Mitochondrial control of the NLRP3 inflammasome

Kepp, Oliver; Galluzzi, Lorenzo; Kroemer, Guido

doi:10.1038/ni0311-199

Cited by 168Inflammasome and immune disordersImmune Response and InflammationMitochondrial Function and Pathology

Mitochondrial control of the NLRP3 inflammasome

Kepp, Oliver, Galluzzi, Lorenzo, Kroemer, Guido·2011·Nature Immunology

DOI 10.1038/ni0311-199

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Strong evidence from mouse studies indicates that blockade of the NLRP3 inflammasome extends healthspan, attenuating multiple age-related degenerative changes linked to inflammageing, including insulin resistance, thymic involution, T cell senescence, bone loss, and physical and cognitive function decline.
“In humans, IL-18 blood levels increase with ageing, and strong evidence from mouse studies indicates that blockade of the NLRP3 inflammasome extends healthspan, attenuating multiple age-related degenerative changes that have been linked to inflammageing, including insulin resistance, thymic involution, T cell senescence, and bone loss as well as physical and cognitive function decline114,117,118.”
From Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty (2018) · cites this paper as [117]

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Molecular pathogenesis in chronic obstructive pulmonary disease and therapeutic potential by targeting AMP‐activated protein kinase
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Spirodalesol analog 8A inhibits NLRP3 inflammasome activation and attenuates inflammatory disease by directly targeting adaptor protein ASC
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Ragweed pollen extract intensifies lipopolysaccharide‐induced priming of NLRP 3 inflammasome in human macrophages
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Immunomodulatory Effects of Danshen (Salvia miltiorrhiza) in BALB/c Mice
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Authors: Kepp, O., Galluzzi, L., & Kroemer, G.
Affiliations: Université Paris-Sud (FR)
Inserm (FR)
Corresponding author: Kroemer, Guido
ORCID: Kepp, Oliver
Galluzzi, Lorenzo
Kroemer, Guido
Venue: Nature Immunology
Publisher: Springer Science and Business Media LLC
Published: 2011-02-15
Volume: 12
Issue: 3
Pages: 199-200
ISSN: 1529-2908 (ISSN-L)
1529-2916
DOI: 10.1038/ni0311-199
OpenAlex: W1981120301
Cited by: 168
References: 12
Citations by year: 2026: 4 · 2025: 4 · 2024: 10 · 2023: 8 · 2022: 16 · 2021: 9 · 2020: 17 · 2019: 12 · 2018: 8 · 2017: 12 · 2016: 14 · 2015: 10 · 2014: 12 · 2013: 16 · 2012: 11
FWCI: 5.72
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Immunology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Keywords: mitochondria, NLRP3 inflammasome, innate immunity, inflammatory cytokines, inflammasome regulation, mitochondrial function
MeSH terms: NLR Family, Pyrin Domain-Containing 3 Protein, Animals, Carrier Proteins, Humans, Immunity, Innate, Mitochondria, Models, Biological, Signal Transduction, Cytokines, Inflammasomes

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