C/EBPβ is required for 'emergency' granulopoiesis

Efficient selection for high-expression transfectants with a novel eukaryotic vector

Niwa, H., Yamamura, K., & Miyazaki, J. (1991) · Gene · doi:10.1016/0378-1119(91)90434-d · Cited by 5,135

A clonogenic common myeloid progenitor that gives rise to all myeloid lineages

Akashi, K., Traver, D., Miyamoto, T., & Weissman, I. L. (2000) · Nature · doi:10.1038/35004599 · Cited by 2,617

Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA

Liu, F., Song, Y. K., & Liu, D. (1999) · Gene Therapy · doi:10.1038/sj.gt.3300947 · Cited by 1,728

Plat-E: an efficient and stable system for transient packaging of retroviruses

MORITA, S., Kojima, T., & Kitamura, T. (2000) · Gene Therapy · doi:10.1038/sj.gt.3301206 · Cited by 1,660

A nuclear factor for IL‐6 expression (NF‐IL6) is a member of a C/EBP family.

Akira, S., Isshiki, H., Sugita, T., Tanabe, O., Kinoshita, S. M., Nishio, Y., Nakajima, T., Hirano, T., & Kishimoto, T. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb08316.x · Cited by 1,450

Stepwise Reprogramming of B Cells into Macrophages

Xie, H., Ye, M., Feng, R., & Graf, T. (2004) · Cell · doi:10.1016/s0092-8674(04)00419-2 · Cited by 987

Mice lacking granulocyte colony-stimulating factor have chronic neutropenia, granulocyte and macrophage progenitor cell deficiency, and impaired neutrophil mobilization

Lieschke, G. J., Grail, D., HODGSON, G. S., Metcalf, D., Stanley, E. G., Cheers, C., Fowler, K., Basu, S., Zhan, Y., & Dunn, A. (1994) · Blood · doi:10.1182/blood.v84.6.1737.1737 · Cited by 956

Impaired Energy Homeostasis in C/EBPα Knockout Mice

Wang, N.-D., Finegold, M. J., Bradley, A., Ou, C. N., Abdelsayed, S. V., Wilde, M. D., Taylor, L. R., Wilson, D. R., & Darlington, G. J. (1995) · Science · doi:10.1126/science.7652557 · Cited by 929

Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein α-deficient mice

Zhang, D.-E., Zhang, P., Wang, N.-D., Hetherington, C. J., Darlington, G. J., & Tenen, D. G. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.2.569 · Cited by 910

Transcription Factors, Normal Myeloid Development, and Leukemia

Tenen, D. G., Hromas, R., Licht, J. D., & Zhang, D.-E. (1997) · Blood · doi:10.1182/blood.v90.2.489 · Cited by 735

The DNA Binding Domain of the Rat Liver Nuclear Protein C/EBP Is Bipartite

Landschulz, W. H., Johnson, P. F., & McKnight, S. L. (1989) · Science · doi:10.1126/science.2494700 · Cited by 634

IL-6DBP, a nuclear protein involved in interleukin-6 signal transduction, defines a new family of leucine zipper proteins related to CEBP

Poli, V., Mancini, F. P., & Cortese, R. (1990) · Cell · doi:10.1016/0092-8674(90)90459-r · Cited by 598

LAP, a novel member of the C/EBP gene family, encodes a liver-enriched transcriptional activator protein.

Descombes, P., Chojkier, M., Lichtsteiner, S., Falvey, E., & Schibler, U. (1990) · Genes & Development · doi:10.1101/gad.4.9.1541 · Cited by 575

Enhancement of Hematopoietic Stem Cell Repopulating Capacity and Self-Renewal in the Absence of the Transcription Factor C/EBPα

Zhang, P., Iwasaki-Arai, J., Iwasaki, H., Fenyus, M. L., Dayaram, T., Owens, B. M., Shigematsu, H., Levantini, E., Huettner, C. S., Lekstrom-Himes, J. A., et al. (2004) · Immunity · doi:10.1016/j.immuni.2004.11.006 · Cited by 528

Targeted disruption of the NF-IL6 gene discloses its essential role in bacteria killing and tumor cytotoxicity by macrophages

Tanaka, T., Akira, S., Yoshida, K., Umemoto, M., Yoneda, Y., Shirafuji, N., Fujiwara, H., Suematsu, S., Yoshida, N., & Kishimoto, T. (1995) · Cell · doi:10.1016/0092-8674(95)90418-2 · Cited by 524

Impaired Production and Increased Apoptosis of Neutrophils in Granulocyte Colony-Stimulating Factor Receptor–Deficient Mice

Liu, F., Wu, H. Y., Wesselschmidt, R. L., Kornaga, T., & Link, D. C. (1996) · Immunity · doi:10.1016/s1074-7613(00)80504-x · Cited by 510

CCAAT/Enhancer Binding Protein α Is a Regulatory Switch Sufficient for Induction of Granulocytic Development from Bipotential Myeloid Progenitors

Radomska, H. S., Huettner, C. S., Zhang, P., Cheng, T., Scadden, D. T., & Tenen, D. G. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.7.4301 · Cited by 466

AML1–ETO downregulates the granulocytic differentiation factor C/EBPα in t(8;21) myeloid leukemia

Pabst, T., Mueller, B. U., Harakawa, N., Schoch, C., Haferlach, T., Behre, G., Hiddemann, W., Zhang, D.-E., & Tenen, D. G. (2001) · Nature Medicine · doi:10.1038/86515 · Cited by 463

A novel temporal expression pattern of three C/EBP family members in differentiating myelomonocytic cells

Scott, L., Civin, C., Rorth, P., & Friedman, A. (1992) · Blood · doi:10.1182/blood.v80.7.1725.1725 · Cited by 409

Lymphoproliferative disorder and imbalanced T-helper response in C/EBP beta-deficient mice

Screpanti, I., Romani, L., Musiani, P., Modesti, A., Fattori, E., Lazzaro, D., Sellitto, C., Scarpa, S., Bellavia, D., & Lattanzio, G. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb07185.x · Cited by 407

An essential role for C/EBPβ in female reproductionPreprint

Sterneck, E., Tessarollo, L., & Johnson, P. F. (1997) · Genes & Development · doi:10.1101/gad.11.17.2153 · Cited by 387

Impaired granulopoiesis, myelodysplasia, and early lethality in CCAAT/enhancer binding protein ɛ-deficient mice

Yamanaka, R., Barlow, C., Lekstrom-Himes, J., Castilla, L. H., Liu, P. P., Eckhaus, M., Decker, T., Wynshaw-Boris, A., & Xanthopoulos, K. G. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.24.13187 · Cited by 383

Control of Granulocytes and Macrophages: Molecular, Cellular, and Clinical Aspects

Metcalf, D. (1991) · Science · doi:10.1126/science.1948028 · Cited by 370

C/EBPα Arrests Cell Proliferation through Direct Inhibition of Cdk2 and Cdk4

Wang, H., Iakova, P. A., Wilde, M., Welm, A. L., Goode, T., Roesler, W. J., & Timchenko, N. A. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00366-5 · Cited by 354

Serum granulocyte colony-stimulating factor levels in healthy volunteers and patients with various disorders as estimated by enzyme immunoassay

Watari, K., Asano, S., Shirafuji, N., Kodo, H., Ozawa, K., Takaku, F., & Kamachi, S. (1989) · Blood · doi:10.1182/blood.v73.1.117.bloodjournal731117 · Cited by 354

Hematopoietic cytokines, transcription factors and lineage commitment

Zhu, J., & Emerson, S. G. (2002) · Oncogene · doi:10.1038/sj.onc.1205318 · Cited by 349

Transactivation by NF-IL6/LAP is enhanced by phosphorylation of its activation domain

Trautwein, C., Caelles, C., van der Geer, P., Hunter, T. R., Karin, M., & Chojkier, M. (1993) · Nature · doi:10.1038/364544a0 · Cited by 340

PU.1 (Spi-1) and C/EBP alpha regulate the granulocyte colony- stimulating factor receptor promoter in myeloid cells

Smith, L., Hohaus, S., Gonzalez, D., Dziennis, S., & Tenen, D. (1996) · Blood · doi:10.1182/blood.v88.4.1234.bloodjournal8841234 · Cited by 332

E2F Repression by C/EBPα Is Required for Adipogenesis and Granulopoiesis In Vivo

Porse, B. T., Pedersen, T. Å., Xu, X., Lindberg, B. G., Wewer, U. M., Friis-Hansen, L. J., & Nerlov, C. (2001) · Cell · doi:10.1016/s0092-8674(01)00516-5 · Cited by 318

BCR-ABL suppresses C/EBPα expression through inhibitory action of hnRNP E2

Perrotti, D., Cesi, V., Trotta, R., Guerzoni, C., Santilli, G., Campbell, K., Iervolino, A., Condorelli, F., Gambacorti-Passerini, C. B., Caligiuri, M. A., et al. (2001) · Nature Genetics · doi:10.1038/ng791 · Cited by 312

Effects of purified bacterially synthesized murine multi-CSF (IL-3) on hematopoiesis in normal adult mice

Metcalf, D., Begley, C. G., Johnson, G., Nicola, N. A., Lopez, A. F., & Williamson, D. (1986) · Blood · doi:10.1182/blood.v68.1.46.46 · Cited by 309

Mice deficient for the IL-3/GM-CSF/IL-5 βc receptor exhibit lung pathology and impaired immune response, while βIL3 receptor-deficient mice are normal

Nishinakamura, R., Nakayama, N., Hirabayashi, Y., Inoue, T., Aud, D., McNeil, T., Azuma, S., Yoshida, S., Toyoda, Y., Aral, K.-I., et al. (1995) · Immunity · doi:10.1016/1074-7613(95)90046-2 · Cited by 309

Macrophage differentiation-specific expression of NF-IL6, a transcription factor for interleukin-6

Natsuka, S., Akira, S., Nishio, Y., Hashimoto, S., Sugita, T., Isshiki, H., & Kishimoto, T. (1992) · Blood · doi:10.1182/blood.v79.2.460.460 · Cited by 289

C/EBPα mutations in acute myeloid leukaemias

Nerlov, C. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1363 · Cited by 286

CCAAT enhancer- binding protein beta is required for normal hepatocyte proliferation in mice after partial hepatectomy.

Greenbaum, L. E., Li, W., Cressman, D. E., Peng, Y., Ciliberto, G., Poli, V, & Taub, R. (1998) · Journal of Clinical Investigation · doi:10.1172/jci3135 · Cited by 270

Hemopoietic responses in mice injected with purified recombinant murine GM-CSF.

Metcalf, D., Begley, C. G., Dj, W., Ec, N., De Lamarter, J., Mermod, J., Thatcher, D. R., & Schmidt, A. S. (1987) · PubMed · Cited by 269

c-Myc Is a Critical Target for C/EBPα in Granulopoiesis

Johansen, L. M., Iwama, A., Lodie, T. A., Sasaki, K., Felsher, D. W., Golub, T. R., & Tenen, D. G. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.11.3789-3806.2001 · Cited by 263

Production of colony-stimulating factors (CSFs) during infection: separate determinations of macrophage-, granulocyte-, granulocyte-macrophage-, and multi-CSFs

Cheers, C., Haigh, A., Kelso, A., Metcalf, D., Stanley, E., & Young, A. M. (1988) · Infection and Immunity · doi:10.1128/iai.56.1.247-251.1988 · Cited by 231

C/EBP, c-Myb, and PU.1 Cooperate To Regulate the Neutrophil Elastase Promoter

Oelgeschläger, M., Nuchprayoon, I., Lüscher, B., & Friedman, A. D. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.9.4717 · Cited by 229

Proliferative effects of purified granulocyte colony‐stimulating factor (G‐CSF) on normal mouse hemopoietic cells

Metcalf, D., & Nicola, N. A. (1983) · Journal of Cellular Physiology · doi:10.1002/jcp.1041160211 · Cited by 218

Block of C/EBPα function by phosphorylation in acute myeloid leukemia with FLT3 activating mutations

Radomska, H. S., Bassères, D. S. D. S., Zheng, R., Zhang, P., Dayaram, T., Yamamoto, Y., Sternberg, D., Lokker, N. A., Giese, N. A., Bohlander, S. K., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20052242 · Cited by 203

Phosphorylation of Rat Serine 105 or Mouse Threonine 217 in C/EBPβ Is Required for Hepatocyte Proliferation Induced by TGFα

Buck, M., Poli, V., van der Geer, P., Chojkier, M., & Hunter, T. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80237-3 · Cited by 162

C/EBPβ: a major PML–RARA‐responsive gene in retinoic acid‐induced differentiation of APL cells

Duprez, E., Wagner, K., Koch, H., & Tenen, D. G. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg556 · Cited by 162

McBindall—A Better Name for CCAAT/Enhancer Binding Proteins?

McKnight, S. L. (2001) · Cell · doi:10.1016/s0092-8674(01)00543-8 · Cited by 152

Phosphorylation of C/EBPα Inhibits Granulopoiesis

Ross, S. E., Radomska, H. S., Wu, B., Zhang, P., Winnay, J. N., Bajnok, L., Hahn, W. S., Schaufele, F., Tenen, D. G., & MacDougald, O. A. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.24.2.675-686.2004 · Cited by 151

Selectively enhanced contextual fear conditioning in mice lacking the transcriptional regulator CCAAT/enhancer binding protein δ

Sterneck, E., Paylor, R. E., Jackson-Lewis, V. R., Libbey, M., Przedborski, S., Tessarollo, L., Crawley, J. N., & Johnson, P. F. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.18.10908 · Cited by 150

“Emergency” granulopoiesis in G-CSF–deficient mice in response to Candida albicans infection

Basu, S., HODGSON, G. S., Zhang, H., Katz, M., Quilici, C., & Dunn, A. R. (2000) · Blood · doi:10.1182/blood.v95.12.3725 · Cited by 144

Regulation of the myeloperoxidase enhancer binding proteins Pu1, C-EBP alpha, -beta, and -delta during granulocyte-lineage specification.

Ford, A. M., Bennett, C. L., Healy, L. E., Towatari, M., Greaves, M. F., & Enver, T. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.20.10838 · Cited by 136

Upregulation of Interleukin 6 and Granulocyte Colony-Stimulating Factor Receptors by Transcription Factor CCAAT Enhancer Binding Protein α (C/EBPα) Is Critical for Granulopoiesis

Zhang, P., Iwama, A., Datta, M. W., Darlington, G. J., Link, D. C., & Tenen, D. G. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.6.1173 · Cited by 130

Differentiation of K562 leukemia cells along erythroid, macrophage, and megakaryocyte lineages.

Sutherland, J. A., Turner, A. R., Mannoni, P., McGann, L. E., & Turc, J. M. (1986) · PubMed · Cited by 111

CCAAT/enhancer-binding proteins are required for granulopoiesis independent of their induction of the granulocyte colony-stimulating factor receptor

Wang, Q., & Friedman, A. D. (2002) · Blood · doi:10.1182/blood.v99.8.2776 · Cited by 90

Expression of C/EBPβ from the C/ebpα gene locus is sufficient for normal hematopoiesis in vivo

Jones, L. C., Lin, M., Chen, S., Krug, U. O., Hofmann, W., Lee, S. B., Lee, Y., & Koeffler, H. P. (2002) · Blood · doi:10.1182/blood.v99.6.2032 · Cited by 87

Essential Requirement of CCAAT/Enhancer Binding Proteins in Embryogenesis

Bégay, V., Smink, J. J., & Leutz, A. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.22.9744-9751.2004 · Cited by 80

Induction of granulocytic differentiation by 2 pathways

Zhang, P., Nelson, E. A., Radomska, H. S., Iwasaki-Arai, J., Akashi, K., Friedman, A. D., & Tenen, D. G. (2002) · Blood · doi:10.1182/blood.v99.12.4406 · Cited by 77

Intravenous Delivery of Naked Plasmid DNA for in Vivo Cytokine Expression

Jiang, J., Yamato, E., & Miyazaki, J. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.6100 · Cited by 73

Antagonistic effect of CCAAT enhancer-binding protein-α and Pax5 in myeloid or lymphoid lineage choice in common lymphoid progenitors

Hsu, C., Fleischman, A. G., Lai, A. Y., Matsumoto, Y., Weissman, I. L., & Kondo, M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510304103 · Cited by 63

Cell cycle inhibition mediated by the outer surface of the C/EBPα basic region is required but not sufficient for granulopoiesis

Wang, Q., Cleaves, R., Kummalue, T., Nerlov, C., & Friedman, A. D. (2003) · Oncogene · doi:10.1038/sj.onc.1206360 · Cited by 47

Multipotent hematopoietic cell lines derived from C/EBPα(−/−) knockout mice display granulocyte macrophage–colony-stimulating factor, granulocyte– colony-stimulating factor, and retinoic acid–induced granulocytic differentiation

Collins, S. J., Ulmer, J., Purton, L. E., & Darlington, G. (2001) · Blood · doi:10.1182/blood.v98.8.2382 · Cited by 33

Ectopic Expression of CCAAT/Enhancer Binding Protein β (C/EBP β ) in Long-Term Bone Marrow Cultures Induces Granulopoiesis and Alters Stromal Cell Function

Popernack, P. M., Truong, L., Kamphuis, M. M. J., & Henderson, A. J. (2001) · Stem Cells and Development · doi:10.1089/152581601753193841 · Cited by 19

C/EBP Is Deregulated by PML-RAR in Acute Promyelocytic Leukemia.

Guibal, F. C., Radomska, H. S., Johansen, L. M., & Tenen, D. G. (2005) · Blood · doi:10.1182/blood.v106.11.3015.3015 · Cited by 3

A Critical Role of Blockade of Cell Differentiation in BCR-ABL-Induced B-Cell Acute Lymphoblastic Leukemia (B-ALL): Basis for Superb Therapeutic Effect on B-ALL in Mice by Promotion of Pro-B Leukemic Cell Differentiation and Treatment with Imatinib.

Hu, Y., Kong, L., Staples, K., Mills, K. D., Monroe, J. G., & Li, S. (2005) · Blood · doi:10.1182/blood.v106.11.844.844 · Cited by 1

Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards

Bronte, V., Brandau, S., Chen, S.-H., Colombo, M. P., Frey, A. B., Greten, T. F., Mandruzzato, S., Murray, P. J., Ochoa, A., Ostrand-Rosenberg, S., et al. (2016) · Nature Communications · doi:10.1038/ncomms12150 · Cited by 2,751

Neutrophils, from Marrow to Microbes

Borregaard, N. (2010) · Immunity · doi:10.1016/j.immuni.2010.11.011 · Cited by 1,674

The multifaceted functions of neutrophils

Mayadas, T. N., Cullere, X., & Lowell, C. A. (2014) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-020712-164023 · Cited by 1,356

Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophils

Galli, S. J., Borregaard, N., & Wynn, T. A. (2011) · Nature Immunology · doi:10.1038/ni.2109 · Cited by 1,055

Densely Interconnected Transcriptional Circuits Control Cell States in Human Hematopoiesis

Novershtern, N., Subramanian, A., Lawton, L. N., Mak, R. H., Haining, W. N., McConkey, M. E., Habib, N., Yosef, N., Chang, C. Y., Shay, T., et al. (2011) · Cell · doi:10.1016/j.cell.2011.01.004 · Cited by 942

Candidemia-Induced Emergency Granulopoiesis Consists of Successive Dual Waves Triggered by the Shift From C/EBPalpha to C/EBPbeta Dependency.

Satake, S., Hirai, H., Shime, N., Nagao, R., Tanaka, R., Yao, H., Hayashi, Y., Ashihara, E., Inaba, T., Fujita, N., et al. (2010) · Blood · doi:10.1182/blood.v116.21.3778.3778

C/EBPβ-Mediated Expansion of Hematopoietic Stem/Progenitors Precedes ‘Emergency’ Granulopoiesis Induced by Candidemia.

Tamura, A., Hirai, H., Hayashi, Y., Yao, H., Yoshioka, S., Miura, Y., Ashihara, E., & Maekawa, T. (2012) · Blood · doi:10.1182/blood.v120.21.2336.2336

CREB Is Involved in the Regulation of C/EBPβ During 'emergency' Granulopoiesis.

Hirai, H., Kamio, N., Matsusue, A., Ogino, S., Kimura, N., Satake, S., Ashihara, E., Maekawa, T., Tenen, D. G., & Imanishi, J. (2009) · Blood · doi:10.1182/blood.v114.22.1457.1457

C/EBPβ Is Involved in the Amplification of Early Granulocyte Precursors during Candidemia-Induced “Emergency” Granulopoiesis

Satake, S., Hirai, H., Hayashi, Y., Shime, N., Tamura, A., Yao, H., Yoshioka, S., Miura, Y., Inaba, T., Fujita, N., et al. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1103007 · Cited by 85

CCAAT/enhancer-binding proteins are required for granulopoiesis independent of their induction of the granulocyte colony-stimulating factor receptor

Wang, Q., & Friedman, A. D. (2002) · Blood · doi:10.1182/blood.v99.8.2776 · Cited by 90