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Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells
Abstract
A major unanswered question is what distinguishes the majority of activated CD8 T cells that die after an acute viral infection from the small fraction (5-10%) that survive to become long-lived memory cells. In this study we show that increased expression of the interleukin 7 receptor alpha-chain (IL-7Ralpha) identifies the effector CD8 T cells that will differentiate into memory cells. IL-7R(hi) effector cells contained increased amounts of antiapoptotic molecules, and adoptive transfer of IL-7R(hi) and IL-7R(lo) effector cells showed that IL-7R(hi) cells preferentially gave rise to memory cells that could persist and confer protective immunity. Thus, selective expression of IL-7R identifies memory cell precursors, and this marker may be useful in predicting the number of memory T cells generated after infection or immunization.
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“Ag-specific CD8 T cells derived from the effector phase of a response can express various combinations of CD127 and KLRG1, which define either more short-lived effector cells (SLECs; CD127−KLRG1+), which are lost during the contraction phase of the immune response, or memory precursor effector cells (MPECs; CD127+KLRG1−), which are more likely to persist and contribute to memory populations [224,”
From Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition) (2021) · cites this paper as [224]
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“Indeed, IL7R is an important marker of functional heterogeneity observed in mouse effector memory CD8+ T cells (Kaech et al., 2003).”
BackgroundIL‐33 synergizes with TCR and IL‐12 signaling to promote the effector function of CD8+ T cells
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ResultUrbani, S., Amadei, B., Fisicaro, P., Tola, D., Orlandini, A., Sacchelli, L., Mori, C., Missale, G., & Ferrari, C. I. (2006) · Hepatology · doi:10.1002/hep.21242 · Cited by 196
Functional signatures in antiviral T-cell immunity for monitoring virus-associated diseases
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“During viral infections, the emergence of CD127 expression on virusspecific CD8 T cells occurs only when the antigen load is contained and sufficient CD4 T-cell help is available (3, 5, 12).”
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Self-citationIntermediates of Metabolism: From Bystanders to Signalling Molecules
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The ABCs of artificial antigen presentation
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InfluentialEnforced PGC-1α expression promotes CD8 T cell fitness, memory formation and antitumor immunity
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“profile of the recently identified subset of effector cells that selectively develops into memory cells (51, 52).”
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Knox, J. J., Cosma, G. L., Betts, M. R., & McLane, L. M. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00217 · Cited by 199
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Hepatic interleukin-7 expression regulates T cell responses.
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“Indeed, memory-activated T cells have been shown to express high amount of IL-7Ra (Kaech et al., 2003).”
BackgroundInfluentialThe metabolic life and times of a T‐cell
Michalek, R. D., & Rathmell, J. C. (2010) · Immunological Reviews · doi:10.1111/j.1600-065x.2010.00911.x · Cited by 186
“One proposed mechanism is the selective upregulation of IL-7Ra on a subset of T cells, which may allow these cells to maintain some homeostatic regulation of nutrient uptake and metabolism (55, 114, 115).”
BackgroundXin, A., Masson, F., Liao, Y., Preston, S., Guan, T., Gloury, R., Olshansky, M., Lin, J., Li, P., Speed, T. P., et al. (2016) · Nature Immunology · doi:10.1038/ni.3410 · Cited by 191
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“Within this population of tetramer-positive CD8 T cells, we also determined the frequency of cells expressing CD127, a marker shown to correlate with the capacity of effector cells to develop into memory cells (36).”
BackgroundDifferentiation of memory B and T cells
Kalia, V., Sarkar, S., Gourley, T. S., Rouse, B. T., & Ahmed, R. (2006) · Current Opinion in Immunology · doi:10.1016/j.coi.2006.03.020 · Cited by 188
“Moreover, recent identification of a memory precursor population within the effector T-cell pool further supports the paradigm that memory T cells pass through an effector phase [56,57 ,58].”
ResultSelf-citationIbegbu, C., Xu, Y., Harris, W. B., Maggio, D. M., Miller, J. D., & Kourtis, A. P. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.10.6088 · Cited by 183
“It has been recently described in a mouse model that expression of the IL-7R (CD127) identifies effector CD8 T cells that give rise to long-lived memory cells (19).”
CD8αα-Mediated Survival and Differentiation of CD8 Memory T Cell Precursors
Madakamutil, L. T., Christen, U., Lena, C. J., Wang-Zhu, Y., Attinger, A., Sundarrajan, M., Ellmeier, W., von Herrath, M. G., Jensen, P. E., Littman, D. R., et al. (2004) · Science · doi:10.1126/science.1092316 · Cited by 183
Role of PI3K/Akt signaling in memory CD8 T cell differentiation
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The function and dysfunction of memory CD 8+ T cells in tumor immunity
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Constitutive Activation of Wnt Signaling Favors Generation of Memory CD8 T Cells
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“IL-7Ra is known for its dynamic gene expression changes during T cell responses, being expressed in naive T cells, downregulated in effectors, and restored to an even higher levels in memory T cells (32, 33).”
BackgroundThe role of mTOR in memory CD8+ T‐cell differentiation
Araki, K., Youngblood, B., & Ahmed, R. (2010) · Immunological Reviews · doi:10.1111/j.0105-2896.2010.00898.x · Cited by 179
“CD127 is highly expressed on naive T cells, but it is uniformly downregulated on all antigen-specific CD8+ T cells after activation.”
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“Because IL-7R is down-modulated upon TCR triggering, it can be assumed that the low IL7R expression on activated CD8 T cells in the lung might be caused by recent viral exposition (16, 20).”
BackgroundPrognostic Immune Markers in Non–Small Cell Lung Cancer
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“On the other hand, it has been shown in vitro that the expression of IL-7R on CD8þ T cells signifies a long-lived memory phenotype (68).”
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Translation is actively regulated during the differentiation of CD8+ effector T cells
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Self-citationPathogen-Induced Inflammatory Environment Controls Effector and Memory CD8+ T Cell Differentiation
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“Originally, these two subsets were solely identified based on CD127 (IL-7Ra) expression levels (1, 2), but more recent studies have used CD127 expression in concert with killer cell lectin-like receptor G1 (KLRG1) expression (3, 4).”
BackgroundThe molecular program induced in T cells undergoing homeostatic proliferation
Goldrath, A. W., Luckey, C. J., Park, R., Benoist, C. O., & Mathis, D. J. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407417101 · Cited by 172
The Loss of TET2 Promotes CD8+ T Cell Memory Differentiation
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Self-citationRapid Culling of the CD4+ T Cell Repertoire in the Transition from Effector to Memory
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“…T cells at the peak of the effector response to acute infection correlates with the ability to survive the contraction phase and progress to memory (Kaech et al., 2003), although IL-7 signals themselves do not appear to be sufficient for this process (Hand et al., 2007; Klonowski et al., 2006; Sun…”
BackgroundInterleukin-2 enhances CD4+ T cell memory by promoting the generation of IL-7Rα–expressing cells
Dooms, H., Wolslegel, K., Lin, P. W., & Abbas, A. K. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20062381 · Cited by 170
Clinical and immunologic aspects of cytomegalovirus infection in solid organ transplant recipients
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Naive B cells generate regulatory T cells in the presence of a mature immunologic synapse
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IL-7 and IL-15 differentially regulate CD8+ T-cell subsets during contraction of the immune response
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Self-citationvan Leeuwen, E. M. M., de Bree, G. J., Remmerswaal, E. B. M., Yong, S. L., Tesselaar, K., ten Berge, I. J. M., & van Lier, R. A. W. (2005) · Blood · doi:10.1182/blood-2005-02-0449 · Cited by 165
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“All these Abs together with those to CD3, CD4, CD8, CD45.”
BackgroundIL-7 and IL-15: therapeutic cytokines for immunodeficiency
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T‐cell memory differentiation: insights from transcriptional signatures and epigenetics
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Self-citationRequirement of B Cells for Generating CD4+ T Cell Memory
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Self-citationCXCR5+ CCR7– CD8 T cells are early effector memory cells that infiltrate tonsil B cell follicles
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ZEB1, ZEB2, and the miR-200 family form a counterregulatory network to regulate CD8+ T cell fates
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“Class I MHC tetramers were generated as described previously (Kaech et al., 2003).”
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“peak of the response following acute infection (22, 23).”
BackgroundResultSignal Integration by Akt Regulates CD8 T Cell Effector and Memory Differentiation
Kim, E. H., Sullivan, J. A., Plisch, E. H., Tejera, M. M., Jatzek, A., Choi, K. Y., & Suresh, M. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1103568 · Cited by 157
Regulation of Antigen-Experienced T Cells: Lessons from the Quintessential Memory Marker CD44
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“In some models of infection, memory CD8+ T cell precursors have been subdivided based on the expression of two surface markers, IL-7 receptor α (IL-7Rα) and killer cell lectin-like receptor subfamily G, member 1 (KLRG1; Kaech et al., 2003; Joshi et al., 2007).”
BackgroundMemory CD8+ T cell differentiation
Obar, J. J., & Lefrançois, L. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05126.x · Cited by 160
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“%) after LCMV infection expresses detectable levels of IL-7Ra (CD127) and those CD127hi cells contained increased amounts of antiapoptotic molecules (Bcl-2, Bcl-XL) (45).”
BackgroundInfluenza vaccine responses in older adults
McElhaney, J. E. (2010) · Ageing Research Reviews · doi:10.1016/j.arr.2010.10.008 · Cited by 155
Characterization of a progenitor cell population in childhood T-cell acute lymphoblastic leukemia
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T Cell Fate at the Single-Cell Level
Buchholz, V. R., Schumacher, T. N., & Busch, D. H. (2015) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032414-112014 · Cited by 158
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“MPECs are the effector CD8 T cells that serve as precursors to a stable pool of memory T cells (17, 37, 38) and T-bet gradient during inflammation directs the differentiation of effector CD8T cells intoMPECs or SLECs (37).”
BackgroundInfluentialEnhanced T cell effector activity by targeting the Mediator kinase module
Freitas, K. A., Belk, J. A., Sotillo, E., Quinn, P. J., Ramello, M. C., Malipatlolla, M. B., Dániel, B., Sándor, K., Klysz, D. D., Bjelajac, J. R., et al. (2022) · Science · doi:10.1126/science.abn5647 · Cited by 159
“Current models hold that upon antigen encounter, naïve T cells differentiate into CCR7 IL7RTbetCD62L SLECs, with most effectors progressing toward a state of terminal differentiation associated with diminished activity, while a fraction express CCR7 and IL7R and differentiate into long-lived memory cells (44, 46, 64,…”
BackgroundAnti-viral CD8 T cells and the cytokines that they love
Cox, M. A., Kahan, S. M., & Zajac, A. J. (2012) · Virology · doi:10.1016/j.virol.2012.09.012 · Cited by 156
“The expression of CD127 is necessary to maintain memory CD8 T cells following the clearance of an infection (Bachmann et al., 2005; Huster et al., 2004; Kaech et al., 2003; Schluns et al., 2000) but, curiously, these cells survive in IL-7 deficient mice (Klonowski et al.”
BackgroundKohlmeier, J. E., Reiley, W. W., Perona‐Wright, G., Freeman, M. L., Yager, E. J., Connor, L. M., Brincks, E. L., Cookenham, T. S., Roberts, A. D., Burkum, C. E., et al. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20102110 · Cited by 155
Day, E., Carmichael, A., ten Berge, I. J. M., Waller, E. C. P., Sissons, J. G. P., & Wills, M. R. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.5.3203 · Cited by 153
“Because IL-7R expression is needed for entry into the memory pool in murine models of infection (8, 9), the expression of IL-7R on Ag-specific cells during the resolution of primary HCMV infection was investigated in the present study.”
BackgroundMa, Y., Li, J., Wang, H., Chiu, Y., Kingsley, C. V., Fry, D., Delaney, S. N., Wei, S. C., Zhang, J., Maitra, A., et al. (2020) · Gastroenterology · doi:10.1053/j.gastro.2020.03.018 · Cited by 154
Transcriptional and Epigenetic Regulation of Effector and Memory CD8 T Cell Differentiation
Chen, Y., Zander, R., Khatun, A., Schauder, D., & Cui, W. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02826 · Cited by 156
“Furthermore, several studies previously demonstrated that MPECs can give rise to both T central memory (TCM) and T effector memory (TEM) populations (1, 5–7) and recent evidence further indicates that the precursors of tissue resident memory cells (TRM) in the skin and small intestine are also derived from less differ…”
BackgroundInfluentialDevelopment, trafficking, and function of memory T‐cell subsets
Lefrançois, L. (2006) · Immunological Reviews · doi:10.1111/j.0105-2896.2006.00393.x · Cited by 154
“(44) demonstrated that a subset of effector cells responding to lymphocytic choriomeningitis virus (LCMV) infection retains IL-7R expression and that this population preferentially survives to become memory cells.”
BackgroundMemories that last forever: strategies for optimizing vaccine T-cell memory.
Ahlers, J., & Belyakov, I. (2010) · Blood · doi:10.1182/blood-2009-06-227546 · Cited by 165
Yao, J., Cui, Q., Fan, W., Ma, Y., Chen, Y., Liu, T., Zhang, X., Xi, Y., Wang, C., Peng, L., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-17492-y · Cited by 149
Willmann, K. L., Klaver, S., Doğu, F., Santos-Valente, E., Garncarz, W., Bilić, I., Mace, E. M., Salzer, E., Conde, C. D., Sic, H., et al. (2014) · Nature Communications · doi:10.1038/ncomms6360 · Cited by 157
Human memory CD8 T cell effector potential is epigenetically preserved during in vivo homeostasis
Abdelsamed, H. A., Moustaki, A., Fan, Y., Dogra, P., Ghoneim, H. E., Zebley, C. C., Triplett, B. M., Sékaly, R., & Youngblood, B. (2017) · The Journal of Experimental Medicine · doi:10.1084/jem.20161760 · Cited by 147
“…number of functionally competent memory CD8 T cells must be sustained in the absence of antigen through cytokine-driven homeostatic proliferation (Vella et al., 1997; Lodolce et al., 1998; Wong and Pamer, 2001; Becker et al., 2002, 2005; Goldrath et al., 2002; Tan et al., 2002; Kaech et al., 2003).”
BackgroundRole of PD-1 in regulating acute infections
Brown, K. E., Freeman, G. J., Wherry, E. J., & Sharpe, A. H. (2010) · Current Opinion in Immunology · doi:10.1016/j.coi.2010.03.007 · Cited by 147
Self-citationSleep in the Intensive Care Unit
Pulak, L. M., & Jensen, L. A. (2014) · Journal of Intensive Care Medicine · doi:10.1177/0885066614538749 · Cited by 154
Kamimura, D., & Bevan, M. J. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.8.5433 · Cited by 147
“Following down-regulation of CD127 expression on activation, effector CD8 T cells that regain high level CD127 expression preferentially give rise to memory cells (3).”
BackgroundFatty acid metabolism in CD 8 + T cell memory: Challenging current concepts
Raud, B., McGuire, P. J., Jones, R. G., Sparwasser, T. D., & Berod, L. (2018) · Immunological Reviews · doi:10.1111/imr.12655 · Cited by 155
Origins of CD 4+ circulating and tissue‐resident memory T‐cells
Nguyen, Q., Deng, T. Z., Witherden, D. A., & Goldrath, A. W. (2019) · Immunology · doi:10.1111/imm.13059 · Cited by 145
Evolution of diverse antiviral CD8+ T cell populations after murine cytomegalovirus infection
Sierro, S. R., Rothkopf, R., & Klenerman, P. (2005) · European Journal of Immunology · doi:10.1002/eji.200425534 · Cited by 144
Buhtoiarov, I. N., Sondel, P. M., Wigginton, J. M., Buhtoiarova, T. N., Yanke, E. M., Mahvi, D. A., & Rakhmilevich, A. L. (2010) · Immunology · doi:10.1111/j.1365-2567.2010.03357.x · Cited by 143
Expression of CD39 on activated T cells impairs their survival in older individuals
Fang, F., Yu, M., Cavanagh, M. M., Hutter Saunders, J., Qi, Q., Ye, Z., Le Saux, S., Sultan, W., Turgano, E., Dekker, C. L., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.01.002 · Cited by 138
“survive and transition into memory cells (Kaech et al., 2003; Sarkar et al., 2008).”
CD4 T-Cell Memory Generation and Maintenance
Gasper, D. J., Tejera, M. M., & Suresh, M. (2014) · Critical Reviews in Immunology · doi:10.1615/critrevimmunol.2014010373 · Cited by 146
Harari, A., Enders, F. B., Cellerai, C., Bart, P., & Pantaleo, G. (2009) · Journal of Virology · doi:10.1128/jvi.02528-08 · Cited by 141
“Cryopreserved blood mononuclear cells (1 106 to 2 106) were stained with appropriate titers of peptideMHC class I tetramer complexes at 4°C for 15 min and then either permeabilized (Cytofix/Cytoperm; BD) and stained at room temperature for 20 min with GrmK, GrmA, GrmB, perforin, CD45RA, CD127, and CD8 or directly stai…”
BackgroundResultInfluentialDeveloping and maintaining protective CD8+ memory T cells
Williams, M. A., Holmes, B., Sun, J. C.-Y., & Bevan, M. J. (2006) · Immunological Reviews · doi:10.1111/j.0105-2896.2006.00389.x · Cited by 144
Impact of Epitope Escape on PD-1 Expression and CD8 T-Cell Exhaustion during Chronic Infection
Blattman, J. N., Wherry, E. J., Ha, S., der Most, R. G. V., & Ahmed, R. (2009) · Journal of Virology · doi:10.1128/jvi.02524-08 · Cited by 142
“CD127 is the alpha chain of the interleukin-7 receptor, is necessary for memory T-cell homeostatic proliferation, and is a surrogate marker of memory T-cell development (20).”
BackgroundSelf-citationStrategies to enhance T-cell reconstitution in immunocompromised patients
van den Brink, M. R. M., Alpdoğan, Ö., & Boyd, R. L. (2004) · Nature reviews. Immunology · doi:10.1038/nri1484 · Cited by 141
Brooks, D. G. (2006) · Journal of Clinical Investigation · doi:10.1172/jci26856 · Cited by 141
“…had increased levels of IL-7 receptor and Bcl-2 expression compared with cells transferred into Cl 13– infected animals (Supplemental Figure 1; supplemental material available online with this article; doi:10.1172/JCI26856DS1), consistent with the development of a memory T cell phenotype (39, 40).”
InfluentialRehr, M., Cahenzli, J., Haas, A., Price, D. A., Emma Gostick, D., Huber, M., Karrer, U. W., & Oxenius, A. (2008) · Journal of Virology · doi:10.1128/jvi.02383-07 · Cited by 138
“and differentiate into long-lived memory cells (9, 37, 41, 59).”
BackgroundIntravaginal immunization with HPV vectors induces tissue-resident CD8+ T cell responses
Çuburu, N., Graham, B. S., Buck, C. B., Kines, R. C., Pang, Y.-Y. S., Day, P. M., Lowy, D. R., & Schiller, J. T. (2012) · Journal of Clinical Investigation · doi:10.1172/jci63287 · Cited by 147
Fuller, M. J., Hildeman, D. A., Sabbaj, S., Gaddis, D. E., Tebo, A. E., Shang, L., Goepfert, P., & Zajac, A. J. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.10.5926 · Cited by 140
Generation of cellular immune memory and B-cell immunity is impaired by natural killer cells
Rydyznski, C. E., Daniels, K. A., Karmele, E. P., Brooks, T., Mahl, S. E., Moran, M. T., Li, C., Sutiwisesak, R., Welsh, R. M., & Waggoner, S. N. (2015) · Nature Communications · doi:10.1038/ncomms7375 · Cited by 137
Mitchell, D. M., Ravkov, E. V., & Williams, M. A. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0904089 · Cited by 140
“They also differentiated into secondary effector CTL as determined by expression of IL-7Ra and KLRG1 (Fig.”
BackgroundInfluentialHenrickson, S. E., Perro, M., Loughhead, S. M., Senman, B. C., Stutte, S., Quigley, M. M., Alexe, G., Iannacone, M., Flynn, M. P., Omid, S., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.08.034 · Cited by 142
“…CD8+ memory differentiation has traditionally examined Ag-experienced T cells expressing specific markers that predict effector or memory fate (Kaech et al., 2003) and are associated with widespread changes in gene expression (Haining et al., 2008; Kaech et al., 2002; Sarkar et al., 2008;…”
BackgroundRéthi, B., Fluur, C., Atlas, A., Krzyżowska, M., Mowafi, F., Grützmeier, S., Milito, A. D., Bellocco, R., Falk, K. I., Rajnavölgyi, É., et al. (2005) · AIDS · doi:10.1097/01.aids.0000189848.75699.0f · Cited by 138
“Bcl-2 is a known target molecule for IL-7 and, in mouse models, lack of IL-7Ra expression on T cells resulted in low Bcl-2 expression in association with impaired memory formation [4,7].”
BackgroundLessons from the study of T-cell differentiation in persistent human virus infection
Appay, V., & Rowland‐Jones, S. (2004) · Seminars in Immunology · doi:10.1016/j.smim.2004.02.007 · Cited by 136
CD8 Cell Division Maintaining Cytotoxic Memory Occurs Predominantly in the Bone Marrow
Parretta, E., Cassese, G., Barba, P., Santoni, A., Guardiola, J., & Rosa, F. D. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.12.7654 · Cited by 136
“According to recent reports, among the Ag-activated CD8 cells expanded at early times after priming, those few that express high levels of CD127 are the committed precursors of long-lived memory CD8 cells (51, 52).”
BackgroundResultInfluentialKim, H., Hong, M. S., Dan, J. M., & Kang, I. (2005) · Blood · doi:10.1182/blood-2005-09-3560 · Cited by 136
van Gisbergen, K. P. J. M., Klarenbeek, P. L., Kragten, N. A. M., Unger, P. A., Nieuwenhuis, M. B. B., Wensveen, F. M., ten Brinke, A., Tak, P. P., Eldering, E., Nolte, M. A., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.04.020 · Cited by 142
“Memory precursors are typified by expression of CD127 and fall into distinct subsets that will form CD62L+ central and CD62L effector memory CD8+ T cells (Huster et al., 2004; Kaech et al., 2003).”
BackgroundInfluentialPremature Aging of T cells Is Associated With Faster HIV-1 Disease Progression
Cao, W., Jamieson, B. D., Hultin, L. E., Hultin, P. M., Effros, R. B., & Detels, R. (2009) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0b013e3181926c28 · Cited by 137
Aspirin prevents metastasis by limiting platelet TXA2 suppression of T cell immunity
Yang, J., Yamashita-Kanemaru, Y., Morris, B. I., Contursi, A., Trajkovski, D., Xu, J., Patrascan, I., Benson, J., Evans, A. C., Conti, A. G., et al. (2025) · Nature · doi:10.1038/s41586-025-08626-7 · Cited by 153
“…T cell responses, since OVA antigen-specific CD8 + T cells responding to infection with Listeria monocytogenes expressing OVA exhibited a less terminally differentiated phenotype with increased levels of the memory marker CD127 in Arhgef1 -cKO compared with cWT mice 26 (Extended Data Fig.”
Koup, R. A., Roederer, M., Lamoreaux, L., Fischer, J., Novik, L., Nason, M., Larkin, B. D., Enama, M. E., Ledgerwood, J. E., Bailer, R. T., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009015 · Cited by 133
“CD127 expression was uniform on Env-specific CD4 T cells, and on most Env-specific CD8 T cells, suggesting that the vaccineinduced T cells are long-lived memory cells capable of homeostatic expansion [31].”
BackgroundZhang, L., Tschumi, B. O., Lopez-Mejia, I. C., Oberle, S. G., Meyer, M., Samson, G., Rüegg, M. A., Hall, M. N., Fajas, L., Zehn, D., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2015.12.095 · Cited by 134
Recall Proliferation Potential of Memory CD8+ T Cells and Antiviral Protection
Bachmann, M. F., Wolint, P., Schwarz, K., & Oxenius, A. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.7.4677 · Cited by 131
Metadata
- Authors
- Kaech, S. M., Tan, J. T., Wherry, E. J., Konieczny, B. T., Surh, C. D., & Ahmed, R.
- Affiliations
- Emory University (US)
- Scripps Research Institute (US)
- Corresponding author
- Ahmed, Rafi
- Venue
- Nature Immunology
- Published
- 2003-11-16
- Volume
- 4
- Issue
- 12
- Pages
- 1191-1198
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W1974842026
- Cited by
- 1,830
- References
- 48
- Citations by year
- 2026: 41 · 2025: 57 · 2024: 42 · 2023: 63 · 2022: 67 · 2021: 69 · 2020: 67 · 2019: 70 · 2018: 56 · 2017: 59 · 2016: 77 · 2015: 73 · 2014: 73 · 2013: 96 · 2012: 91
- FWCI
- 30.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Keywords
- CD127, CD8+ T cells, effector T cells, memory T cells, apoptosis, adoptive transfer, viral infection, protective immunity, memory T cell generation
- MeSH terms
- Animals, Antigens, Surface, Cell Differentiation, Immunologic Memory, Lymphocyte Activation, Lymphocytic Choriomeningitis, Lymphocytic choriomeningitis virus, Mice, Transgenic, Signal Transduction, Gene Expression, T-Lymphocyte Subsets, CD8-Positive T-Lymphocytes, Cell Lineage, Adoptive Transfer, Receptors, Interleukin-7, Oligonucleotide Array Sequence Analysis, Mice
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