) · Journal of Biological Rhythms · doi:10.1177/0748730415611761 · Cited by 43
The mutual interplay of lipid metabolism and the cells of the immune system in relation to atherosclerosis
Getz, G. S., & Reardon, C. A. (2014) · Clinical Lipidology · doi:10.2217/clp.14.50 · Cited by 43
Lipid-driven immunometabolic responses in atherosclerosis
Gisterå, A., & Ketelhuth, D. F. J. (2018) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000540 · Cited by 43
The Interconnection Between Immuno-Metabolism, Diabetes, and CKD
Bonacina, F., Baragetti, A., Catapano, A. L., & Norata, G. D. (2019) · Current Diabetes Reports · doi:10.1007/s11892-019-1143-4 · Cited by 45
Targeting cholesterol metabolism in Cancer: From molecular mechanisms to therapeutic implications
Lu, J., Chen, S., Bai, X., Liao, M., Qiu, Y., Zheng, L., & Yu, H. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115907 · Cited by 44
T cell metabolism in chronic viral infection
Pallett, L. J., Schmidt, N. M., & Schurich, A. (2019) · Clinical & Experimental Immunology · doi:10.1111/cei.13308 · Cited by 44
ACLY ubiquitination by CUL3-KLHL25 induces the reprogramming of fatty acid metabolism to facilitate iTreg differentiation
Tian, M., Hao, F., Jin, X., Sun, X. J., Jiang, Y., Wang, Y., Li, D., Chang, T., Zou, Y., Peng, P., et al. (2021) · eLife · doi:10.7554/elife.62394 · Cited by 41
The Pivotal Role of the Dysregulation of Cholesterol Homeostasis in Cancer: Implications for Therapeutic Targets
Mok, E. H. K., & Lee, T. K. (2020) · Cancers · doi:10.3390/cancers12061410 · Cited by 43
Metabolic Reprogramming of Immune Cells at the Maternal-Fetal Interface and the Development of Techniques for Immunometabolism
Wei, Y., Ding, J., Li, J., Cai, S., Liu, S., Hong, L., Yin, T., Zhang, Y., & Diao, L. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.717014 · Cited by 40
The low-density lipoprotein receptor–mTORC1 axis coordinates CD8+ T cell activation
Bonacina, F., Moregola, A., Svecla, M., Coe, D., Uboldi, P., Fraire, S., Beretta, S., Beretta, G., Pellegatta, F., Catapano, A. L., et al. (2022) · The Journal of Cell Biology · doi:10.1083/jcb.202202011 · Cited by 41
Cellular metabolism hijacked by viruses for immunoevasion: potential antiviral targets
Li, J., Wang, Y., Deng, H., Su, L., & Qiu, H. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1228811 · Cited by 40
Mevalonate metabolism governs cancer immune surveillance
Gruenbacher, G., & Thurnher, M. (2017) · OncoImmunology · doi:10.1080/2162402x.2017.1342917 · Cited by 40
Role of T Cells in the Pathogenesis of Rheumatoid Arthritis: Focus on Immunometabolism Dysfunctions
Masoumi, M., Alesaeidi, ‬., Khorramdelazad, H., Behzadi, M., Baharlou, R., Alizadeh‐Fanalou, S., & Karami, J. (2022) · Inflammation · doi:10.1007/s10753-022-01751-9 · Cited by 41
NADPH Selective Depletion Nanomedicine‐Mediated Radio‐Immunometabolism Regulation for Strengthening Anti‐PDL1 Therapy against TNBC
Wang, Y., Gao, D., Jin, L., Ren, X., Ouyang, Y., Zhou, Y., He, X., Jia, L., Tian, Z., Wu, D., et al. (2022) · Advanced Science · doi:10.1002/advs.202203788 · Cited by 39
Metabolic Reprogramming of Glycolysis, Lipids, and Amino Acids in Tumors: Impact on CD8 + T Cell Function and Targeted Therapeutic Strategies
Liang, P., Li, Z., Chen, Z., Chen, Z., Jin, T., He, F., Chen, X., Gou, H., & Yang, K. (2025) · The FASEB Journal · doi:10.1096/fj.202403019r · Cited by 42
Searching for the real function of mTOR signaling in the regulation of PD-L1 expression
Sun, S. (2020) · Translational Oncology · doi:10.1016/j.tranon.2020.100847 · Cited by 38
Role of the Sterol Regulatory Element Binding Protein Pathway in Tumorigenesis
Jiang, T., Zhang, G., & Lou, Z. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.01788 · Cited by 41
Impact of cholesterol-pathways on breast cancer development, a metabolic landscape
González-Ortiz, A., Galindo‐Hernández, O., Acevedo, G. N. H., Hurtado-Ureta, G., & García‐González, V. (2021) · Journal of Cancer · doi:10.7150/jca.54637 · Cited by 40
ACC1-expressing pathogenic T helper 2 cell populations facilitate lung and skin inflammation in mice
Nakajima, T., Kanno, T., Yokoyama, S., Sasamoto, S., Asou, H. K., Tumes, D. J., Ohara, O., Nakayama, T., & Endo, Y. (2021) · The Journal of Experimental Medicine · doi:10.1084/jem.20210639 · Cited by 39
Interferon Control of the Sterol Metabolic Network: Bidirectional Molecular Circuitry-Mediating Host Protection
Robertson, K. A., & Ghazal, P. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00634 · Cited by 38
tRNA m1A modification regulates cholesterol biosynthesis to promote antitumor immunity of CD8+ T cells
Miao, S., Li, H., Song, X., Liu, Y., Wang, G., Kan, C., Ye, Y., Liu, R., & Li, H. (2024) · The Journal of Experimental Medicine · doi:10.1084/jem.20240559 · Cited by 37
Metabolic adaptations of cells at the vascular-immune interface during atherosclerosis
Bonacina, F., Dalt, L. D., Catapano, A. L., & Norata, G. D. (2020) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2020.100918 · Cited by 37
Metabolic regulation of infection and inflammation
Chauhan, P. S., & Saha, B. (2018) · Cytokine · doi:10.1016/j.cyto.2018.11.016 · Cited by 39
Precise targeting of lipid metabolism in the era of immuno-oncology and the latest advances in nano-based drug delivery systems for cancer therapy
Zhang, H., Li, Y., Huang, J., Shen, L., & Yang, X. W. (2024) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2024.07.021 · Cited by 38
Targeting tumor metabolism to augment CD8+ T cell anti-tumor immunity
Liu, H., Yang, W., & Jiang, J. (2024) · Journal of Pharmaceutical Analysis · doi:10.1016/j.jpha.2024.101150 · Cited by 38
Integrated regulation of the cellular metabolism and function of immune cells in adipose tissue
Oishi, Y., & Manabe, I. (2016) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.12539 · Cited by 37
The Lysophosphatidylcholine Transporter MFSD2A Is Essential for CD8+ Memory T Cell Maintenance and Secondary Response to Infection
Piccirillo, A., Hyzny, E. J., Beppu, L. Y., Menk, A. V., Wallace, C. T., Hawse, W. F., Buechel, H. M., Wong, B. H., Foo, J. C., Cazenave‐Gassiot, A., et al. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1801585 · Cited by 37
Impact of Lipid Metabolism on Antitumor Immune Response
Mabrouk, N., Lecoeur, B., Bettaı̈eb, A., Paul, C., & Végran, F. (2022) · Cancers · doi:10.3390/cancers14071850 · Cited by 36
Posttranslational control of lipogenesis in the tumor microenvironment
Zhu, Y., Lin, X., Zhou, X., Prochownik, E. V., Wang, X., & Li, Y. (2022) · Journal of Hematology & Oncology · doi:10.1186/s13045-022-01340-1 · Cited by 39
Treatment of Dyslipidemia in Allogeneic Hematopoietic Stem Cell Transplant Patients
Marini, B. L., Choi, S. W., Byersdorfer, C. A., Cronin, S. M., & Frame, D. G. (2014) · Transplantation and Cellular Therapy · doi:10.1016/j.bbmt.2014.10.027 · Cited by 35
Lipid Metabolism in Breast Cancer: From Basic Research to Clinical Application
Huang, X., Liu, B., & Shen, S. (2025) · Cancers · doi:10.3390/cancers17040650 · Cited by 34
The Metabolic Profile of Tumor and Virally Infected Cells Shapes Their Microenvironment Counteracting T Cell Immunity
Magalhaes, I., Yogev, O., Mattsson, J., & Schurich, A. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02309 · Cited by 34
Acsbg1 Dependent Mitochondrial Fitness is a Metabolic Checkpoint for Tissue T reg Cell Homeostasis
Kanno, T., Nakajima, T., Kawashima, Y., Yokoyama, S., Asou, H. K., Sasamoto, S., Hayashizaki, K., Kinjo, Y., Ohara, O., Nakayama, T., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109921 · Cited by 35
T-Cell Metabolism in Hematopoietic Cell Transplantation
Nguyen, H. D., Kuril, S., Bastian, D. A., & Yu, X. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00176 · Cited by 34
ABCG1 Is Required for Pulmonary B-1 B Cell and Natural Antibody Homeostasis
Baldán, Á., Gonen, A., Choung, C., Que, X., Marquart, T. J., Hernández, I., Björkhem, I., Ford, D. A., Witztum, J. L., & Tarling, E. J. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1400606 · Cited by 32
The Role of Fatty Acid Oxidation in the Metabolic Reprograming of Activated T-Cells
Byersdorfer, C. A. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00641 · Cited by 33
Insight into the role of mTOR and metabolism in T cells reveals new potential approaches to preventing graft rejection
Lo, Y.-C., Lee, C.-F., & Powell, J. D. (2014) · Current Opinion in Organ Transplantation · doi:10.1097/mot.0000000000000098 · Cited by 33
Mevalonate promotes differentiation of regulatory T cells
Acharya, S., Timilshina, M., & Chang, J. (2019) · Journal of Molecular Medicine · doi:10.1007/s00109-019-01784-y · Cited by 34
Cholesterol-modifying drugs in COVID-19
Schmidt, N. M., Wing, P. A. C., McKeating, J. A., & Maini, M. K. (2020) · Oxford Open Immunology · doi:10.1093/oxfimm/iqaa001 · Cited by 32
Modulating Cholesterol Homeostasis to Build a Better T Cell
Kidani, Y., & Bensinger, S. J. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.05.015 · Cited by 32
Self-citation
Targeting T Cell Metabolism in Inflammatory Skin Disease
von Meyenn, L., Bertschi, N., & Schlapbach, C. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02285 · Cited by 32
Metabolic drives affecting Th17/Treg gene expression changes and differentiation: impact on immune‐microenvironment regulation
Brescia, C., Audia, S., Pugliano, A., Scaglione, F., Iuliano, R., Trapasso, F., Perrotti, N., Chiarella, E., & Amato, R. (2024) · Apmis · doi:10.1111/apm.13378 · Cited by 34
Microbial metabolites and their influence on the tumor microenvironment
Duan, H., Xu, B., Luo, P., Chen, T., & Zou, J. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1675677 · Cited by 31
Genome-wide analysis reveals TNFAIP8L2 as an immune checkpoint regulator of inflammation and metabolism
Li, T., Wang, W., Gong, S., Sun, H., Zhang, H., Yang, A., Chen, Y. H., & Li, X. (2018) · Molecular Immunology · doi:10.1016/j.molimm.2018.05.007 · Cited by 31
T Cell Metabolism in Cancer Immunotherapy
Aksoylar, H., Tijaro-Ovalle, N. M., Boussiotis, V. A., & Patsoukis, N. (2020) · Immunometabolism · doi:10.20900/immunometab20200020 · Cited by 31
Immunologic Aspects of Dyslipidemia: a Critical Regulator of Adaptive Immunity and Immune Disorders
Kim, D., Chung, H., Lee, J.-E., Kim, J., Hwang, J., & Chung, Y. (2021) · Journal of Lipid and Atherosclerosis · doi:10.12997/jla.2021.10.2.184 · Cited by 33
CD20 positive CD8 T cells are a unique and transcriptionally-distinct subset of T cells with distinct transmigration properties
Vlaming, M. R., Bilemjian, V., Freile, J. Á., Lourens, H. J., van Rooij, N., Huls, G. A., van Meerten, T., de Bruyn, M., & Bremer, E. (2021) · Scientific Reports · doi:10.1038/s41598-021-00007-0 · Cited by 31
Metabolites in the Tumor Microenvironment Reprogram Functions of Immune Effector Cells Through Epigenetic Modifications
Li, Y., Wu, Y., & Hu, Y. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.641883 · Cited by 31
Lipid homeostasis and mevalonate pathway in COVID-19: Basic concepts and potential therapeutic targets
Proto, M., Fiore, D., Piscopo, C., Pagano, C., Galgani, M., Bruzzaniti, S., Laezza, C., Gazzerro, P., & Bifulco, M. (2021) · Progress in Lipid Research · doi:10.1016/j.plipres.2021.101099 · Cited by 30
Metabolism of T Lymphocytes in Health and Disease
Gaber, T., Chen, Y., Krauß, P.-L., & Buttgereit, F. (2018) · International review of cytology · doi:10.1016/bs.ircmb.2018.06.002 · Cited by 32
Cholesterol metabolism in innate and adaptive response
Reboldi, A., & Dang, E. V. (2018) · F1000Research · doi:10.12688/f1000research.15500.1 · Cited by 32
Tabula Sapiens reveals transcription factor expression, senescence effects, and sex-specific features in cell types from 28 human organs and tissuesPreprint
Quake, S. R. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.12.03.626516 · Cited by 35
Remodeling metabolic fitness: Strategies for improving the efficacy of chimeric antigen receptor T cell therapy
Shen, L., Xiao, Y., Tian, J., & Lu, Z. (2022) · Cancer Letters · doi:10.1016/j.canlet.2022.01.006 · Cited by 31
Harnessing the Induction of CD8+ T-Cell Responses Through Metabolic Regulation by Pathogen-Recognition-Receptor Triggering in Antigen Presenting Cells
Nicoli, F., Paul, S., & Appay, V. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02372 · Cited by 29
Dysregulation of cholesterol homeostasis in cancer pathogenesis
Mordzińska-Rak, A., Verdeil, G., Hamon, Y., Błaszczak, E., & Trombik, T. (2025) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-025-05617-9 · Cited by 30
Metabolic features of innate lymphoid cells
Yu, H., Jacquelot, N., & Belz, G. T. (2022) · The Journal of Experimental Medicine · doi:10.1084/jem.20221140 · Cited by 31
Reduction of Proinflammatory Effector Functions Through Remodeling of Fatty Acid Metabolism in CD8 + T Cells From Rheumatoid Arthritis Patients
Kraus, F. V., Keck, S., Klika, K. D., Graf, J., Carvalho, R. A., Lorenz, H., & Souto‐Carneiro, M. (2023) · Arthritis & Rheumatology · doi:10.1002/art.42456 · Cited by 29
T-cell Cholesterol Accumulation, Aging, and Atherosclerosis
Bazioti, V., Halmos, B., & Westerterp, M. (2023) · Current Atherosclerosis Reports · doi:10.1007/s11883-023-01125-y · Cited by 27
Innate and Adaptive Immune Cell Metabolism in Tumor Microenvironment
Wu, D. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-94-024-1170-6_7 · Cited by 27
Inhibition of stearoyl‐CoA desaturases suppresses follicular help T‐ and germinal center B‐ cell responses
Son, Y. M., Cheon, I. S., Goplen, N. P., Dent, A. L., & Sun, J. (2020) · European Journal of Immunology · doi:10.1002/eji.201948257 · Cited by 27
TCR-signaling events in cellular metabolism and specialization
Chisolm, D. A., & Weinmann, A. S. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00292 · Cited by 26
The mevalonate pathway in breast cancer biology
Göbel, A., Riffel, R. M., Hofbauer, L. C., & Rachner, T. D. (2022) · Cancer Letters · doi:10.1016/j.canlet.2022.215761 · Cited by 25
The role of lipid metabolism in shaping the expansion and the function of regulatory T cells
Grimaldos, A. P., Bini, S., Pacella, I., Rossi, A., Costanzo, A. D., Minicocci, I., D’Erasmo, L., Arca, M., & Piconese, S. (2021) · Clinical & Experimental Immunology · doi:10.1093/cei/uxab033 · Cited by 25
Global Trends in Research of Lipid Metabolism in T lymphocytes From 1985 to 2022: A Bibliometric Analysis
Chen, P., Zhong, C., Jin, S., Zhang, Y., Li, Y., Xia, Q., Cheng, J., Fan, X., & Lin, H. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.884030 · Cited by 25
Metabolic hallmarks of natural killer cells in the tumor microenvironment and implications in cancer immunotherapy
Yang, Y., Chen, L., Zheng, B., & Zhou, S. (2022) · Oncogene · doi:10.1038/s41388-022-02562-w · Cited by 27
T cell receptor sequences are the dominant factor contributing to the phenotype of CD8+ T cells with specificities against immunogenic viral antigens
Chen, D. G., Xie, J., Su, Y., & Heath, J. R. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113279 · Cited by 26
T cell metabolism and susceptibility to autoimmune diseases
Galgani, M., Rosa, V. D., & Matarese, G. (2015) · Molecular Immunology · doi:10.1016/j.molimm.2015.07.035 · Cited by 27
Metabolic plasticity of T cell fate decision
Pan, X., Wang, J., Zhang, L., Li, G., & Huang, B. (2023) · Chinese Medical Journal · doi:10.1097/cm9.0000000000002989 · Cited by 26
Lipid Metabolism: An Emerging Player in Sjögren’s Syndrome
Chang, K., Luo, P., Guo, Z., Yang, L., Pu, J., Han, F., Cai, F., Tang, J., & Wang, X. (2025) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-025-09023-8 · Cited by 24
Effect of inhibiting ACAT‑1 expression on the growth and metastasis of Lewis lung carcinoma
Bi, M., Qiao, X., Zhang, H., Wu, H., Gao, Z., Zhou, H., Shi, M., Wang, Y., Yang, J., Hu, J., et al. (2019) · Oncology Letters · doi:10.3892/ol.2019.10427 · Cited by 26
Fatostatin promotes anti-tumor immunity by reducing SREBP2 mediated cholesterol metabolism in tumor-infiltrating T lymphocytes
Zhu, L., Shi, Y., Feng, Z., Yuan, D., Guo, S., Wang, Y., Shen, H., Li, Y., Yan, F., & Wang, Y. (2024) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2024.176519 · Cited by 23
Focusing on CD8+ T-cell phenotypes: improving solid tumor therapy
Yao, Z., Zeng, Y., Liu, C., Jin, H., Wang, H., Zhang, Y., Ding, C., Chen, G., & Wu, D. (2024) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-024-03195-5 · Cited by 27
Cholesterol metabolism in tumor immunity: Mechanisms and therapeutic opportunities for cancer
Guo, X., Zhu, B., Li, J., Guo, P., Niu, Y., Shi, J., Yokoyama, W., Huang, Q., & Shao, D. (2025) · Biochemical Pharmacology · doi:10.1016/j.bcp.2025.116802 · Cited by 23
The Role of Cholesterol Metabolism and Its Regulation in Tumor Development
Wu, Y., Song, W., Su, M., He, J., Hu, R., & Zhao, Y. (2025) · Cancer Medicine · doi:10.1002/cam4.70783 · Cited by 23
Deciphering the deterministic role of TCR signaling in T cell fate determination
Qin, Z., & Xu, T. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1562248 · Cited by 30
Dietary Cholesterol Causes Inflammatory Imbalance and Exacerbates Morbidity in Mice Infected with Influenza A Virus
Louie, A. Y., Tingling, J. D., Dray, E. L., Hussain, J., McKim, D. B., Swanson, K. S., & Steelman, A. J. (2022) · The Journal of Immunology · doi:10.4049/jimmunol.2100927 · Cited by 24
Lipids for CD8+ TILs: Beneficial or harmful?
Wu, D., & Chen, Y. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1020422 · Cited by 24
An ACAT inhibitor suppresses SARS-CoV-2 replication and boosts antiviral T cell activity
Wing, P. A. C., Schmidt, N. M., Peters, R., Erdmann, M., Brown, R. L., Wang, H., Swadling, L., COVIDsortium Investigators, Newman, J., Thakur, N., et al. (2023) · PLoS Pathogens · doi:10.1371/journal.ppat.1011323 · Cited by 23
Reviewing the impact of lipid synthetic flux on Th17 function
Kidani, Y., & Bensinger, S. J. (2017) · Current Opinion in Immunology · doi:10.1016/j.coi.2017.03.012 · Cited by 23
Self-citation
The significance of lipid metabolism reprogramming of tumor-associated macrophages in hepatocellular carcinoma
Xie, Q.-J., Zeng, Y., Zhang, X., & Yu, F. (2024) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-024-03748-9 · Cited by 24
ICI-induced cardiovascular toxicity: mechanisms and immune reprogramming therapeutic strategies
Zheng, J., Yi, Y., Tian, T., Luo, S., Liang, X., & Bai, Y. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1550400 · Cited by 24
Integrating Metabolic Modulation and Nanomedicine for Cancer Immunotherapy
Zhou, X., Deng, R., Liao, Z., Huang, X., Huang, J., Yang, H., Leong, K. W., & Zhong, Y. (2025) · Advanced Science · doi:10.1002/advs.202510004 · Cited by 26
Interplay of Immunometabolism and Epithelial–Mesenchymal Transition in the Tumor Microenvironment
Chou, M.-Y., & Yang, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22189878 · Cited by 23
Lipid metabolism of hepatocellular carcinoma impacts targeted therapy and immunotherapy
Feng, X.-C., Liu, F., Chen, W.-Y., Du, J. T., & Liu, H. (2023) · World Journal of Gastrointestinal Oncology · doi:10.4251/wjgo.v15.i4.617 · Cited by 21
Lipid metabolism: a central modulator of RORγt-mediated Th17 cell differentiation
Kanno, T., Miyako, K., & Endo, Y. (2024) · International Immunology · doi:10.1093/intimm/dxae031 · Cited by 20
Cholesterol 25-hydroxylase is a metabolic switch to constrain T cell–mediated inflammation in the skin
Takahashi, H., Nomura, H., Iriki, H., Kubo, A., Isami, K., Mikami, Y., Mukai, M., Sasaki, T., Yamagami, J., Kudoh, J., et al. (2021) · Science Immunology · doi:10.1126/sciimmunol.abb6444 · Cited by 22
Fatty Acid Metabolism and T Cells in Multiple Sclerosis
Pompura, S. L., Hafler, D. A., & Dominguez‐Villar, M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.869197 · Cited by 23
Lipid metabolism in tumor-infiltrating T cells: mechanisms and applications
Ke, X., Zou, M.-W., & Xu, C. (2022) · Life Metabolism · doi:10.1093/lifemeta/loac038 · Cited by 21
Th17 cells in the liver: balancing autoimmunity and pathogen defense
Taniki, N., Nakamoto, N., Chu, P., Ichikawa, M., Teratani, T., & Kanai∥, T. (2022) · Seminars in Immunopathology · doi:10.1007/s00281-022-00917-9 · Cited by 22
CYP51-mediated cholesterol biosynthesis is required for the proliferation of CD4+ T cells in Sjogren’s syndrome
Yin, J., Fu, J., Shao, Y., Xu, J., Li, H., Chen, C., Zhao, Y., Zheng, Z., Yu, C., Zheng, L., et al. (2022) · Clinical and Experimental Medicine · doi:10.1007/s10238-022-00939-5 · Cited by 20
Metabolism along the life journey of T cells
Peng, M., & Li, M. O. (2023) · Life Metabolism · doi:10.1093/lifemeta/load002 · Cited by 20
T cell metabolism in metabolic disease-associated autoimmunity
Amersfoort, J., & Kuiper, J. (2017) · Immunobiology · doi:10.1016/j.imbio.2017.03.001 · Cited by 20
Metabolism in Immune Cell Differentiation and Function
Chapman, N. M., Shrestha, S., & Chi, H. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-94-024-1170-6_1 · Cited by 22
Differential Metabolome in Rheumatoid Arthritis: a Brief Perspective
Agnihotri, P., Monu, M., Ramani, S., Chakraborty, D., Saquib, M., & Biswas, S. (2021) · Current Rheumatology Reports · doi:10.1007/s11926-021-00989-w · Cited by 20
Decoding the crosstalk between mevalonate metabolism and T cell function
Kennewick, K. T., & Bensinger, S. J. (2023) · Immunological Reviews · doi:10.1111/imr.13200 · Cited by 20
Self-citation
Oleic acid triggers metabolic rewiring of T cells poising them for T helper 9 differentiation
Reilly, N. A., Sonnet, F., Dekkers, K. F., Kwekkeboom, J. C., Sinke, L., Hilt, S. T., Suleiman, H. M., Hoeksema, M. A., Mei, H., van Zwet, E. W., et al. (2024) · iScience · doi:10.1016/j.isci.2024.109496 · Cited by 20

Authors: Kidani, Y., Elsaesser, H., Hock, M. B., Vergnes, L., Williams, K. J., Argus, J. P., Marbois, B. N., Komisopoulou, E., Wilson, E. B., Osborne, T. F., Graeber, T. G., Reue, K., Brooks, D. G., & Bensinger, S. J.
Affiliations: University of California, Los Angeles (US)
Sanford Burnham Prebys Medical Discovery Institute (US)
Corresponding author: Bensinger, Steven J
ORCID: Hock, M Benjamin
Vergnes, Laurent
Williams, Kevin J
Argus, Joseph P
Wilson, Elizabeth B
Osborne, Timothy F
Graeber, Thomas G
Reue, Karen
Brooks, David G
Bensinger, Steven J
Venue: Nature Immunology
Publisher: Springer Science and Business Media LLC
Published: 2013-04-07
Volume: 14
Issue: 5
Pages: 489-499
ISSN: 1529-2908 (ISSN-L)
1529-2916
DOI: 10.1038/ni.2570
PMC: PMC3652626
OpenAlex: W2025714915
Cited by: 552
References: 38
Citations by year: 2026: 39 · 2025: 63 · 2024: 55 · 2023: 48 · 2022: 61 · 2021: 52 · 2020: 42 · 2019: 39 · 2018: 29 · 2017: 34 · 2016: 28 · 2015: 32 · 2014: 23 · 2013: 7
FWCI: 16.58
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: www.springer.com/tdm (tdm)
Locations: Nature Immunology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: National Heart, Lung, and Blood Institute (P01HL090553, R01HL048044)
National Cancer Institute (T32-CA009120-36, T32CA009120)
National Institute of General Medical Sciences (T32GM008496, T32-GM008469)
National Institute of Allergy and Infectious Diseases (AI093768, U01AI082975, R01AI093768, R01AI085043, AI082975, AI085043)
National Center for Research Resources (S10RR026744)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Keywords: SREBP, CD8+ T cells, T cell metabolic reprogramming, clonal expansion, T cell blastogenesis, membrane lipid synthesis, homeostatic proliferation, viral infection, adaptive immunity, T cell activation
MeSH terms: Animals, Cell Differentiation, Cells, Cultured, Lymphocyte Activation, Mice, Inbred C57BL, Mice, Mutant Strains, Signal Transduction, CD8-Positive T-Lymphocytes, Transgenes, RNA, Small Interfering, Cell Proliferation, Mice, Sterol Regulatory Element Binding Protein 1, Sterol Regulatory Element Binding Protein 2, Adaptive Immunity

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Sterol regulatory element–binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks