Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients

Zehir, Ahmet, Benayed, Ryma, Shah, Ronak H, Syed, Aijazuddin, Middha, Sumit, Kim, Hyunjae R, Srinivasan, Preethi, Gao, Jianjiong +92 more·2017·Nature Medicine

DOI 10.1038/nm.4333

Cited by (1,010)

Items 801–900 of 1,010

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Tyler D. Hitchman, Gabriella Bayshtok, Emilie Ceraudo, Amanda R. Moore, Cindy Lee, Ruobing Jia, Naitao Wang, Mohini R. Pachai, Alexander Noor Shoushtari, Jasmine H. Francis et al. · 2020 · Clinical Cancer Research
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Alberto Pavan, Andrea Boscolo Bragadin, Lorenzo Calvetti, Alessandra Ferro, Elisabetta Zulato, Ilaria Attili, Giorgia Nardo, Alessandro Dal Maso, Stefano Frega, Andrea Giovanni Menin et al. · 2021 · Translational Lung Cancer Research
Selective advantage of epigenetically disrupted cancer cells via phenotypic inertia
Ioannis Loukas, Fabrizio Simeoni, Marta Milan, Paolo Inglese, Harshil Patel, Robert J. Goldstone, Philip East, Stephanie Strohbuecker, Richard Mitter, Bhavik Talsania et al. · 2022 · Cancer Cell
Genetic Alterations of Metastatic Colorectal Cancer
Testa, Ugo, Castelli, Germana, Pelosi, Elvira · 2020 · Biomedicines
PIK3CA mutations in plasma circulating tumor DNA predict survival and treatment outcomes in patients with advanced cancers
Ecaterina E Ileana Dumbrava, S. Greg Call, Helen J. Huang, A.L. Stuckett, Kiran Madwani, Abha Adat, David S. Hong, Sarina Anne Piha-Paul, Vivek Subbiah, Daniel D. Karp et al. · 2021 · ESMO Open
Genome engineering for estrogen receptor mutations reveals differential responses to anti-estrogens and new prognostic gene signatures for breast cancer
Alison Harrod, Chun‐Fui Lai, Isabella Goldsbrough, Georgia M. Simmons, Natasha Oppermans, Daniela Barsotti Santos, Balázs Győrffy, Rebecca C. Allsopp, Bradley J. Toghill, K. Balachandran et al. · 2022 · Oncogene
The role of chromatin remodeler SMARCA4/BRG1 in brain cancers: a potential therapeutic target
Sophie M. Navickas, Katherine A. Giles, Kate H. Brettingham‐Moore, Phillippa C. Taberlay · 2023 · Oncogene
Genomic Profiling Reveals Germline Predisposition and Homologous Recombination Deficiency in Pancreatic Acinar Cell Carcinoma
Diana L. Mandelker, Antonio Marra, Binbin Zheng-Lin, Pier Selenica, Juan Blanco-Heredia, Yingjie Zhu, Andrea M. Gazzo, Donna Wong, Zarina Yelskaya, Vikas Rai et al. · 2023 · Journal of Clinical Oncology
Clinical Utility and Benefits of Comprehensive Genomic Profiling in Cancer
Melissa Yuwono Tjota, Jeremy P. Segal, Peng Wang · 2024 · The Journal of Applied Laboratory Medicine
Cotargeting CDK4/6 and BRD4 Promotes Senescence and Ferroptosis Sensitivity in Cancer
Xianbing Zhu, Zheng Fu, Kendall Dutchak, Azadeh Arabzadeh, Simon Milette, Jutta Steinberger, Geneviève Morin, Anie Monast, Virginie Pilon, Tim Kong et al. · 2024 · Cancer Research
Targeting the RAS upstream and downstream signaling pathway for cancer treatment
Md. Arafat Hossain · 2024 · European Journal of Pharmacology
Molecular Profiling of Tumor Tissue and Plasma Cell-Free DNA from Patients with Non-Langerhans Cell Histiocytosis
Filip Jankú, Eli L. Diamond, Aaron Michael Goodman, Vaijayanthi Kandadai Raghavan, Tamara Griffey Barnes, Shumei Kato, Omar Ibrahim Abdel-Wahab, Benjamin Heath Durham, Funda Meric‐Bernstam, Razelle Kurzrock · 2019 · Molecular Cancer Therapeutics
Impact of DNA integrity on the success rate of tissue‐based next‐generation sequencing: Lessons from nationwide cancer genome screening project SCRUM‐Japan GI‐SCREEN
Takeshi Kuwata, Masashi Wakabayashi, Yutaka Hatanaka, Eiichi Morii, Yoshinao Oda, Kenichi Taguchi, Masayuki Noguchi, Yuichi Ishikawa, Takashi Nakajima, Shigeki Sekine et al. · 2020 · Pathology International
A Pan-Cancer Study of Somatic TERT Promoter Mutations and Amplification in 30,773 Tumors Profiled by Clinical Genomic Sequencing
Sounak Gupta, Chad Vanderbilt, Yun-Te Lin, Jamal K. Benhamida, Achim A. Jungbluth, Satshil Rana, Amir Momeni Boroujeni, Jason C. Chang, Tiffany Mcfarlane, Paulo A. Salazar et al. · 2020 · Journal of Molecular Diagnostics
Efficacy and Safety of Trametinib in Non-V600 BRAF Mutant Melanoma: A Phase II Study
Caroline A. Nebhan, Douglas Buckner Johnson, Ryan Joseph Sullivan, R. Amaria, Keith T. Flaherty, Jeffrey Alan Sosman, Michael A. Davies · 2021 · The Oncologist
The NHS England 100,000 Genomes Project: feasibility and utility of centralised genome sequencing for children with cancer
Jamie Trotman, Ruth Armstrong, Helen V. Firth, Claire Trayers, James A. Watkins, Kieren S. J. Allinson, Thomas S. Jacques, James Christopher Nicholson, G.A. Amos Burke, John C. Ambrose et al. · 2022 · British Journal of Cancer
Durable and dynamic hTERT immune responses following vaccination with the long-peptide cancer vaccine UV1: long-term follow-up of three phase I clinical trials
Espen B. Ellingsen, Elin Aamdal, Tormod Kyrre Guren, Wolfgang A. Lilleby, Paal Fredrik Brunsvig, Sara M. Mangsbo, Steinar Aamdal, Eivind J. Hovig, Nadia Mensali, Gustav Gaudernack et al. · 2022 · Journal for ImmunoTherapy of Cancer
Pancreas cancer and <i>BRCA</i> : A critical subset of patients with improving therapeutic outcomes
Momtaz, Parisa, O’Connor, Catherine A., Chou, Joanne F., Capanu, Marinela, Park, Wungki, Bandlamudi, Chaitanya, Berger, Michael F., Kelsen, David P., Suehnholz, Sarah P., Chakravarty, Debyani et al. · 2021 · Cancer
Genomic Landscape and Clinical Utility in Korean Advanced Pan-Cancer Patients from Prospective Clinical Sequencing: K-MASTER Program
Kyong Hwa Park, Jung Yoon Choi, Ah-Reum Lim, Ju Won Kim, Yoon Ji Choi, Soo Hyun Lee, Jae Sook Sung, Hee-Joon Chung, Byunghyun Jang, Dayoung Yoon et al. · 2021 · Cancer Discovery
Comprehensive genomic profiling of EWSR1/FUS::CREB translocation-associated tumors uncovers prognostically significant recurrent genetic alterations and methylation-transcriptional correlates
Josephine Kam Tai K. Dermawan, Fabio Vanoli, Laurie Herviou, Yun‐Shao Sung, Lei Zhang, Samuel Singer, William D. Tap, Ryma Benayed, Tejus Bale, Jamal K. Benhamida et al. · 2022 · Modern Pathology
FOXA1 repression drives lineage plasticity and immune heterogeneity in bladder cancers with squamous differentiation
Joshua I. Warrick, Wenhuo Hu, Hironobu Yamashita, Vonn Walter, Lauren Shuman, Jenna M. Craig, Lan Lin Gellert, Mauro A. A. Castro, A. Gordon Robertson, Fengshen Kuo et al. · 2022 · Nature Communications
LKB1-Dependent Regulation of TPI1 Creates a Divergent Metabolic Liability between Human and Mouse Lung Adenocarcinoma
Benjamin D. Stein, John R. Ferrarone, Eric E. Gardner, Jae Won Chang, David Wu, Pablo E. Hollstein, Roger J. Liang, Min Yuan, Qiuying Chen, John S. Coukos et al. · 2023 · Cancer Discovery
Undifferentiated and Dedifferentiated Metastatic Melanomas Masquerading as Soft Tissue Sarcomas: Mutational Signature Analysis and Immunotherapy Response
Israel S. Kasago, Walid Khaled Chatila, Cecilia M. Lezcano, Christopher A. Febres‐Aldana, Nikolaus D. Schultz, Chad Vanderbilt, Snjezana Doğan, Edmund K. Bartlett, Sandra P. D’Angelo, William D. Tap et al. · 2023 · Modern Pathology
Clinical and molecular characteristics of early-onset vs average-onset esophagogastric cancer
Melissa Amy Lumish, Henry S. Walch, Steven Brad Maron, Walid Khaled Chatila, Yelena M. Kemel, Anna Maio, Geoffrey Yuyat Ku, David H. Ilson, Elizabeth Won, Jia Li et al. · 2023 · JNCI Journal of the National Cancer Institute
Dysregulation of different modes of programmed cell death by epigenetic modifications and their role in cancer
Roxana Damiescu, Thomas Efferth, M. Dawood · 2024 · Cancer Letters
BRCA genetic testing and counseling in breast cancer: how do we meet our patients’ needs?
Peter Christian Dubsky, Christian Jackisch, Seock‐Ah Im, Kelly K. Hunt, Chien‐Feng Li, Sheila Unger, Shani Paluch–Shimon · 2024 · npj Breast Cancer
DLB class : a probabilistic molecular classifier to guide clinical investigation and practice in diffuse large B-cell lymphoma
Bjoern Chapuy, Timothy Wood, Chip Stewart, Andrew J Dunford, Kirsty Wienand, Sumbul Jawed Khan, Nazli Serin, Meng Wang, Eleonora Calabretta, Joji Shimono et al. · 2024 · Blood
Genomic distinctions between metastatic lower and upper tract urothelial carcinoma revealed through rapid autopsy
Brian R. Winters, Navonil De Sarkar, Sonali Arora, Hamid Bolouri, Sujata Jana, Funda Vakar‐Lopez, Heather H. Cheng, Michael Thomas Schweizer, Evan Y. Yu, Petros D. Grivas et al. · 2019 · JCI Insight
Catalog of 5′ fusion partners in RET+ NSCLC Circa 2020
Sai‐Hong Ignatius Ou, Viola Weijia Zhu · 2020 · JTO Clinical and Research Reports
Molecular Profiling–Based Precision Medicine in Cancer: A Review of Current Evidence and Challenges
Qi Zhang, Qihan Fu, Xueli Bai, Tingbo Liang · 2020 · Frontiers in Oncology
Pediatric Mesothelioma With ALK Fusions
Pedram Argani, Derrick Wen Quan Lian, Abbas Agaimy, Markus Metzler, Sara Elizabeth Wobker, Andrés Matoso, Jonathan I. Epstein, Yun‐Shao Sung, Lei Zhang, Cristina R. Antonescu · 2021 · The American Journal of Surgical Pathology
The Pan-Tumor Landscape of Targetable Kinase Fusions in Circulating Tumor DNA
Jessica Lee, Mehlika H. Hazar-Rethinam, Brennan James Decker, Ole V. Gjoerup, Russell William Madison, Daniel S. Lieber, Jon Chung, Alexa Betzig Schrock, James Creeden, Jeffrey Michael Venstrom et al. · 2021 · Clinical Cancer Research
Co-existing TP53 and ARID1A mutations promote aggressive endometrial tumorigenesis
Jake J. Reske, Mike R. Wilson, Jeanne Holladay, Rebecca A. Siwicki, Hilary J. Skalski, Shannon K. Harkins, Marie Adams, John Ian Risinger, Galen H. Hostetter, Ken Yu Lin et al. · 2021 · PLoS Genetics
Abnormal oxidative metabolism in a quiet genomic background underlies clear cell papillary renal cell carcinoma
Xu, Jianing, Reznik, Ed, Lee, Ho-Joon, Gundem, Gunes, Jonsson, Philip, Sarungbam, Judy, Bialik, Anna, Sanchez-Vega, Francisco, Creighton, Chad J, Hoekstra, Jake et al. · 2019 · eLife
From Images to Genes: Radiogenomics Based on Artificial Intelligence to Achieve Non‐Invasive Precision Medicine in Cancer Patients
Yusheng Guo, Tianxiang Li, Bingxin Gong, Yan Hu, Sichen Wang, Lian Yang, Chuansheng Zheng · 2024 · Advanced Science
Precision Medicine in Hormone Receptor-Positive Breast Cancer
Azadeh Nasrazadani, Roby Antony Thomas, Steffi Oesterreich, Adrian V. Lee · 2018 · Frontiers in Oncology
Structural snapshots of RAF kinase interactions
Soheila Rezaei Adariani, Marcel Buchholzer, Mohammad Akbarzadeh, Saeideh Nakhaei‐Rad, Radovan Dvorský, Mohammad Reza Ahmadian · 2018 · Biochemical Society Transactions
PreMedKB: an integrated precision medicine knowledgebase for interpreting relationships between diseases, genes, variants and drugs
Ying Yu, Yunjin Wang, Zhaojie Xia, Xiangyu Zhang, Kailiang Jin, Jingcheng Yang, Luyao Ren, Zheng Zhou, Dong Su Yu, Tao Qing et al. · 2018 · Nucleic Acids Research
Harnessing Clinical Sequencing Data for Survival Stratification of Patients With Metastatic Lung Adenocarcinomas
Ronglai Shen, Axel S. Martin, Ai Ni, Matthew David Hellmann, Kathryn Cecilia Arbour, Emmet Jordan, Arshi Arora, Ryan N. Ptashkin, Ahmet Zehir, Mark G. Kris et al. · 2019 · JCO Precision Oncology
Exploiting epigenetic vulnerabilities in solid tumors: Novel therapeutic opportunities in the treatment of SWI/SNF-defective cancers
Roman M. Chabanon, Daphné Morel, Sophie C. Postel-Vinay · 2019 · Seminars in Cancer Biology
Tissue-Plasma TMB Comparison and Plasma TMB Monitoring in Patients With Metastatic Non-small Cell Lung Cancer Receiving Immune Checkpoint Inhibitors
Alex Friedlaender, Thierry P. Nouspikel, Yann Christinat, Liza K.F. Ho, Thomas McKee, Alfredo Addeo · 2020 · Frontiers in Oncology
Durable Complete Response With Immune Checkpoint Inhibitor in Breast Cancer With High Tumor Mutational Burden and APOBEC Signature
Saranya Chumsri, Ethan S. Sokol, Aixa E. Soyano‐Muller, Ricardo Daniel Parrondo, Gina A. Reynolds, Aziza Nassar, E. Aubrey Thompson · 2020 · Journal of the National Comprehensive Cancer Network
Genetic Characteristics of Colorectal Neuroendocrine Carcinoma: More Similar to Colorectal Adenocarcinoma
Luohai Chen, Man Liu, Yixuan Zhang, Yu Guo, Minhu Chen, Jie Chen · 2020 · Clinical Colorectal Cancer
Clinicopathologic and genomic characterization of PD-L1-positive uterine cervical carcinoma
Richard S.P. Huang, James Haberberger, Karthikeyan Murugesan, Natalie A. Danziger, Matthew Hiemenz, Eric Allan Severson, Daniel L. Duncan, Shakti H Ramkissoon, Jeffrey S. Ross, Julia Andrea Elvin et al. · 2021 · Modern Pathology
Targeting mutated GTPase KRAS in tumor therapies
Guangjin Fan, Linlin Lou, Zhendong Song, Xiaolei Zhang, Xiao‐Feng Xiong · 2021 · European Journal of Medicinal Chemistry
Utility of comprehensive genomic profiling in directing treatment and improving patient outcomes in advanced non-small cell lung cancer
Shen Zhao, Zhonghan Zhang, Jianhua Zhan, Xin Zhao, Xinru Chen, Liyun Xiao, Kui Wu, Yuxiang Ma, Mengzhen Li, Yunpeng Yang et al. · 2021 · BMC Medicine
Emerging Roles for Mammalian Target of Rapamycin (mTOR) Complexes in Bladder Cancer Progression and Therapy
Jianya Huan, Petros D. Grivas, Jasmine Birch, Donna Elizabeth Hansel · 2022 · Cancers
Diagnostic yield and clinical relevance of expanded genetic testing for cancer patients
Ozge Ceyhan‐Birsoy, Gowtham Jayakumaran, Yelena M. Kemel, Maksym Misyura, Umut Aypar, Sowmya Jairam, Ciyu Yang, Yirong Li, Nikita N. Mehta, Anna Maio et al. · 2022 · Genome Medicine
MatchMiner: an open-source platform for cancer precision medicine
Harry Klein, Tali Mazor, Ethan Siegel, Pavel Trukhanov, Andrea Ovalle, Catherine Del Vecchio Fitz, Zachary Zwiesler, Priti Kumari, Bernd Van Der Veen, Eric Marriott et al. · 2022 · npj Precision Oncology
ARID1A mutations confer intrinsic and acquired resistance to cetuximab treatment in colorectal cancer
Johnson, Radia M., Qu, Xueping, Lin, Chu-Fang, Huw, Ling-Yuh, Venkatanarayan, Avinashnarayan, Sokol, Ethan, Ou, Fang-Shu, Ihuegbu, Nnamdi, Zill, Oliver A., Kabbarah, Omar et al. · 2022 · Nature Communications
Genomic correlates of response and resistance to immune checkpoint inhibitors in carcinomas of unknown primary
Elie Rassy, Stergios Boussios, Nicholas A. Pavlidis · 2021 · European Journal of Clinical Investigation
Pan-Cancer Comparative and Integrative Analyses of Driver Alterations Using Japanese and International Genomic Databases
Sara Horie, Yuki Saito, Yasunori Kogure, Kota Mizuno, Yuta Ito, Mariko Tabata, Takanori Kanai∥, Koichi Murakami, Junji Koya, Keisuke Kataoka · 2024 · Cancer Discovery
Long-read sequencing of an advanced cancer cohort resolves rearrangements, unravels haplotypes, and reveals methylation landscapes
Kieran O’Neill, Erin Pleasance, Jeremy Fan, Vahid Akbari, Glenn Chang, Katherine Dixon, Veronika Csizmók, Signe MacLennan, Vanessa Porter, Andrew Galbraith et al. · 2024 · Cell Genomics
Clinical Use of Precision Oncology Decision Support
Amber M. Johnson, Yekaterina B. Khotskaya, Lauren Brusco, Jia Zeng, Vijaykumar R. Holla, Ann Marie Bailey, Beate C. Litzenburger, Nora Sánchez, Md Abu Shufean, Sarina Anne Piha-Paul et al. · 2017 · JCO Precision Oncology
Antitumor activity of pan‐ HER inhibitors in HER 2‐positive gastric cancer
Takahiro Yoshioka, Kazuhiko Shien, Kei Namba, Hidejiro Torigoe, Hiroki Sato, Shuta Tomida, Hiromasa Yamamoto, Hiroaki Asano, Junichi Soh, Kazunori Tsukuda et al. · 2018 · Cancer Science
Clinical tumour sequencing for precision oncology: time for a universal strategy
Michael L. Cheng, Michael F. Berger, David Michael Hyman, David B. Solit · 2018 · Nature reviews. Cancer
Integrative Molecular Analysis of Patients With Advanced and Metastatic Cancer
Verena Sailer, Kenneth Eng, Tuo Zhang, Rohan Bareja, David J. Pisapia, Alexandros Sigaras, Bhavneet Bhinder, Alessandro Romanel, David C. Wilkes, Evan Sticca et al. · 2019 · JCO Precision Oncology
Diffuse capillary malformation with overgrowth contains somatic PIK3CA variants
Jeremy A. Goss, Dennis J. Konczyk, Patrick J. Smits, Christopher L. Sudduth, Joyce E. Bischoff, Marilyn G. Liang, Arin K. Greene · 2020 · Clinical Genetics
CDK12: cellular functions and therapeutic potential of versatile player in cancer
Květa Pilařová, Jan Herudek, Dalibor Blažek · 2020 · NAR Cancer
Melanomas with activating RAF1 fusions: clinical, histopathologic, and molecular profiles
Erik Abraham Williams, Nikunj Shah, Meagan Montesion, Radwa Raed Sharaf, Dean C. Pavlick, Ethan S. Sokol, Brian Michael Alexander, Jeff M. Venstrom, Julia Andrea Elvin, Jeffrey S. Ross et al. · 2020 · Modern Pathology
Rb and p53-Deficient Myxofibrosarcoma and Undifferentiated Pleomorphic Sarcoma Require Skp2 for Survival
Li, George Z., Okada, Tomoyo, Kim, Young-Mi, Agaram, Narasimhan P., Sanchez-Vega, Francisco, Shen, Yawei, Tsubokawa, Norifumi, Rios, Jordan, Martin, Axel S., Dickson, Mark A. et al. · 2020 · Cancer Research
Comprehensive genomic profiling for patients with chemotherapy‐naïve advanced cancer
Tomohiro Kondo, Junichi Matsubara, Pham Nguyen Quy, Keita Fukuyama, Motoo Nomura, Taro Funakoshi, Keitaro Doi, Yuichi Sakamori, Masahiro Yoshioka, Akira Yokoyama et al. · 2020 · Cancer Science
Natural history, response to systemic therapy, and genomic landscape of plasmacytoid urothelial carcinoma
Min Yuen Teo, Hikmat A Al‐Ahmadie, Kenneth Seier, Christopher Tully, Ashley Marie Regazzi, Eugene J. Pietzak, David B. Solit, Satish K. Tickoo, Victor E. Reuter, Eugene K. Cha et al. · 2021 · British Journal of Cancer
Comprehensive Molecular Profiling of Desmoplastic Small Round Cell Tumor
Emily Kanaya Slotkin, Anita S. Bowman, Max Fine Levine, Filemon S. Dela Cruz, Diego F. Coutinho, Glorymar D. Ibanez Sanchez, Néstor Rosales, Shakeel I. Modak, William D. Tap, Mrinal M. Gounder et al. · 2021 · Molecular Cancer Research
Proteomic analysis of lung cancer cells reveals a critical role of BCAT1 in cancer cell metastasis
Lin Mao, Chen Jin, Xue Mei Lu, Canlin Yang, Yi Gang Ding, Mingming Wang, Yunpeng Zhang, Yuying Tian, Xing Li, Yunyun Fu et al. · 2021 · Theranostics
Tumor-Based Genetic Testing and Familial Cancer Risk
Andrea D. Forman, Jilliane Sotelo · 2019 · Cold Spring Harbor Perspectives in Medicine
Genetic alterations of Keap1 confers chemotherapeutic resistance through functional activation of Nrf2 and Notch pathway in head and neck squamous cell carcinoma
Syed Shahidul Islam, Khawlah Qassem, Shafiqul Islam, Rashed Rezwan Parag, Mohammed Z. Rahman, Walid A. Farhat, Herman Yeger, Abdelilah Aboussekhra, Bedri Karakas, Abu Shadat Mohammod Noman · 2022 · Cell Death and Disease
The discrete roles of individual FOXO transcription factor family members in B-cell malignancies
Jamie Lees, Jodie Hay, Michael W. Moles, Alison M. Michie · 2023 · Frontiers in Immunology
Unified framework for patient-derived, tumor-organoid-based predictive testing of standard-of-care therapies in metastatic colorectal cancer
Tao Tan, Dmitri Mouradov, Margaret Lee, Grace Gard, Yumiko Hirokawa, Shan Li, Cong Lin, Fuqiang Li, Huijuan Luo, Kui Wu et al. · 2023 · Cell Reports Medicine
Single-cell long-read targeted sequencing reveals transcriptional variation in ovarian cancer
Ashley Byrne, Daniel Le, Kostianna Sereti, Hari Menon, Samir Vaidya, Neha Patel, Jessica M. Lund, Ana Xavier‐Magalhães, Minyi Shi, Yuxin Liang et al. · 2024 · Nature Communications
Human-correlated genetic models identify precision therapy for liver cancer
Miryam Müller, Stephanie May, Holly Hall, Timothy James Kendall, Lynn McGarry, Lauriane Blukacz, Sandro Nuciforo, Αναστασία Γεωργακοπούλου, Thomas Jamieson, Narisa Phinichkusolchit et al. · 2025 · Nature
Implementation of “clinical sequencing” in cancer genome medicine in Japan
Takashi Kohno · 2017 · Cancer Science
BRAF , NRAS , and GNAQ Mutations in Conjunctival Melanocytic Nevi
Jasmine H. Francis, Hans E. Grossniklaus, Larissa A. Habib, Brian P. Marr, David H. Abramson, Klaus Johannes BUSAM · 2018 · Investigative Ophthalmology & Visual Science
Downregulation of TRIM58 expression is associated with a poor patient outcome and enhances colorectal cancer cell invasion
Min Liu, Xiaowen Zhang, Jian Qiang Cai, Yichen Li, Qianxin Luo, Haiyong Wu, Zihuan Yang, Lei Wang, Daici Chen · 2018 · Oncology Reports
DNA repair defects in prostate cancer: impact for screening, prognostication and treatment
Evan W. Warner, Steven Yip, Kim N. Chi, Alexander William Wyatt · 2018 · British Journal of Urology
Designing gene panels for tumor mutational burden estimation: the need to shift from ‘correlation’ to ‘accuracy’
Hao‐Xiang Wu, Zixian Wang, Qi Zhao, Feng Wang, Rui‐Hua Xu · 2019 · Journal for ImmunoTherapy of Cancer
Genomic Characterization of ERBB2-Driven Biliary Cancer and a Case of Response to Ado-Trastuzumab Emtansine
Sebastián Mondaca, Pedram Razavi, Chong‐Rui Xu, Michael David Offin, Mackenzie L. Myers, Maurizio Scaltriti, Jaclyn Frances Hechtman, Mikaela Bradley, Eileen Mary O'Reilly, Michael F. Berger et al. · 2019 · JCO Precision Oncology
Next-generation sequencing implicates oncogenic roles for p53 and JAK/STAT signaling in microcystic adnexal carcinomas
May P. Chan, Komal R. Plouffe, Chia‐Jen Liu, Nallasivam Palanisamy, Shannon L. Carskadon, Lili Zhao, Rosalynn M. Nazarian, Alison B. Durham, Timothy M. Johnson, Aleodor A. Andea et al. · 2019 · Modern Pathology
Lung cancer cytology and small biopsy specimens: diagnosis, predictive biomarker testing, acquisition, triage, and management
Simon Sung, Jonas J. Heymann, John P. Crapanzano, Andre Luis Moreira, Catherine A. Shu, William A. Bulman, Anjali Saqi · 2020 · Journal of the American Society of Cytopathology
Enhancing chemotherapy response through augmented synthetic lethality by co-targeting nucleotide excision repair and cell-cycle checkpoints
Yi Wen Kong, Erik C. Dreaden, Sandra Morandell, Wen Zhou, Sanjeev S. Dhara, Ganapathy Sriram, Fred C. Lam, Jesse Christopher Patterson, Mohiuddin Quadir, Anh Dinh et al. · 2020 · Nature Communications
Clinical Outcome of Leiomyosarcomas With Somatic Alteration in Homologous Recombination Pathway Genes
Evan Rosenbaum P. E, Philip Jonsson, Kenneth Seier, Li‐Xuan Qin, Ping Chi, Mark Andrew Dickson, Mrinal M. Gounder, Ciara Marie Kelly, Mary Louise Keohan, Benjamin Alexander Nacev et al. · 2020 · JCO Precision Oncology
TERT promoter mutations and melanoma survival: A comprehensive literature review and meta-analysis
Sara Gandini, Ines Zanna, Simone De Angelis, Domenico Palli, Sara Raimondi, Simone Ribero, Giovanna Masala, Mariano Suppa, Federica Bellerba, Federica Corso et al. · 2021 · Critical Reviews in Oncology/Hematology
Sequential Administration of XPO1 and ATR Inhibitors Enhances Therapeutic Response in TP53-mutated Colorectal Cancer
Akira Inoue, Frederick Scott Robinson, Rosalba Minelli, Hideo Tomihara, Bahar Salimian Rizi, Johnathon Lynn Rose, Takahiro Kodama, Sanjana Srinivasan, Angela L. Harris, Andy M. Zuniga et al. · 2021 · Gastroenterology
Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer
Athea Vichas, Amanda K. Riley, Naomi T. Nkinsi, Shriya Kamlapurkar, Phoebe C. R. Parrish, April Lo, Fujiko F. Duke, Jennifer Chen, Iris Fung, Jacqueline Watson et al. · 2021 · Nature Communications
Deconvoluting Mechanisms of Acquired Resistance to RAF Inhibitors in BRAFV600E-Mutant Human Glioma
Karisa C. Schreck, Andrew Morin, Guisheng Zhao, Amy N. Allen, Patrick Flannery, Michael Glantz, Adam L. Green, Chris Jones, Kenneth L. Jones, Lindsay Baker Kilburn et al. · 2021 · Clinical Cancer Research
Constructing germline research cohorts from the discarded reads of clinical tumor sequences
Alexander Gusev, Stefan Groha, Kodi Taraszka, Yevgeniy R. Semenov, Noah Zaitlen · 2021 · Genome Medicine
GLI1 Gene Alterations in Neoplasms of the Genitourinary and Gynecologic Tract
Pedram Argani, Baris Boyraz, Esther Oliva, Andres Matoso, John Gross, Eddie Fridman, Lei Zhang, Brendan C. Dickson, Cristina R. Antonescu · 2021 · The American Journal of Surgical Pathology
Expanding the Molecular Diversity of CIC-Rearranged Sarcomas With Novel and Very Rare Partners
Konstantinos D. Linos, Josephine Kam Tai K. Dermawan, Tejus Bale, Marc K. Rosenblum, Samuel Singer, William D. Tap, Mark Andrew Dickson, Jason L. Hornick, Cristina R. Antonescu · 2023 · Modern Pathology
Identification of a Novel Nomogram to Predict Progression Based on the Circadian Clock and Insights Into the Tumor Immune Microenvironment in Prostate Cancer
Dechao Feng, Qiao Xiong, Facai Zhang, Xu Shi, Hang Xu, Wuran Wei, Jianzhong Ai, Lu Yang · 2022 · Frontiers in Immunology
Genomic and Transcriptomic Characteristics of Metastatic Thyroid Cancers with Exceptional Responses to Radioactive Iodine Therapy
Laura Boucai, Mahesh Saqcena, Fengshen Kuo, Ravinder K. Grewal, Nicholas D. Socci, Jeffrey A. Knauf, Gnana Prakasam Krishnamoorthy, Mabel M. Ryder, Alan Loh Ho, Ronald A. Ghossein et al. · 2023 · Clinical Cancer Research
Detecting liquid remnants of solid tumors treated with curative intent: Circulating tumor DNA as a biomarker of minimal residual disease (Review)
Huijuan Chen, Qiming Zhou · 2023 · Oncology Reports
Whole exome sequencing analysis of canine urothelial carcinomas without BRAF V595E mutation: Short in-frame deletions in BRAF and MAP2K1 suggest alternative mechanisms for MAPK pathway disruption
Rachael J. Thomas, Claire A. Wiley, Emma L. Droste, James B. Robertson, Brant Allen Inman, Matthew Breen · 2023 · PLoS Genetics
Hippo pathway in non-small cell lung cancer: mechanisms, potential targets, and biomarkers
Hongge Liang, Yan Xu, Jing Zhao, Minjiang Chen, Mengzhao Wang · 2024 · Cancer Gene Therapy
Genomic testing for pancreatic cancer in clinical practice as real-world evidence
Hideyuki Hayashi, Shigeki Tanishima, Kyōkō Fujii, Ryo Mori, Yasunobu Okamura, Emmy Yanagita, Ryosuke Matsuoka, Toraji Amano, Ichiro Kinoshita, Yoshito Komatsu et al. · 2018 · Pancreatology
ALK Fusions in Renal Cell Carcinoma: Response to Entrectinib
Jessica J. Tao, Wei Ge, Roopal Patel, Patrick C. Fagan, Xueli Hao, Julia A. Bridge, Maria E. Arcila, Hikmat A Al‐Ahmadie, Chung‐Han Lee, Gary Li et al. · 2018 · JCO Precision Oncology
Cancer-Specific Thresholds Adjust for Whole Exome Sequencing–Based Tumor Mutational Burden Distribution
Evan M. Fernandez, Kenneth Eng, Shaham Beg, Himisha Beltran, Bishoy M. Faltas, Juan Miguel Mosquera, David M. Nanus, David J. Pisapia, Rema A. Rao, Brian D. Robinson et al. · 2019 · JCO Precision Oncology
Substantial batch effects in TCGA exome sequences undermine pan-cancer analysis of germline variants
Roni Rasnic, Nadav Brandes, Or Zuk, Michal Linial B · 2019 · BMC Cancer
Modeling rectal cancer to advance neoadjuvant precision therapy
Harinarayanan Janakiraman, Yun Zhu, Scott A. Becker, Cindy Wang, Ashley W. Cross, Emily Curl, David Lewin, Brenda J. Hoffman, Graham Walter Warren, Elizabeth Goodwin Hill et al. · 2020 · International Journal of Cancer
Interplay between DNA damage repair and apoptosis shapes cancer evolution through aneuploidy and microsatellite instability
Noam Auslander, Yuri I. Wolf, Eugene V. Koonin · 2020 · Nature Communications
Ultrarapid EGFR Mutation Screening Followed by Comprehensive Next-Generation Sequencing: A Feasible, Informative Approach for Lung Carcinoma Cytology Specimens With a High Success Rate
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