Cited by 79Gut microbiota and healthFatty Acid Research and HealthMicrobial Metabolites in Food Biotechnology

Conjugated linoleic acid supplementation under a high-fat diet modulates stomach protein expression and intestinal microbiota in adult mice

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Chaplin, Alice, Parra, Pilar, Serra, Francisca, Palou, Andreu·2015·PLoS ONE

Abstract

The gastrointestinal tract constitutes a physiological interface integrating nutrient and microbiota-host metabolism. Conjugated linoleic acids (CLA) have been reported to contribute to decreased body weight and fat accretion. The modulation by dietary CLA of stomach proteins related to energy homeostasis or microbiota may be involved, although this has not been previously analysed. This is examined in the present study, which aims to underline the potential mechanisms of CLA which contribute to body weight regulation. Adult mice were fed either a normal fat (NF, 12% kJ content as fat) or a high-fat (HF, 43% kJ content as fat) diet. In the latter case, half of the animals received daily oral supplementation of CLA. Expression and content of stomach proteins and specific bacterial populations from caecum were analysed. CLA supplementation was associated with an increase in stomach protein expression, and exerted a prebiotic action on both Bacteroidetes/Prevotella and Akkermansia muciniphila. However, CLA supplementation was not able to override the negative effects of HF diet on Bifidobacterium spp., which was decreased in both HF and HF+CLA groups. Our data show that CLA are able to modulate stomach protein expression and exert a prebiotic effect on specific gut bacterial species.

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Crossref · 10.1371/journal.pone.0125091

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  • Ingestion of conjugated linoleic acid induced changes in gut microbiota, increasing Bacteroides/Prevotella species and ghrelin levels in gastric mucosa of mice.

    “In addition, ingestion of conjugated linoleic acid induced changes in the gut microbiota, increasing Bacteroides/Prevotella species and ghrelin levels in the gastric mucosa of mice [319].”

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Research works printed but not linked: 1

  1. [54]Dunphy JL, Taylor RG, Fuller PJ. Tissue distribution of rat glucagon receptor and GLP-1 receptor gene expression. Mol Cell Endocrinol. 1998; 141(1–2): 179– 86. Epub 1998/09/02.. 9723898

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Authors
Chaplin, A., Parra, P., Serra, F., & Palou, A.
Affiliations
Centro de Investigación Biomédica en Red (ES)
Corresponding author
Serra, Francisca
Venue
PLoS ONE
Published
2015-04-27
Volume
10
Issue
4
Pages
e0125091
ISSN
1932-6203 (ISSN-L)
OpenAlex
W2009680880
Cited by
79
References
71
Citations by year
2026: 1 · 2025: 4 · 2024: 11 · 2023: 7 · 2022: 7 · 2021: 6 · 2020: 12 · 2019: 9 · 2018: 9 · 2017: 4 · 2016: 6 · 2015: 3
FWCI
3.18
Type
journal article
Language
en
Open access
Locations
  • PLoS ONE (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Hispana (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Docusalut (Conselleria de Salut i Consum del Govern de les Illes Balears) (submittedVersion, cc-by)
  • O2 - Repositori Institucional (Universitat Oberta de Catalunya) (submittedVersion, cc-by)
Funders
  • Université Abdelmalek Essaadi
  • European Commission (244995)
  • Govern de les Illes Balears
  • Instituto de Salud Carlos III
  • European Social Fund
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
  • Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
Keywords
conjugated linoleic acid, high-fat diet, gut microbiota, prebiotic activity, Akkermansia muciniphila, Bifidobacterium, body weight regulation, fat accretion, energy homeostasis, cecum
MeSH terms
Gastrointestinal Microbiome, Animals, Cecum, Gastric Mucosa, Male, Mice, Inbred C57BL, Stomach, Protein Biosynthesis, Dietary Supplements, Leptin, Linoleic Acids, Conjugated, Mice, Ghrelin, Diet, High-Fat, Real-Time Polymerase Chain Reaction

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