Targeting cellular senescence prevents age-related bone loss in mice

Farr, Joshua N, Xu, Ming, Weivoda, Megan M, Monroe, David G, Fraser, Daniel G, Onken, Jennifer L, Negley, Brittany A, Sfeir, Jad G +10 more·2017·Nature Medicine
DOI 10.1038/nm.4385

Cited by (129)

Items 101–129 of 129

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  2. The power of proteomics to monitor senescence-associated secretory phenotypes and beyond: toward clinical applications
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  4. Heterochronic parabiosis regulates the extent of cellular senescence in multiple tissues
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  5. Targeting p16-induced senescence prevents cigarette smoke-induced emphysema by promoting IGF1/Akt1 signaling in mice
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  9. Osteocyte Cellular Senescence
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  10. Multiparametric senescent cell phenotyping reveals targets of senolytic therapy in the aged murine skeleton
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  11. Increased cellular senescence in doxorubicin-induced murine ovarian injury: effect of senolytics
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  12. Multiparametric senescent cell phenotyping reveals CD24 osteolineage cells as targets of senolytic therapy in the aged murine skeleton
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  13. The struggle of a good friend getting old: cellular senescence in viral responses and therapy
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  14. Sexually dimorphic estrogen sensing in skeletal stem cells controls skeletal regeneration
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  15. The Senolytic Drug Fisetin Attenuates Bone Degeneration in the Zmpste24−/− Progeria Mouse Model
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  16. Multiple Myeloma Cells Alter Adipogenesis, Increase Senescence-Related and Inflammatory Gene Transcript Expression, and Alter Metabolism in Preadipocytes
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  17. Role of senescence in the chronic health consequences of COVID-19
    Wissler Gerdes, Erin O., Vanichkachorn, Greg, Verdoorn, Brandon P., Hanson, Gregory J., Joshi, Avni Y., Murad, M. Hassan, Rizza, Stacey A., Hurt, Ryan T., Tchkonia, Tamar, Kirkland, James L. · 2022 · Translational Research
  18. Distinct senotypes in p16- and p21-positive cells across human and mouse aging tissues
    Saul, Dominik, Jurk, Diana, Doolittle, Madison L, Kosinsky, Robyn Laura, Han, Yeaeun, Zhang, Xu, Franco, Ana Catarina, Kim, Sung Y, Wyles, Saranya P, Prakash, Y S et al. · 2025 · The EMBO Journal
  19. Senopathies-Diseases Associated with Cellular Senescence
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  20. Modulation of fracture healing by senescence-associated secretory phenotype (SASP): a narrative review of the current literature
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  21. In vitro and in vivo effects of zoledronic acid on senescence and senescence-associated secretory phenotype markers
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  22. Glycyrrhizin mitigates inflammatory bone loss and promotes expression of senescence-protective sirtuins in an aging mouse model of periprosthetic osteolysis
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  23. Context‐dependent roles of cellular senescence in normal, aged, and disease states
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  24. Ascorbic Acid Attenuates Senescence of Human Osteoarthritic Osteoblasts
    Burger, Maximilian, Steinitz, Amir, Geurts, Jeroen, Pippenger, Benjamin, Schaefer, Dirk, Martin, Ivan, Barbero, Andrea, Pelttari, Karoliina · 2017 · International Journal of Molecular Sciences
  25. Parathyroid hormone signaling in mature osteoblasts/osteocytes protects mice from age-related bone loss
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  26. Obesity, Senescence, and Senolytics
    Chaib, Selim, Tchkonia, Tamara, Kirkland, James L. · 2021 · Handbook of Experimental Pharmacology
  27. BMP9 reduces age-related bone loss in mice by inhibiting osteoblast senescence through Smad1-Stat1-P21 axis
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  28. The life and times of cellular senescence in skeletal muscle: Friend or foe for homeostasis and adaptation?
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  29. Serum amyloid P secreted by bone marrow adipocytes drives skeletal amyloidosis
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