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IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction
Abstract
Type I interferons are central mediators for antiviral responses. Using high-throughput functional screening of interferon inducers, we have identified here a molecule we call interferon-beta promoter stimulator 1 (IPS-1). Overexpression of IPS-1 induced type I interferon and interferon-inducible genes through activation of IRF3, IRF7 and NF-kappaB transcription factors. TBK1 and IKKi protein kinases were required for the IPS-1-mediated interferon induction. IPS-1 contained an N-terminal CARD-like structure that mediated interaction with the CARD of RIG-I and Mda5, which are cytoplasmic RNA helicases that sense viral infection. 'Knockdown' of IPS-1 by small interfering RNA blocked interferon induction by virus infection. Thus, IPS-1 is an adaptor involved in RIG-I- and Mda5-mediated antiviral immune responses.
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“A breakthrough in establishing the role for mitochondria in RLR-activated antiviral immunity was the identification of the RLR mitochondrial adaptor protein MAVS (mitochondrial antiviral-signaling protein)(Kawai et al., 2005; Meylan et al., 2005; Seth et al., 2005; Xu et al., 2005) localization to the outer mitochondrial membrane is indispensable for its function.”
From Mitochondria in the Regulation of Innate and Adaptive Immunity (2015) · cites this paper as Kawai et al., 2005
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“RIG-I is critical for type I IFN transcription during viral infection (76).”
From Into the Eye of the Cytokine Storm (2012) · cites this paper as [76]
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Self-citation
Metadata
- Authors
- Kawai, T., Takahashi, K., Sato, S., Coban, C., Kumar, H., Kato, H., Ishii, K. J., Takeuchi, O., & Akira, S.
- Affiliations
- Japan Science and Technology Agency (JP)
- Kyoto University (JP)
- Research Institute for Microbial Diseases, The University of Osaka (JP)
- Corresponding author
- Akira, Shizuo
- ORCID
- Venue
- Nature Immunology
- Published
- 2005-08-28
- Volume
- 6
- Issue
- 10
- Pages
- 981-988
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W2137303998
- Cited by
- 2,562
- References
- 39
- Citations by year
- 2026: 56 · 2025: 76 · 2024: 79 · 2023: 83 · 2022: 100 · 2021: 114 · 2020: 135 · 2019: 131 · 2018: 120 · 2017: 120 · 2016: 110 · 2015: 132 · 2014: 163 · 2013: 149 · 2012: 152
- FWCI
- 43.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
- Keywords
- IPS-1, type I interferon induction, RIG-I, MDA5, IRF3, IRF7, NF-κB, TBK1, IKKi, antiviral innate immunity, interferon-stimulated genes, viral sensing
- MeSH terms
- DEAD Box Protein 58, Interferon-Induced Helicase, IFIH1, Amino Acid Sequence, Animals, Cells, Cultured, DNA-Binding Proteins, Humans, Interferon Inducers, Interferon Type I, Molecular Sequence Data, Receptors, Immunologic, RNA, Messenger, Transcription Factors, Vesicular stomatitis Indiana virus, NF-kappa B, Sequence Alignment, Interferon-beta, Protein Serine-Threonine Kinases, Protein Structure, Tertiary, RNA Helicases, Adaptor Proteins, Signal Transducing, Interferon Regulatory Factor-3, Interferon Regulatory Factor-7, Mice, I-kappa B Kinase, DEAD-box RNA Helicases
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