Cited by 2,562interferon and immune responsesImmune Response and InflammationRNA regulation and disease

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IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction

Kawai, Taro, Takahashi, Ken, Sato, Shintaro, Coban, Cevayir, Kumar, Himanshu, Kato, Hiroki, Ishii, Ken J, Takeuchi, Osamu, Akira, Shizuo·2005·Nature Immunology

DOI 10.1038/ni1243

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Abstract

Type I interferons are central mediators for antiviral responses. Using high-throughput functional screening of interferon inducers, we have identified here a molecule we call interferon-beta promoter stimulator 1 (IPS-1). Overexpression of IPS-1 induced type I interferon and interferon-inducible genes through activation of IRF3, IRF7 and NF-kappaB transcription factors. TBK1 and IKKi protein kinases were required for the IPS-1-mediated interferon induction. IPS-1 contained an N-terminal CARD-like structure that mediated interaction with the CARD of RIG-I and Mda5, which are cytoplasmic RNA helicases that sense viral infection. 'Knockdown' of IPS-1 by small interfering RNA blocked interferon induction by virus infection. Thus, IPS-1 is an adaptor involved in RIG-I- and Mda5-mediated antiviral immune responses.

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Authors: Kawai, T., Takahashi, K., Sato, S., Coban, C., Kumar, H., Kato, H., Ishii, K. J., Takeuchi, O., & Akira, S.
Affiliations: Japan Science and Technology Agency (JP)
Kyoto University (JP)
Research Institute for Microbial Diseases, The University of Osaka (JP)
Corresponding author: Akira, Shizuo
ORCID: Kawai, Taro
Takahashi, Ken
Sato, Shintaro
Coban, Cevayir
Kumar, Himanshu
Kato, Hiroki
Ishii, Ken J
Takeuchi, Osamu
Akira, Shizuo
Venue: Nature Immunology
Publisher: Springer Science and Business Media LLC
Published: 2005-08-28
Volume: 6
Issue: 10
Pages: 981-988
ISSN: 1529-2908 (ISSN-L)
1529-2916
DOI: 10.1038/ni1243
OpenAlex: W2137303998
Cited by: 2,562
References: 39
Citations by year: 2026: 56 · 2025: 76 · 2024: 79 · 2023: 83 · 2022: 100 · 2021: 114 · 2020: 135 · 2019: 131 · 2018: 120 · 2017: 120 · 2016: 110 · 2015: 132 · 2014: 163 · 2013: 149 · 2012: 152
FWCI: 43.76
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Immunology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
Keywords: IPS-1, type I interferon induction, RIG-I, MDA5, IRF3, IRF7, NF-κB, TBK1, IKKi, antiviral innate immunity, interferon-stimulated genes, viral sensing
MeSH terms: DEAD Box Protein 58, Interferon-Induced Helicase, IFIH1, Amino Acid Sequence, Animals, Cells, Cultured, DNA-Binding Proteins, Humans, Interferon Inducers, Interferon Type I, Molecular Sequence Data, Receptors, Immunologic, RNA, Messenger, Transcription Factors, Vesicular stomatitis Indiana virus, NF-kappa B, Sequence Alignment, Interferon-beta, Protein Serine-Threonine Kinases, Protein Structure, Tertiary, RNA Helicases, Adaptor Proteins, Signal Transducing, Interferon Regulatory Factor-3, Interferon Regulatory Factor-7, Mice, I-kappa B Kinase, DEAD-box RNA Helicases

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IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction

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