Cited by 425Hematopoietic Stem Cell TransplantationBlood disorders and treatmentsAcute Myeloid Leukemia Research

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C/EBPβ is required for 'emergency' granulopoiesis

Hirai, Hideyo, Zhang, Pu, Dayaram, Tajhal, Hetherington, Christopher J, Mizuno, Shin-ichi, Imanishi, Jiro, Akashi, Koichi, Tenen, Daniel G·2006·Nature Immunology

DOI 10.1038/ni1354

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Abstract

During 'emergency' situations such as infections, host defense requires rapid mobilization of bone marrow granulocyte progenitors. 'Steady-state' granulopoiesis is absolutely dependent on the C/EBPalpha transcription factor, but the transcriptional mechanisms underlying emergency granulopoiesis remain unclear. Here we show that large numbers of granulocytes were generated from C/EBPalpha-deficient progenitors after cytokine stimulation in vivo. Cytokine treatment or fungal infection induced upregulation of C/EBPbeta but not C/EBPalpha or C/EBPepsilon transcripts in granulocyte progenitors, and C/EBPbeta-deficient progenitors showed decreased emergency-induced granulopoiesis in vitro and in vivo. C/EBPbeta inhibited proliferation less severely than did C/EBPalpha. These data suggest a critical function for C/EBPbeta in emergency granulopoiesis, which demands both differentiation and proliferation of granulocyte precursors.

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Authors: Hirai, H., Zhang, P., Dayaram, T., Hetherington, C. J., Mizuno, S.-I., Imanishi, J., Akashi, K., & Tenen, D. G.
Affiliations: Harvard University (US)
Kyushu University (JP)
Corresponding author: Tenen, Daniel G
ORCID: Hirai, Hideyo
Zhang, Pu
Akashi, Koichi
Tenen, Daniel G
Venue: Nature Immunology
Publisher: Springer Science and Business Media LLC
Published: 2006-06-04
Volume: 7
Issue: 7
Pages: 732-739
ISSN: 1529-2908 (ISSN-L)
1529-2916
DOI: 10.1038/ni1354
OpenAlex: W1986957385
Cited by: 425
References: 61
Citations by year: 2026: 23 · 2025: 22 · 2024: 29 · 2023: 24 · 2022: 15 · 2021: 22 · 2020: 32 · 2019: 19 · 2018: 21 · 2017: 21 · 2016: 24 · 2015: 25 · 2014: 22 · 2013: 23 · 2012: 20
FWCI: 7.73
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Immunology (publishedVersion)
PubMed (publishedVersion)
Funders: National Heart, Lung, and Blood Institute (R01HL056745, HL56745)
Topics: Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
Health Sciences › Medicine › Hematology › Blood disorders and treatments
Health Sciences › Medicine › Hematology › Acute Myeloid Leukemia Research
Keywords: C/EBPβ, emergency granulopoiesis, C/EBPα, granulocyte progenitors, transcription factors, cytokine induction, fungal infection, granulocytic differentiation, progenitor cell proliferation
MeSH terms: Animals, Candidiasis, Cell Cycle, Cell Differentiation, Cells, Cultured, Colony-Forming Units Assay, Estradiol, Granulocytes, Hematopoiesis, Hematopoietic Stem Cells, Humans, Infections, Interleukin-3, Mice, Inbred C57BL, Radiation Chimera, Receptors, Estrogen, Recombinant Fusion Proteins, Transduction, Genetic, Up-Regulation, Granulocyte-Macrophage Colony-Stimulating Factor, Granulocyte Colony-Stimulating Factor, K562 Cells, Animals, Congenic, CCAAT-Enhancer-Binding Proteins, CCAAT-Enhancer-Binding Protein-alpha, CCAAT-Enhancer-Binding Protein-beta, Mice

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C/EBPβ is required for 'emergency' granulopoiesis

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