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The meaning, the sense and the significance: translating the science of mesenchymal stem cells into medicine
Open accessAbstract
Mesenchymal stem cells (MSCs) are the focus of intensive efforts worldwide directed not only at elucidating their nature and unique properties but also developing cell-based therapies for a diverse range of diseases. More than three decades have passed since the original formulation of the concept, revolutionary at the time, that multiple connective tissues could emanate from a common progenitor or stem cell retained in the postnatal bone marrow. Despite the many important advances made since that time, substantial ambiguities still plague the field regarding the nature, identity, function, mode of isolation and experimental handling of MSCs. These uncertainties have a major impact on their envisioned therapeutic use.
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Cites
Multilineage potential of adult human mesenchymal stem cells
Pittenger, M. F., Mackay, A. M., Beck, S. C., Jaiswal, R. K., Douglas, R., Mosca, J. D., Moorman, M. A., Simonetti, D. W., Craig, S., & Marshak, D. R. (1999) · Science · doi:10.1126/science.284.5411.143 · Cited by 21,052
Dominici, M., Le Blanc, K., Mueller, I., Slaper-Cortenbach, I., Marini, F. C., Krause, D. S., Deans, R. J., Keating, A., Prockop, D. J., & Horwitz, E. M. (2006) · Cytotherapy · doi:10.1080/14653240600855905 · Cited by 17,766
A perivascular origin for mesenchymal stem cells in multiple human organs
Crisan, M., Yap, S., Casteilla, L., Chen, C.-W., Corselli, M., Park, T. S., Andriolo, G., Sun, B., Zheng, B., Zhang, L., et al. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2008.07.003 · Cited by 3,991
Cited by
Mesenchymal Stromal Cells: Clinical Challenges and Therapeutic Opportunities
Galipeau, J., & Sensébé, L. (2018) · Cell Stem Cell · doi:10.1016/j.stem.2018.05.004 · Cited by 1,819
Plasticity of mesenchymal stem cells in immunomodulation: pathological and therapeutic implications
Wang, Y., Chen, X., Cao, W., & Shi, Y. (2014) · Nature Immunology · doi:10.1038/ni.3002 · Cited by 1,452
Applying extracellular vesicles based therapeutics in clinical trials – an ISEV position paper
Lener, T., Gimona, M., Aigner, L., Börger, V., Buzas, E., Camussi, G., Chaput, N., Chatterjee, D., Court, F. A., del Portillo, H. A., et al. (2015) · Journal of Extracellular Vesicles · doi:10.3402/jev.v4.30087 · Cited by 1,491
Priming approaches to improve the efficacy of mesenchymal stromal cell-based therapies
Noronha, N. D. C., Mizukami, A., Caliári-Oliveira, C., Cominal, J. G., Rocha, J. L. M., Covas, D. T., Swiech, K., & Malmegrim, K. C. R. (2019) · Stem Cell Research & Therapy · doi:10.1186/s13287-019-1224-y · Cited by 623
Endometrial stem/progenitor cells: the first 10 years
Gargett, C. E., Schwab, K. E., & Deane, J. A. (2015) · Human Reproduction Update · doi:10.1093/humupd/dmv051 · Cited by 561
Bone remodeling: an operational process ensuring survival and bone mechanical competence
Bolamperti, S., Villa, I., & Rubinacci, A. (2022) · Bone Research · doi:10.1038/s41413-022-00219-8 · Cited by 482
Moll, G., Ankrum, J. A., Kamhieh-Milz, J., Bieback, K., Ringdén, O., Volk, H.-D., Geissler, S., & Reinke, P. (2019) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2018.12.006 · Cited by 440
Sacchetti, B., Funari, A., Remoli, C., Giannicola, G., Kogler, G., Liedtke, S., Cossu, G., Serafini, M., Sampaolesi, M., Tagliafico, E., et al. (2016) · Stem Cell Reports · doi:10.1016/j.stemcr.2016.05.011 · Cited by 428
Self-citationTransforming growth factor‐β in stem cells and tissue homeostasis
Xu, X., Zheng, L., Yuan, Q., Zhen, G., Crane, J. L., Zhou, X., & Cao, X. (2018) · Bone Research · doi:10.1038/s41413-017-0005-4 · Cited by 414
Bianco, P., & Robey, P. G. (2015) · Development · doi:10.1242/dev.102210 · Cited by 402
Self-citationOrlova, V. V., van den Hil, F. E., Petrus-Reurer, S., Drabsch, Y., ten Dijke, P., & Mummery, C. L. (2014) · Nature Protocols · doi:10.1038/nprot.2014.102 · Cited by 365
Marquez-Curtis, L. A., Janowska-Wieczorek, A., McGann, L. E., & Elliott, J. A. W. (2015) · Cryobiology · doi:10.1016/j.cryobiol.2015.07.003 · Cited by 346
Skeletal muscle tissue engineering: methods to form skeletal myotubes and their applications
Ostrovidov, S., Hosseini, V., Ahadian, S., Fujie, T., Parthiban, S. P., Ramalingam, M., Bae, H., Kaji, H., & Khademhosseini, A. (2014) · Tissue Engineering Part B: Reviews · doi:10.1089/ten.teb.2013.0534 · Cited by 302
Apoptotic vesicles restore liver macrophage homeostasis to counteract type 2 diabetes
Zheng, C., Sui, B., Zhang, X., Hu, J., Chen, J., Liu, J., Wu, D., Ye, Q., Xiang, L., Qiu, X., et al. (2021) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12109 · Cited by 219
Wu, M., Zhang, R., Zou, Q., Chen, Y., Zhou, M., Li, X., Ran, R., & Chen, Q. (2018) · Scientific Reports · doi:10.1038/s41598-018-23396-1 · Cited by 206
The immune reaction and degradation fate of scaffold in cartilage/bone tissue engineering
Yang, D., Xiao, J., Wang, B., Li, L., Kong, X., & Liao, J. (2019) · Materials Science and Engineering: C · doi:10.1016/j.msec.2019.109927 · Cited by 192
Galland, S., & Stamenkovic, I. (2020) · The Journal of Pathology · doi:10.1002/path.5357 · Cited by 165
The perivascular origin of pathological fibroblasts
Di Carlo, S. E., & Peduto, L. (2018) · Journal of Clinical Investigation · doi:10.1172/jci93558 · Cited by 164
Lin, R.-Z., Moreno-Luna, R., Li, D., Jaminet, S.-C., Greene, A. K., & Melero-Martin, J. M. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1405388111 · Cited by 161
Multipotent stromal cells: One name, multiple identities
Soliman, H., Theret, M., Scott, W., Hill, L., Underhill, T. M., Hinz, B., & Rossi, F. M. V. (2021) · Cell Stem Cell · doi:10.1016/j.stem.2021.09.001 · Cited by 147
Thompson, E. M., Matsiko, A., Farrell, E., Kelly, D. J., & O'Brien, F. J. (2015) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.1918 · Cited by 147
Alimperti, S., Mirabella, T., Bajaj, V., Polacheck, W., Pirone, D. M., Duffield, J., Eyckmans, J., Assoian, R. K., & Chen, C. S. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1618333114 · Cited by 122
Todeschi, M. R., El Backly, R., Capelli, C., Daga, A., Patrone, E., Introna, M., Cancedda, R., & Mastrogiacomo, M. (2015) · Stem Cells and Development · doi:10.1089/scd.2014.0490 · Cited by 103
Cruz, F. F., Borg, Z. D., Goodwin, M., Sokocevic, D., Wagner, D., McKenna, D. H., Rocco, P. R. M., & Weiss, D. J. (2015) · Stem Cells Translational Medicine · doi:10.5966/sctm.2014-0268 · Cited by 84
Bioengineering approaches to treat the failing heart: from cell biology to 3D printing
Yadid, M., Oved, H., Silberman, E., & Dvir, T. (2022) · Nature Reviews Cardiology · doi:10.1038/s41569-021-00603-7 · Cited by 83
Liu, W., Li, R., Yin, J., Guo, S., Chen, Y., Fan, H., Li, G., Li, Z., Li, X., Zhang, X., et al. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1396-5 · Cited by 80
Tracking stem cells with superparamagnetic iron oxide nanoparticles: perspectives and considerations
Jasmin, Souza, G. T., Andrade Louzada, R., Rosado-de-Castro, P. H., Mendez-Otero, R., & Carvalho, A. C. C. (2017) · International Journal of Nanomedicine · doi:10.2147/ijn.s126530 · Cited by 78
Mechanisms of marrow adiposity and its implications for skeletal health
Veldhuis-Vlug, A. G., & Rosen, C. J. (2017) · Metabolism · doi:10.1016/j.metabol.2016.11.013 · Cited by 71
Jia, X.-H., Feng, G.-W., Wang, Z.-L., Du, Y., Shen, C., Hui, H., Peng, D., Li, Z.-J., Kong, D.-L., & Tian, J. (2016) · Oncotarget · doi:10.18632/oncotarget.8064 · Cited by 62
Wang, X., Wang, K., Yu, M., Velluto, D., Hong, X., Wang, B., Chiu, A., Melero-Martin, J. M., Tomei, A. A., & Ma, M. (2022) · Science Advances · doi:10.1126/sciadv.abn0071 · Cited by 62
Current progress of mesenchymal stem cell membrane-camouflaged nanoparticles for targeted therapy
Fan, L., Wei, A., Gao, Z., & Mu, X. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114451 · Cited by 57
Forbes, S., Bond, A. R., Thirlwell, K. L., Burgoyne, P., Samuel, K., Noble, J., Borthwick, G., Colligan, D., McGowan, N. W. A., Lewis, P. S., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aan5907 · Cited by 54
Shafiee, A., Patel, J., Yi Wong, H., Donovan, P., Hutmacher, D. W., Fisk, N. M., & Khosrotehrani, K. (2017) · The FASEB Journal · doi:10.1096/fj.201600937 · Cited by 47
Srinivasan, A., Sathiyanathan, P., Yin, L., Liu, T. M., Lam, A., Ravikumar, M., Smith, R. A. A., Loh, H. P., Zhang, Y., Ling, L., et al. (2022) · Cytotherapy · doi:10.1016/j.jcyt.2021.11.009 · Cited by 44
Sato, M., Saitoh, I., Kiyokawa, Y., Iwase, Y., Kubota, N., Ibano, N., Noguchi, H., Yamasaki, Y., & Inada, E. (2021) · Cells · doi:10.3390/cells10123338 · Cited by 29
Hurdles to uptake of mesenchymal stem cells and their progenitors in therapeutic products
Childs, P. G., Reid, S., Salmeron-Sanchez, M., & Dalby, M. J. (2020) · Biochemical Journal · doi:10.1042/bcj20190382 · Cited by 27
Epigenetic control of mesenchymal stem cells orchestrates bone regeneration
Wang, X., Yu, F., & Ye, L. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1126787 · Cited by 24
Acute Myeloid Leukaemia Drives Metabolic Changes in the Bone Marrow Niche
Maynard, R. S., Hellmich, C., Bowles, K. M., & Rushworth, S. A. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.924567 · Cited by 17
Russo, S., Scotto di Carlo, F., Maurizi, A., Fortunato, G., Teti, A., Licastro, D., Settembre, C., Mello, T., & Gianfrancesco, F. (2023) · Bone Research · doi:10.1038/s41413-023-00250-3 · Cited by 11
Metadata
- Authors
- Bianco, P., Cao, X., Frenette, P. S., Mao, J. J., Robey, P. G., Simmons, P. J., & Wang, C.-Y.
- Venue
- Nature Medicine
- Published
- 2013-01
- Volume
- 19
- Issue
- 1
- Pages
- 35-42
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W1998650056
- Cited by
- 1,197
- References
- 3
- FWCI
- 65.52
- Type
- journal article
- Language
- en
- Open access
- green
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