Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients
Zehir, Ahmet, Benayed, Ryma, Shah, Ronak H, Syed, Aijazuddin, Middha, Sumit, Kim, Hyunjae R, Srinivasan, Preethi, Gao, Jianjiong +92 more·2017·Nature Medicine
DOI 10.1038/nm.4333
Cited by (1,010)
Items 901–1,000 of 1,010
- Pharmacoproteomics Identifies Kinase Pathways that Drive the Epithelial-Mesenchymal Transition and Drug Resistance in Hepatocellular CarcinomaMartin G. Golkowski, Ho-Tak Lau, Marina Chan, Heidi L. Kenerson, Venkata Narayana Vidadala, Anna Shoemaker, Dustin J. Maly, Raymond S. W. Yeung, Taranjit S. Gujral, Shao‐En Ong · 2020 · Cell Systems
- The mutational landscape of melanoma brain metastases presenting as the first visceral site of recurrenceRoy Rabbie, Peter M. Ferguson, Kim Wong, Dominique‐Laurent Couturier, Una Moran, Clinton P. Turner, Patrick O. Emanuel, Kerstin Haas, Jodi M. Saunus, Morgan R. Davidson et al. · 2020 · British Journal of Cancer
- Phase I Basket Study of Taselisib, an Isoform-Selective PI3K Inhibitor, in Patients with PIK3CA -Mutant CancersKomal L. Jhaveri, Matthew T. Chang, Dejan Juric, Cristina Saura, Valentina Gambardella, Anton Melnyk, Manish R. Patel, Vincent Ribrag, Cynthia X. Ma, Raid M. Aljumaily et al. · 2020 · Clinical Cancer Research
- Targeting the De Novo Purine Synthesis Pathway Through Adenylosuccinate Lyase Depletion Impairs Liver Cancer Growth by Perturbing Mitochondrial FunctionTingting Jiang, Francisco J. Sánchez Rivera, Yadira M. Soto‐Feliciano, Qiyuan Yang, Chun‐Qing Song, Arjun Bhuatkar, Cole M. Haynes, Michael T. Hemann, Wen Xue · 2020 · Hepatology
- Advances in anti-BRAF therapies for lung cancerGiandomenico Roviello, Alberto D’Angelo, Marianna Sirico, Matteo Pittacolo, Felipe Umpierre Conter, Navid Sobhani · 2021 · Investigational New Drugs
- KRAS G12C Mutation Is Associated with Increased Risk of Recurrence in Surgically Resected Lung AdenocarcinomaGregory D. Jones, Raul Caso, Kay See Tan, Brooke Mastrogiacomo, Francisco Sánchez-Vega, Yuan Liu, James G. Connolly, Yonina R. Murciano‐Goroff, Matthew Joseph Bott, Prasad S. Adusumilli et al. · 2021 · Clinical Cancer Research
- Trailblazing Precision Medicine in Europe: a joint view by Genomic Medicine Sweden and the Centers for Personalized Medicine, ZPM, in Germany.A. Stenzinger, A. Edsjö, C. Ploeger, Mikaela Friedman, S. Fröhling, V. Wirta, T. Seufferlein, J. Botling, J. Duyster, Michael Akhras et al. · 2021 · Seminars in Cancer Biology
- Expanding the spectrum of thyroid carcinoma with somatic DICER1 mutation: a survey of 829 thyroid carcinomas using MSK-IMPACT next-generation sequencing platformCharles A. Ghossein, Snjezana Doğan, Nada A. Farhat, Iñigo Landa, Bin Xu · 2021 · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin
- SRDFM: Siamese Response Deep Factorization Machine to improve anti-cancer drug recommendationRan Su, Yixuan Huang, Degan Zhang, Guobao Xiao, Leyi Wei · 2021 · Briefings in Bioinformatics
- Advancing molecular tumour boards: highly needed to maximise the impact of precision medicineJoris van de Haar, Louisa Rose Hoes, Emile E. Voest · 2019 · ESMO Open
- Methylthioadenosine Phosphorylase Genomic Loss in Advanced Gastrointestinal CancersNatalie Y.L. Ngoi, Tin‐Yun Tang, Catia Fava Gaspar, Dean C. Pavlick, Gregory M. Buchold, Emma L. Scholefield, Vamsi Parimi, Richard S.P. Huang, Tyler Janovitz, Natalie A. Danziger et al. · 2024 · The Oncologist
- 2016 New Horizons Lecture: Beyond Imaging—Radiology of TomorrowHedvig Hricak · 2018 · Radiology
- Anaplastic Lymphoma Kinase Mutation ( ALK F1174C) in Small Cell Carcinoma of the Prostate and Molecular Response to AlectinibBenedito A. Carneiro, Sahithi Pamarthy, Ami N. Shah, Vinay Sagar, Kenji Unno, Huiying Han, Ximing J. Yang, Rubens Barros Costa, Rebecca J. Nagy, Richard Burnham Lanman et al. · 2018 · Clinical Cancer Research
- The impact of phosphatases on proliferative and survival signaling in cancerGoutham Narla, Jaya Sangodkar, Christopher B. Ryder · 2018 · Cellular and Molecular Life Sciences
- Oncogenic c-terminal cyclin D1 (CCND1) mutations are enriched in endometrioid endometrial adenocarcinomasJia L. Xu, Douglas I. Lin · 2018 · PLoS ONE
- A scalable solution for tumor mutational burden from formalin-fixed, paraffin-embedded samples using the Oncomine Tumor Mutation Load AssayRuchi Chaudhary, Luca Quagliata, Philip M. Jermann, Ilaria Alborelli, Dinesh Cyanam, Vinay Mittal, Warren Tom, Janice K. Au-Young, Seth E. Sadis, Fiona C. L. Hyland · 2018 · Translational Lung Cancer Research
- Relationship between formalin reagent and success rate of targeted sequencing analysis using formalin fixed paraffin embedded tissuesKenji Amemiya, Yosuke Hirotsu, Toshio Oyama, Masao Omata · 2018 · Clinica Chimica Acta
- Biomarkers: What Role Do They Play (If Any) for Diagnosis, Prognosis and Tumor Response Prediction for Hepatocellular Carcinoma?James J. Harding, Danny N. Khalil, Ghassan K. Abou‐Alfa · 2019 · Digestive Diseases and Sciences
- Genetic and histologic spatiotemporal evolution of recurrent, multifocal, multicentric and metastatic glioblastomaMaria-Magdalena Georgescu, Adriana Olar · 2020 · Acta Neuropathologica Communications
- Impact and Diagnostic Gaps of Comprehensive Genomic Profiling in Real-World Clinical PracticeAditi Puri Singh, Elaine Shum, Lakshmi N. Rajdev, Haiying Cheng, Sanjay Goel, Roman Perez-Soler, Balázs Halmos · 2020 · Cancers
- BAP1 is a haploinsufficient tumor suppressor linking chronic pancreatitis to pancreatic cancer in miceStephanie Perkail, Jaclyn Andricovich, Kai Yan, Alexandros Tzatsos · 2020 · Nature Communications
- The emerging role of antibody-drug conjugates in urothelial carcinomaMichael William Lattanzi, Jonathan E. Rosenberg · 2020 · Expert Review of Anticancer Therapy
- Molecular and clinicopathological features of appendiceal mucinous neoplasmsYuka Yanai, Tsuyoshi Saito, Takuo Hayashi, Yoichi Akazawa, Noboru Yatagai, Sho Tsuyama, Shigeki Tomita, Shu Hirai, Kanako Ogura, Toshiharu Matsumoto et al. · 2020 · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin
- Direct plasmonic detection of circulating RAS mutated DNA in colorectal cancer patientsRoberta D’Agata, Noemi Bellassai, Matteo Allegretti, Andrea Rozzi, Saša Korom, Alex Manicardi, Elisa Melucci, Edoardo O. Pescarmona, Roberto Corradini, Patrizio Giacomini et al. · 2020 · Biosensors and Bioelectronics
- Dual inhibition of DNA-PK and DNA polymerase theta overcomes radiation resistance induced by p53 deficiencyRashmi J. Kumar, Hui Xiao Chao, Dennis A. Simpson, Wanjuan Feng, Min-Guk Cho, Victoria Roberts, Aurora R Sullivan, Sonam Shah, Anne‐Sophie Wozny, Katerina D. Fagan‐Solis et al. · 2020 · NAR Cancer
- Mutations in the RAS/MAPK Pathway Drive Replication Repair–Deficient Hypermutated Tumors and Confer Sensitivity to MEK InhibitionBrittany B. Campbell, Melissa A. Galati, Simone C. Stone, Alexandra N. Riemenschneider, Melissa Edwards, Sumedha Sudhaman, Robert Siddaway, Martin Komosa, Nuno M. Nunes, Liana Figueiredo Nobre et al. · 2021 · Cancer Discovery
- PTEN mutations predict benefit from tumor treating fields (TTFields) therapy in patients with recurrent glioblastomaAntonio Dono, Sonali Mitra, Mauli Shah, Takeshi Takayasu, Jay‐Jiguang Zhu, Nitin Tandon, Chirag B. Patel, Yoshua Esquenazi, Leomar Y. Ballester · 2021 · Journal of Neuro-Oncology
- Prognostic and immunological role of CD36: A pan-cancer analysisYongjian Chen, Weixin Liao, Shaozhuo Huang, Yunfang Yu, Jing‐Yun Wen, Jie Chen, Dagui Lin, Xiangyuan Wu, Nan Jiang, Xing Li · 2021 · Journal of Cancer
- TSC2-mutant uterine sarcomas with JAZF1-SUZ12 fusions demonstrate hybrid features of endometrial stromal sarcoma and PEComa and are responsive to mTOR inhibitionSarah Chiang, Varshini Vasudevaraja, Jonathan Serrano, Colin J.R. Stewart, Esther Oliva, Amir Momeni Boroujeni, Achim A. Jungbluth, Arnaud Da Cruz Paula, Edaise M. da Silva, Britta Weigelt et al. · 2021 · Modern Pathology
- Trends in Diagnosis and Treatment of Metastatic Cancer in the United StatesEric J. Lehrer, Kelsey C. Stoltzfus, Brianna M. Jones, Niraj Jaysukh Gusani, Vonn Walter, Ming Wang, Daniel Michael Trifiletti, Shankar Siva, Alexander V. Louie, Nicholas George Zaorsky · 2021 · American Journal of Clinical Oncology
- LTF Regulates the Immune Microenvironment of Prostate Cancer Through JAK/STAT3 PathwayQi Zhao, Yingying Cheng, Ying Xiong · 2021 · Frontiers in Oncology
- EGFR suppresses p53 function by promoting p53 binding to DNA-PKcs: a noncanonical regulatory axis between EGFR and wild-type p53 in glioblastomaJie Ding, Xiaolong Li, Sabbir Khan, Chen Zhang, Feng Gao, Shayak Sen, Amanda R. Wasylishen, Yang Zhao, Guillermina Lozano, Dimpy Koul et al. · 2022 · Neuro-Oncology
- Molecular profiling and target actionability for precision medicine in neuroendocrine neoplasms: real-world dataAlice Boilève, Matthieu Faron, Sarah Fodil-Cherif, Arnaud Bayle, Livia Lamartina, David Planchard, Lambros Tselikas, Christina Kanaan, Jean‐Yves Scoazec, Michel Pierre Ducreux et al. · 2023 · European Journal of Cancer
- Prognostic and Predictive Biomarkers in the Era of Immunotherapy for Lung CancerLucile Pabst, Sébastien Lopes, Basil Bertrand, Quentin Creusot, Maria Kotovskaya, Erwan Pencreach, Michèle Beau‐Faller, Céline Mascaux · 2023 · International Journal of Molecular Sciences
- Practice-Level Variation in Molecular Testing and Use of Targeted Therapy for Patients With Non–Small Cell Lung Cancer and Colorectal CancerThomas J. Roberts, Kenneth L. Kehl, Gabriel A. Brooks, Lynette Marie Sholl, Alexi A. Wright, Mary Beth Landrum, Nancy Lynn Keating · 2023 · JAMA Network Open
- Reactivation of telomerase reverse transcriptase expression in cancer: the role of TERT promoter mutationsMaria Lina Tornesello, Andrea Cerasuolo, Noemy Starita, Sara Amiranda, Patrizia Bonelli, Franca Maria Tuccillo, Franco M. Buonaguro, Luigi Buonaguro, Anna Lucia Tornesello · 2023 · Frontiers in Cell and Developmental Biology
- HER2 and HLA-A*02 dual CAR-T cells utilize LOH in a NOT logic gate to address on-target off-tumor toxicityDavid Bassan, Leehee Weinberger, Jason Yi, Tanya Kim, Michael R. Weist, Gregor B. Adams, Orit Foord, Neta Chaim, Sarit Tabak, Nir Bujanover et al. · 2023 · Journal for ImmunoTherapy of Cancer
- CDK4/6i-treated HR+/HER2- breast cancer tumors show higher ESR1 mutation prevalence and more altered genomic landscapeNayan Chaudhary, Alejandro Martinez Chibly, Ann Collier, Jorge Martinalbo, Pablo Perez-Moreno, Heather M. Moore, Patricia Luhn, Ciara Metcalfe, Marc A. Hafner · 2024 · npj Breast Cancer
- Building a translational cancer dependency map for The Cancer Genome AtlasXu Shi, Christos Gekas, Daniel Verduzco, Sakina M. Petiwala, Cynthia T. Jeffries, Charles Lu, Erin Murphy, Tifani Anton, Andy H. Vo, Zhiguang Xiao et al. · 2024 · Nature Cancer
- DNA liquid biopsy-based prediction of cancer-associated venous thromboembolismJustin Jee, Angela Rose Brannon, Rohan Kumar Singh, Andriy Derkach, Christopher John Fong, Adrian V. Lee, Lauren Gray, Karl Pichotta, Anisha Luthra, Monica S. Diosdado et al. · 2024 · Nature Medicine
- Comparative Genomic Profiling of Matched Primary and Metastatic Tumors in Renal Cell CarcinomaMaria F. Becerra, Ed Reznik, Almedina Redzematovic, Daniel M. Tennenbaum, Mahyar Y. Kashan, Mazyar Ghanaat, Jozefina Casuscelli, Brandon J. Manley, Philip Jonsson, Renzo G. DiNatale et al. · 2017 · European Urology Focus
- GNAQ Mutations in Diffuse and Solitary Choroidal HemangiomasJasmine H. Francis, Tatyana Milman, Hans E. Grossniklaus, Daniel Myron Albert, Robert Folberg, Gregory M. Levitin, Sarah E. Coupland, Federica Catalanotti, David Z. Rabady, Cyriac Kandoth et al. · 2018 · Ophthalmology
- ESR1 mutations in metastatic lobular breast cancer patientsChristine Desmedt, Julien Pingitore, Françoise Rothé, Caterina Marchiò, Florian Clatot, Ghizlane Rouas, François Richard, François Bertucci, Odette Mariani, Christine Galant et al. · 2019 · npj Breast Cancer
- Immunotherapy in Gynecologic Cancers: What We Know Now and Where We Are HeadedKimberly L. Levinson, Oliver Dorigo, Krista M. Rubin, Kathleen N. Moore · 2019 · American Society of Clinical Oncology Educational Book
- The prognostic value of tumor mutation burden in EGFR-mutant advanced lung adenocarcinoma, an analysis based on cBioPortal data baseXiao‐Dong Jiao, Xi He, Bao‐Dong Qin, Ke Liu, Ying Wu, Jun Liu, Ting Hou, Yuan‐Sheng Zang · 2019 · Journal of Thoracic Disease
- Clinical and molecular characterization of primary sclerosing epithelioid fibrosarcoma of bone and review of the literatureYusuke Tsuda, Brendan Craig Dickson, Sarah Dry, Noah C. Federman, Albert J.H. Suurmeijer, David Michael Swanson, Yun‐Shao Sung, Lei Zhang, John H. Healey, Cristina R. Antonescu · 2019 · Genes Chromosomes and Cancer
- Lung-only melanoma: UV mutational signature supports origin from occult cutaneous primaries and argues against the concept of primary pulmonary melanomaChen Yang, Francisco Sánchez-Vega, Jason C. Chang, Walid Khaled Chatila, Alexander Noor Shoushtari, Marc Ladanyi, William David Travis, Klaus Johannes BUSAM, Natasha Rekhtman · 2020 · Modern Pathology
- Discovering functional evolutionary dependencies in human cancersMarco Mina, Arvind Iyer, Daniele Tavernari, Franck Raynaud, Giovanni Ciriello · 2020 · Nature Genetics
- Targeting Germline- and Tumor-Associated Nucleotide Excision Repair Defects in CancerSabine Topka, Zoe Steinsnyder, Vignesh Ravichandran, Kaitlyn A. Tkachuk, Yelena M. Kemel, Chaitanya Bandlamudi, Mogens Winkel Madsen, Helena F. Furberg, Ouathek Ouerfelli, Charles M. Rudin et al. · 2020 · Clinical Cancer Research
- Comprehensive molecular profiling broadens treatment options for breast cancer patientsHitomi Kawaji, Makoto Kubo, Nami Yamashita, Hidetaka Yamamoto, Masaya Kai, Atsuko Kajihara, Mai Yamada, Kanako Kurata, Kazuhisa Kaneshiro, Yurina Harada et al. · 2020 · Cancer Medicine
- The genomic and immunologic profiles of pure pulmonary sarcomatoid carcinoma in Chinese patientsFei Zhou, Yan Huang, Weijing Cai, Jin Li, Chunxia Su, Shengxiang Ren, Chunyan Wu, Caicun Zhou · 2021 · Lung Cancer
- Genomic alterations in PIK3CA-mutated breast cancer result in mTORC1 activation and limit the sensitivity to PI3Kα inhibitorsYan-Yan Cai, Guotai Xu, Fan Wu, Flavia Michelini, Carmen Chan, X. Qu, P. Selenica, Erik M. Ladewig, P. Castel, Yuan-Ming Cheng et al. · 2021 · Cancer Research
- IDH2 R172 Mutations Across Poorly Differentiated Sinonasal Tract MalignanciesStefanie Glöß, Philipp Sebastian Jurmeister, Anne Thieme, Simone Schmid, Wei Y. Cai, Rene Serrette, Sven Perner, Julika Ribbat‐Idel, Axel Pagenstecher, Hendrik Bläker et al. · 2021 · The American Journal of Surgical Pathology
- Pan‐cancer analysis of prognostic metastatic phenotypesNicholas George Zaorsky, Xi Wang, Sara M. Garrett, Eric J. Lehrer, Christine S. Lin, David J. DeGraff, Daniel Eidelberg Spratt, Daniel Michael Trifiletti, Amar Upadhyaya Kishan, Timothy Norman Showalter et al. · 2021 · International Journal of Cancer
- Inhibition of nonsense-mediated decay rescues p53β/γ isoform expression and activates the p53 pathway in MDM2-overexpressing and select p53-mutant cancersJayanthi P. Gudikote, Tina Cascone, Alissa Poteete, Piyada Sitthideatphaiboon, Qiuyu Wu, Naoto Morikawa, Fahao Zhang, Shaohua Peng, Pan Tong, Lerong Li et al. · 2021 · Journal of Biological Chemistry
- Molecular characterization of uterine and ovarian tumors with mixed epithelial and germ cell features confirms frequent somatic derivationStephanie L. Skala, Chia‐Jen Liu, Aaron M. Udager, Andrew P. Sciallis · 2020 · Modern Pathology
- Functional Drug Screening in the Era of Precision MedicineGiulia C. Napoli, William Douglas Figg, Cindy H. Chau · 2022 · Frontiers in Medicine
- Integrated molecular and clinical analysis of BRAF-mutant glioma in adultsKarisa C. Schreck, Pinky Langat, Varun M. Bhave, Taibo Li, E. L. Woodward, Christine A. Pratilas, Charles G. Eberhart, Wenya Linda Bi · 2023 · npj Precision Oncology
- Reliable interpretability of biology-inspired deep neural networks2023
- Microsatellite Instability and Mismatch Repair Deficiency Define a Distinct Subset of Lung Cancers Characterized by Smoking Exposure, High Tumor Mutational Burden, and Recurrent Somatic MLH1 InactivationSoo‐Ryum Yang, Erika Gedvilaite, Ryan N. Ptashkin, Jason C. Chang, John Ziegler, Douglas A. Mata, Liliana B. Villafania, Khédoudja Nafa, Jaclyn Frances Hechtman, Ryma Benayed et al. · 2023 · Journal of Thoracic Oncology
- Tumor sequencing of African ancestry reveals differences in clinically relevant alterations across common cancersEvelyn Mawunyo Jiagge, Dexter X. Jin, Justin Y. Newberg, Tomin E. Perea-Chamblee, Kelly R. Pekala, Christopher John Fong, Michele Waters, David Ma, Yvonne Dei‐Adomakoh, Gilles Erb et al. · 2023 · Cancer Cell
- Comprehensive genomic profiling of breast cancers characterizes germline-somatic mutation interactions mediating therapeutic vulnerabilitiesChao Chen, Cai‐Jin Lin, Yu‐Chen Pei, Ding Ma, Li Liao, Si‐Yuan Li, Lei Fan, Gen‐Hong Di, Song‐Yang Wu, Xiyu Liu et al. · 2023 · Cell Discovery
- Classification of non-TCGA cancer samples to TCGA molecular subtypes using compact feature setsKyle Ellrott, Christopher K. Wong, Christina S. F. Yau, Mauro A.A. Castro, Jordan Lee, Brian Karlberg, Jasleen Grewal, Vincenzo Lagani, Bahar Tercan, Verena Friedl et al. · 2025 · Cancer Cell
- Rates ofERBB2Alterations across Melanoma Subtypes and a Complete Response to Trastuzumab Emtansine in anERBB2-Amplified Acral MelanomaLee S. Gottesdiener, Shannon O'Connor, Klaus Johannes BUSAM, Helen H. Won, David B. Solit, David Michael Hyman, Alexander Noor Shoushtari · 2018 · Clinical Cancer Research
- Frequent ESR1 and CDK Pathway Copy-Number Alterations in Metastatic Breast CancerAhmed Basudan, Nolan Priedigkeit, Ryan James Hartmaier, Ethan S. Sokol, Amir Bahreini, Rebecca Jean Watters, Michelle M. Boisen, Rohit Bhargava, Kurt Richard Weiss, Maria Margarete Karsten et al. · 2018 · Molecular Cancer Research
- Targeted next-generation sequencing of well-differentiated rectal, gastric, and appendiceal neuroendocrine tumors to identify potential targetsHa Young Park, Mi Jung Kwon, Ho Suk Kang, Yun Joong Kim, Nan Young Kim, Min Jeong Kim, Kyueng‐Whan Min, Kyung Chan Choi, Eun Sook Nam, Seong Jin Cho et al. · 2019 · Human Pathology
- Targeted mutation detection in breast cancer using MammaSeq™Nicholas G. Smith, Rekha Gyanchandani, Osama Shiraz Shah, Grzegorz T. Gurda, Peter C. Lucas, Ryan James Hartmaier, Adam Brufsky, Shannon Puhalla, Amir Bahreini, Karthik Joshua Kota et al. · 2019 · Breast Cancer Research
- Genomic Alteration Burden in Advanced Prostate Cancer and Therapeutic ImplicationsMatthew J. Ryan, Rohit Bose · 2019 · Frontiers in Oncology
- Supportive roles of brain macrophages in CNS metastases and assessment of new approaches targeting their functionsHua You, Szymon Baluszek, Bozena Kaminska · 2020 · Theranostics
- Discovery through clinical sequencing in oncologyMark T.A. Donoghue, Alison M. Schram, David Michael Hyman, Barry S. Taylor · 2020 · Nature Cancer
- Cyclin Pathway Genomic Alterations Across 190,247 Solid Tumors: Leveraging Large-Scale Data to Inform Therapeutic DirectionsDenis L. Fontes Jardim, Sherri Z. Millis, Jeffrey S. Ross, Michelle Sue-Ann Woo, Siraj Mahamed Ali, Razelle Kurzrock · 2020 · The Oncologist
- Pan-cancer identification of clinically relevant genomic subtypes using outcome-weighted integrative clusteringArshi Arora, Adam B. Olshen, Venkatraman Seshan, Ronglai Shen · 2020 · Genome Medicine
- Machine learning of genomic features in organotropic metastases stratifies progression risk of primary tumorsBiaobin Jiang, Quanhua Mu, Fufang Qiu, Xuefeng Li, Weiqi Xu, Jun Yu, Weilun Fu, Yong Bao Cao, Jiguang Wang · 2021 · Nature Communications
- Benchmarking HLA genotyping and clarifying HLA impact on survival in tumor immunotherapyXiangyong Li, Chi Zhou, Ke Chen, Bingding Huang, Qi Liu, Hao Ye · 2021 · Molecular Oncology
- Growth Hormone/Insulin Growth Factor Axis in Sex Steroid Associated Disorders and Related CancersRachel Bleach, Mark Sherlock, Michael O’Reilly, Marie McIlroy · 2021 · Frontiers in Cell and Developmental Biology
- Optimizing the diagnosis and management of ductal prostate cancerWeranja K. B. Ranasinghe, Daniel D. Shapiro, Miao Zhang, Tharakeswara Kumar Bathala, Nora Maria Navone, Timothy C. Thompson, Bradley McIntosh Broom, Ana M. Aparicio, Shi‐Ming Tu, Chad Z. Tang et al. · 2021 · Nature Reviews Urology
- Precision Medicine for Hepatocellular Carcinoma: Clinical PerspectiveDanijel A. Galun, Dragana Danilo Mijac, Aleksandar Filipović, Aleksandar Bogdanović, Marko Zivanovic, Dragan Mašulović · 2022 · Journal of Personalized Medicine
- AKT mutant allele-specific activation dictates pharmacologic sensitivitiesTripti Shrestha-Bhattarai, Tambudzai Shamu, Alexander N. Gorelick, Matthew T. Chang, Debyani Chakravarty, Elena I. Gavrila, Mark T.A. Donoghue, JianJong Gao, Swati Patel, Sizhi Paul Gao et al. · 2022 · Nature Communications
- Somatic ARID1A mutation stratifies patients with gastric cancer to PD-1 blockade and adjuvant chemotherapyYun Gu, Puran Zhang, Jieti Wang, Chao Lin, Hao Liu, He Li, Hongyong He, Ruochen Li, Heng Zhang, Weijuan Zhang · 2022 · Cancer Immunology Immunotherapy
- Therapeutic targeting of FOS in mutant TERT cancers through removing TERT suppression of apoptosis via regulating survivin and TRAIL-R2Rengyun Liu, Jie Tan, Xiaopei Shen, Ke Jiang, Chaoqun Wang, Guangwu Zhu, Mingzhao Xing · 2021 · Proceedings of the National Academy of Sciences
- Neoplasia risk in patients with Lynch syndrome treated with immune checkpoint blockadeEmily C. Harrold, Michael Bonner Foote, Benoı̂t Rousseau, Henry S. Walch, Yelena M. Kemel, Allison L. Richards, Fergus Keane, Andrea Cercek, Rona D. Yaeger, Dana E. Rathkopf et al. · 2023 · Nature Medicine
- Enhanced clinical assessment of hematologic malignancies through routine paired tumor and normal sequencingRyan N. Ptashkin, Mark David Ewalt, Gowtham Jayakumaran, Iwona J Kiecka, Anita S. Bowman, JinJuan Yao, Jacklyn Casanova, Yun-Te David Lin, Kseniya Petrova‐Drus, Abhinita S. Mohanty et al. · 2023 · Nature Communications
- Dabrafenib and trametinib administration in patients with BRAF V600E/R or non-V600 BRAF mutated advanced solid tumours (BELIEVE, NCCH1901): a multicentre, open-label, and single-arm phase II trialTatsunori Shimoi, Kuniko Sunami, Makoto Tahara, Satoshi Nishiwaki, Shota Tanaka, Eishi Baba, Masashi Kanai, Ichiro Kinoshita, Hidekazu Shirota, Hideyuki Hayashi et al. · 2024 · EClinicalMedicine
- Analytical Validation of Clinical Whole-Genome and Transcriptome Sequencing of Patient-Derived Tumors for Reporting Targetable Variants in CancerK. Wrzeszczynski, Vanessa Felice, A. Abhyankar, Lukasz Kozon, Heather Geiger, Dina Manaa, Ferrah London, Dino Robinson, Xiaolan Fang, D. Lin et al. · 2018 · Journal of Molecular Diagnostics
- Brain metastasis in epithelial ovarian cancer by BRCA1/2 mutation statusMarina Stasenko, Paulina Cybulska, Noah Z. Feit, Vicky Makker, Jason A. Konner, Roisin Eilish O'Cearbhaill, Kaled M. Alektiar, Kathryn P. Beal, Ginger J. Gardner, Kara Long Roche et al. · 2019 · Gynecologic Oncology
- A P53-Independent DNA Damage Response Suppresses Oncogenic Proliferation and Genome InstabilityKaterina D. Fagan‐Solis, Dennis A. Simpson, Rashmi J. Kumar, Luciano Gastón Martelotto, Lisle E. Mose, Naim U. Rashid, Alice Y. Ho, Simon N. Powell, Yuetao Wen, Joel S. Parker et al. · 2020 · Cell Reports
- Actionable Mutation Profiles of Non-Small Cell Lung Cancer patients from Vietnamese populationAnh-Thu Huynh Dang, Vu-Uyen Tran, Thanh-Truong Tran, Hong-Anh Thi Pham, Dinh-Thong Vu Le, Lam Nguyen, Ngoc Vu Nguyen, Thai-Hoa Thi Nguyen, Chu Van Nguyen, Ha Thu Le et al. · 2020 · Scientific Reports
- Comprehensive Analysis of MEN1 Mutations and Their Role in CancerDevi D. Nelakurti, Amrit L. Pappula, Swetha Rajasekaran, Wayne O. Miles, Ruben C. Petreaca · 2020 · Cancers
- BET, SRC, and BCL2 family inhibitors are synergistic drug combinations with PARP inhibitors in ovarian cancerGoldie Y.L. Lui, Reid C. Shaw, Franz X. Schaub, Isabella N. Stork, Kay E. Gurley, Caroline Bridgwater, Robert L. Diaz, Rachele Rosati, Hallie A. Swan, Tan A. Ince et al. · 2020 · EBioMedicine
- Association of clock-like mutational signature with immune checkpoint inhibitor outcome in patients with melanoma and NSCLCWei Chong, Zhe Wang, Liang Shang, Shengtao Jia, Jin Liu, Zhen Fang, Fengying Du, Hao Wu, Yang Liu, Yang Chen et al. · 2020 · Molecular Therapy — Nucleic Acids
- CTLA4 has a profound impact on the landscape of tumor-infiltrating lymphocytes with a high prognosis value in clear cell renal cell carcinoma (ccRCC)Shiyi Liu, Feiyan Wang, Wei Tan, Li Zhang, Fangfang Dai, Yanqing Wang, Yaqi Fan, Mengqin Yuan, Dongyong Yang, Yajing Zheng et al. · 2020 · Cancer Cell International
- Immunotherapy in Breast Cancer Patients: A Focus on the Use of the Currently Available Biomarkers in OncologyCarmen Criscitiello, Elena Guerini‐Rocco, Giulia Viale, Caterina Fumagalli, Elham Sajjadi, Konstantinos Venetis, Roberto Piciotti, Marco Invernizzi, Umberto Malapelle, Nicola Fusco · 2021 · Anti-Cancer Agents in Medicinal Chemistry
- PD-L1P146R is prognostic and a negative predictor of response to immunotherapy in gastric cancerQing Li, Zhiwei Zhou, Lu Jia, Hao Luo, Shunan Wang, Yu Peng, Meng-Sheng Deng, Guanbin Song, Jian-Min Wang, Xi Wei et al. · 2021 · Molecular Therapy
- Mutant p53 elicits context-dependent pro-tumorigenic phenotypesJennifer J. McCann, Irina A. Vasilevskaya, Christopher M. McNair, Peter Gallagher, Neermala Poudel Neupane, Renée de Leeuw, Ayesha A. Shafi, Emanuela Dylgjeri, Amy C. Mandigo, Matthew Joseph Schiewer et al. · 2021 · Oncogene
- PI3KCA Mutations in Uterine Cervix CarcinomaIoannis A. Voutsadakis · 2021 · Journal of Clinical Medicine
- Defining Novel DNA Virus-Tumor Associations and Genomic Correlates Using Prospective Clinical Tumor/Normal Matched Sequencing DataChad Vanderbilt, Anita S. Bowman, Sumit Middha, Kseniya Petrova‐Drus, Yi‐Wei Tang, Xin Chen, Youxiang Wang, Jason C. Chang, Natasha Rekhtman, Klaus Johannes BUSAM et al. · 2022 · Journal of Molecular Diagnostics
- Genomic alterations in cholangiocarcinoma: clinical significance and relevance to therapyMarianeve Carotenuto, Alessandra Sacco, Laura Forgione, Nicola Normanno · 2022 · Exploration of Targeted Anti-tumor Therapy
- Immunotherapy and Microbiota for Targeting of Liver Tumor-Initiating Stem-like CellsKeigo Machida, Stanley M. Tahara · 2022 · Cancers
- Tumor-immune microenvironment and NRF2 associate with clinical efficacy of PD-1 blockade combined with chemotherapy in lung squamous cell carcinomaJianchun Duan, Yun Zhang, Ran Chen, Liang Liang, Yi Huo, Shun Lü, Jun Zhao, Chunhong Hu, Yuping Sun, Kunyu Yang et al. · 2023 · Cell Reports Medicine
- Comprehensive genomic profiling in routine clinical practice leads to a low rate of benefit from genotype-directed therapyTalal Hilal, Mari Nakazawa, Jacob Hodskins, John Lee Villano, Aju Mathew, Gaurav Goel, Lars M. Wagner, Susanne M. Arnold, Philip A. DeSimone, Lowell Brian Anthony et al. · 2017 · BMC Cancer