Inflammasome-mediated innate immunity in Alzheimer’s disease

Neuroinflammation in Alzheimer's disease

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The Inflammasome

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A role for mitochondria in nlrp3 inflammasome activation

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Gout-associated uric acid crystals activate the NALP3 inflammasome

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The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5

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Cryopyrin activates the inflammasome in response to toxins and ATP

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Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

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Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

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Cutting Edge: NF-κB Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

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NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

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Activation and regulation of the inflammasomes

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Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

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The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

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AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

Hornung, V., Ablasser, A., Charrel-Dennis, M., Bauernfeind, F., Horvath, G., Caffrey, D. R., Latz, E., & Fitzgerald, K. A. (2009) · Nature · doi:10.1038/nature07725 · Cited by 2,627 · see citing works

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

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K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter

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Targeting the NLRP3 inflammasome in inflammatory diseases

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AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

Fernandes-Alnemri, T., Yu, J.-W., Datta, P., Wu, J., & Alnemri, E. S. (2009) · Nature · doi:10.1038/nature07710 · Cited by 1,831 · see citing works

Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling

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NALP3 Forms an IL-1β-Processing Inflammasome with Increased Activity in Muckle-Wells Autoinflammatory Disorder

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Self-propagation of pathogenic protein aggregates in neurodegenerative diseases

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Depletion of microglia and inhibition of exosome synthesis halt tau propagation

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Disease-Associated Microglia: A Universal Immune Sensor of Neurodegeneration

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Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration

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Oxidative stress and mitochondrial dysfunction in Alzheimer’s disease

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Microglial Dysfunction and Defective β-Amyloid Clearance Pathways in Aging Alzheimer's Disease Mice

Hickman, S. E., Allison, E. K., & El Khoury, J. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.0616-08.2008 · Cited by 1,329 · see citing works

The P2X7 Receptor in Infection and Inflammation

Di Virgilio, F., Dal Ben, D., Sarti, A. C., Giuliani, A. L., & Falzoni, S. (2017) · Immunity · doi:10.1016/j.immuni.2017.06.020 · Cited by 1,267 · see citing works

Systemic inflammation and disease progression in Alzheimer disease

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Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease

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Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1β via Ipaf

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The P2X7 Receptor: A Key Player in IL-1 Processing and Release

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Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer’s disease

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Exogenous Induction of Cerebral ß-Amyloidogenesis Is Governed by Agent and Host

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Mechanism of Oxidative Stress in Neurodegeneration

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The NLR Gene Family: A Standard Nomenclature

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The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response

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Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin

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Oxidative Stress and the Pathogenesis of Alzheimer's Disease

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Reactive microglia in patients with senile dementia of the Alzheimer type are positive for the histocompatibility glycoprotein HLA-DR

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HIN-200 Proteins Regulate Caspase Activation in Response to Foreign Cytoplasmic DNA

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The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response

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Central and Systemic Endotoxin Challenges Exacerbate the Local Inflammatory Response and Increase Neuronal Death during Chronic Neurodegeneration

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Deubiquitination of NLRP3 by BRCC3 Critically Regulates Inflammasome Activity

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Reconstituted NALP1 Inflammasome Reveals Two-Step Mechanism of Caspase-1 Activation

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Enhanced Proteolysis of β-Amyloid in APP Transgenic Mice Prevents Plaque Formation, Secondary Pathology, and Premature Death

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Critical Role for Cryopyrin/Nalp3 in Activation of Caspase-1 in Response to Viral Infection and Double-stranded RNA

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NLRs join TLRs as innate sensors of pathogens

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Apoptosis and Oxidative Stress in Neurodegenerative Diseases

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Substantial sulfatide deficiency and ceramide elevation in very early Alzheimer's disease: potential role in disease pathogenesis

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Gene expression changes in the course of normal brain aging are sexually dimorphic

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Cutting Edge: TNF-α Mediates Sensitization to ATP and Silica via the NLRP3 Inflammasome in the Absence of Microbial Stimulation

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An Essential Role for the NLRP3 Inflammasome in Host Defense against the Human Fungal Pathogen Candida albicans

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Role of the Toll-Like Receptor 4 in Neuroinflammation in Alzheimer’s Disease

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Inflammasome Components NALP 1 and 3 Show Distinct but Separate Expression Profiles in Human Tissues Suggesting a Site-specific Role in the Inflammatory Response

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Amyloid, hypometabolism, and cognition in Alzheimer disease: An [11C]PIB and [18F]FDG PET study

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Locus ceruleus controls Alzheimer's disease pathology by modulating microglial functions through norepinephrine

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Cryopyrin/NALP3 binds ATP/dATP, is an ATPase, and requires ATP binding to mediate inflammatory signaling

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Intrathecal inflammation precedes development of Alzheimer's disease

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Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study

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Critical function for Naip5 in inflammasome activation by a conserved carboxy-terminal domain of flagellin

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ATP is released by monocytes stimulated with pathogen-sensing receptor ligands and induces IL-1β and IL-18 secretion in an autocrine way

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The inflammasomes: mechanisms of activation and function

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TLR2 Is a Primary Receptor for Alzheimer’s Amyloid β Peptide To Trigger Neuroinflammatory Activation

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A NOD2–NALP1 complex mediates caspase-1-dependent IL-1β secretion in response to Bacillus anthracis infection and muramyl dipeptide

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Inflammatory repertoire of Alzheimer's disease and nondemented elderly microglia in vitro

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In vivo radioligand binding to translocator protein correlates with severity of Alzheimer’s disease

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Inflammasomes: too big to miss

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A Molecular Platform in Neurons Regulates Inflammation after Spinal Cord Injury

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The LPS receptor (CD14) links innate immunity with Alzheimer's disease

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Neuronal NLRP1 inflammasome activation of Caspase-1 coordinately regulates inflammatory interleukin-1-beta production and axonal degeneration-associated Caspase-6 activation

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Potassium‐inhibited processing of IL‐1 beta in human monocytes.

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PYPAF1, a PYRIN-containing Apaf1-like Protein That Assembles with ASC and Regulates Activation of NF-κB

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Ceramides in Alzheimer’s Disease: Key Mediators of Neuronal Apoptosis Induced by Oxidative Stress and A <b> <i>β</i> </b> Accumulation

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Danger-associated molecular patterns in Alzheimer’s disease

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Expression of interleukin-18 is increased in the brains of Alzheimer’s disease patients

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Pro-inflammatory interleukin-18 increases Alzheimer’s disease-associated amyloid-β production in human neuron-like cells

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The NAIP – NLRC 4 inflammasome in innate immune detection of bacterial flagellin and type III secretion apparatus

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Amyloid β-degrading cryptidases: insulin degrading enzyme, presequence peptidase, and neprilysin

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In vivo changes in microglial activation and amyloid deposits in brain regions with hypometabolism in Alzheimer’s disease

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Microglial activation in Alzheimer's disease: an (R)-[11C]PK11195 positron emission tomography study

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BindingDB Entry 50021757: Ferroptosis and its modulators: A raising target for cancer and Alzheimer's disease.

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