The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
TH2, allergy and group 2 innate lymphoid cells
Open accessAbstract
The initiation of type 2 immune responses by the epithelial cell–derived cytokines IL-25, IL-33 and TSLP has been an area of extensive research in the past decade. Such studies have led to the identification of a new innate lymphoid subset that produces the canonical type 2 cytokines IL-5, IL-9 and IL-13 in response to IL-25 and IL-33. These group 2 or type 2 innate lymphoid cells (ILC2 cells) represent a critical source of type 2 cytokines in vivo and serve an important role in orchestrating the type 2 response to helminths and allergens. Further characterization of ILC2 cell biology will enhance the understanding of type 2 responses and may identify new treatments for asthma, allergies and parasitic infections. Interactions between ILC2 cells and the adaptive immune system, as well as examination of potential roles for ILC2 cells in the maintenance of homeostasis, promise to be particularly fruitful areas of future research.
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Cites
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T cell subsets and their signature cytokines in autoimmune and inflammatory diseases
Raphael, I., Nalawade, S., Eagar, T. N., & Forsthuber, T. G. (2015) · Cytokine · doi:10.1016/j.cyto.2014.09.011 · Cited by 1,160
Akdis, M., Aab, A., Altunbulakli, C., Azkur, K., Costa, R. A., Crameri, R., Duan, S., Eiwegger, T., Eljaszewicz, A., Ferstl, R., et al. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2016.06.033 · Cited by 912
Anti-inflammatory and immune-regulatory cytokines in rheumatoid arthritis
Chen, Z., Bozec, A., Ramming, A., & Schett, G. (2019) · Nature Reviews Rheumatology · doi:10.1038/s41584-018-0109-2 · Cited by 719
Type 2 cytokines: mechanisms and therapeutic strategies
Wynn, T. A. (2015) · Nature Reviews Immunology · doi:10.1038/nri3831 · Cited by 678
Activated Type 2 Innate Lymphoid Cells Regulate Beige Fat Biogenesis
Lee, M.-W., Odegaard, J. I., Mukundan, L., Qiu, Y., Molofsky, A. B., Nussbaum, J. C., Yun, K., Locksley, R. M., & Chawla, A. (2015) · Cell · doi:10.1016/j.cell.2014.12.011 · Cited by 677
Metadata
- Authors
- Licona-Limón, P., Kim, L. K., Palm, N. W., & Flavell, R. A.
- Venue
- Nature Immunology
- Published
- 2013-05-20
- Volume
- 14
- Issue
- 6
- Pages
- 536-542
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W1993734178
- Cited by
- 646
- References
- 9
- FWCI
- 33.04
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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