The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
The transcription factor IRF4 is essential for TCR affinity–mediated metabolic programming and clonal expansion of T cells
Open accessAbstract
During immune responses, T cells are subject to clonal competition, which leads to the predominant expansion of high-affinity clones; however, there is little understanding of how this process is controlled. We found here that the transcription factor IRF4 was induced in a manner dependent on affinity for the T cell antigen receptor (TCR) and acted as a dose-dependent regulator of the metabolic function of activated T cells. IRF4 regulated the expression of key molecules required for the aerobic glycolysis of effector T cells and was essential for the clonal expansion and maintenance of effector function of antigen-specific CD8+ T cells. Thus, IRF4 is an indispensable molecular 'rheostat' that 'translates' TCR affinity into the appropriate transcriptional programs that link metabolic function with the clonal selection and effector differentiation of T cells.
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Self-citationThe transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation
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Transcriptional control of effector and memory CD8+ T cell differentiation
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FoxOs Are Critical Mediators of Hematopoietic Stem Cell Resistance to Physiologic Oxidative Stress
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Metabolic Regulation of T Lymphocytes
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Requirement for the Transcription Factor LSIRF/IRF4 for Mature B and T Lymphocyte Function
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Metadata
- Authors
- Man, K., Miasari, M., Shi, W., Xin, A., Henstridge, D. C., Preston, S., Pellegrini, M., Belz, G. T., Smyth, G. K., Febbraio, M. A., Nutt, S. L., & Kallies, A.
- Venue
- Nature Immunology
- Published
- 2013-09-22
- Volume
- 14
- Issue
- 11
- Pages
- 1155-1165
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W2145026575
- Cited by
- 405
- References
- 9
- FWCI
- 16.20
- Type
- journal article
- Language
- en
- Open access
- green
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- Man, K., Miasari, M., Shi, W., Xin, A., Henstridge, D. C., Preston, S., Pellegrini, M., Belz, G. T., Smyth, G. K., Febbraio, M. A., Nutt, S. L., & Kallies, A. (2013). The transcription factor IRF4 is essential for TCR affinity–mediated metabolic programming and clonal expansion of T cells. Nature Immunology. https://doi.org/10.1038/ni.2710
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