Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients

Zehir, Ahmet, Benayed, Ryma, Shah, Ronak H, Syed, Aijazuddin, Middha, Sumit, Kim, Hyunjae R, Srinivasan, Preethi, Gao, Jianjiong +92 more·2017·Nature Medicine

DOI 10.1038/nm.4333

Cited by (1,010)

Items 601–700 of 1,010

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Erratum: Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients
Ahmet Zehir, Ryma Benayed, Ronak H. Shah, Aijazuddin Syed, Sumit Middha, Hyunjae Ryan Kim, Preethi Srinivasan, Jianjiong Gao, Debyani Chakravarty, Sean M. Devlin et al. · 2017 · Nature Medicine
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NFE2L2/KEAP1 Mutations Correlate with Higher Tumor Mutational Burden Value/PD-L1 Expression and Potentiate Improved Clinical Outcome with Immunotherapy
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Clinical use of a machine learning histopathological image signature in diagnosis and survival prediction of clear cell renal cell carcinoma
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Michael David Offin, Narek Shaverdian, Andreas Rimner, Stephanie M Lobaugh, Annemarie Fernandes Shepherd, Charles B. Simone, Daphna Y. Gelblum, Abraham Jing-Ching Wu, Nancy Y. Lee, Mark G. Kris et al. · 2020 · Radiotherapy and Oncology
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Yanhui Chen, Yating Wang, Hongli Luo, Xue Meng, Wei Zhu, Di Wang, Hui Zeng, Henghui Zhang · 2020 · Experimental Hematology and Oncology
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Justin Taylor, Mark T.A. Donoghue, Caleb Ho, Kseniya Petrova‐Drus, Hikmat A Al‐Ahmadie, Samuel Aaron Funt, Yanming Zhang, Umut Aypar, Pavitra Rao, Shweta S. Chavan et al. · 2020 · Journal of Clinical Investigation
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Neeraj Agarwal, Sebastien Ly Rinaldetti, Bassem Ben Cheikh, Qiong Zhou, Evan P. Hass, Robert T. Jones, Molishree Umesh Joshi, Daniel V. LaBarbera, Simon Knott, Thomas R. Cech et al. · 2021 · Proceedings of the National Academy of Sciences
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Qiyun Xiao, Johannes Werner, Nachiyappan Venkatachalam, Kim E. Boonekamp, Matthias P A Ebert, Tianzuo Zhan · 2022 · Biomolecules
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Yuhua Meng, Zhimeng Yao, Xiurong Ke, Mengyuan Hu, Hongzheng Ren, Shegan Gao, Hao Zhang · 2024 · Journal of Controlled Release
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Elena Fountzilas, Apostolia Maria Tsimberidou · 2018 · Expert Review of Clinical Pharmacology
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Guannan Wang, Ming‐Fang Wu, Amy C. Durham, Enrico Radaelli, Nicola J. Mason, Xiaowei Xu, David B. Roth · 2020 · PLoS ONE
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Josef Leibold, Marcus A. Ruscetti, Zhen Cao, Yu-Jui Ho, Timour Baslan, Min Zou, Wassim M. Abida, Judith Feucht, Teng Han, Francisco M. Barriga et al. · 2020 · Cancer Discovery
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Julian E. Riedesser, Matthias P A Ebert, Johannes Betge · 2022 · Therapeutic Advances in Medical Oncology
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Junyu Long, Dongxu Wang, Anqiang Wang, Peipei Chen, Yu Syuan Lin, Jin‐Song Bian, Xu Yang, Mingjun Zheng, Haohai Zhang, Yongchang Zheng et al. · 2022 · Genome Medicine
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Hanae Ida, Takafumi Koyama, Takaaki Mizuno, Kuniko Sunami, Takashi Kubo, Kazuki Sudo, Kayoko Tao, Makoto Hirata, Kan Yonemori, Ken Kato et al. · 2022 · Cancer Science
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Huaxin Song, Jiale Wu, Yigang Tang, Yuting Dai, Xinrong Xiang, Ya Li, Lili Wu, Jiaqi Wu, Ying Liang, Yangfei Xing et al. · 2023 · Science Translational Medicine
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Natasha Rekhtman, Sam E. Tischfield, Christopher A. Febres‐Aldana, Jake June-Koo Lee, Jason C. Chang, Benjamin O. Herzberg, Pier Selenica, Hyung Jun Woo, Chad Vanderbilt, Soo‐Ryum Yang et al. · 2024 · Cancer Discovery
Optimal therapy for patients with hepatocellular carcinoma and resistance or intolerance to sorafenib: challenges and solutions
Emily Miller Ray, Hanna Kelly Sanoff · 2017 · Journal of Hepatocellular Carcinoma
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Sherri Z. Millis, Denis L. Fontes Jardim, Lee A. Albacker, Jeffrey S. Ross, Vincent A. Miller, Siraj Mahamed Ali, Razelle Kurzrock · 2018 · Cancer
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Rui Li, Dongsheng Han, Jiping Shi, Yanxi Han, Ping Tan, Rui Zhang, Jinming Li · 2020 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
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Kristyn Galbraith, Vinod Kumar, Kalil G. Abdullah, Jamie M. Walker, Steven H. Adams, Timothy Prior, Ryan Dimentberg, Fraser C Henderson, Kanish Mirchia, Adwait Amod Sathe et al. · 2020 · Journal of Neuropathology & Experimental Neurology
Identification and functional characterization of new missense SNPs in the coding region of the TP53 gene
Flora Doffe, Vincent Carbonnier, Manon Tissier, Bernard Leroy, Isabelle Martins, Johanna Sofia Margareta Mattsson, Patrick Micke, Šárka Pavlová, Šárka Pospı́šilová, Jana Šmardová et al. · 2020 · Cell Death and Differentiation
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Jorge Gómez Tejeda Zañudo, Maurizio Scaltriti, Réka Albert · 2017 · Cancer Convergence
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Lorena Salgueiro, Christopher Buccitelli, Konstantina Rowald, Kálmán Somogyi, Sridhar Kandala, Jan O. Korbel, Rocı́o Sotillo · 2020 · EMBO Molecular Medicine
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Hongchen Cai, Su Kit Chew, Chuan Li, Min K. Tsai, Laura Andrejka, Christopher W. Murray, Nicholas W. Hughes, Emily G. Shuldiner, Emily L. Ashkin, Rui Tang et al. · 2021 · Cancer Discovery
Significance and limitations of the use of next-generation sequencing technologies for detecting mutational signatures
Ammal Abbasi, Ludmil B. Alexandrov · 2021 · DNA repair
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Olusegun Isaac Alatise, Gregory Knapp, Avinash S. Sharma, Walid Khaled Chatila, Olukayode Adeolu Arowolo, Olalekan O. Olasehinde, Olusola Comfort Famurewa, Adeleye Dorcas Omisore, Akinwumi Oluwole Komolafe, Olaejirinde Olaniyi Olaofe et al. · 2021 · Nature Communications
Artificial intelligence-aided clinical annotation of a large multi-cancer genomic dataset
Kenneth L. Kehl, Wenxin Vincent Xu, Alexander Gusev, Ziad Bakouny, Toni K. Choueiri, Irbaz Bin Riaz, Haitham Elmarakeby, Eliezer M. Van Allen, Deborah Schrag · 2021 · Nature Communications
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Daniel N. Kazdal, Véronique Hofman, Petros Christopoulos, Marius Ilié, Albrecht Stenzinger, Paul M Hofman · 2022 · Genes Chromosomes and Cancer
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Zhenwu Xu, Jiawei Dai, Dandan Wang, Hui Juan Lu, Heng Dai, Hao Ye, Jianlei Gu, Shengjia Chen, Bingding Huang · 2019 · OncoTargets and Therapy
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