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Cited by 443

The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.

Activation of neuronal P2X7 receptor–pannexin-1 mediates death of enteric neurons during colitis

Open access
Gulbransen, Brian D, Bashashati, Mohammad, Hirota, Simon A, Gui, Xianyong, Roberts, Jane A, MacDonald, Justin A, Muruve, Daniel A, McKay, Derek M, Beck, Paul L, Mawe, Gary M, Thompson, Roger J, Sharkey, Keith A·2012·Nature Medicine
DOI 10.1038/nm.2679
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Abstract

Inflammatory bowel diseases (IBDs) are chronic relapsing and remitting conditions associated with long-term gut dysfunction resulting from alterations to the enteric nervous system and a loss of enteric neurons. The mechanisms underlying inflammation-induced enteric neuron death are unknown. Here using in vivo models of experimental colitis we report that inflammation causes enteric neuron death by activating a neuronal signaling complex composed of P2X7 receptors (P2X7Rs), pannexin-1 (Panx1) channels, the Asc adaptor protein and caspases. Inhibition of P2X7R, Panx1, Asc or caspase activity prevented inflammation-induced neuron cell death. Preservation of enteric neurons by inhibiting Panx1 in vivo prevented the onset of inflammation-induced colonic motor dysfunction. Panx1 expression was reduced in Crohn's disease but not ulcerative colitis. We conclude that activation of neuronal Panx1 underlies neuron death and the subsequent development of abnormal gut motility in IBD. Targeting Panx1 represents a new neuroprotective strategy to ameliorate the progression of IBD-associated dysmotility.

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Crossref · 10.1038/nm.2679

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Metadata

Authors
Gulbransen, B. D., Bashashati, M., Hirota, S. A., Gui, X., Roberts, J. A., MacDonald, J. A., Muruve, D. A., McKay, D. M., Beck, P. L., Mawe, G. M., Thompson, R. J., & Sharkey, K. A.
Venue
Nature Medicine
Publisher
Springer Science and Business Media LLC
Published
2012-03-18
Volume
18
Issue
4
Pages
600-604
ISSN
  • 1078-8956 (ISSN-L)
  • 1546-170X
DOI
10.1038/nm.2679
OpenAlex
W2055692928
Cited by
443
References
38
FWCI
26.76
Type
journal article
Language
en
Open access
green

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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