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Cited by 591

The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.

Resolvins RvE1 and RvD1 attenuate inflammatory pain via central and peripheral actions

Open access
Xu, Zhen-Zhong, Zhang, Ling, Liu, Tong, Park, Jong Yeon, Berta, Temugin, Yang, Rong, Serhan, Charles N, Ji, Ru-Rong·2010·Nature Medicine
DOI 10.1038/nm.2123
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Abstract

Inflammatory pain, such as arthritis pain, is a growing health problem. Inflammatory pain is generally treated with opioids and cyclooxygenase (COX) inhibitors, but both are limited by side effects. Recently, resolvins, a unique family of lipid mediators, including RvE1 and RvD1 derived from omega-3 polyunsaturated fatty acid, have shown marked potency in treating disease conditions associated with inflammation. Here we report that peripheral (intraplantar) or spinal (intrathecal) administration of RvE1 or RvD1 in mice potently reduces inflammatory pain behaviors induced by intraplantar injection of formalin, carrageenan or complete Freund's adjuvant (CFA), without affecting basal pain perception. Intrathecal RvE1 injection also inhibits spontaneous pain and heat and mechanical hypersensitivity evoked by intrathecal capsaicin and tumor necrosis factor-α (TNF-α). RvE1 has anti-inflammatory activity by reducing neutrophil infiltration, paw edema and proinflammatory cytokine expression. RvE1 also abolishes transient receptor potential vanilloid subtype-1 (TRPV1)- and TNF-α–induced excitatory postsynaptic current increases and TNF-α–evoked N-methyl-D-aspartic acid (NMDA) receptor hyperactivity in spinal dorsal horn neurons via inhibition of the extracellular signal–regulated kinase (ERK) signaling pathway. Thus, we show a previously unknown role for resolvins in normalizing the spinal synaptic plasticity that has been implicated in generating pain hypersensitivity. Given the potency of resolvins and the well-known side effects of opioids and COX inhibitors, resolvins may represent new analgesics for treating inflammatory pain.

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Metadata

Authors
Xu, Z.-Z., Zhang, L., Liu, T., Park, J. Y., Berta, T., Yang, R., Serhan, C. N., & Ji, R.-R.
Venue
Nature Medicine
Publisher
Springer Science and Business Media LLC
Published
2010-04-11
Volume
16
Issue
5
Pages
592-597
ISSN
  • 1078-8956 (ISSN-L)
  • 1546-170X
DOI
10.1038/nm.2123
OpenAlex
W2067637071
Cited by
591
References
8
FWCI
28.34
Type
journal article
Language
en
Open access
green

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