Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients

Zehir, Ahmet, Benayed, Ryma, Shah, Ronak H, Syed, Aijazuddin, Middha, Sumit, Kim, Hyunjae R, Srinivasan, Preethi, Gao, Jianjiong +92 more·2017·Nature Medicine

DOI 10.1038/nm.4333

Cited by (1,010)

Items 701–800 of 1,010

Use of Biomarkers and Imaging for Early Detection of Pancreatic Cancer
Shingo Kato, Kazufumi Honda · 2020 · Cancers
Genomic Profiling Aids Classification of Diagnostically Challenging Uterine Mesenchymal Tumors With Myomelanocytic Differentiation
Pier Selenica, Niamh Conlon, Carlene Gonzalez, Denise Frosina, Achim A. Jungbluth, Regina G. H. Beets‐Tan, Mamta Rao, Yanming Zhang, Ryma Benayed, Marc Ladanyi et al. · 2020 · The American Journal of Surgical Pathology
Targeting KRAS-Mutant Non–Small-Cell Lung Cancer: One Mutation at a Time, With a Focus on KRAS G12C Mutations
Timothy Francis Burns, Hossein Borghaei, Suresh S. Ramalingam, Tony S.K. Mok, Solange Peters · 2020 · Journal of Clinical Oncology
Cancer-specific loss of TERT activation sensitizes glioblastoma to DNA damage
Alexandra M. Amen, Christof Fellmann, Katarzyna M. Soczek, Shawn M. Ren, Rachel J. Lew, Gavin J. Knott, Jesslyn E. Park, Andrew McKinney, Andrew Mancini, Jennifer A. Doudna et al. · 2021 · Proceedings of the National Academy of Sciences
Precision Oncology: a Clinical and Patient Perspective
Ulrik Lassen, Lydia Makaroff, Albrecht Stenzinger, Antoîne Italiano, Gilles Vassal, Jesús García‐Foncillas, Bernard P. Avouac · 2021 · Future Oncology
NSD1 mediates antagonism between SWI/SNF and polycomb complexes and is required for transcriptional activation upon EZH2 inhibition
Yiannis Drosos, Jacquelyn Myers, Beisi Xu, Kaeli M. Mathias, Emma C. Beane, Sandi Radko-Juettner, Robert J. Mobley, Margaret E. Larsen, Federica Piccioni, Xiaotu Ma et al. · 2022 · Molecular Cell
The Impact of PIK3R1 Mutations and Insulin–PI3K–Glycolytic Pathway Regulation in Prostate Cancer
Goutam Chakraborty, Subhiksha Nandakumar, Rahim Hirani, Bastien Nguyen, Konrad Hermann Stopsack, Christoph K. Kreitzer, Sai Harisha Rajanala, Romina Ghale, Ying Zhang Mazzu, Nagavarakishore Pillarsetty et al. · 2022 · Clinical Cancer Research
Comprehensive Molecular Characterization of Gallbladder Carcinoma and Potential Targets for Intervention
Nicolás A. Giraldo, Esther N Drill, Baby Anusha Satravada, Imane El Dika, Angela Rose Brannon, Josephine Kam Tai K. Dermawan, Abhinita S. Mohanty, Kerem Özcan, Debyani Chakravarty, Ryma Benayed et al. · 2022 · Clinical Cancer Research
Expanded genetic testing of GIST patients identifies high proportion of non-syndromic patients with germline alterations
Diana L. Mandelker, Antonio Marra, Nikita N. Mehta, Pier Selenica, Zarina Yelskaya, Ciyu Yang, Joshua Somar, Miika M. Mehine, Maksym Misyura, Olca Baştürk et al. · 2023 · npj Precision Oncology
Structural basis of histone H2A lysine 119 deubiquitination by Polycomb repressive deubiquitinase BAP1/ASXL1
Jonathan F. Thomas, Marco Igor Valencia‐Sánchez, Simone Tamburri, Susan L. Gloor, Samantha Rustichelli, Victoria Godínez-López, Pablo De Ioannes, Rachel Lee, Stephen Abini-Agbomson, Kristjan H. Gretarsson et al. · 2023 · Science Advances
New Developments in the Molecular Mechanisms of Pancreatic Tumorigenesis
Matthäus Felsenstein, Ralph H. Hruban, Laura DeLong Wood · 2017 · Advances in Anatomic Pathology
Rare but Recurrent ROS1 Fusions Resulting From Chromosome 6q22 Microdeletions are Targetable Oncogenes in Glioma
Monika Ashok Davare, Jacob J. Henderson, Anupriya Agarwal, Jacob P. Wagner, Sudarshan R. Iyer, Nameeta Shah, Randy L Woltjer, Romel Somwar, Stephen W. Gilheeney, Ana DeCarvalo et al. · 2018 · Clinical Cancer Research
Salt-Inducible Kinase 2: An Oncogenic Signal Transmitter and Potential Target for Cancer Therapy
Fangyu Chen, Liuwei Chen, Qin Qin, Xinchen Sun · 2019 · Frontiers in Oncology
Tumor Mutational Burden Is Site Specific in Non–Small-Cell Lung Cancer and Is Highest in Lung Adenocarcinoma Brain Metastases
Matthew K. Stein, Manjari K Pandey, Joanne Xiu, Hongseok Tae, Jeffrey J. Swensen, Sandeep Mittal, Andrew Jacob Brenner, Wolfgang Michael Korn, Amy B. Heimberger, Mike G. Martin · 2019 · JCO Precision Oncology
Whole Genome Analysis of Ovarian Granulosa Cell Tumors Reveals Tumor Heterogeneity and a High-Grade TP53-Specific Subgroup
Joline F. Roze, Glen R. Monroe, Joachim Kutzera, Jolijn W. Groeneweg, Ellen Stelloo, Sterre T. Paijens, Hans W. Nijman, Hannah S. van Meurs, Luc R.C.W. van Lonkhuijzen, Jurgen M.J. Piek et al. · 2020 · Cancers
Age, sex, and specific gene mutations affect the effects of immune checkpoint inhibitors in colorectal cancer
Anqi Lin, Hongman Zhang, Xigang Hu, Xiaoting Chen, Gang Wu, Peng Luo, Jian Zhang · 2020 · Pharmacological Research
Plasma DNA-Based Molecular Diagnosis, Prognostication, and Monitoring of Patients With <i>EWSR1</i> Fusion-Positive Sarcomas
Shukla, Neerav N., Patel, Juber A., Magnan, Heather, Zehir, Ahmet, You, Daoqi, Tang, Jiabin, Meng, Fanli, Samoila, Aliaksandra, Slotkin, Emily K., Ambati, Srikanth R. et al. · 2017 · JCO Precision Oncology
Larotrectinib Treatment for Patients With TRK Fusion-Positive Salivary Gland Cancers
Xiuning Le, Christina S. Baik, Jessica Ruth Bauman, Jill Gilbert, Marcia S. Brose, Juneko E. Grilley‐Olson, Tejas Patil, Ray McDermott, Luis Estuardo Raez, Jennifer Maria Johnson et al. · 2022 · The Oncologist
Reversion mutations in germline BRCA1/2-mutant tumors reveal a BRCA-mediated phenotype in non-canonical histologies
Yonina R. Murciano‐Goroff, Alison M. Schram, Ezra Y. Rosen, Helen H. Won, Yixiao Gong, Anne Marie Noronha, Yelena Yuriy Janjigian, Zsofia Kinga Stadler, Jason C. Chang, Soo‐Ryum Yang et al. · 2022 · Nature Communications
Serum albumin: a pharmacokinetic marker for optimizing treatment outcome of immune checkpoint blockade
Ming Zheng · 2022 · Journal for ImmunoTherapy of Cancer
Tumor mutation burden in the prognosis and response of lung cancer patients to immune-checkpoint inhibition therapies
Paraskevi Vryza, Timo Fischer, Elena Mistakidi, Apostolos Zaravinos · 2023 · Translational Oncology
Entrectinib in TRK and ROS1 Fusion-Positive Metastatic Pancreatic Cancer
Michael Jon Pishvaian, Ignacio Garrido‐Laguna, Stephen V. Liu, Pratik S. Multani, Edna Chow‐Maneval, Christian Diego Rolfo · 2018 · JCO Precision Oncology
Immunosuppressive circuits in tumor microenvironment and their influence on cancer treatment efficacy
Alessandra Tuccitto, Eriomina Shahaj, Elisabetta Vergani, Simona Ferro, Veronica Huber, Monica Rodolfo, Chiara Castelli, Licia Rivoltini, Viviana Vallacchi · 2018 · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin
High tumor mutation burden is associated with DNA damage repair gene mutation in breast carcinomas
Ping Mei, C. Eric Freitag, Lai Wei, Yunxiang Zhang, Anil Vasdev Parwani, Zaibo Li · 2020 · Diagnostic Pathology
From Genes to -Omics: The Evolving Molecular Landscape of Malignant Peripheral Nerve Sheath Tumor
Kathryn M. Lemberg, Jiawan Wang, Christine A. Pratilas · 2020 · Genes
Clinical implications of prospective genomic profiling of metastatic breast cancer patients
Courtney T. van Geelen, Peter Stephen Savas, Zhi Ling Teo, Stephen James Luen, Chen-Fang Weng, Yi-An Ko, Keilly S. Kuykhoven, Franco Caramia, Roberto Salgado, Prudence A. Francis et al. · 2020 · Breast Cancer Research
BRAF Mutation in Colorectal Cancers: From Prognostic Marker to Targetable Mutation
Izuma Nakayama, Toru Hirota, Eiji Shinozaki · 2020 · Cancers
Genomic Alterations in Head and Neck Squamous Cell Carcinoma: Level of Evidence According to ESMO Scale for Clinical Actionability of Molecular Targets (ESCAT)
Grégoire Marret, Ivan Bièche, Célia Dupain, Édith Borcoman, Pauline du Rusquec, Francesco Ricci, S. Hescot, Marie‐Paule Sablin, Patricia Tresca, Diana Bello et al. · 2021 · JCO Precision Oncology
Genomic Profiling of Prostate Cancer: An Updated Review
Koji Hatano, Norio Nonomura · 2021 · The World Journal of Men s Health
APOBEC mutagenesis, kataegis, chromothripsis in EGFR-mutant osimertinib-resistant lung adenocarcinomas
Pier Selenica, Antonio Marra, Noura J. Choudhury, Andrea M. Gazzo, Christina J. Falcon, Juber Patel, Xin Pei, Yingjie Zhu, Charlotte K.Y. Ng, Michael Curry et al. · 2022 · Annals of Oncology
PIK3CA mutation as an acquired resistance driver to EGFR-TKIs in non-small cell lung cancer: Clinical challenges and opportunities
Xiaohong Liu, Wuxuan Mei, Pengfei Zhang, Changchun Zeng · 2024 · Pharmacological Research
The mutational landscape of recurrent versus nonrecurrent human papillomavirus–related oropharyngeal cancer
R. Alex Harbison, Mark W. Kubik, Eric Quentin Konnick, Qing Hua Zhang, Seok‐Geun Lee, Heuijoon Park, Jianan Zhang, Christopher S. Carlson, Chu Chen, Stephen M. Schwartz et al. · 2018 · JCI Insight
NOXA genetic amplification or pharmacologic induction primes lymphoma cells to BCL2 inhibitor-induced cell death
Yuxuan Liu, Patrizia Mondello, Tatiana Erazo, Neeta Bala Tannan, Zahra Asgari, Elisa de Stanchina, Gouri J. Nanjangud, Venkatraman Seshan, Shenqiu Wang, Hans‐Guido Wendel et al. · 2018 · Proceedings of the National Academy of Sciences
Functional significance of U2AF1 S34F mutations in lung adenocarcinomas
Mohammad Shahrokh Esfahani, Luke J. Lee, Young-Jun Jeon, Ryan A. Flynn, Henning Stehr, Angela Bik‐Yu Hui, Noriko Ishisoko, Eric Kildebeck, Aaron M. Newman, Scott Victor Bratman et al. · 2019 · Nature Communications
PBRM1 mutation and preliminary response to immune checkpoint blockade treatment in non-small cell lung cancer
Huaqiang Zhou, Jiaqing Liu, Yaxiong Zhang, Yan Huang, Jiayi Shen, Yunpeng Yang, Wenfeng Fang, Li Zhang · 2020 · npj Precision Oncology
E-cadherin immunohistochemical expression in invasive lobular carcinoma of the breast: correlation with morphology and CDH1 somatic alterations
Anne Grabenstetter, Abhinita S. Mohanty, Satshil Rana, Ahmet Zehir, Angela Rose Brannon, Timothy M. D’Alfonso, Deborah F. DeLair, Lee K. Tan, Dara S. Ross · 2020 · Human Pathology
Prospective high-throughput genome profiling of advanced cancers: results of the PERMED-01 clinical trial
François Bertucci, Anthony Gonçalvès, Arnaud Guillé, José Adélaı̈de, Sèverine Garnier, Nadine Carbuccia, Emilien Billon, Pascal Finetti, Patrick Sfumato, Audrey Monneur et al. · 2021 · Genome Medicine
Toward a More Precise Future for Oncology
Murciano-Goroff, Yonina R., Taylor, Barry S., Hyman, David M., Schram, Alison M. · 2020 · Cancer Cell
Reimagining patient-centric cancer clinical trials: a multi-stakeholder international coalition
Bob T. Li, Bobby Daly, Mary Krystyna Gospodarowicz, Monica M. Bertagnolli, Otis Webb Brawley, Bruce Allan Chabner, Lola A. Fashoyin‐Aje, R. Angelo de Claro, Elizabeth F. Franklin, Jennifer Mills et al. · 2022 · Nature Medicine
Clonal evolution during metastatic spread in high-risk neuroblastoma
Gunes Gundem, Max Fine Levine, Stephen S. Roberts, Irene Y. Cheung, Juan Santiago Medina-Martinez, Yi Feng, Juan Arango Ossa, Loic Chadoutaud, Mathieu Rita, Georgios Asimomitis et al. · 2023 · Nature Genetics
First-line regorafenib with nivolumab and chemotherapy in advanced oesophageal, gastric, or gastro-oesophageal junction cancer in the USA: a single-arm, single-centre, phase 2 trial
Samuel Louis Cytryn, Ryan H. Moy, Darren Cowzer, Ronak H. Shah, Joanne F. Chou, Smita Suhas Joshi, Geoffrey Yuyat Ku, Steven Brad Maron, Avni Mukund Desai, Jessica Yang et al. · 2023 · The Lancet Oncology
Prevalence of ROS1 fusion in Chinese patients with non‐small cell lung cancer
Qing Zhang, Chunyan Wu, Wei Ding, Zhihong Zhang, Xueshan Qiu, Dianbin Mu, Haiqing Zhang, Yanfeng Xi, Jianhua Zhou, Liheng Ma et al. · 2018 · Thoracic Cancer
Genomic landscape of inverted urothelial papilloma and urothelial papilloma of the bladder
Sumit Isharwal, Wenhuo Hu, Judy Sarungbam, Ying‐Bei Chen, Anuradha Gopalan, Samson W. Fine, Satish K. Tickoo, Sahussapont Joseph Sirintrapun, Sana Jadallah, Florence L. Loo et al. · 2019 · The Journal of Pathology
Routine Plasma-Based Genotyping to Comprehensively Detect Germline, Somatic, and Reversion BRCA Mutations among Patients with Advanced Solid Tumors
Neelima Vidula, Thereasa A. Rich, Oliver A. Sartor, Jennifer L. Yen, Aaron I. Hardin, Tracy Nance, Michael B. Lilly, Mohammad Amin Nezami, Sandip Pravin Patel, Benedito A. Carneiro et al. · 2020 · Clinical Cancer Research
Not All Wnt Activation Is Equal: Ligand-Dependent versus Ligand-Independent Wnt Activation in Colorectal Cancer
Sam O. Kleeman, Simon John Leedham · 2020 · Cancers
Chasing the Target: New Phenomena of Resistance to Novel Selective RET Inhibitors in Lung Cancer. Updated Evidence and Future Perspectives
Sara Fancelli, Enrico Caliman, Francesca Mazzoni, Marco Brugia, Francesca Castiglione, Luca Voltolini, Serena Pillozzi, Lorenzo Antonuzzo · 2021 · Cancers
RAS and RHO family GTPase mutations in cancer: twin sons of different mothers?
Richard G. Hodge, Antje Schaefer, Sarah V. Howard, Channing J. Der · 2020 · Critical Reviews in Biochemistry and Molecular Biology
Meta-Analysis and Systematic Review of the Genomics of Mucosal Melanoma
Natasa Broit, Peter A. Johansson, Chloe B. Rodgers, Sebastian Walpole, Felicity Newell, Nicholas K. Hayward, Antonia L. Pritchard · 2021 · Molecular Cancer Research
Oncogenic IDH mutations increase heterochromatin-related replication stress without impacting homologous recombination
Juan M. Schvartzman, Grace Forsyth, Henry S. Walch, Walid Khaled Chatila, Angelo Taglialatela, Brian J. Lee, Xiaolu Zhu, Steven Gershik, Francesco V. Cimino, Anthony Santella et al. · 2023 · Molecular Cell
Nrf2 Signaling in Renal Cell Carcinoma: A Potential Candidate for the Development of Novel Therapeutic Strategies
Valentina Schiavoni, Monica Emanuelli, Giulio Milanese, Andrea Benedetto Galosi, Veronica Pompei, Eleonora Salvolini, Roberto Campagna · 2024 · International Journal of Molecular Sciences
Precision oncology: separating the wheat from the chaff
Jordi Remón, Rodrigo Dienstmann · 2018 · ESMO Open
Association between histone lysine methyltransferase KMT2C mutation and clinicopathological factors in breast cancer
Xiaoqing Chen, Guochun Zhang, Bo Chen, Yulei Wang, Liping Guo, Li Cao, Chongyang Ren, Lingzhu Wen, Ning Liao · 2019 · Biomedicine & Pharmacotherapy
Tumour mutational burden: primary versus metastatic tissue creates systematic bias
Désirée Schnidrig, Samra Turajlic, Kevin Litchfield · 2019 · Immuno-Oncology Technology
A Review of Precision Oncology Knowledgebases for Determining the Clinical Actionability of Genetic Variants
Xuanyi Li, Jeremy Lyle Warner · 2020 · Frontiers in Cell and Developmental Biology
Stimuli‐Responsive Iron Oxide Nanotheranostics: A Versatile and Powerful Approach for Cancer Therapy
Morgan E. Lorkowski, Prabhani U. Atukorale, Ketan B. Ghaghada, Efstathios Karathanasis · 2020 · Advanced Healthcare Materials
Roles of the Dynamic Tumor Immune Microenvironment in the Individualized Treatment of Advanced Clear Cell Renal Cell Carcinoma
Enyu Lin, Xuechao Liu, Yanjun Liu, Zedan Zhang, Lu Xie, Kaiwen Tian, Jiumin Liu, Yuming Yu · 2021 · Frontiers in Immunology
Integrated clinico-molecular profiling of appendiceal adenocarcinoma reveals a unique grade-driven entity distinct from colorectal cancer
Kanwal P. S. Raghav, John Paul Shen, Alexandre Andrade dos Anjos Jacome, Jennifer L. Guerra, Christopher P. Scally, Melissa W. Taggart, Wai Chin Foo, Aurelio Matamoros, Kenna R Mills Shaw, Keith F. Fournier et al. · 2020 · British Journal of Cancer
Gastric-type adenocarcinoma of the cervix: Clinical outcomes and genomic drivers
Sarah Ehmann, Dib Sassine, Alli M. Straubhar, Aaron M. Praiss, Carol A Aghajanian, Kaled M. Alektiar, Vance A. Broach, Karen Anne Cadoo, Elizabeth Lin Jewell, Amir Momeni Boroujeni et al. · 2022 · Gynecologic Oncology
The Efficacy of Tumor Mutation Burden as a Biomarker of Response to Immune Checkpoint Inhibitors
Camille M. Moeckel, Katrina Bakhl, Ilias Georgakopoulos‐Soares, Apostolos Zaravinos · 2023 · International Journal of Molecular Sciences
Molecular Characterization of Endometrial Carcinomas in Black and White Patients Reveals Disparate Drivers with Therapeutic Implications
Britta Weigelt, Antonio Marra, Pier Selenica, Eric Rios‐Doria, Amir Momeni Boroujeni, Michael F. Berger, Kanika S. Arora, David Nemirovsky, Alexia E. Iasonos, Debyani Chakravarty et al. · 2023 · Cancer Discovery
Precision medicine in the era of multi-omics: can the data tsunami guide rational treatment decision?
Mihaela D. Aldea, Luc Friboulet, Sébastien Apcher, Fanny Jaulin, Fernanda Mosele, Tony Sourisseau, Jean‐Charles Soria, Sergey I. Nikolaev, Fabrice André · 2023 · ESMO Open
Loss of Kmt2c or Kmt2d drives brain metastasis via KDM6A-dependent upregulation of MMP3
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An Open Library of Human Kinase Domain Constructs for Automated Bacterial Expression
Steven K. Albanese, Daniel L. Parton, Mehtap Işık, Lucelenie Rodríguez‐Laureano, Sonya M. Hanson, Julie M. Behr, Scott Gradia, Chris Jeans, Nicholas M. Levinson, Markus A. Seeliger et al. · 2018 · Biochemistry
Toward automation of germline variant curation in clinical cancer genetics
Vignesh Ravichandran, Zarina Shameer, Yelena M. Kemel, Michael Francis Walsh, Karen Anne Cadoo, Steven M. Lipkin, Diana L. Mandelker, Liying Zhang, Zsofia Kinga Stadler, Mark E. Robson et al. · 2019 · Genetics in Medicine
Increased activation of PI3 kinase-δ predisposes to B-cell lymphoma
Anne Durandy, Sven Kracker · 2020 · Blood
Germline alterations in patients with biliary tract cancers: A spectrum of significant and previously underappreciated findings
Hannah Maynard, Zsofia Kinga Stadler, Michael F. Berger, David B. Solit, Michele Ly, Maeve Aine Lowery, Diana L. Mandelker, Liying Zhang, Emmett Jordan, Imane El Dika et al. · 2020 · Cancer
Tumor neoantigenicity assessment with CSiN score incorporates clonality and immunogenicity to predict immunotherapy outcomes
Tianshi Lu, Shidan Wang, Lin Xu, Qinbo Zhou, Nirmish Singla, Jianjun Gao, Subrata Manna, Laurentiu M. Pop, Zhiqun Xie, Mingyi Chen et al. · 2020 · Science Immunology
BRCA Mutations, Homologous DNA Repair Deficiency, Tumor Mutational Burden, and Response to Immune Checkpoint Inhibition in Recurrent Ovarian Cancer
Ying L. Liu, Pier Selenica, Qin C Zhou, Alexia E. Iasonos, Margaret K. Callahan, Noah Z. Feit, Julia L. Boland, Ignacio Vázquez-Garćıa, Diana L. Mandelker, Ahmet Zehir et al. · 2020 · JCO Precision Oncology
Genetic and epigenetic landscape of IDH-wildtype glioblastomas with FGFR3-TACC3 fusions
Douglas A. Mata, Jamal K. Benhamida, Andrew L. Lin, Chad Vanderbilt, Soo‐Ryum Yang, Liliana B. Villafania, Donna C. Ferguson, Philip Jonsson, Alexandra Michelle Miller, Viviane S. Tabar et al. · 2020 · Acta Neuropathologica Communications
The genotypes and phenotypes of missense mutations in the proline domain of the p53 protein
David Hoyos, Benjamin D. Greenbaum, Arnold J. Levine · 2022 · Cell Death and Differentiation
Genomic and molecular features distinguish young adult cancer from later-onset cancer
William Lee, Zishan Wang, Miriam Saffern, Tomi Wei Jun, Kuan‐lin Huang · 2021 · Cell Reports
Tumor monocyte content predicts immunochemotherapy outcomes in esophageal adenocarcinoma
Thomas M. Carroll, Joseph A. Chadwick, Richard P. Owen, Michael Joseph White, Joseph Kaplinsky, Iliana Peneva, Anna Frangou, Phil F. Xie, Jaeho Chang, Andrew J. L. Roth et al. · 2023 · Cancer Cell
Next-generation sequencing in drug development: target identification and genetically stratified clinical trials
Abolfazl Doostparast Torshizi, Kai Wang · 2018 · Drug Discovery Today
Ampullary cancer: Evaluation of somatic and germline genetic alterations and association with clinical outcomes
Winston Wong, Maeve Aine Lowery, Michael F. Berger, Yelena M. Kemel, Barry S. Taylor, Ahmet Zehir, Preethi Srinivasan, Chaitanya Bandlamudi, Joanne F. Chou, Marinela Capanu et al. · 2019 · Cancer
Trials in progress: IMagyn050/GOG 3015/ENGOT-OV39. A Phase III, multicenter, randomized study of atezolizumab versus placebo administered in combination with paclitaxel, carboplatin, and bevacizumab to patients with newly-diagnosed stage III or stage IV ovarian, fallopian tube, or primary peritoneal cancer
Kathleen N. Moore, Sandro Pignata · 2019 · International Journal of Gynecological Cancer
Small lung tumor biopsy samples are feasible for high quality targeted next generation sequencing
Hidenori Kage, Shinji Kohsaka, Aya Shinozaki‐Ushiku, Yoshihisa Hiraishi, Jiro Sato, Kazuhiro Nagayama, Tetsuo Ushiku, Daiya Takai, Jun Nakajima, Kiyoshi Miyagawa et al. · 2019 · Cancer Science
Molecular Profiles and Metastasis Markers in Chinese Patients with Gastric Carcinoma
Chao Chen, Chunmei Shi, Xiaochun Huang, Jianwei Zheng, Zhongyi Zhu, Qiaolian Li, Si Qiu, Zhiqing Huang, Zhenkun Zhuang, Riping Wu et al. · 2019 · Scientific Reports
Precision medicine for gastrointestinal cancer: Recent progress and future perspective
Tasuku Matsuoka, Masakazu Yashiro · 2019 · World Journal of Gastrointestinal Oncology
TERT mutations correlate with higher TMB value and unique tumor microenvironment and may be a potential biomarker for anti‐CTLA4 treatment
Huahua Li, Jia Li, Chenyue Zhang, Chenxing Zhang, Haiyong Wang · 2020 · Cancer Medicine
Molecular Profiling-Based Assignment of Cancer Therapy (NCI-MPACT): A Randomized Multicenter Phase II Trial
Alice P. Chen, Shivaani Kummar, Nancy Moore, Larry Rubinstein, Yingdong Zhao, Paul Mickey Williams, Alida Palmisano, David Sims, Geraldine O’Sullivan Coyne, Christina L. Rosenberger et al. · 2021 · JCO Precision Oncology
Treatment Strategies for ARID1A-Deficient Ovarian Clear Cell Carcinoma
Kazuaki Takahashi, Masataka Takenaka, Aikou Okamoto, David D.L. Bowtell, Takashi Kohno · 2021 · Cancers
Genomic Characterization of Concurrent Alterations in Non-Small Cell Lung Cancer (NSCLC) Harboring Actionable Mutations
Antonio Passaro, Ilaria Attili, Alessandra Rappa, Davide Vacirca, Alberto Ranghiero, Caterina Fumagalli, Juliana Guarize, Lorenzo Spaggiari, Filippo de Marinis, Massimo C.P. Barberis et al. · 2021 · Cancers
EGFR-RAD51 fusion variant in lung adenocarcinoma and response to erlotinib: A case report
You‐cai Zhu, Wenxian Wang, C. Xu, Zhengbo Song, Kaiqi Du, Gang Chen, Tangfeng Lv, Yong Song · 2017 · Lung Cancer
Clinicopathologic and Genomic Landscape of Non-Small Cell Lung Cancer Brain Metastases
Richard S.P. Huang, Lukas Harries, Brennan James Decker, Matthew Hiemenz, Karthikeyan Murugesan, James Creeden, Khaled A. Tolba, Laura P. Stabile, Shakti H Ramkissoon, Timothy Francis Burns et al. · 2022 · The Oncologist
Future directions for precision oncology in prostate cancer
Kei Mizuno, Himisha Beltran · 2022 · The Prostate
Current and future applications of liquid biopsy in non-small-cell lung cancer—a narrative review
Bartłomiej Tomasik, Marcin Tomasz Skrzypski, Michał Bieńkowski, Rafał Dziadziuszko, Jacek Jassem · 2023 · Translational Lung Cancer Research
SLC27A4-mediated selective uptake of mono-unsaturated fatty acids promotes ferroptosis defense in hepatocellular carcinoma
Ziwen Li, Xinyi Liao, Yameng Hu, Man Li, Miaoling Tang, Shuxia Zhang, Shuang Mo, Xincheng Li, Suwen Chen, Wanying Qian et al. · 2023 · Free Radical Biology and Medicine
β-catenin inhibitors in cancer therapeutics: intricacies and way forward
Arundhathi J. R. Dev, Meenakshi Vachher, Chandra Prakash Prasad · 2023 · Bioengineered
Association of the Genomic Profile of Medullary Thyroid Carcinoma with Tumor Characteristics and Clinical Outcomes in an International Multicenter Study
Bin Xu, Kartik Viswanathan, Mahsa Seyed Ahadi, Sara Ahmadi, Bayan Alzumaili, Mohamed Amine Bani, Éric Baudin, David Blake Behrman, Marzia Capelletti, Angela S. Y. Chou et al. · 2023 · Thyroid
APOBEC3 mutagenesis drives therapy resistance in breast cancer
Avantika Gupta, Andrea M. Gazzo, Pier Selenica, Anton Mikhailovich Safonov, Fresia G. Pareja, Edaise M. da Silva, David N. Brown, Hong Shao, Yingjie Zhu, Juber Patel et al. · 2025 · Nature Genetics
Ongoing genome doubling shapes evolvability and immunity in ovarian cancer
Andrew McPherson, Ignacio Vázquez-Garćıa, Matthew A. Myers, Duaa Hassan Al-Rawi, Matthew Zatzman, Adam C. Weiner, Samuel S. Freeman, Neeman Mohibullah, Gryte Satas, Marc J. Williams et al. · 2025 · Nature
Prostate cancer immunotherapy
Marco Antonio De Velasco, Hirotsugu Uemura · 2017 · Current Opinion in Urology
MET alterations detected in blood-derived circulating tumor DNA correlate with bone metastases and poor prognosis
Sadakatsu Ikeda, Maria Clemence Schwaederle, Mandakini Mohindra, Denis L. Fontes Jardim, Razelle Kurzrock · 2018 · Journal of Hematology & Oncology
Utility of TERT Promoter Mutations for Cutaneous Primary Melanoma Diagnosis
Nancy E. Thomas, Sharon N. Edmiston, Yi‐Hsuan Tsai, Joel S. Parker, Paul B. Googe, Klaus Johannes BUSAM, GLYNIS A. SCOTT, Daniel C. Zedek, Eloise Parrish, Honglin Hao et al. · 2018 · American Journal of Dermatopathology
How theBRAFV600E Mutation Defines a Distinct Subgroup of Colorectal Cancer: Molecular and Clinical Implications
Catherine Bond, Vicki Whitehall · 2018 · Gastroenterology Research and Practice
Phase II trial with axitinib in recurrent and/or metastatic salivary gland cancers of the upper aerodigestive tract
Laura D. Locati, Stefano Cavalieri, Cristiana Bergamini, Carlo Resteghini, Salvatore Alfieri, Giuseppina Calareso, Paolo Bossi, Federica Perrone, Elena Tamborini, Pasquale Quattrone et al. · 2019 · Head & Neck
Tumor biology and multidisciplinary strategies of oligometastasis in gastrointestinal cancers
Yue Zhao, Jiahui Li, Dai Li, Zhefang Wang, Jiangang Zhao, Xiaolin Wu, Qiye Sun, Peter Ping Lin, Patrick Sven Plum, Alexander Ioannis Damanakis et al. · 2019 · Seminars in Cancer Biology
Implementation and use of whole exome sequencing for metastatic solid cancer
Manon Réda, Corentin Richard, Aurélie Bertaut, Julie Niogret, Thomas Collot, Jean-David Fumet, Julie Blanc, Caroline Truntzer, Isabelle Desmoulins, Sylvain Ladoire et al. · 2020 · EBioMedicine
Phase and context shape the function of composite oncogenic mutations
Alexander N. Gorelick, Francisco J. Sánchez Rivera, Yanyan Cai, Craig M. Bielski, Evan Biederstedt, Philip Jonsson, Allison L. Richards, Neil Vasan, Alexander V. Penson, Noah D. Friedman et al. · 2020 · Nature
Fibroblast Growth Factor Receptor 3 Alteration Status is Associated with Differential Sensitivity to Platinum-based Chemotherapy in Locally Advanced and Metastatic Urothelial Carcinoma
Min Yuen Teo, José Maurício Mota, Karissa A. Whiting, Han A. Li, Samuel Aaron Funt, Chung‐Han Lee, David B. Solit, Hikmat A Al‐Ahmadie, Matthew I. Milowsky, Arjun Vasant Balar et al. · 2020 · European Urology