Orphan nuclear receptor NR4A1 regulates transforming growth factor-β signaling and fibrosis

Wound repair and regeneration

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Cellular and molecular mechanisms of fibrosis

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TGFβ signalling in context

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Scleroderma

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BMP-7 counteracts TGF-β1–induced epithelial-to-mesenchymal transition and reverses chronic renal injury

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NADPH oxidase-4 mediates myofibroblast activation and fibrogenic responses to lung injury

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Activation of canonical Wnt signalling is required for TGF-β-mediated fibrosis

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Quantitative and reproducible murine model of excisional wound healing

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GS domain mutations that constitutively activate T beta R-I, the downstream signaling component in the TGF-beta receptor complex.

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Conversion of Bcl-2 from Protector to Killer by Interaction with Nuclear Orphan Receptor Nur77/TR3

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Cytochrome c Release and Apoptosis Induced by Mitochondrial Targeting of Nuclear Orphan Receptor TR3

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Autophagy releases lipid that promotes fibrogenesis by activated hepatic stellate cells in mice and in human tissues

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The transcription factor NR4A1 (Nur77) controls bone marrow differentiation and the survival of Ly6C- monocytes

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Methylation determines fibroblast activation and fibrogenesis in the kidney

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Nerve growth factor induces a gene homologous to the glucocorticoid receptor gene

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Host Responses in Tissue Repair and Fibrosis

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Surgical Approaches to Create Murine Models of Human Wound Healing

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SD-208, a Novel Transforming Growth Factor β Receptor I Kinase Inhibitor, Inhibits Growth and Invasiveness and Enhances Immunogenicity of Murine and Human Glioma CellsIn vitroandIn vivo

Uhl, M., Aulwurm, S., Wischhusen, J., Weiler, M., Ma, J. Y., Almirez, R., Mangadu, R., Liu, Y.-W., Platten, M., Herrlinger, U., et al. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1013 · Cited by 414

Cytosporone B is an agonist for nuclear orphan receptor Nur77

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Abrogation of nuclear receptors Nr4a3 andNr4a1 leads to development of acute myeloid leukemia

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NR4A orphan nuclear receptors are transcriptional regulators of hepatic glucose metabolism

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Unimpaired Thymic and Peripheral T Cell Death in Mice Lacking the Nuclear Receptor NGFI-B (Nur77)

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Platelet-derived serotonin links vascular disease and tissue fibrosis

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Mutations in Fibrillin-1 Cause Congenital Scleroderma: Stiff Skin Syndrome

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Rosiglitazone Abrogates Bleomycin-Induced Scleroderma and Blocks Profibrotic Responses Through Peroxisome Proliferator-Activated Receptor-γ

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Nuclear receptors versus inflammation: mechanisms of transrepression

Pascual, G., & Glass, C. K. (2006) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2006.08.005 · Cited by 228

Sp1 and Smad Proteins Cooperate to Mediate Transforming Growth Factor-β1-induced α2(I) Collagen Expression in Human Glomerular Mesangial Cells

Poncelet, A.-C., & Schnaper, H. W. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m006442200 · Cited by 227

Efficient temporally‐controlled targeted mutagenesis in smooth muscle cells of the adult mouse

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Postnatal induction of transforming growth factor β signaling in fibroblasts of mice recapitulates clinical, histologic, and biochemical features of scleroderma

Sonnylal, S., Denton, C. P., Zheng, B., Keene, D. R., He, R., Adams, H. P., VanPelt, C. S., Geng, Y. J., Deng, J. M., Behringer, R. R., et al. (2007) · Arthritis & Rheumatism · doi:10.1002/art.22328 · Cited by 198

Nuclear receptor NR4A1 promotes breast cancer invasion and metastasis by activating TGF-β signalling

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Inactivation of the Orphan Nuclear Receptor TR3/Nur77 Inhibits Pancreatic Cancer Cell and Tumor Growth

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A TLR2/S100A9/CXCL-2 signaling network is necessary for neutrophil recruitment in acute and chronic liver injury in the mouse

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Orphan nuclear receptor TR3/Nur77 regulates VEGF-A–induced angiogenesis through its transcriptional activity

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During negative selection, Nur77 family proteins translocate to mitochondria where they associate with Bcl-2 and expose its proapoptotic BH3 domain

Thompson, J., & Winoto, A. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20080101 · Cited by 162

Nur77 Regulates Lipolysis in Skeletal Muscle Cells

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Regulation of Nur77 nuclear export by c-Jun N-terminal kinase and Akt

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Vitamin D receptor regulates TGF-β signalling in systemic sclerosis

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Protective Function of Transcription Factor TR3 Orphan Receptor in Atherogenesis: Decreased Lesion Formation in Carotid Artery Ligation Model in TR3 Transgenic Mice

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Regulation of Plasminogen Activator Inhibitor-1 Expression by Transforming Growth Factor-β-induced Physical and Functional Interactions between Smads and Sp1

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Tyrosine kinase signaling in fibrotic disorders

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Nuclear receptor Nr4a1 modulates both regulatory T-cell (Treg) differentiation and clonal deletion

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The nuclear receptor TR3 regulates mTORC1 signaling in lung cancer cells expressing wild-type p53

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A Unique Pharmacophore for Activation of the Nuclear Orphan Receptor Nur77 In vivo and In vitro

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The orphan receptor TR3 suppresses intestinal tumorigenesis in mice by downregulating Wnt signalling

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Activation of pregnane X receptor inhibits experimental dermal fibrosis

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EMT: 2016

Nieto, M. A., Huang, R. Y.-J., Jackson, R. A., & Thiery, J. P. (2016) · Cell · doi:10.1016/j.cell.2016.06.028 · Cited by 4,492

TGF-β: the master regulator of fibrosis

Meng, X.-M., Nikolic-Paterson, D. J., & Lan, H. Y. (2016) · Nature Reviews Nephrology · doi:10.1038/nrneph.2016.48 · Cited by 3,528

Mechanisms of hepatic stellate cell activation

Tsuchida, T., & Friedman, S. L. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.38 · Cited by 2,909

Hepatic stellate cells as key target in liver fibrosis

Higashi, T., Friedman, S. L., & Hoshida, Y. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.05.007 · Cited by 1,485

TGF-β and the TGF-β family: context-dependent roles in cell and tissue physiology

Morikawa, M., Derynck, R., & Miyazono, K. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a021873 · Cited by 1,321