The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance
Open accessAbstract
Thyroid hormones have widespread cellular effects; however it is unclear whether their effects on the central nervous system (CNS) contribute to global energy balance. Here we demonstrate that either whole-body hyperthyroidism or central administration of triiodothyronine (T3) decreases the activity of hypothalamic AMP-activated protein kinase (AMPK), increases sympathetic nervous system (SNS) activity and upregulates thermogenic markers in brown adipose tissue (BAT). Inhibition of the lipogenic pathway in the ventromedial nucleus of the hypothalamus (VMH) prevents CNS-mediated activation of BAT by thyroid hormone and reverses the weight loss associated with hyperthyroidism. Similarly, inhibition of thyroid hormone receptors in the VMH reverses the weight loss associated with hyperthyroidism. This regulatory mechanism depends on AMPK inactivation, as genetic inhibition of this enzyme in the VMH of euthyroid rats induces feeding-independent weight loss and increases expression of thermogenic markers in BAT. These effects are reversed by pharmacological blockade of the SNS. Thus, thyroid hormone–induced modulation of AMPK activity and lipid metabolism in the hypothalamus is a major regulator of whole-body energy homeostasis.
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Cites
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Metadata
- Authors
- López, M., Varela, L., Vázquez, M. J., Rodríguez-Cuenca, S., González, C. R., Velagapudi, V. R., Morgan, D. A., Schoenmakers, E., Agassandian, K., Lage, R., de Morentin, P. B. M., Tovar, S., Nogueiras, R., Carling, D., Lelliott, C., Gallego, R., Orešič, M., Chatterjee, K., Saha, A. K., Rahmouni, K., Diéguez, C., & Vidal-Puig, A.
- Venue
- Nature Medicine
- Published
- 2010-08-29
- Volume
- 16
- Issue
- 9
- Pages
- 1001-1008
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W2164577763
- Cited by
- 681
- References
- 16
- FWCI
- 29.29
- Type
- journal article
- Language
- en
- Open access
- green
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- López, M., Varela, L., Vázquez, M. J., Rodríguez-Cuenca, S., González, C. R., Velagapudi, V. R., Morgan, D. A., Schoenmakers, E., Agassandian, K., Lage, R., de Morentin, P. B. M., Tovar, S., Nogueiras, R., Carling, D., Lelliott, C., Gallego, R., Orešič, M., Chatterjee, K., Saha, A. K., . . . Vidal-Puig, A. (2010). Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance. Nature Medicine. https://doi.org/10.1038/nm.2207
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
