Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients

Zehir, Ahmet, Benayed, Ryma, Shah, Ronak H, Syed, Aijazuddin, Middha, Sumit, Kim, Hyunjae R, Srinivasan, Preethi, Gao, Jianjiong +92 more·2017·Nature Medicine

DOI 10.1038/nm.4333

Cited by (1,010)

Items 301–400 of 1,010

Poly (ADP-Ribose) Polymerase Inhibitors: Talazoparib in Ovarian Cancer and Beyond
Stergios Boussios, Charlotte Abson, Michele Moschetta, Elie Rassy, Afroditi Karathanasi, Tahir Bhat, Faisal Iftikhar Ahmed Ghumman, Matin Sheriff, Nicholas A. Pavlidis · 2020 · Drugs in R&D
Impact of Lineage Plasticity to and from a Neuroendocrine Phenotype on Progression and Response in Prostate and Lung Cancers
Mark A. Rubin, Robert Glen Bristow, Phillip Thienger, Caroline Dive, Marcin B. Imielinski · 2020 · Molecular Cell
An <i>In Vivo Kras</i> Allelic Series Reveals Distinct Phenotypes of Common Oncogenic Variants
Zafra, Maria Paz, Parsons, Marie J., Kim, Jangkyung, Alonso-Curbelo, Direna, Goswami, Sukanya, Schatoff, Emma M., Han, Teng, Katti, Alyna, Fernandez, Maria Teresa Calvo, Wilkinson, John E. et al. · 2020 · Cancer Discovery
Cell-free DNA profiling of metastatic prostate cancer reveals microsatellite instability, structural rearrangements and clonal hematopoiesis
Markus Mayrhofer, Bram De Laere, Tom Whitington, Peter Van Oyen, Christophe Ghysel, J Ampe, Piet Ost, Wim Demey, Lucien Hoekx, Dirk L. A. L. Schrijvers et al. · 2018 · Genome Medicine
Engaging chromatin: PRC2 structure meets function
Paul Chammas, Ivano Mocavini, Luciano Di Croce · 2019 · British Journal of Cancer
Spatial and single-cell transcriptomics decipher the cellular environment containing HLA-G+ cancer cells and SPP1+ macrophages in colorectal cancer
Yuki Ozato, Yasuhiro Kojima, Yuta Kobayashi, Yuuichi Hisamatsu, Takeo Toshima, Yusuke Yonemura, Takaaki Masuda, Kouichi Kagawa, Yasuhiro Goto, Mitsuaki Utou et al. · 2023 · Cell Reports
Gene Fusions in Thyroid Cancer
Valentina D. Yakushina, Larisa V. Lerner, А. В. Лавров · 2017 · Thyroid
The Predictive Value of Tumor Mutation Burden on Efficacy of Immune Checkpoint Inhibitors in Cancers: A Systematic Review and Meta-Analysis
Yongfeng Wu, Jinming Xu, Chengli Du, Yihua Wu, Dajing Xia, Wang Lv, Jian Hu · 2019 · Frontiers in Oncology
Advances in Artificial Intelligence (AI)-assisted approaches in drug screening
Samvedna Singh, Himanshi Gupta, Priyanshu Sharma, Shakti Sahi · 2023 · Artificial Intelligence Chemistry
Association of Broad-Based Genomic Sequencing With Survival Among Patients With Advanced Non–Small Cell Lung Cancer in the Community Oncology Setting
Carolyn Jean Presley, Daiwei Tang, Pamela R. Soulos, Anne C. Chiang, Janina A. Longtine, Kerin B. Adelson, Roy S. Herbst, Weiwei Zhu, Nathan Coleman Nussbaum, Rachael A Sorg et al. · 2018 · JAMA
Adrenocortical carcinoma — towards genomics guided clinical care
Joakim Crona, Felix Beuschlein · 2019 · Nature Reviews Endocrinology
BRAF — a tumour-agnostic drug target with lineage-specific dependencies
Hanrahan, Aphrothiti J., Chen, Ziyu, Rosen, Neal, Solit, David B. · 2024 · Nature Reviews Clinical Oncology
Clinical Genomic Sequencing of Pediatric and Adult Osteosarcoma Reveals Distinct Molecular Subsets with Potentially Targetable Alterations
Suehara, Yoshiyuki, Alex, Deepu, Bowman, Anita, Middha, Sumit, Zehir, Ahmet, Chakravarty, Debyani, Wang, Lu, Jour, George, Nafa, Khedoudja, Hayashi, Takuo et al. · 2019 · Clinical Cancer Research
Mutation Hotspots in the β-Catenin Gene: Lessons from the Human Cancer Genome Databases.
Sewoon Kim, Sunjoo Jeong-Yu · 2019 · Europe PMC (PubMed Central)
Practical considerations in screening for genetic alterations in cholangiocarcinoma
Tanios Bekaii‐Saab, John A. Bridgewater, Nicola Normanno · 2021 · Annals of Oncology
Activity of Adagrasib (MRTX849) in Brain Metastases: Preclinical Models and Clinical Data from Patients with KRASG12C-Mutant Non–Small Cell Lung Cancer
Joshua K. Sabari, Vamsidhar Velcheti, K. Shimizu, Matthew R. Strickland, Rebecca Suk Heist, Mohini Singh, Naema Nayyar, Anita Giobbie‐Hurder, Subba Rao Digumarthy, Justin F. Gainor et al. · 2022 · Clinical Cancer Research
DNAJB1-PRKACA fusions occur in oncocytic pancreatic and biliary neoplasms and are not specific for fibrolamellar hepatocellular carcinoma
Monika Vyas, Jaclyn Frances Hechtman, Yanming Zhang, Ryma Benayed, Aslihan Yavas, Gökçe Aşkan, Jinru Shia, David S. Klimstra, Olca Baştürk · 2019 · Modern Pathology
Disruption of the β1L Isoform of GABP Reverses Glioblastoma Replicative Immortality in a TERT Promoter Mutation-Dependent Manner
Andrew Mancini, Ana Xavier‐Magalhães, Wendy S. Woods, Kien-Thiet Nguyen, Alexandra M. Amen, Josie L. Hayes, Christof Fellmann, Michael Gapinske, Andrew McKinney, Chibo Hong et al. · 2018 · Cancer Cell
Sequentially inducible mouse models reveal that Npm1 mutation causes malignant transformation of Dnmt3a-mutant clonal hematopoiesis
Matthew A. Loberg, Rebecca K. Bell, Leslie O. Goodwin, Elizabeth Eudy, Linde A. Miles, Jennifer Myers SanMiguel, Kira A. Young, David E. Bergstrom, Ross L. Levine, Rebekka K. Schneider et al. · 2019 · Leukemia
Targeted Therapy in Advanced Melanoma With Rare BRAF Mutations
Christian Menzer, Alexander Maxwell Menzies, Matteo Salvatore Carlino, Irene L. M. Reijers, Emma Josephine Groen, Thomas Eigentler, Jan Willem B. de Groot, Astrid A.M. van der Veldt, Douglas Buckner Johnson, Frank Meiß et al. · 2019 · Journal of Clinical Oncology
The ectonucleotidase CD39 identifies tumor-reactive CD8+ T cells predictive of immune checkpoint blockade efficacy in human lung cancer
Andrew T. Chow, Fathema Z. Uddin, Michael Liu, Anton Dobrin, Barzin Y. Nabet, Levi Mark B Mangarin, Yonit Lavin, Hira A. Rizvi, Sam E. Tischfield, Àlvaro Quintanal-Villalonga et al. · 2022 · Immunity
DNA methylation-based classification of sinonasal undifferentiated carcinoma
Snjezana Doğan, Varshini Vasudevaraja, Bin Xu, Jonathan Serrano, Ryan N. Ptashkin, Hun Jae Jung, Sarah Chiang, Achim A. Jungbluth, Marc A. Cohen, Ian Ganly et al. · 2019 · Modern Pathology
RET Gene Fusions in Malignancies of the Thyroid and Other Tissues
Massimo Santoro, Marialuisa Moccia, Giorgia Federico, Francesca Carlomagno · 2020 · Genes
The Clinical Activity of PD-1/PD-L1 Inhibitors in Metastatic Non–Clear Cell Renal Cell Carcinoma
Rana R. McKay, Dominick Bossé, Wanling Xie, Stephanie A. M. Wankowicz, Abdallah Flaifel, Raphael Brandão Moreira, Aly‐Khan A. Lalani, Dylan J. Martini, Xiao X. Wei, David A. Braun et al. · 2018 · Cancer Immunology Research
Pan-cancer analysis of ARID1A Alterations as Biomarkers for Immunotherapy Outcomes
Tao Jiang, Xiaoxia Chen, Chunxia Su, Shengxiang Ren, Caicun Zhou · 2019 · Journal of Cancer
Yield and Utility of Germline Testing Following Tumor Sequencing in Patients With Cancer
Stephen E. Lincoln, Robert Luke Nussbaum, Allison W. Kurian, Sarah M. Nielsen, Kingshuk Das, Scott T. Michalski, Shan Yang, Nhu Ngo, Amie M Blanco, Edward D. Esplin · 2020 · JAMA Network Open
Genomic alterations of ERBB receptors in cancer: clinical implications
Rosalin Mishra, Ariella B. Hanker, Joan T. Garrett · 2017 · Oncotarget
Variant classification in precision oncology
Jonas Leichsenring, Peter Horak, Simon Kreutzfeldt, Christoph Heining, Petros Christopoulos, Anna‐Lena Volckmar, Olaf Neumann, Martina Kirchner, Carolin Ploeger, Jan Budczies et al. · 2019 · International Journal of Cancer
Cancer Susceptibility Mutations in Patients With Urothelial Malignancies
Maria Isabel Carlo, Vignesh Ravichandran, Preethi Srinavasan, Chaitanya Bandlamudi, Yelena M. Kemel, Ozge Ceyhan‐Birsoy, Semanti Mukherjee, Diana L. Mandelker, Joshua L. Chaim, Andrea Knežević et al. · 2019 · Journal of Clinical Oncology
FOXA1 mutations reveal distinct chromatin profiles and influence therapeutic response in breast cancer
Arruabarrena-Aristorena, Amaia, Maag, Jesper L.V., Kittane, Srushti, Cai, Yanyan, Karthaus, Wouter R., Ladewig, Erik, Park, Jane, Kannan, Srinivasaraghavan, Ferrando, Lorenzo, Cocco, Emiliano et al. · 2020 · Cancer Cell
Intraductal papillary mucinous neoplasms arise from multiple independent clones, each with distinct mutations
Fischer, Catherine G., Beleva Guthrie, Violeta, Braxton, Alicia M., Zheng, Lily, Wang, Pei, Song, Qianqian, Griffin, James F., Chianchiano, Peter E., Hosoda, Waki, Niknafs, Noushin et al. · 2019 · Gastroenterology
Bronchiolar Adenoma
Jason C. Chang, Joseph Montecalvo, Laetitia A Borsu, Shaohua Lu, Brandon T. Larsen, William D. Wallace, Wichit Sae‐Ow, Alexander Craig Mackinnon, Hyunjae Ryan Kim, Anita S. Bowman et al. · 2018 · The American Journal of Surgical Pathology
A Biomarker-enriched, Randomized Phase II Trial of Adavosertib (AZD1775) Plus Paclitaxel and Carboplatin for Women with Platinum-sensitive <i>TP53</i> -mutant Ovarian Cancer
Oza, Amit M., Estevez-Diz, Maria, Grischke, Eva-Maria, Hall, Marcia, Marmé, Frederik, Provencher, Diane, Uyar, Denise, Weberpals, Johanne I., Wenham, Robert M., Laing, Naomi et al. · 2020 · Clinical Cancer Research
Detection of Early Human Papillomavirus–Associated Cancers by Liquid Biopsy
Rama Rao Damerla, Nancy Y. Lee, Daoqui You, Rekha Soni, Rachna Shah, Marsha Reyngold, Nora Katabi, Vanessa Wu, Sean Matthew McBride, Chiaojung Jillian Tsai et al. · 2019 · JCO Precision Oncology
Tumor mutational and indel burden: a systematic pan-cancer evaluation as prognostic biomarkers
Hao‐Xiang Wu, Zixian Wang, Qi Zhao, Dongliang Chen, Ming-Ming He, Lu-Ping Yang, Yingnan Wang, Ying Jin, Chao Ren, Hui Luo et al. · 2019 · Annals of Translational Medicine
Pan-Cancer Efficacy of Vemurafenib in BRAF V600-Mutant Non-Melanoma Cancers
Vivek Subbiah, Igor J. Puzanov, Jean‐Yves Blay, Ian Chau, Albert Craig Lockhart, Noopur S Raje, Juergen Wolf, Jose M Baselga, Funda Meric‐Bernstam, Jason Roszik et al. · 2020 · Cancer Discovery
In silico saturation mutagenesis of cancer genes
Ferran Muiños, Francisco Martínez-Jiménez, Oriol Pich, Abel González-Pérez, Núria López-Bigas · 2021 · Nature
Dysregulated Signalling Pathways Driving Anticancer Drug Resistance
Nauf Bou Antoun, Athina‐Myrto Chioni · 2023 · International Journal of Molecular Sciences
A clinical benchmark of public self-supervised pathology foundation models
Campanella, Gabriele, Chen, Shengjia, Singh, Manbir, Verma, Ruchika, Muehlstedt, Silke, Zeng, Jennifer, Stock, Aryeh, Croken, Matt, Veremis, Brandon, Elmas, Abdulkadir et al. · 2025 · Nature Communications
Integrative clinical and molecular characterization of translocation renal cell carcinoma
Ziad Bakouny, Ananthan Sadagopan, Praful Kumar Ravi, Nebiyou Y. Metaferia, Jiao Li, Shatha AbuHammad, Stephen Tang, Thomas Denize, Emma R. Garner, Xin Yuan Gao et al. · 2022 · Cell Reports
The value of cell‐free DNA for molecular pathology
Caitlin M. Stewart, Prachi D. Kothari, Florent C. Mouliere, Richard James Mair, Saira Somnay, Ryma Benayed, Ahmet Zehir, Britta Weigelt, Sarah‐Jane Dawson, Maria E. Arcila et al. · 2018 · The Journal of Pathology
CHASMplus Reveals the Scope of Somatic Missense Mutations Driving Human Cancers
Collin J. Tokheim, Rachel Karchin · 2019 · Cell Systems
Transcriptome Characterization of Matched Primary Breast and Brain Metastatic Tumors to Detect Novel Actionable Targets
Damir Varešlija, Nolan Priedigkeit, Ailís Fagan, Siobhan P. Purcell, Nicola S. Cosgrove, Philip J. O’Halloran, Elspeth Ward, Sinéad Cocchiglia, Ryan James Hartmaier, Carlos A. Castro et al. · 2018 · JNCI Journal of the National Cancer Institute
Genome-wide identification and analysis of prognostic features in human cancers
Joan C. Smith, Jason M. Sheltzer · 2022 · Cell Reports
Activation of KRAS Mediates Resistance to Targeted Therapy in MET Exon 14–mutant Non–small Cell Lung Cancer
Ken Suzawa, Michael David Offin, Daniel Lu, Christopher Kurzatkowski, Morana Vojnic, Roger S. Smith, Joshua K. Sabari, Huichun Tai, Marissa S. Mattar, Inna Khodos et al. · 2018 · Clinical Cancer Research
A Prospective Study of Circulating Tumor DNA to Guide Matched Targeted Therapy in Lung Cancers
Joshua K. Sabari, Michael David Offin, Dennis P. Stephens, Ai Ni, Adrian V. Lee, Nick Pavlakis, Stephen John Clarke, Connie Irene Diakos, Sutirtha Datta, Nidhi Tandon et al. · 2018 · JNCI Journal of the National Cancer Institute
Personalized immunotherapy in cancer precision medicine
Kazuma Kiyotani, Yujiro Toyoshima, Yusuke Nakamura · 2021 · Cancer Biology and Medicine
Base editing sensor libraries for high-throughput engineering and functional analysis of cancer-associated single nucleotide variants
Francisco J. Sánchez Rivera, Bianca Jay Diaz, Edward R. Kastenhuber, Henri Schmidt, Alyna Katti, Margaret C. Kennedy, Vincent Tem, Yu-Jui Ho, Josef Leibold, Stella V. Paffenholz et al. · 2022 · Nature Biotechnology
Oxidative Stress and Cancer Therapy: Controlling Cancer Cells Using Reactive Oxygen Species
Songhyun Ju, Manish Kumar Singh, Sunhee Han, Jyotsna Suresh Ranbhise, Joohun Ha, Wonchae Choe, Kyung‐Sik Yoon, Seung Geun Yeo, Sung Soo Kim, Insug Kang · 2024 · International Journal of Molecular Sciences
CDKN2A Alterations and Response to Immunotherapy in Solid Tumors
Elio Adib, Amin H. Nassar, Elie W. Akl, Sarah Abou Alaiwi, Pier Vitale Nuzzo, Tarek H. Mouhieddine, Guru Sonpavde, Robert I. Haddad, Kent William Mouw, Marios Giannakis et al. · 2021 · Clinical Cancer Research
Computational analysis of cancer genome sequencing data
Isidro Cortés‐Ciriano, D. Gulhan, Jake June-Koo Lee, Giorgio E. M. Melloni, Peter J. Park · 2021 · Nature Reviews Genetics
Whole-genome and transcriptome analysis enhances precision cancer treatment options
Erin Pleasance, A. Bohm, Laura M. Williamson, Jessica Nelson, Yaoqing Shen, Melika Bonakdar, Emma Titmuss, Veronika Csizmók, Kathleen Wee, Sina Hosseinzadeh et al. · 2022 · Annals of Oncology
Carcinogenesis and management of human papillomavirus-associated cervical cancer
Misako Kusakabe, Ayumi Taguchi, Kenbun Sone, Mayuyo Mori, Yutaka Osuga · 2023 · International Journal of Clinical Oncology
A concise review on cancer treatment methods and delivery systems
Elham Bidram, Yasaman Esmaeili, Hadi Ranji‐Burachaloo, Nuha Al-Zaubai, Ali Zarrabi, Alastair G. Stewart, Dave E. Dunstan · 2019 · Journal of Drug Delivery Science and Technology
Genomic Landscape of Uterine Sarcomas Defined Through Prospective Clinical Sequencing
Martee Leigh Hensley, Shweta S. Chavan, David B. Solit, Rajmohan Murali, Robert A. Soslow, Sarah Chiang, Achim A. Jungbluth, Chaitanya Bandlamudi, Preethi Srinivasan, William D. Tap et al. · 2020 · Clinical Cancer Research
Portrait of a cancer: mutational signature analyses for cancer diagnostics
Van Hoeck, Arne, Tjoonk, Niels H., van Boxtel, Ruben, Cuppen, Edwin · 2019 · BMC Cancer
Emerging agents and regimens for hepatocellular carcinoma
Xiao‐Dong Zhu, Hui‐Chuan Sun · 2019 · Journal of Hematology & Oncology
Pan-cancer Analysis of CDK12 Alterations Identifies a Subset of Prostate Cancers with Distinct Genomic and Clinical Characteristics
Bastien Nguyen, José Maurício Mota, Subhiksha Nandakumar, Konrad Hermann Stopsack, Emily Steinberger Weg, Dana E. Rathkopf, Michael J. Morris, Howard I. Scher, Philip W. Kantoff, Anuradha Gopalan et al. · 2020 · European Urology
The role of TP53 in acute myeloid leukemia: Challenges and opportunities
Karina Barbosa, Sha Li, Peter D. Adams, Aniruddha J. Deshpande · 2019 · Genes Chromosomes and Cancer
Respiratory complex and tissue lineage drive recurrent mutations in tumour mtDNA
Alexander N. Gorelick, Minsoo Kim, Walid Khaled Chatila, Konnor La, A. Ari Hakimi, Michael F. Berger, Barry S. Taylor, Payam A. Gammage, Ed Reznik · 2021 · Nature Metabolism
Pan-cancer analysis of longitudinal metastatic tumors reveals genomic alterations and immune landscape dynamics associated with pembrolizumab sensitivity
S.Y. Cindy Yang, Scott C. Lien, Ben X. Wang, Derek Clouthier, Youstina Hanna, Iulia Cirlan, Kelsey Zhu, Jeffrey P. Bruce, Samah El Ghamrasni, Marco Adelmo James Iafolla et al. · 2021 · Nature Communications
Development of genome-derived tumor type prediction to inform clinical cancer care
Penson, Alexander, Camacho, Niedzica, Zheng, Youyun, Varghese, Anna M., Al-Ahmadie, Hikmat, Razavi, Pedram, Chandarlapaty, Sarat, Vallejo, Christina E., Vakiani, Efsevia, Gilewski, Teresa et al. · 2020 · JAMA Oncology
A pilot study of ultra-deep targeted sequencing of plasma DNA identifies driver mutations in hepatocellular carcinoma
Ismaïl Labgaa, Carlos Villacorta-Martín, Delia D’Avola, Amanda J. Craig, Johann von Felden, Sebastião N. Martins-Filho, Daniela Sia, Ashley Stueck, Stephen C. Ward, Maria Isabel Fiel et al. · 2018 · Oncogene
Harmonization of Tumor Mutational Burden Quantification and Association With Response to Immune Checkpoint Blockade in Non–Small-Cell Lung Cancer
Natalie I. Vokes, David Liu, Biagio Ricciuti, Elizabeth Jimenez-Aguilar, Hira A. Rizvi, Felix Dietlein, Meng He, Claire A. Margolis, Haitham Elmarakeby, Jeffrey Girshman et al. · 2019 · JCO Precision Oncology
Genetic Determinants of EGFR-Driven Lung Cancer Growth and Therapeutic Response In Vivo
Giorgia Foggetti, Chuan Li, Hongchen Cai, Jessica A. Hellyer, Wen-Yang Lin, Deborah O. Ayeni, Katherine Hastings, Jungmin Choi, Anna Wurtz, Laura Andrejka et al. · 2021 · Cancer Discovery
Dynamic prostate cancer transcriptome analysis delineates the trajectory to disease progression
Marco Bolis, Daniela Bossi, Arianna Vallerga, Valentina Ceserani, Manuela Cavalli, Daniela Impellizzieri, Laura Di Rito, Eugenio Zoni, Simone Mosole, Angela Rita Elia et al. · 2021 · Nature Communications
Landscape of somatic alterations in large-scale solid tumors from an Asian population
Liqun Wu, Herui Yao, Hui Chen, Aodi Wang, Kun Guo, Wenli Gou, Yanfei Yu, Xiang Li, Ming Yao, S. H. Yuan et al. · 2022 · Nature Communications
Genomic analysis of hairy cell leukemia identifies novel recurrent genetic alterations
Benjamin Heath Durham, Bartlomiej M. Getta, Sascha Dietrich, Justin Taylor, Helen H. Won, James M. Bogenberger, Sasinya N. Scott, Eun Hee Kim, Young Rock Chung, Stephen S. Chung et al. · 2017 · Blood
Mutational landscape of gastric cancer and clinical application of genomic profiling based on target next-generation sequencing
Hui Cai, Changqing Jing, Xusheng Chang, Dan Ding, Ting Han, Junchi Yang, Zhengmao Lu, Xuguang Hu, Zhaorui Liu, Jinshen Wang et al. · 2019 · Journal of Translational Medicine
Significance of BRCA2 and RB1 Co-loss in Aggressive Prostate Cancer Progression
Goutam Chakraborty, Joshua Armenia, Ying Zhang Mazzu, Subhiksha Nandakumar, Konrad Hermann Stopsack, Mohammad Omar Atiq, Kazumasa Komura, Lina E. Jehane, Rahim Hirani, Kalyani Chadalavada et al. · 2019 · Clinical Cancer Research
EANO guideline on rational molecular testing of gliomas, glioneuronal, and neuronal tumors in adults for targeted therapy selection
David Capper, Guido Reifenberger, Pim J. French, Leonille Schweizer, Michael Weller, Mehdi Touat, Simone P. Niclou, Philipp Euskirchen, Christine Haberler, Monika E. Hegi et al. · 2023 · Neuro-Oncology
Molecular Biomarkers of Disease Outcomes and Mechanisms of Acquired Resistance to First-Line Osimertinib in Advanced EGFR-Mutant Lung Cancers
Noura J. Choudhury, Antonio Marra, Jane Sze Yin Sui, Jessica R. Flynn, Soo‐Ryum Yang, Christina J. Falcon, Pier Selenica, Adam Jacob Schoenfeld, Natasha Rekhtman, Daniel Richard Gomez et al. · 2022 · Journal of Thoracic Oncology
Majority of B2M -Mutant and -Deficient Colorectal Carcinomas Achieve Clinical Benefit From Immune Checkpoint Inhibitor Therapy and Are Microsatellite Instability-High
Sumit Middha, Rona D. Yaeger, Jinru Shia, Zsofia Kinga Stadler, Sarah King, Shanna Guercio, Viktoriya Paroder, ‬David D. B. Bates, Satshil Rana, Luis Alberto Diaz et al. · 2019 · JCO Precision Oncology
Comprehensive Next-Generation Sequencing Unambiguously Distinguishes Separate Primary Lung Carcinomas From Intrapulmonary Metastases: Comparison with Standard Histopathologic Approach
Jason C. Chang, Deepu Alex, Matthew Joseph Bott, Kay See Tan, Venkatraman Seshan, Andrew Golden, Jennifer L. Sauter, Darren J. Buonocore, Chad Vanderbilt, Sounak Gupta et al. · 2019 · Clinical Cancer Research
Transcriptomics and solid tumors: The next frontier in precision cancer medicine
Apostolia Maria Tsimberidou, Elena Fountzilas, Leonidas G. Bleris, Razelle Kurzrock · 2020 · Seminars in Cancer Biology
The Impact of Next-Generation Sequencing on Cancer Genomics: From Discovery to Clinic
Elaine R. Mardis · 2018 · Cold Spring Harbor Perspectives in Medicine
Clinical and molecular characterization of patients with cancer of unknown primary in the modern era
Anna M. Varghese, A. Arora, Marinela Capanu, Niedzica Camacho, Helen H. Won, Ahmet Zehir, Jianjiong Gao, Debyani Chakravarty, Nikolaus D. Schultz, David S. Klimstra et al. · 2017 · Annals of Oncology
ERBB3 mutations in cancer: biological aspects, prevalence and therapeutics
Nicolas Kiavué, Luc Cabel, Samia Melaabi, Guillaume Bataillon, Céline Callens, Florence Lerebours, Jean‐Yves Pierga, François‐Clément Bidard · 2019 · Oncogene
Genetic Heterogeneity of BRAF Fusion Kinases in Melanoma Affects Drug Responses
Thomas Botton, Eric Talevich, Vivek Kumar Mishra, Tongwu Zhang, Alan Hunter Shain, Céline Berquet, Alexander Gagnon, Robert L. Judson, Robert Ballotti, Antoni Ribas et al. · 2019 · Cell Reports
Efficacy and Determinants of Response to HER Kinase Inhibition in HER2 -Mutant Metastatic Breast Cancer
Lillian Mary Smyth, Sarina Anne Piha-Paul, Helen H. Won, Alison M. Schram, Cristina Saura, Sherene Loi, Janice M. Lu, Geoffrey Ira Shapiro, Dejan Juric, Ingrid A. Mayer et al. · 2019 · Cancer Discovery
Chromosome arm aneuploidies shape tumour evolution and drug response
Ankit Shukla, Thu H.M. Nguyen, Sarat Moka, Jonathan J. Ellis, John P. Grady, Harald Oey, Alexandre S. Cristino, Kum Kum Khanna, Dirk P. Kroese, Lutz Krause et al. · 2020 · Nature Communications
Clinical significance of clonal hematopoiesis in the interpretation of blood liquid biopsy
Hiu Ting Chan, Satoshi Nagayama, Yoon Ming Chin, Masumi Otaki, Rie Hayashi, Kazuma Kiyotani, Yosuke Fukunaga, Masashi Ueno, Yusuke Nakamura, Siew‐Kee Low · 2020 · Molecular Oncology
Clinicopathologic and Genomic Analysis of TP53 -Mutated Endometrial Carcinomas
Amir Momeni Boroujeni, Wissam Dahoud, Chad Vanderbilt, Sarah Chiang, Rajmohan Murali, Eric Rios‐Doria, Kaled M. Alektiar, Carol A Aghajanian, Nadeem R. Abu‐Rustum, Marc Ladanyi et al. · 2021 · Clinical Cancer Research
Harmonization and Standardization of Panel-Based Tumor Mutational Burden Measurement: Real-World Results and Recommendations of the Quality in Pathology Study
Albrecht Stenzinger, Volker Endris, Jan Budczies, Sabine Merkelbach‐Bruse, Daniel N. Kazdal, Wolfgang Dietmaier, Nicole Pfarr, Udo Siebolts, Michael Hummel, Sylvia Herold et al. · 2020 · Journal of Thoracic Oncology
Multi-omics strategies for biomarker discovery and application in personalized oncology
Ziming Jiang, Haoxuan Zhang, Yibo Gao, Yingli Sun · 2025 · Molecular Biomedicine
Tumor-Infiltrating Clonal Hematopoiesis
Oriol Pich, Elsa Bernard, Maria Zagorulya, Andrew Rowan, Constandina Pospori, Ramy Slama, Hector Huerga Encabo, Jennifer O’Sullivan, Despoina Papazoglou, Panayiotis Anastasiou et al. · 2025 · New England Journal of Medicine
Pancreatic Cancer Microenvironment and Cellular Composition: Current Understandings and Therapeutic Approaches
Truong, Linh-Huyen, Pauklin, Siim · 2021 · Cancers
Epigenomic Reprogramming as a Driver of Malignant Glioma
Richard E. Phillips, Alexey A. Soshnev, C. David Allis · 2020 · Cancer Cell
Comprehensive Molecular and Clinicopathologic Analysis of 200 Pulmonary Invasive Mucinous Adenocarcinomas Identifies Distinct Characteristics of Molecular Subtypes
Jason C. Chang, Michael David Offin, Christina J. Falcon, David N. Brown, Brian R. Houck-Loomis, Fanli Meng, Vasilisa A. Rudneva, Helen H. Won, Sharon Amir, Joseph Montecalvo et al. · 2021 · Clinical Cancer Research
Widespread Selection for Oncogenic Mutant Allele Imbalance in Cancer
Craig M. Bielski, Mark T.A. Donoghue, Mayur M. Gadiya, Aphrothiti J. Hanrahan, Helen H. Won, Matthew T. Chang, Philip Jonsson, Alexander V. Penson, Alexander N. Gorelick, Christopher Harris et al. · 2018 · Cancer Cell
What makes a kinase promiscuous for inhibitors?
Sonya M. Hanson, G. Georghiou, M. Thakur, W. Miller, J. Rest, J. Chodera, M. Seeliger · 2019 · Cell Chemical Biology
RAC1 Takes the Lead in Solid Tumors
Pradip K. De, Jennifer Carlson Aske, Nandini Dey · 2019 · Cells
Mining TCGA database for tumor mutation burden and their clinical significance in bladder cancer
Jia Lv, Yongze Zhu, Alin Ji, Qi Zhang, Guodong Liao · 2020 · Bioscience Reports
Minor intron retention drives clonal hematopoietic disorders and diverse cancer predisposition
Daichi Inoue, Jacob Tyler Polaski, Justin Taylor, Pau Castel, Sisi Chen, Susumu S. Kobayashi, Simon J. Hogg, Yasutaka Hayashi, Jose Mario Bello Pineda, Ettaib El Marabti et al. · 2021 · Nature Genetics
Clinicogenomic landscape of pancreatic adenocarcinoma identifies KRAS mutant dosage as prognostic of overall survival
Anna M. Varghese, Maria Perry, Joanne F. Chou, Subhiksha Nandakumar, Daniel M. Muldoon, Amanda Erakky, Amanda Zucker, Christopher John Fong, Miika M. Mehine, Bastien Nguyen et al. · 2025 · Nature Medicine
Building consensus on the application of organoid-based drug sensitivity testing in cancer precision medicine and drug development
Xiang, Dongxi, He, Aina, Zhou, Rong, Wang, Yonggang, Xiao, Xiuying, Gong, Ting, Kang, Wenyan, Lin, Xiaolin, Wang, Xiaochen, PDO-based DST Consortium11 et al. · 2024 · Theranostics
The histone demethylase UTX/KDM6A in cancer: Progress and puzzles
Wolfgang A. Schulz, Alexander Lang, Julian Koch, Annemarie Greife · 2019 · International Journal of Cancer
Clinical practice guidance for next-generation sequencing in cancer diagnosis and treatment (edition 2.1)
Yoichi Naito, Hiroyuki Aburatani, Toraji Amano, Eishi Baba, Toru Furukawa, Tetsu Hayashida, Eiso Hiyama, Sadakatsu Ikeda, Masashi Kanai, Motohiro Kato et al. · 2020 · International Journal of Clinical Oncology
Role of receptor tyrosine kinases mediated signal transduction pathways in tumor growth and angiogenesis—New insight and futuristic vision
Xiao Lin Huang, Muhammad Imran Khan, Jing Wang, Rizwan Ali, Syed Wajahat Ali, Qurat ul ain Zahra, Ahsan Kazmi, Arbelo Lolai, Yü Huang, Alamdar Hussain et al. · 2021 · International Journal of Biological Macromolecules
A pan-cancer organoid platform for precision medicine
Larsen, Brian M., Kannan, Madhavi, Langer, Lee F., Leibowitz, Benjamin D., Bentaieb, Aicha, Cancino, Andrea, Dolgalev, Igor, Drummond, Bridgette E., Dry, Jonathan R., Ho, Chi-Sing et al. · 2021 · Cell Reports