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IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction
Abstract
Type I interferons are central mediators for antiviral responses. Using high-throughput functional screening of interferon inducers, we have identified here a molecule we call interferon-beta promoter stimulator 1 (IPS-1). Overexpression of IPS-1 induced type I interferon and interferon-inducible genes through activation of IRF3, IRF7 and NF-kappaB transcription factors. TBK1 and IKKi protein kinases were required for the IPS-1-mediated interferon induction. IPS-1 contained an N-terminal CARD-like structure that mediated interaction with the CARD of RIG-I and Mda5, which are cytoplasmic RNA helicases that sense viral infection. 'Knockdown' of IPS-1 by small interfering RNA blocked interferon induction by virus infection. Thus, IPS-1 is an adaptor involved in RIG-I- and Mda5-mediated antiviral immune responses.
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“A breakthrough in establishing the role for mitochondria in RLR-activated antiviral immunity was the identification of the RLR mitochondrial adaptor protein MAVS (mitochondrial antiviral-signaling protein)(Kawai et al., 2005; Meylan et al., 2005; Seth et al., 2005; Xu et al., 2005) localization to the outer mitochondrial membrane is indispensable for its function.”
From Mitochondria in the Regulation of Innate and Adaptive Immunity (2015) · cites this paper as Kawai et al., 2005
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“RIG-I is critical for type I IFN transcription during viral infection (76).”
From Into the Eye of the Cytokine Storm (2012) · cites this paper as [76]
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Janeway, C. A., & Medzhitov, R. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.083001.084359 · Cited by 8,394
Akira, S., & Takeda, K. (2004) · Nature reviews. Immunology · doi:10.1038/nri1391 · Cited by 8,312
Self-citationTakeda, K., Kaisho, T., & Akira, S. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141126 · Cited by 6,143
Self-citationRecognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3
Alexopoulou, L., Holt, A. C., Medzhitov, R., & Flavell, R. A. (2001) · Nature · doi:10.1038/35099560 · Cited by 6,129
Yoneyama, M., Kikuchi, M., Natsukawa, T., Shinobu, N., Imaizumi, T., Miyagishi, M., Taira, K., Akira, S., & Fujita, T. (2004) · Nature Immunology · doi:10.1038/ni1087 · Cited by 4,022
Self-citationSpecies-specific recognition of single-stranded RNA via toll-like receptor 7 and 8
Heil, F., Hemmi, H., Hochrein, H., Ampenberger, F., Kirschning, C., Akira, S., Lipford, G., Wagner, H., & Bauer, S. (2004) · Science · doi:10.1126/science.1093620 · Cited by 3,947
Self-citationInnate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA
Diebold, S. S., Kaisho, T., Hemmi, H., Akira, S., & Reis e Sousa, C. (2004) · Science · doi:10.1126/science.1093616 · Cited by 3,444
Self-citationRole of Adaptor TRIF in the MyD88-Independent Toll-Like Receptor Signaling Pathway
Yamamoto, M., Sato, S., Hemmi, H., Hoshino, K., Kaisho, T., Sanjo, H., Takeuchi, O., Sugiyama, M., Okabe, M., Takeda, K., et al. (2003) · Science · doi:10.1126/science.1087262 · Cited by 3,286
Self-citationIKKε and TBK1 are essential components of the IRF3 signaling pathway
Fitzgerald, K. A., McWhirter, S. M., Faia, K. L., Rowe, D. C., Latz, E., Golenbock, D. T., Coyle, A. J., Liao, S.-M., & Maniatis, T. (2003) · Nature Immunology · doi:10.1038/ni921 · Cited by 2,680
Triggering the Interferon Antiviral Response Through an IKK-Related Pathway
Sharma, S., tenOever, B. R., Grandvaux, N., Zhou, G., Lin, R., & Hiscott, J. B. (2003) · Science · doi:10.1126/science.1081315 · Cited by 1,685
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Ubiquitin-mediated activation of TAK1 and IKK
Adhikari, A., Xu, M., & Chen, Z. J. (2007) · Oncogene · doi:10.1038/sj.onc.1210413 · Cited by 464
Innate Immunity in the Respiratory Epithelium
Parker, D., & Prince, A. S. (2011) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2011-0011rt · Cited by 474
Triggering the Innate Antiviral Response through IRF-3 Activation
Hiscott, J. B. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.r700002200 · Cited by 454
Mitochondria and cell signalling
Tait, S. W. G., & Green, D. R. (2012) · Journal of Cell Science · doi:10.1242/jcs.099234 · Cited by 453
Robbins, M., Judge, A. D., & MacLachlan, I. (2009) · Oligonucleotides · doi:10.1089/oli.2009.0180 · Cited by 463
Cardenas, W. B., Loo, Y., Gale, M., Hartman, A. L., Kimberlin, C. R., Martínez‐Sobrido, L., Saphire, E. O., & Basler, C. F. (2006) · Journal of Virology · doi:10.1128/jvi.02199-05 · Cited by 450
Toll-like receptors and innate immunity
Uematsu, S., & Akira, S. (2006) · Journal of Molecular Medicine · doi:10.1007/s00109-006-0084-y · Cited by 445
Self-citationDetection of Microbial Infections Through Innate Immune Sensing of Nucleic Acids
Tan, J. X., Sun, L., Chen, J., & Chen, Z. J. (2018) · Annual Review of Microbiology · doi:10.1146/annurev-micro-102215-095605 · Cited by 449
Besch, R., Poeck, H., Hohenauer, T., Senft, D., Häcker, G. A., Berking, C., Hornung, V., Endres, S., Ruzicka, T., Rothenfußer, S., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci37155 · Cited by 434
Structural basis of RNA recognition and activation by innate immune receptor RIG-I
Jiang, F., Ramanathan, A., Miller, M. T., Tang, G., Gale, M., Patel, S. S., & Marcotrigiano, J. (2011) · Nature · doi:10.1038/nature10537 · Cited by 439
Recognition of viruses by cytoplasmic sensors
Wilkins, C. R., & Gale, M. (2010) · Current Opinion in Immunology · doi:10.1016/j.coi.2009.12.003 · Cited by 428
RIG-I in RNA virus recognition
Kell, A. M., & Gale, M. (2015) · Virology · doi:10.1016/j.virol.2015.02.017 · Cited by 424
Baum, A., Sachidanandam, R., & García‐Sastre, A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005077107 · Cited by 424
Regulation of antiviral responses by a direct and specific interaction between TRAF3 and Cardif
Saha, S. K., Pietras, E. M., He, J. Q., Kang, J. R., Liu, S.-Y., Oganesyan, G., Shahangian, A., Zarnegar, B. J., Shiba, T. L., Wang, Y., et al. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601220 · Cited by 423
Central roles of NLRs and inflammasomes in viral infection
Kanneganti, T. (2010) · Nature reviews. Immunology · doi:10.1038/nri2851 · Cited by 435
The adaptor protein CARD9 is required for innate immune responses to intracellular pathogens
Hsu, Y.-M. S., Zhang, Y., You, Y., Wang, D., Li, H., Duramad, O., Qin, F. X.-F., Dong, C., & Lin, X. (2006) · Nature Immunology · doi:10.1038/ni1426 · Cited by 420
Ubiquitination in signaling to and activation of IKK
Chen, Z. J. (2012) · Immunological Reviews · doi:10.1111/j.1600-065x.2012.01108.x · Cited by 433
Devaraj, S. G., Wang, N., Chen, Z., Chen, Z., Tseng, M., Barretto, N., Lin, R., Peters, C. J., Tseng, C.-T. K., Baker, S. C., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m704870200 · Cited by 411
Mitochondria in innate immune signaling
Banoth, B., & Cassel, S. L. (2018) · Translational Research · doi:10.1016/j.trsl.2018.07.014 · Cited by 410
Bosinger, S. E., Li, Q., Gordon, S. N., Klatt, N. R., Duan, L., Xu, L., Francella, N., Sidahmed, A. M. E., Smith, A. J., Cramer, E. M., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci40115 · Cited by 419
Loss of DExD/H Box RNA Helicase LGP2 Manifests Disparate Antiviral Responses
Venkataraman, T., Valdes, M., Elsby, R., Kakuta, S., Cáceres, G., Saijo, S., Iwakura, Y., & Barber, G. N. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.10.6444 · Cited by 400
5′-triphosphate RNA requires base-paired structures to activate antiviral signaling via RIG-I
Schmidt, A., Schwerd, T., Hamm, W., Hellmuth, J. C., Cui, S., Wenzel, M., Hoffmann, F. S., Michallet, M.-C., Besch, R., Hopfner, K.-P., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0900971106 · Cited by 398
Interferons and viral infections
Fensterl, V., & Sen, G. C. (2009) · BioFactors · doi:10.1002/biof.6 · Cited by 406
Mitochondria: diversity in the regulation of the NLRP3 inflammasome
Gurung, P., Lukens, J. R., & Kanneganti, T.-D. (2015) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2014.11.008 · Cited by 393
Alveolar Macrophages Are the Primary Interferon-α Producer in Pulmonary Infection with RNA Viruses
Kumagai, Y., Takeuchi, O., Kato, H., Kumar, H., Matsui, K., Morii, E., Aozasa, K., Kawai, T., & Akira, S. (2007) · Immunity · doi:10.1016/j.immuni.2007.07.013 · Cited by 390
Self-citationViral and therapeutic control of IFN-β promoter stimulator 1 during hepatitis C virus infection
Loo, Y., Owen, D. M., Li, K., Erickson, A. K., Johnson, C., Fish, P. M., Carney, D. S., Wang, T., Ishida, H., Yoneyama, M., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601523103 · Cited by 389
5′-triphosphate-siRNA: turning gene silencing and Rig-I activation against melanoma
Poeck, H., Besch, R., Maihoefer, C., Renn, M., Tormo, D., Morskaya, S. S., Kirschnek, S., Gaffal, E., Landsberg, J., Hellmuth, J., et al. (2008) · Nature Medicine · doi:10.1038/nm.1887 · Cited by 387
Self-citationTakeda, K., & Akira, S. (2007) · Current Protocols in Immunology · doi:10.1002/0471142735.im1412s77 · Cited by 380
Self-citationZhang, Z., Kim, T., Bao, M., Facchinetti, V., Jung, S. Y., Ghaffari, A. A., Qin, J., Cheng, G., & Liu, Y. (2011) · Immunity · doi:10.1016/j.immuni.2011.03.027 · Cited by 387
Viral targeting of DEAD box protein 3 reveals its role in TBK1/IKKε‐mediated IRF activation
Schröder, M., Baran, M., & Bowie, A. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.143 · Cited by 374
Activation of STAT6 by STING Is Critical for Antiviral Innate Immunity
Chen, H., Sun, H., You, F., Sun, W., Zhou, X., Chen, L., Yang, J., Wang, Y., Tang, H., Guan, Y., et al. (2011) · Cell · doi:10.1016/j.cell.2011.09.022 · Cited by 383
NLRs at the intersection of cell death and immunity
Ting, J. P.-Y., Willingham, S. B., & Bergstralh, D. T. (2008) · Nature Reviews Immunology · doi:10.1038/nri2296 · Cited by 371
Toll-Like Receptors and RNA Helicases: Two Parallel Ways to Trigger Antiviral Responses
Meylan, E., & Tschopp, J. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.05.012 · Cited by 372
Zhu, J., Huang, X., & Yang, Y. (2007) · Journal of Virology · doi:10.1128/jvi.02192-06 · Cited by 370
Cytosolic Viral Sensor RIG-I Is a 5'-Triphosphate–Dependent Translocase on Double-Stranded RNA
Myong, S., Cui, S., Cornish, P. V., Kirchhofer, A., Gack, M. U., Jung, J. U., Hopfner, K., & Ha, T. (2009) · Science · doi:10.1126/science.1168352 · Cited by 368
Chien, Y., Kim, S., Bumeister, R., Loo, Y., Kwon, S. W., Johnson, C., Balakireva, M. G., Roméo, Y., Kopelovich, L., Gale, M., et al. (2006) · Cell · doi:10.1016/j.cell.2006.08.034 · Cited by 367
Allen, I. C., Moore, C. B., Schneider, M., Lei, Y. L., Davis, B. K., Scull, M. A., Gris, D., Roney, K. E., Zimmermann, A. G., Bowzard, J. B., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.03.026 · Cited by 365
Comparative Structure and Function Analysis of the RIG-I-Like Receptors: RIG-I and MDA5
Brisse, M. E., & Ly, H. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01586 · Cited by 379
Impact of mRNA chemistry and manufacturing process on innate immune activation
Nelson, J., Sorensen, E. W., Mintri, S., Rabideau, A. E., Zheng, W., Besin, G., Khatwani, N., Su, S. V., Miracco, E. J., Issa, W. J., et al. (2020) · Science Advances · doi:10.1126/sciadv.aaz6893 · Cited by 354
Viral Infections Activate Types I and III Interferon Genes through a Common Mechanism
Onoguchi, K., Yoneyama, M., Takemura, A., Akira, S., Taniguchi, T., Namiki, H., & Fujita, T. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m608618200 · Cited by 354
Self-citationMAVS recruits multiple ubiquitin E3 ligases to activate antiviral signaling cascades
Liu, S., Chen, J., Cai, X., Wu, J., Chen, X., Wu, Y.-T., Sun, L., & Chen, Z. J. (2013) · eLife · doi:10.7554/elife.00785 · Cited by 354
Oshiumi, H., Matsumoto, M., Hatakeyama, S., & Seya, T. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m804259200 · Cited by 353
Onomoto, K., Jogi, M., Yoo, J., Narita, R., Morimoto, S., Takemura, A., Sambhara, S. R., Kawaguchi, A., Osari, S., Nagata, K., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0043031 · Cited by 359
The role of ubiquitylation in immune defence and pathogen evasion
Jiang, X., & Chen, Z. J. (2011) · Nature reviews. Immunology · doi:10.1038/nri3111 · Cited by 352
Mitochondria as a Cellular Hub in Infection and Inflammation
Andrieux, P., Chevillard, C., Cunha-Neto, E., & Nunes, J. P. S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111338 · Cited by 346
TRIMmunity: The Roles of the TRIM E3-Ubiquitin Ligase Family in Innate Antiviral Immunity
Rajsbaum, R., García‐Sastre, A., & Versteeg, G. A. (2013) · Journal of Molecular Biology · doi:10.1016/j.jmb.2013.12.005 · Cited by 354
Recognition of viruses by innate immunity
Takeuchi, O., & Akira, S. (2007) · Immunological Reviews · doi:10.1111/j.1600-065x.2007.00562.x · Cited by 341
Self-citationPCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4
You, F., Sun, H., Zhou, X., Sun, W., Liang, S., Zhai, Z., & Jiang, Z. (2009) · Nature Immunology · doi:10.1038/ni.1815 · Cited by 340
RIG‐I‐like receptors: cytoplasmic sensors for non‐self RNA
Kato, H., Takahasi, K., & Fujita, T. (2011) · Immunological Reviews · doi:10.1111/j.1600-065x.2011.01052.x · Cited by 340
Self-citationNew insights into the evasion of host innate immunity by Mycobacterium tuberculosis
Chai, Q., Wang, L., Liu, C. H., & Ge, B. (2020) · Cellular and Molecular Immunology · doi:10.1038/s41423-020-0502-z · Cited by 347
Li, S., Wang, L., Berman, M. A., Kong, Y., & Dorf, M. E. (2011) · Immunity · doi:10.1016/j.immuni.2011.06.014 · Cited by 334
Liu, B., Zhang, M., Chu, H., Zhang, H., Wu, H. M., Song, G., Wang, P., Zhao, K., Hou, J., Wang, X., et al. (2016) · Nature Immunology · doi:10.1038/ni.3641 · Cited by 333
Kim, T., Pazhoor, S., Bao, M., Zhang, Z., Hanabuchi, S., Facchinetti, V., Bover, L. C., Plumas, J., Chaperot, L., Qin, J., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1006539107 · Cited by 332
Fredericksen, B. L., Keller, B. C., Fornek, J. L., Katze, M. G., & Gale, M. (2007) · Journal of Virology · doi:10.1128/jvi.01305-07 · Cited by 328
Soulat, D., Bürckstümmer, T., Westermayer, S., Gonçalves, A., Bauch, A., Stefanovic, A., Hantschel, O. D., Bennett, K. L., Decker, T., & Superti‐Furga, G. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.126 · Cited by 326
Disruption of innate immunity due to mitochondrial targeting of a picornaviral protease precursor
Yang, Y., Liang, Y., Qu, L., Chen, Z., Yi, M., Li, K., & Lemon, S. M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611506104 · Cited by 319
Liu, P., Jamaluddin, M., Li, K., Garofalo, R. P., Casola, A., & Brasier, A. R. (2006) · Journal of Virology · doi:10.1128/jvi.01740-06 · Cited by 319
The NEMO adaptor bridges the nuclear factor-κB and interferon regulatory factor signaling pathways
Zhao, T., Yang, L., Sun, Q., Arguello, M., Ballard, D. W., Hiscott, J. B., & Lin, R. (2007) · Nature Immunology · doi:10.1038/ni1465 · Cited by 317
Mitochondrial dynamics regulate the RIG-I-like receptor antiviral pathway
Castanier, C., Garcin, D., Vazquez, A., & Arnoult, D. (2010) · The EMBO Reports · doi:10.1038/embor.2009.258 · Cited by 316
Structural basis for ubiquitin-mediated antiviral signal activation by RIG-I
Peisley, A., Wu, B., Xu, H., Chen, Z. J., & Hur, S. (2014) · Nature · doi:10.1038/nature13140 · Cited by 321
RIG-I, MDA5 and TLR3 Synergistically Play an Important Role in Restriction of Dengue Virus Infection
Nasirudeen, A. M. A., Wong, H. H., Thien, P., Xu, S., Lam, K., & Liu, D. X. (2011) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0000926 · Cited by 314
Slater, L., Bartlett, N. W., Haas, J., Zhu, J., Message, S. D., Walton, R. P., Sykes, A., Dahdaleh, S., Clarke, D. L., Belvisi, M. G., et al. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1001178 · Cited by 330
Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection
Liehl, P., Zuzarte-Luís, V., Chan, J., Zillinger, T., Baptista, F., Carapau, D., Konert, M., Hanson, K. K., Carret, C., Lassnig, C., et al. (2014) · Nature Medicine · doi:10.1038/nm.3424 · Cited by 313
Mechanisms and pathways of innate immune activation and regulation in health and cancer
Cui, J., Chen, Y., Wang, H. Y., & Wang, R. (2014) · Human Vaccines & Immunotherapeutics · doi:10.4161/21645515.2014.979640 · Cited by 327
Koyama, S., Ishii, K. J., Kumar, H., Tanimoto, T., Coban, C., Uematsu, S., Kawai, T., & Akira, S. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.7.4711 · Cited by 315
Self-citationFunction of RIG-I-like Receptors in Antiviral Innate Immunity
Yoneyama, M., & Fujita, T. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.r700007200 · Cited by 307
Mukherjee, A., Morosky, S. A., Delorme‐Axford, E., Dybdahl-Sissoko, N., Oberste, M. S., Wang, T., & Coyne, C. B. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1001311 · Cited by 316
Wies, E., Wang, M. K., Maharaj, N. P., Chen, K., Zhou, S., Finberg, R. W., & Gack, M. U. (2013) · Immunity · doi:10.1016/j.immuni.2012.11.018 · Cited by 316
Nlrp6 regulates intestinal antiviral innate immunity
Wang, P., Zhu, S., Yang, L., Cui, S., Pan, W., Jackson, R., Zheng, Y., Rongvaux, A., Sun, Q., Yang, G., et al. (2015) · Science · doi:10.1126/science.aab3145 · Cited by 304
TRADD Protein Is an Essential Component of the RIG-like Helicase Antiviral Pathway
Michallet, M., Meylan, E., Ermolaeva, M., Vázquez, J., Rebsamen, M., Curran, J. A., Poeck, H., Bscheider, M., Hartmann, G., König, M. F., et al. (2008) · Immunity · doi:10.1016/j.immuni.2008.03.013 · Cited by 304
Recognition of viral nucleic acids in innate immunity
Yoneyama, M., & Fujita, T. (2009) · Reviews in Medical Virology · doi:10.1002/rmv.633 · Cited by 313
Österlund, P., Pietilä, T. E., Veckman, V., Kotenko, S. V., & Julkunen, I. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.6.3434 · Cited by 301
mda-5, but not RIG-I, is a common target for paramyxovirus V proteins
Childs, K., Stock, N., Ross, C., Andrejeva, J., Hilton, L. S., Skinner, M. A., Randall, R. E., & Goodbourn, S. (2006) · Virology · doi:10.1016/j.virol.2006.09.023 · Cited by 299
RNA- and Virus-Independent Inhibition of Antiviral Signaling by RNA Helicase LGP2
Komuro, A., & Horvath, C. M. (2006) · Journal of Virology · doi:10.1128/jvi.01325-06 · Cited by 298
Lei, Y. L., Wen, H., Yu, Y., Taxman, D. J., Zhang, L., Widman, D. G., Swanson, K. V., Wen, K. W., Damania, B., Moore, C., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.03.025 · Cited by 297
Miyashita, M., Oshiumi, H., Matsumoto, M., & Seya, T. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.01368-10 · Cited by 297
Maheshwari, A., Ray, S. C., & Thuluvath, P. J. (2008) · The Lancet · doi:10.1016/s0140-6736(08)61116-2 · Cited by 304
McWhirter, S. M., Barbalat, R., Monroe, K. M., Fontana, M. F., Hyodo, M., Joncker, N. T., Ishii, K. J., Akira, S., Colonna, M., Chen, Z. J., et al. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20082874 · Cited by 301
Self-citationHow the Noninflammasome NLRs Function in the Innate Immune System
Ting, J. P. ‐., Duncan, J. A., & Lei, Y. L. (2010) · Science · doi:10.1126/science.1184004 · Cited by 288
Ichinohe, T., Yamazaki, T., Koshiba, T., & Yanagi, Y. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1312571110 · Cited by 291
Viral apoptosis is induced by IRF‐3‐mediated activation of Bax
Chattopadhyay, S., Marques, J. T., Yamashita, M., Peters, K. L., Smith, K., Desai, A., Williams, B. R. G., & Sen, G. C. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.50 · Cited by 281
IFN? induction by influenza A virus is mediated by RIG-I which is regulated by the viral NS1 protein
Opitz, B., Rejaibi, A., Dauber, B., Eckhard, J., Vinzing, M., Schmeck, B., Hippenstiel, S., Suttorp, N., & Wolff, T. (2006) · Cellular Microbiology · doi:10.1111/j.1462-5822.2006.00841.x · Cited by 281
Kaiser, W. J., Upton, J. W., & Mocarski, E. S. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.9.6427 · Cited by 277
NLRX1 Negatively Regulates TLR-Induced NF-κB Signaling by Targeting TRAF6 and IKK
Xia, X., Cui, J., Wang, H. Y., Zhu, L., Matsueda, S., Wang, Q., Yang, X., Hong, J. K., Songyang, Z., Chen, Z. J., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.02.022 · Cited by 276
Toll-Like Receptor Signaling and Its Inducible Proteins
Satoh, T., & Akira, S. (2016) · Microbiology Spectrum · doi:10.1128/microbiolspec.mchd-0040-2016 · Cited by 274
Self-citationWang, Y., Ning, X., Gao, P., Wu, S., Sha, M., Lv, M., Zhou, X., Gao, J., Fang, R., Meng, G., et al. (2017) · Immunity · doi:10.1016/j.immuni.2017.02.011 · Cited by 279
Innate Immune Recognition in Infectious and Noninfectious Diseases of the Lung
Opitz, B., van Laak, V., Eitel, J., & Suttorp, N. (2010) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200909-1427so · Cited by 287
Klotho suppresses RIG-I-mediated senescence-associated inflammation
Liu, F., Wu, S., Ren, H., & Gu, J. (2011) · Nature Cell Biology · doi:10.1038/ncb2167 · Cited by 268
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Metadata
- Authors
- Kawai, T., Takahashi, K., Sato, S., Coban, C., Kumar, H., Kato, H., Ishii, K. J., Takeuchi, O., & Akira, S.
- Affiliations
- Japan Science and Technology Agency (JP)
- Kyoto University (JP)
- Research Institute for Microbial Diseases, The University of Osaka (JP)
- Corresponding author
- Akira, Shizuo
- ORCID
- Venue
- Nature Immunology
- Published
- 2005-08-28
- Volume
- 6
- Issue
- 10
- Pages
- 981-988
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W2137303998
- Cited by
- 2,562
- References
- 39
- Citations by year
- 2026: 56 · 2025: 76 · 2024: 79 · 2023: 83 · 2022: 100 · 2021: 114 · 2020: 135 · 2019: 131 · 2018: 120 · 2017: 120 · 2016: 110 · 2015: 132 · 2014: 163 · 2013: 149 · 2012: 152
- FWCI
- 43.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
- Keywords
- IPS-1, type I interferon induction, RIG-I, MDA5, IRF3, IRF7, NF-κB, TBK1, IKKi, antiviral innate immunity, interferon-stimulated genes, viral sensing
- MeSH terms
- DEAD Box Protein 58, Interferon-Induced Helicase, IFIH1, Amino Acid Sequence, Animals, Cells, Cultured, DNA-Binding Proteins, Humans, Interferon Inducers, Interferon Type I, Molecular Sequence Data, Receptors, Immunologic, RNA, Messenger, Transcription Factors, Vesicular stomatitis Indiana virus, NF-kappa B, Sequence Alignment, Interferon-beta, Protein Serine-Threonine Kinases, Protein Structure, Tertiary, RNA Helicases, Adaptor Proteins, Signal Transducing, Interferon Regulatory Factor-3, Interferon Regulatory Factor-7, Mice, I-kappa B Kinase, DEAD-box RNA Helicases
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