The DOI matches its Crossref record; 117 of the 117 references it cites were found in a registry or an index.
Understanding immunosenescence to improve responses to vaccines
Open accessAbstract
In the older adult, the benefits of vaccination to prevent infectious disease are limited, mainly because of the adaptive immune system's inability to generate protective immunity. The age-dependent decrease in immunological competence, often referred to as 'immunosenescence', results from the progressive deterioration of innate and adaptive immune responses. Most insights into mechanisms of immunological aging have been derived from studies of mouse models. In this Review, we explore how well such models are applicable to understanding the aging process throughout the 80-100 years of human life and discuss recent advances in identifying and characterizing the mechanisms that underlie age-associated defective adaptive immunity in humans.
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“These and other models, for which it has been shown that accelerated aging depends, at least partly, on cellular senescence, are valuable for studying the impact of senescence on health and lifespan”
From Guidelines for minimal information on cellular senescence experimentation in vivo (2024) · cites this paper as [100]
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In the citing paper
“Mouse models of rapid telomere shortening, dysfunctional mitosis or impaired DNA repair (Terc, BubR1, and Ercc1 mutant mice, respectively), display high levels of cellular senescence and accelerated aging86,99,100.”
From Guidelines for minimal information on cellular senescence experimentation in vivo (2024) · cites this paper as [100]
Experimental — accuracy not yet measuredIn the citing paper
“Evidence of waning adaptive immunity is already apparent in mid adulthood, as early as at the age of 50 years, with increasing clinical relevance in the 7th–10th decade of life”
From Successful and Maladaptive T Cell Aging (2017) · cites this paper as Goronzy and Weyand, 2013
In the citing paper
“Mechanistically, immunosenescence is only partially explained by organismal and cellular senescence.”
From Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention (2019) · cites this paper as [23]
In the citing paper
“Therefore, these hallmarks of immunosenescence would be markedly affected by the history of the individual exposure to pathogens (6, 23).”
From Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention (2019) · cites this paper as [23]
In the citing paper
“The hallmarks of immunosenescence include: (i) a reduced ability to respond to new antigens; (ii) the accumulation of memory T cells; (iii) a lingering level of low-grade inflammation termed “inflamm-aging.””
From Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention (2019) · cites this paper as [23]
In the citing paper
“T cell clones specific for HCMV dominate the repertoire in the older people and contribute to the contraction in diversity in the memory compartment (23).”
From Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention (2019) · cites this paper as [23]
In the citing paper
“In contrast, high frequencies of antigen-specific T cells reactive to HCMV persist throughout life.”
From Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention (2019) · cites this paper as [23]
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Citations
Cites
Wherry, E. J. (2011) · Nature Immunology · doi:10.1038/ni.2035 · Cited by 4,062
Of Mice and Not Men: Differences between Mouse and Human Immunology
Mestas, J., & Hughes, C. C. W. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.5.2731 · Cited by 3,822
The PD‐1 pathway in tolerance and autoimmunity
Francisco, L. M., Sage, P. T., & Sharpe, A. H. (2010) · Immunological Reviews · doi:10.1111/j.1600-065x.2010.00923.x · Cited by 2,300
Vaccine Adjuvants: Putting Innate Immunity to Work
Coffman, R. L., Sher, A., & Seder, R. A. (2010) · Immunity · doi:10.1016/j.immuni.2010.10.002 · Cited by 1,983
Changes in thymic function with age and during the treatment of HIV infection
Douek, D. C., McFarland, R. D., Keiser, P. H., Gage, E. A., Massey, J. M., Haynes, B. F., Polis, M. A., Haase, A. T., Feinberg, M. B., Sullivan#, J. L., et al. (1998) · Nature · doi:10.1038/25374 · Cited by 1,893
Metabolic Regulation of T Lymphocytes
MacIver, N. J., Michalek, R. D., & Rathmell, J. C. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032712-095956 · Cited by 1,244
Age-related changes in lymphocyte development and function
Linton, P. J., & Dorshkind, K. A. (2004) · Nature Immunology · doi:10.1038/ni1033 · Cited by 1,199
miR-181a Is an Intrinsic Modulator of T Cell Sensitivity and Selection
Li, Q.-J., Chau, J., Ebert, P. J. R., Sylvester, G., Min, H., Liu, G., Braich, R. S., Manoharan, M., Soutschek, J., Skare, P., et al. (2007) · Cell · doi:10.1016/j.cell.2007.03.008 · Cited by 1,165
Redefining Chronic Viral Infection
Virgin, H. W., Wherry, E. J., & Ahmed, R. (2009) · Cell · doi:10.1016/j.cell.2009.06.036 · Cited by 1,031
Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age
Pang, W. W., Price, E. A., Sahoo, D., Beerman, I., Maloney, W. J., Rossi, D. J., Schrier, S. L., & Weissman, I. L. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1116110108 · Cited by 991
Research works printed but not linked: 1
- Boraschi, D. et al. Ageing and Immunity. Sci. Transl. Med. (in the press).
Cited by
Sorted by citations
Items 801–841 of 841
Lee, Y. (2026) · Cureus · doi:10.7759/cureus.105873
“Furthermore, the mechanisms underlying the dramatic increase in NK cell activity following autologous blood infusion warrant further investigation, particularly in the context of immunosenescence [12].”
Champiat, S. (2019) · theses.fr (ABES) · doi:10.70675/e358773dz1898z4feezbb3bzbdee7c7f20a6
Exploration de la réponse de l'hôte au travers de différentes approches globales
Daumas, A. (2019) · theses.fr (ABES) · doi:10.70675/c844f815z3aa0z4983z9077z1aaa7156ac85
Statistical biophysics models of immune repertoire dynamics
Koraichi, M. B. (2022) · theses.fr (ABES) · doi:10.70675/625cdda6zca1dz443dzb6f4z3637549945b7
Inflammation, aging and chronic diseases : implication of inflammasomes
Guerville, F. (2023) · theses.fr (ABES) · doi:10.70675/eac3286czda71z4606z9c90z3d3efeaf1afe
Postigo, T., Ortega, A., Álvaro‐Meca, A., Vélez, D., García‐Mateo, N., Tedim, A. P., Almansa, R., Eiros, J. M., de Gonzalo‐Calvo, D., Moncusí‐Moix, A., et al. (2026) · GeroScience · doi:10.1007/s11357-026-02212-z
Djaharuddin, I., Nurmala, D. R., Nurjaya, I., Rasiha, R., & Tobing, D. L. (2026) · Exploration of Immunology · doi:10.37349/ei.2026.1003250
CD25+ cell depletion enhances protective immunity of PR8 inactivated influenza vaccine in aged mice
Zhang, Y. G., Liu, L., Chen, T., Li, M., Shi, X., & Liu, Y. (2026) · Virology · doi:10.1016/j.virol.2026.110938
Wang, S., Liu, Q., Zhou, P., Hu, W., & Liu, J. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1754915
“Speci fi cally, the reduced activity of age-related T cells, which are crucial for controlling VZV, further elevates the risk of infection in the elderly population (40).”
Effects of micronutrient supplementation on immune function in older adults: a meta-analysis
Li, D., Wang, T., Xiao, L., & Li, K. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1732861
Liu, R., Xie, T., Zhao, J., Zuo, C. Y., Gao, Q., & Kuang, Y. (2026) · Expert Opinion on Biological Therapy · doi:10.1080/14712598.2026.2688136
“Goronzy and Weyand reported that with increasing age, decreased thymic output leads to shrinkage of the peripheral T cell pool, while NK cells, as a key component of the innate immune system, may increase to compensate for the decline in adaptive immune function [19].”
InfluentialZhou, H., Wei, B., 覃温露, Shi, J. H., Ren, C., Zhang, J. M., Yang, C., Zhao, Z., & Ning, S. (2026) · Biology Direct · doi:10.1186/s13062-026-00860-x
Leukocyte profiles reveal sex and age differences in immune investment in a polygynous bat
Wilkinson, G. S., Kaiser, J. A., Armenta, K., Cunningham, A. S. G., Hex, S. B. S. W., Lawson, A. M., & Rayner, J. G. (2026) · Journal of Animal Ecology · doi:10.1111/1365-2656.70296
Research progress on the mechanism and intervention strategies of immunosenescence
Zhong-Yu, H. U., Chan-Chan, X. I. A. O., Yu-Dai, X. U., & Chen, G. (2026) · Shengming kexue · doi:10.3724/cbls.2026102
Song, Y. E., Yan, J., Ou, B. S., Saouaf, O. M., Eckman, N., & Appel, E. A. (2026) · Advanced Science · doi:10.1002/advs.76481
“While vaccination is a crucial tool for preventing infectious diseases, elderly populations also suffer from reduced vaccine efficacy due to age-related immunosenescence [ 4–6 ].”
Li, X., Pan, X., & Lu, H. (2026) · Research Square · doi:10.21203/rs.3.rs-10155388/v1
Chen, H., Zhang, Z., Wen, Z., Yang, Z., Li, L., Wang, S., Gao, Q., Liu, H., Liu, L., & Chen, Y. (2026) · Journal of Controlled Release · doi:10.1016/j.jconrel.2026.115262
Zhang, Q., Shen, K., & Liu, S. (2026) · Cells · doi:10.3390/cells15161457
“DNA methylation changes, histone modifications, chromatin accessibility, and non-coding RNAs can affect immune-cell differentiation, inflammatory memory, and exhaustion-like states [25–28 , 114– Understanding transcriptional control of immune aging has practical implications.”
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Engwerda, C. R., & Engel, J. A. (2026) · doi:10.1002/9781394383054.ch9
Wang, D., Shi, X., & Zhang, Y. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103307
Joshi, M., Carré, C., Çevirgel, A., Bijvank, E., Chabaud-Riou, M., Courtois, V., Chautard, É., Larocque, D., Burny, W., Beckers, L., et al. (2026) · medRxiv · doi:10.64898/2026.08.26.26361408
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Arhami, O., & Rohani, P. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.08.27.747648
Remodeling of innate antiviral immunity in aging
Zhang, X., & Yang, Q. (2026) · Cell Insight · doi:10.1016/j.cellin.2026.100362
“Rather, it represents a remodeling of immune set points, signaling thresholds, cellular composition, and tissue micro-environments (Goronzy & Weyand, 2013, 2019; Nikolich-� Zugich, 2018).”
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Jin, Z., Liu, W., Li, J., Zeng, Z., Che, B., Liu, J., Shen, L., & Cao, Y. (2026) · Journal of the National Cancer Center · doi:10.1016/j.jncc.2026.08.002
Network-orchestrated regulation of thymic dysfunction and restoration
Sun, W., Chen, H., Guo, W., Guo, Q., Guan, Y., Li, M., Qin, G., Zhang, Y., & Wei, W. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1896047
“…accelerates during puberty, and follows a highly conserved trajectory characterized by progressive disruption of epithelial architecture, stromal remodeling, and declining thymopoiesis and thymic output, establishing thymic involution as a major bottle-neck contributing to immunosenescence (7, 8).”
A transitional senescence program drives inflammatory monocyte state expansion in aging humansPreprint
Vasilopoulos, T., Turano, P. S., Garza‐Martinez, L., Akbulut, E., Konda, M., Herbig, U., Fitzgerald-Bocarsly, P. A., & Martínez‐Zamudio, R. I. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.09.09.750459
Thymic function as a central determinant of immune competence and clinical outcomes
Taviani, A., Genah, S., Mancusi, A., Luca, C. D. D., Rosichini, M., Locatelli, F., & Velardi, E. (2026) · Seminars in Immunopathology · doi:10.1007/s00281-026-01088-7
Cao, Y., Liang, Y., Zhao, C., Zhou, Z., Yu, S., Yang, Q., & Shao, L. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103387
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Yousef, A., Seubert, J. M., Power, C., & Nathoo, N. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1944657
“These senescent B cells are characterized by higher levels of signaling via CD80, CD86, and CD40, which lead to increased in fl ammatory T cell responses and worsening MS disease (158, 159).”
Shim, E., Eun, B. W., & Choi, W. S. (2026) · Frontiers in Public Health · doi:10.3389/fpubh.2026.1833971
“However, substantial residual disease burden persists among vaccinated older individuals due to immunosenescence, the age-related decline in immune function with aging (6).”
Lu, W., & Yan, J. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1908166
Zheng, L., Cao, W., Wang, Y., Xu, T., Wang, F., Zhang, L., Liu, X., & Li, T. (2026) · Frontiers in Aging · doi:10.3389/fragi.2026.1847033
Humoral Immunogenicity of mRNA-1010, an mRNA-based Seasonal Influenza Vaccine, in Adults ≥50 Years
Leroux‐Roels, I., Malkin, E. M., Chen, H., Avanesov, A., Chen, R., Fidler, B., Das, R., & Wilson, E. M. P. (2026) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofag646
Estimating Immune Age from B-Cell Receptor Repertoire Using Machine Learning
Liu, T., & Yang, F. (2026) · International Conference on Bioinformatics and Biomedical Technology (ICBBT) · doi:10.1145/3822521.3822540
Kulkarni, G., Zor, F., Külahçı, Y., Brennen, B., Gorantla, V. S., & Jackson, J. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-16110-0.00009-1
The mask of sanity: Cancer and autoimmunity as complementary failures of semiotic classification
Bukkuri, A. (2026) · Mathematical Biosciences & Engineering · doi:10.3934/mbe.2026109
Metadata
- Authors
- Goronzy, J. J., & Weyand, C. M.
- Affiliations
- Stanford Medicine (US)
- VA Palo Alto Health Care System (US)
- Corresponding author
- Goronzy, Jörg J
- Venue
- Nature Immunology
- Published
- 2013-04-18
- Volume
- 14
- Issue
- 5
- Pages
- 428-436
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- PMC
- PMC4183346
- OpenAlex
- W1992431343
- Cited by
- 827
- References
- 115
- Citations by year
- 2026: 66 · 2025: 62 · 2024: 89 · 2023: 76 · 2022: 61 · 2021: 83 · 2020: 58 · 2019: 68 · 2018: 46 · 2017: 59 · 2016: 53 · 2015: 53 · 2014: 38 · 2013: 15
- FWCI
- 4.65
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Nature Immunology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Heart, Lung, and Blood Institute (P01HL058000, R01HL117913)
- National Eye Institute (R01EY011916)
- National Institute of Allergy and Infectious Diseases (R01AI044142, U01AI089859, R01AI44142, R01AI108906, U19AI090019, R01AI108891, U19AI057266)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR042527)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Keywords
- immunosenescence, immunological aging, older adults, vaccine response, innate immune dysregulation, mouse models of aging
- MeSH terms
- Aged, Aged, 80 and over, Aging, Animals, Communicable Disease Control, Humans, Immunocompetence, Vaccination, Vaccines, Cellular Senescence, Mice, Adaptive Immunity
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