The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Notch-mediated expansion of human cord blood progenitor cells capable of rapid myeloid reconstitution
Open accessAbstract
Delayed myeloid engraftment after cord blood transplantation (CBT) is thought to result from inadequate numbers of progenitor cells in the graft and is associated with increased early transplant–related morbidity and mortality. New culture strategies that increase the number of cord blood progenitors capable of rapid myeloid engraftment after CBT would allow more widespread use of this stem cell source for transplantation. Here we report the development of a clinically relevant Notch-mediated ex vivo expansion system for human CD34+ cord blood progenitors that results in a marked increase in the absolute number of stem/progenitor cells, including those capable of enhanced repopulation in the marrow of immunodeficient nonobese diabetic–severe combined immunodeficient (NOD-SCID) mice. Furthermore, when cord blood progenitors expanded ex vivo in the presence of Notch ligand were infused in a clinical setting after a myeloablative preparative regimen for stem cell transplantation, the time to neutrophil recovery was substantially shortened. To our knowledge, this is the first instance of rapid engraftment derived from ex vivo expanded stem/progenitor cells in humans.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Dependence of Human Stem Cell Engraftment and Repopulation of NOD/SCID Mice on CXCR4
Peled, A., Petit, I., Kollet, O., Magid, M., Ponomaryov, T., Byk, T., Nagler, A., Ben-Hur, H., Many, A., Shultz, L., et al. (1999) · Science · doi:10.1126/science.283.5403.845 · Cited by 1,644
Barker, J. N., Weisdorf, D. J., DeFor, T. E., Blazar, B. R., McGlave, P. B., Miller, J. S., Verfaillie, C. M., & Wagner, J. E. (2005) · Blood · doi:10.1182/blood-2004-07-2717 · Cited by 865
Rubinstein, P., Dobrila, L., Rosenfield, R. E., Adamson, J. W., Migliaccio, G., Migliaccio, A. R., Taylor, P. E., & Stevens, C. E. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.22.10119 · Cited by 819
Varnum-Finney, B., Xu, L., Brashem-Stein, C., Nourigat, C., Flowers, D., Bakkour, S., Pear, W. S., & Bernstein, I. D. (2000) · Nature Medicine · doi:10.1038/81390 · Cited by 643
Self-citationBrunstein, C. G., Barker, J. N., Weisdorf, D. J., DeFor, T. E., Miller, J. S., Blazar, B. R., McGlave, P. B., & Wagner, J. E. (2007) · Blood · doi:10.1182/blood-2007-04-067215 · Cited by 501
Conneally, E., Cashman, J., Petzer, A., & Eaves, C. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.18.9836 · Cited by 448
Bhatia, M., Bonnet, D., Kapp, U., Wang, J. C. Y., Murdoch, B., & Dick, J. E. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.4.619 · Cited by 386
Transplantation of ex vivo expanded cord blood
Shpall, E. J., Quinones, R., Giller, R., Zeng, C., Baron, A. E., Jones, R. B., Bearman, S. I., Nieto, Y., Freed, B., Madinger, N., et al. (2002) · Biology of Blood and Marrow Transplantation · doi:10.1053/bbmt.2002.v8.pm12171483 · Cited by 372
Jaroscak, J., Goltry, K., Smith, A., Waters-Pick, B., Martin, P. L., Driscoll, T. A., Howrey, R., Chao, N., Douville, J., Burhop, S., et al. (2003) · Blood · doi:10.1182/blood-2001-12-0290 · Cited by 302
Delaney, C., Varnum-Finney, B., Aoyama, K., Brashem-Stein, C., & Bernstein, I. D. (2005) · Blood · doi:10.1182/blood-2005-03-1131 · Cited by 278
Self-citationVarnum-Finney, B., Brashem-Stein, C., & Bernstein, I. D. (2003) · Blood · doi:10.1182/blood-2002-06-1862 · Cited by 267
Self-citationLima, M. J. G. D., McMannis, J., Gee, A. P., Komanduri, K. V., Couriel, D., Andersson, B. S., Hosing, C. M., Khouri, I. F., Jones, R. B., Champlin, R. E., et al. (2008) · Bone Marrow Transplantation · doi:10.1038/sj.bmt.1705979 · Cited by 265
Delta-1 enhances marrow and thymus repopulating ability of human CD34+CD38– cord blood cells
Ohishi, K., Varnum-Finney, B., & Bernstein, I. D. (2002) · Journal of Clinical Investigation · doi:10.1172/jci16167 · Cited by 191
Self-citationMilner, L., Kopan, R., Martin, D., & Bernstein, I. (1994) · Blood · doi:10.1182/blood.v83.8.2057.2057 · Cited by 177
Self-citationDelta-1 enhances marrow and thymus repopulating ability of human CD34+CD38– cord blood cells
Ohishi, K., Varnum-Finney, B., & Bernstein, I. D. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0216167 · Cited by 173
Self-citationSuzuki, T., Yokoyama, Y., Kumano, K., Takanashi, M., Kōzuma, S., Takato, T., Nakahata, T., Nishikawa, M., Sakano, S., Kurokawa, M., et al. (2006) · Stem Cells · doi:10.1634/stemcells.2006-0258 · Cited by 86
Zohar, S. (2014) · Wiley StatsRef: Statistics Reference Online · doi:10.1002/9781118445112.stat07082 · Cited by 21
Inhibition of Cord Blood Cell Expansion by Human Herpesvirus 6 In Vitro
Nitsche, A., Fleischmann, J., Klima, K.-M., Radonić, A., Thulke, S., & Siegert, W. (2004) · Stem Cells and Development · doi:10.1089/154732804323046800 · Cited by 5
Cited by
Hematopoiesis: a human perspective
Doulatov, S., Notta, F., Laurenti, E., & Dick, J. E. (2012) · Cell stem cell · doi:10.1016/j.stem.2012.01.006 · Cited by 895
Umbilical cord blood transplantation: the first 25 years and beyond
Ballen, K. K., Gluckman, E., & Broxmeyer, H. E. (2013) · Blood · doi:10.1182/blood-2013-02-453175 · Cited by 709
Leukaemogenesis induced by an activating β-catenin mutation in osteoblasts
Kode, A., Manavalan, J. S., Mosialou, I., Bhagat, G., Rathinam, C. V., Luo, N., Khiabanian, H., Lee, A., Murty, V. V., Friedman, R., et al. (2014) · Nature · doi:10.1038/nature12883 · Cited by 532
Frenette, P. S., Pinho, S., Lucas, D., & Scheiermann, C. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032712-095919 · Cited by 462
Jagannathan-Bogdan, M., & Zon, L. I. (2013) · Development · doi:10.1242/dev.083147 · Cited by 346
Metadata
- Authors
- Delaney, C., Heimfeld, S., Brashem-Stein, C., Voorhies, H., Manger, R. L., & Bernstein, I. D.
- Venue
- Nature Medicine
- Published
- 2010-01-17
- Volume
- 16
- Issue
- 2
- Pages
- 232-236
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W2028860972
- Cited by
- 771
- References
- 18
- FWCI
- 48.67
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
