Amyloid generation and dysfunctional immunoproteasome activation with disease progression in animal model of familial Alzheimer’s disease

Aso, Ester; Lomoio, Selene; López‐González, Irene; Joda, Laura; Carmona, Margarita; Fernández‐Yagüe, Núria; Moreno, Jesús; Juvés, Salvador; Pujol, Aurora; Pamplona, Reinald; Portero‐Otin, Manuel; Martín, Virginia; Díaz, Mario; Ferrer, Isidro

doi:10.1111/j.1750-3639.2011.00560.x

Cited by 119Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeuroinflammation and Neurodegeneration Mechanisms

Amyloid generation and dysfunctional immunoproteasome activation with disease progression in animal model of familial Alzheimer’s disease

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Aso, Ester, Lomoio, Selene, López‐González, Irene, Joda, Laura, Carmona, Margarita, Fernández‐Yagüe, Núria, Moreno, Jesús, Juvés, Salvador +6 more·2012·Brain Pathology

DOI 10.1111/j.1750-3639.2011.00560.xPMC PMC8057644

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Abstract

Double-transgenic amyloid precursor protein/presenilin 1 (APP/PS1) mice express a chimeric mouse/human APP bearing the Swedish mutation (Mo/HuAPP695swe) and a mutant human PS1-dE9 both causative of familial Alzheimer's disease (FAD). Transgenic mice show impaired memory and learning performance from the age of 6 months onwards. Double-transgenic APP/PS1 mice express altered APP and PS1 mRNAs and proteins, reduced β-secretase 1 (BACE1) mRNA and normal BACE1 protein, all of which suggest a particular mechanism of amyloidogenesis when compared with sporadic AD. The first β-amyloid plaques in APP/PS1 mice appear at 3 months, and they increase in number and distribution with disease progression in parallel with increased levels of brain soluble β-amyloid 1-42 and 1-40, but also with reduced 1-42/1-40 ratio with age. Amyloid deposition in plaques is accompanied by altered mitochondria and increased oxidative damage, post-translational modifications and accumulation of altered proteins at the dystrophic neurites surrounding plaques. Degradation pathways are also modified with disease progression including activation of the immunoproteasome together with variable alterations of the different protease activities of the ubiquitin-proteasome system. Present observations show modifications in the production of β-amyloid and activation and malfunction of the subcellular degradation pathways that have general implications in the pathogenesis of AD and more particularly in specificities of FAD amyloidogenesis.

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IHC for SOD1 labels areas of high oxidative stress, specifically around Aβ plaques, and is associated with dystrophic neurites.
“IHC for SOD1 labels areas of high oxidative stress, specifically around Aβ plaques, and is associated with dystrophic neurites [21,48].”
From Centella Asiatica Improves Memory and Promotes Antioxidative Signaling in 5XFAD Mice (2019) · cites this paper as [48]
Elevated SOD expression is indicative of high levels of oxidative stress associated with Aβ plaques in Alzheimer's disease brains.
“Elevated SOD expression is indicative of the high levels of oxidative stress associated with Aβ plaques in Alzheimer’s disease brains [21,48,80,104].”
From Centella Asiatica Improves Memory and Promotes Antioxidative Signaling in 5XFAD Mice (2019) · cites this paper as [48]

THE UBIQUITIN SYSTEM
Hershko, A., & Ciechanover, A. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.425 · Cited by 8,840 · see citing works
The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction
Glickman, M. H., & Ciechanover, A. J. (2002) · Physiological Reviews · doi:10.1152/physrev.00027.2001 · Cited by 4,216 · see citing works
Aβ Oligomers – a decade of discovery
Walsh, D. M., & Selkoe, D. J. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04426.x · Cited by 1,938 · see citing works
The 26S Proteasome: A Molecular Machine Designed for Controlled Proteolysis
Voges, D., Zwickl, P., & Baumeister, W. P. (1999) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.68.1.1015 · Cited by 1,894 · see citing works
Familial Alzheimer's Disease–Linked Presenilin 1 Variants Elevate Aβ1–42/1–40 Ratio In Vitro and In Vivo
Borchelt, D. R., Thinakaran, G., Eckman, C. B., Lee, M. K., Davenport, F., Ratovitsky, T., Prada, C.-M., Kim, G., Seekins, S., Yager, D., et al. (1996) · Neuron · doi:10.1016/s0896-6273(00)80230-5 · Cited by 1,478 · see citing works
Phosphorylation of Ser-129 Is the Dominant Pathological Modification of α-Synuclein in Familial and Sporadic Lewy Body Disease
Anderson, J. P., Walker, D., Goldstein, J. M., de Laat, R., Banducci, K., Caccavello, R. J., Barbour, R., Huang, J., Kling, K., Lee, M., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m600933200 · Cited by 1,418 · see citing works
Mitochondrial abnormalities in Alzheimer's disease
Hirai, K., Aliev, G., Nunomura, A., Fujioka, H., Russell, R. L., Atwood, C. S., Johnson, A. B., Kress, Y., Vinters, H. V., Tabaton, M., et al. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-09-03017.2001 · Cited by 1,367 · see citing works
Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease
Yao, J., Irwin, R. W., Zhao, L., Nilsen, J., Hamilton, R. T., & Brinton, R. D. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0903563106 · Cited by 940 · see citing works
Soluble amyloid β-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration
Jin, M., Shepardson, N., Yang, T., Chen, G., Walsh, D., & Selkoe, D. J. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1017033108 · Cited by 876 · see citing works
Impaired Proteasome Function in Alzheimer's Disease
Keller, J. N., Hanni, K. B., & Markesbery, W. R. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0750436.x · Cited by 848 · see citing works
Mitochondrial Aβ: a potential focal point for neuronal metabolic dysfunction in Alzheimer's disease
Caspersen, C., Wang, N., Yao, J., Sosunov, A., Chen, X., Lustbader, J. W., Xu, H. W., Stern, D., McKhann, G., & Du Yan, S. (2005) · The FASEB Journal · doi:10.1096/fj.05-3735fje · Cited by 738 · see citing works
Elevated β-secretase expression and enzymatic activity detected in sporadic Alzheimer disease
Yang, L.-B., Lindholm, K., Yan, R., Citron, M., Xia, W., Yang, X.-L., Beach, T., Sue, L., Wong, P., Price, D., et al. (2003) · Nature Medicine · doi:10.1038/nm0103-3 · Cited by 729 · see citing works
ULTRASTRUCTURAL STUDIES IN ALZHEIMER'S PRESENILE DEMENTIA.
Terry, R. D., Gonatas, N. K., & WEISS, M. (1964) · PubMed · Cited by 650 · see citing works
Mechanisms of tau-induced neurodegeneration
Iqbal, K., Liu, F., Gong, C.-X., Alonso, A. D. C., & Grundke-Iqbal, I. (2009) · Acta Neuropathologica · doi:10.1007/s00401-009-0486-3 · Cited by 628 · see citing works
Neuropathology and Pathogenesis of Encephalitis following Amyloid β Immunization in Alzheimer's Disease
Ferrer, I., Boada, M., Guerra, M. L. S., Rey, M. J., & Costa‐Jussà, F. R. (2004) · Brain Pathology · doi:10.1111/j.1750-3639.2004.tb00493.x · Cited by 567 · see citing works
Self-citation
Increased expression of the amyloid precursor β‐secretase in Alzheimer's disease
Holsinger, R. M. D., McLean, C. A., Beyreuther, K., Masters, C. L., & Evin, G. (2002) · Annals of Neurology · doi:10.1002/ana.10208 · Cited by 562 · see citing works
Brain cytochrome oxidase in Alzheimer's disease
Kish, S. J., Bergeron, C., Rajput, A., Dozic, S., Mastrogiacomo, F., Chang, L., Wilson, J. M., DiStefano, L. M., & Nobrega, J. N. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb09439.x · Cited by 537 · see citing works
Neurotoxicity of Alzheimer’s disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio
Kuperstein, I., Broersen, K., Benilova, I., Rozenski, J., Jonckheere, W., Debulpaep, M., Vandersteen, A., Segers‐Nolten, I., Van Der Werf, K., Subramaniam, V., et al. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.211 · Cited by 532 · see citing works
Cortical Cytochrome Oxidase Activity Is Reduced in Alzheimer's Disease
Mutisya, E. M., Bowling, A. C., & Beal, M. F. (1994) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1994.63062179.x · Cited by 531 · see citing works
Energetics, epigenetics, mitochondrial genetics
Wallace, D. C., & Fan, W. (2009) · Mitochondrion · doi:10.1016/j.mito.2009.09.006 · Cited by 507 · see citing works
Amyloid β peptide load is correlated with increased β-secretase activity in sporadic Alzheimer's disease patients
Li, R., Lindholm, K., Yang, L., Yue, X., Citron, M., Yan, R., Beach, T. G., Sue, L. I., Sabbagh, M. N., Cai, H., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0205689101 · Cited by 493 · see citing works
Evolution of neuronal changes in the course of Alzheimer’s disease
Braak, H., & Braak, E. (1998) · Journal of neural transmission. Supplementum · doi:10.1007/978-3-7091-6467-9_11 · Cited by 482 · see citing works
ALZHEIMER’S DISEASE —AN ELECTRON MICROSCOPICAL STUDY
KIDD, M. (1964) · Brain · doi:10.1093/brain/87.2.307 · Cited by 462 · see citing works
THE PROTEASOME
Bochtler, M., Ditzel, L., Groll, M., Hartmann, C., & Huber, R. (1999) · Annual Review of Biophysics and Biomolecular Structure · doi:10.1146/annurev.biophys.28.1.295 · Cited by 433 · see citing works
Episodic-like memory deficits in the APPswe/PS1dE9 mouse model of Alzheimer's disease: Relationships to β-amyloid deposition and neurotransmitter abnormalities
Savonenko, A. V., Xu, G. M., Melnikova, T., Morton, J. L., Gonzales, V., Wong, M. P., Price, D. L., Tang, F., Markowska, A. L., & Borchelt, D. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2004.10.022 · Cited by 396 · see citing works
Aβ inhibits the proteasome and enhances amyloid and tau accumulation
Tseng, B. P., Green, K. N., Chan, J. L., Blurton-Jones, M., & LaFerla, F. M. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.04.014 · Cited by 384 · see citing works
β-Site Amyloid Precursor Protein Cleaving Enzyme 1 Levels Become Elevated in Neurons around Amyloid Plaques: Implications for Alzheimer's Disease Pathogenesis
Zhao, J., Fu, Y., Yasvoina, M., Shao, P., Hitt, B., O'Connor, T., Logan, S., Maus, E., Citron, M., Berry, R., et al. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.4396-06.2007 · Cited by 365 · see citing works
Current Advances on Different Kinases Involved in Tau Phosphorylation, and Implications in Alzheimers Disease and Tauopathies
Ferrer, I., Gómez‐Isla, T., Puig, B., Freixes, M., Ribé, E. M., Dalfó, E., & Ávila, J. (2005) · Current Alzheimer Research · doi:10.2174/1567205052772713 · Cited by 302 · see citing works
Self-citation
Partial Reduction of BACE1 Has Dramatic Effects on Alzheimer Plaque and Synaptic Pathology in APP Transgenic Mice
McConlogue, L., Buttini, M., Anderson, J. P., Brigham, E. F., Chen, K. S., Freedman, S. B., Games, D., Johnson-Wood, K., Lee, M., Zeller, M., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m611687200 · Cited by 300 · cited 1× · see citing works
“Interestingly, reduced levels of BACE1 in double PDAPP/BACE(–/–) transgenic mice are associated with reduced b-amyloid plaque formation (40), and oral administration of a selective BACE1 inhibitor decreases b-amyloid production in vivo (24).”
Background
β-Secretase Activity Increases with Aging in Human, Monkey, and Mouse Brain
Fukumoto, H., Rosene, D. L., Moss, M. B., Raju, S., Hyman, B. T., & Irizarry, M. C. (2004) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)63159-8 · Cited by 294 · see citing works
Time sequence of maturation of dystrophic neurites associated with Aβ deposits in APP/PS1 transgenic mice
Blanchard, V., Moussaoui, S., Czech, C., Touchet, N., Bonici, B., Planche, M., Canton, T., Jedidi, I., Gohin, M., Wirths, O., et al. (2003) · Experimental Neurology · doi:10.1016/s0014-4886(03)00252-8 · Cited by 283 · see citing works
Concurrence of α-synuclein and tau brain pathology in the Contursi kindred
Duda, J. E., Giasson, B. I., Mabon, M. E., Miller, D. C., Golbe, L. I., Lee, V. M. ‐., & Trojanowski, J. Q. (2002) · Acta Neuropathologica · doi:10.1007/s00401-002-0563-3 · Cited by 274 · see citing works
Aβ-degrading enzymes: potential for treatment of Alzheimer disease
Miners, J. S., Barua, N., Kehoe, P. G., Gill, S., & Love, S. (2011) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3182345e46 · Cited by 265 · see citing works
The ubiquitin‐proteasome system in Alzheimer's disease
Oddo, S. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00276.x · Cited by 262 · see citing works
Chapter 37 Selective vulnerability of corticocortical and hippocampal circuits in aging and Alzheimer's disease
Morrison, J. H., & Hof, P. R. (2002) · Progress in brain research · doi:10.1016/s0079-6123(02)36039-4 · Cited by 241 · see citing works
Substrate Binding and Catalysis by Ubiquitin C-Terminal Hydrolases: Identification of Two Active Site Residues
Larsen, C. N., Price, J. S., & Wilkinson, K. D. (1996) · Biochemistry · doi:10.1021/bi960099f · Cited by 219 · see citing works
Oral administration of a potent and selective non‐peptidic BACE‐1 inhibitor decreases β‐cleavage of amyloid precursor protein and amyloid‐β production in vivo
Hussain, I., Hawkins, J., Harrison, D. C., Hille, C. J., Wayne, G. J., Cutler, L., Buck, T., Walter, D. S., Demont, E. H., Howes, C., et al. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04260.x · Cited by 197 · see citing works
Induction of Intracellular Tau Aggregation Is Promoted by α-Synuclein Seeds and Provides Novel Insights into the Hyperphosphorylation of Tau
Waxman, E. A., & Giasson, B. I. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0297-11.2011 · Cited by 193 · see citing works
Fibrillization of ?-synuclein and tau in familial Parkinson's disease caused by the A53T ?-synuclein mutation
Kotzbauer, P. T. (2004) · Experimental Neurology · doi:10.1016/j.expneurol.2004.01.007 · Cited by 176 · see citing works
The role of tau kinases in Alzheimer's disease.
Dolan, P. J., & Johnson, G. V. W. (2010) · PubMed · Cited by 174 · see citing works
Current status on Alzheimer disease molecular genetics: from past, to present, to future
Bettens, K., Sleegers, K., & Broeckhoven, C. V. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq142 · Cited by 167 · see citing works
Alzheimer's Disease: A Lesson from Mitochondrial Dysfunction
Moreira, P. I., Santos, M. S., & Oliveira, C. R. (2007) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1703 · Cited by 150 · see citing works
Core Proteins of the Secretory Machinery
Lang, T., & Jahn, R. (2007) · Handbook of experimental pharmacology · doi:10.1007/978-3-540-74805-2_5 · Cited by 145 · see citing works
Phosphorylation of tau and α-synuclein in synaptic-enriched fractions of the frontal cortex in Alzheimer’s disease, and in Parkinson’s disease and related α-synucleinopathies
Muntané, G., Dalfó, E., Martı́nez, A., & Ferrer, I. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.01.030 · Cited by 143 · see citing works
Self-citation
Mitochondrial dysfunction in sporadic and genetic Alzheimer's disease
Hauptmann, S., Keil, U., Scherping, I., Bonert, A., Eckert, A., & Müller, W. E. (2006) · Experimental Gerontology · doi:10.1016/j.exger.2006.03.012 · Cited by 134 · see citing works
Animal Models of Alzheimer's Disease: Therapeutic Implications
Woodruff‐Pak, D. S. (2008) · Journal of Alzheimer s Disease · doi:10.3233/jad-2008-15401 · Cited by 133 · see citing works
Axonopathy in an APP/PS1 transgenic mouse model of Alzheimer’s disease
Wirths, O., Weis, J., Szczygielski, J., Multhaup, G., & Bayer, T. A. (2006) · Acta Neuropathologica · doi:10.1007/s00401-006-0041-4 · Cited by 130 · see citing works
The Role of Ubiquitin C-Terminal Hydrolase L1 in Neurodegenerative Disorders
Gong, B., & Leznik, E. (2007) · Drug News & Perspectives · doi:10.1358/dnp.2007.20.6.1138160 · Cited by 120 · see citing works
Beta-Secretase: Structure, Function, and Evolution
Venugopal, C., Demos, C., Rao, K. S. J., Pappolla, M. A., & Sambamurti, K. (2008) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152708784936626 · Cited by 120 · see citing works
The various aggregation states of β-amyloid 1–42 mediate different effects on oxidative stress, neurodegeneration, and BACE-1 expression
Tamagno, E., Bardini, P., Guglielmotto, M., Danni, O., & Tabaton, M. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.01.021 · Cited by 117 · see citing works
The hippocampus and long-term object memory in the rat
Vnek, N., & Rothblat, L. A. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-08-02780.1996 · Cited by 113 · see citing works
Calpain Activation Promotes BACE1 Expression, Amyloid Precursor Protein Processing, and Amyloid Plaque Formation in a Transgenic Mouse Model of Alzheimer Disease
Liang, B., Duan, B.-Y., Zhou, X., Gong, J., & Luo, Z. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.117960 · Cited by 109 · see citing works
Molecular dissection of the 11S REG (PA28) proteasome activators
Li, J., & RECHSTEINER, M. C. (2001) · Biochimie · doi:10.1016/s0300-9084(01)01236-6 · Cited by 86 · see citing works
Expression of stress‐activated kinases c‐Jun N‐terminal kinase (SAPK/JNK‐P) and p38 kinase (p38‐P), and tau hyperphosphorylation in neurites surrounding βA plaques in APP Tg2576 mice
Puig, B., Gómez‐Isla, T., Ribé, E. M., Cuadrado‐Tejedor, M., Torrejón-Escribano, B., Dalfó, E., & Ferrer, I. (2004) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2004.00569.x · Cited by 85 · see citing works
Self-citation
Deposition of Hyperphosphorylated Tau in Cerebellum of PS1 E280A Alzheimer's Disease
Sepulveda‐Falla, D., Matschke, J., Bernreuther, C., Hagel, C., Puig, B., Villegas, A., Garcia, G., Zea, J., Gomez‐Mancilla, B., Ferrer, I., et al. (2011) · Brain Pathology · doi:10.1111/j.1750-3639.2010.00469.x · Cited by 82 · see citing works
Self-citation
Oxidative inactivation of the proteasome in Alzheimer's disease
Cecarini, V., Ding, Q., & Keller, J. N. (2007) · Free Radical Research · doi:10.1080/10715760701286159 · Cited by 79 · see citing works
Dystrophic neurites of senile plaques in Alzheimer’s disease are deficient in cytochrome c oxidase
Pérez-Gracia, E., Torrejón-Escribano, B., & Ferrer, I. (2008) · Acta Neuropathologica · doi:10.1007/s00401-008-0370-6 · Cited by 72 · see citing works
Self-citation
Functional implications of the association of tau with the plasma membrane
Pooler, A. M., & Hanger, D. P. (2010) · Biochemical Society Transactions · doi:10.1042/bst0381012 · Cited by 72 · see citing works
Synaptophysin and chromogranin A immunoreactivities in senile plaques of Alzheimer's disease
Brion, J., Couck, A., Bruce, M. T., Anderton, B. H., & Flament-Durand, J. (1991) · Brain Research · doi:10.1016/0006-8993(91)90697-t · Cited by 71 · see citing works
The ultrastructure of senile plaques.
Luse, S. A., & Smith, K. R. (1964) · PubMed · Cited by 66 · see citing works
β‐Secretase‐1 elevation in aged monkey and Alzheimer’s disease human cerebral cortex occurs around the vasculature in partnership with multisystem axon terminal pathogenesis and β‐amyloid accumulation
Cai, Y., Xiong, K., Zhang, X., Cai, H., Luo, X., Feng, J., Clough, R. W., Struble, R. G., Patrylo, P. R., Chu, Y., et al. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07376.x · Cited by 64 · see citing works
Changes in serum dopamine-beta-hydroxylase activity during cold pressor test in subjects with high and low basal activity of this enzyme
Laurian, L., Oberman, Z., Kisch, E. S., & Fitermann, A. (1982) · Journal of Neural Transmission · doi:10.1007/bf01243404 · Cited by 63 · see citing works
Association of a Presenilin 1 S170F Mutation With a Novel Alzheimer Disease Molecular Phenotype
Piccini, A., Zanusso, G., Borghi, R., Noviello, C., Monaco, S., Russo, R., Damonte, G., Armirotti, A., Gelati, M., Giordano, R., et al. (2007) · Archives of Neurology · doi:10.1001/archneur.64.5.738 · Cited by 55 · see citing works
Stress kinases involved inTau phosphorylation in alzheimer’s disease, tauopathies and APP transgenic mice
Ferrer, I. (2004) · Neurotoxicity Research · doi:10.1007/bf03033283 · Cited by 53 · see citing works
Self-citation
Early Growth Response 1 (Egr-1) Regulates Phosphorylation of Microtubule-associated Protein Tau in Mammalian Brain
Lu, Y., Li, T., Qureshi, H. Y., Han, D. C., & Paudel, H. K. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.220962 · Cited by 53 · see citing works
Dystrophic Neurites of Senile Plaques are Defective in Proteins Involved in Exocytosis and Neurotransmission
Ferrer, I., Martı́, E., Tortosa, A., & Blasi, J. (1998) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199803000-00002 · Cited by 49 · see citing works
Self-citation
Widespread axonal damage in the brain of drug abusers as evidenced by accumulation of β‐amyloid precursor protein (β‐APP): an immunohistochemical investigation
Büttner, A., Rohrmoser, K., Mall, G., Penning, R., & Weis, S. (2006) · Addiction · doi:10.1111/j.1360-0443.2006.01505.x · Cited by 48 · see citing works
β‐Amyloid regulates leptin expression and tau phosphorylation through the mTORC1 signaling pathway
Marwarha, G., Dasari, B., Prasanthi, J. R. P., Schommer, J., & Ghribi, O. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06929.x · Cited by 39 · see citing works
Role of Protein Phosphatase 2A in Alzheimers Disease
Rudrabhatla, P., & Pant, H. C. (2011) · Current Alzheimer Research · doi:10.2174/156720511796717168 · Cited by 37 · see citing works
The Catalytic Core of γ-Secretase: Presenilin Revisited
Steiner, H. (2008) · Current Alzheimer Research · doi:10.2174/156720508783954677 · Cited by 33 · see citing works
Aggregation State and Neurotoxic Properties of Alzheimer β-Amyloid Peptide
Mohamed, A., Cortez, L. M., & Chaves, E. (2011) · Current Protein and Peptide Science · doi:10.2174/138920311795860214 · Cited by 29 · see citing works
Mitochondrial bioenergetics is defective in presymptomatic Tg2576 AD Mice
Varghese, M., Zhao, W., Wang, J., Cheng, A., Qian, X., Chaudhry, A., Ho, L., & Pasinetti, G. M. (2011) · Translational Neuroscience · doi:10.2478/s13380-011-0011-8 · Cited by 22 · see citing works
Characterization of the Brain β-Amyloid Isoform Pattern at Different Ages of Tg2576 Mice
Mustafiz, T., Portelius, E., Gustavsson, M. K., Hölttä, M., Zetterberg, H., Blennow, K., Nordberg, A. K., & Lithner, C. U. (2011) · Neurodegenerative Diseases · doi:10.1159/000323871 · Cited by 22 · see citing works

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Bachiller, S., Jiménez-Ferrer, I., Paulus, A., Yang, Y., Swanberg, M., Deierborg, T., & Boza‐Serrano, A. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00488 · Cited by 706 · see citing works
Oxidative Stress and Advanced Lipoxidation and Glycation End Products (ALEs and AGEs) in Aging and Age-Related Diseases
Moldogazieva, N. T., Mokhosoev, I. M., Melnikova, T. I., Porozov, Y. B., & Terentiev, A. A. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/3085756 · Cited by 504 · see citing works
A Practical Review of Proteasome Pharmacology
Thibaudeau, T. A., & Smith, D. M. (2019) · Pharmacological Reviews · doi:10.1124/pr.117.015370 · Cited by 354 · see citing works
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Jacobs, H. I. L., Hopkins, D. A., Mayrhofer, H. C., Bruner, E., van Leeuwen, F. W., Raaijmakers, W., & Schmahmann, J. D. (2017) · Brain · doi:10.1093/brain/awx194 · Cited by 339 · see citing works
The ubiquitin-proteasome system in neurodegenerative diseases: precipitating factor, yet part of the solution
Dantuma, N. P., & Bott, L. C. (2014) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2014.00070 · Cited by 336 · see citing works
CB 2 Cannabinoid Receptor Agonist Ameliorates Alzheimer-Like Phenotype in AβPP/PS1 Mice
Aso, E., Juvés, S., Maldonado, R. J., & Ferrer, I. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-130137 · Cited by 205 · see citing works
Self-citation
Early alterations in energy metabolism in the hippocampus of APPswe/PS1dE9 mouse model of Alzheimer's disease
Pedrós, I., Petrov, D., Allgaier, M., Sureda, F. X., Barroso, E., Beas‐Zárate, C., Auladell, C., Pallàs, M., Vázquez‐Carrera, M., Casadesús, G., et al. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.05.025 · Cited by 203 · see citing works
Altered Mitochondrial DNA Methylation Pattern in Alzheimer Disease–Related Pathology and in Parkinson Disease
Blanch, M., Mosquera, J. L., Ansoleaga, B., Ferrer, I., & Barrachina, M. (2016) · The American Journal of Pathology · doi:10.1016/j.ajpath.2015.10.004 · Cited by 192 · see citing works
Self-citation
Reactive glia show increased immunoproteasome activity in Alzheimer’s disease
Orre, M., Kamphuis, W., Dooves, S., Kooijman, L., Chan, E. T., Kirk, C. J., Dimayuga Smith, V., Koot, S., Mamber, C., Jansen, A. H., et al. (2013) · Brain · doi:10.1093/brain/awt083 · Cited by 180 · see citing works
Neuroprotective Role of Trans-Resveratrol in a Murine Model of Familial Alzheimer's Disease
Porquet, D., Griñán‐Ferré, C., Ferrer, I., Camins, A., Sanfeliu, C., del Valle, J., & Pallàs, M. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-140444 · Cited by 178 · see citing works
Self-citation
Defining Alzheimer as a common age-related neurodegenerative process not inevitably leading to dementia
Ferrer, I. (2012) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2012.03.005 · Cited by 174 · see citing works
Self-citation
Altered lipid composition in cortical lipid rafts occurs at early stages of sporadic Alzheimer's disease and facilitates APP/BACE1 interactions
Fabelo, N., Martín, M. V., Marín, R., Moreno, D., Ferrer, I., & Díaz, M. L. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.02.005 · Cited by 164 · see citing works
Self-citation
Cannabis-based medicine reduces multiple pathological processes in AβPP/PS1 mice
Aso, E., Sánchez-Pla, A., Vegas-Lozano, E., Maldonado, R., & Ferrer, I. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-141014 · Cited by 154 · see citing works
Self-citation
Retinal changes in Alzheimer's disease— integrated prospects of imaging, functional and molecular advances
Gupta, V. B., Chitranshi, N., den Haan, J., Mirzaei, M., You, Y., Lim, J. K. H., Basavarajappa, D. K., Godinez, A., Angelantonio, S. D., Sachdev, P. S., et al. (2020) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2020.100899 · Cited by 143 · see citing works
Neuroinflammatory Signals in Alzheimer Disease and APP/PS1 Transgenic Mice
López‐González, I., Schlüter, A., Aso, E., Garcia‐Esparcia, P., Ansoleaga, B., Llorens, F., Carmona, M., Moreno, J. R., Fuso, A., Portero‐Otín, M., et al. (2015) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0000000000000176 · Cited by 125 · see citing works
Self-citation
Distinct patterns of APP processing in the CNS in autosomal-dominant and sporadic Alzheimer disease
Pera, M., Alcolea, D. A., Sánchez‐Valle, R., Guardia‐Laguarta, C., Colom‐Cadena, M., Badiola, N., Suárez‐Calvet, M., Lladó, A., Barrera-Ocampo, A. A., Falla, D. S., et al. (2012) · Acta Neuropathologica · doi:10.1007/s00401-012-1062-9 · Cited by 120 · see citing works
Self-citation
CB1 Agonist ACEA Protects Neurons and Reduces the Cognitive Impairment of AβPP/PS1 Mice
Aso, E., Palomer, E., Juvés, S., Maldonado, R. J., Muñoz, F. J., & Ferrer, I. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-111862 · Cited by 120 · see citing works
Self-citation
Ozone: a natural bioactive molecule with antioxidant property as potential new strategy in aging and in neurodegenerative disorders
Scassellati, C., Galoforo, A. C., Bonvicini, C., Esposito, C., & Ricevuti, G. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101138 · Cited by 121 · see citing works
Olfactory Receptors in Non-Chemosensory Organs: The Nervous System in Health and Disease
Ferrer, I., Garcia‐Esparcia, P., Carmona, M., Carro, E., Aronica, E., Kovács, G. G., Grison, A., & Gustincich, S. (2016) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2016.00163 · Cited by 114 · see citing works
Self-citation
proBDNF is modified by advanced glycation end products in Alzheimer’s disease and causes neuronal apoptosis by inducing p75 neurotrophin receptor processing
Fleitas, C., Piñol‐Ripoll, G., Marfull‐Oromí, P., Rocandio, D., Ferrer, I., Rampon, C., Egea, J., & Espinet, C. (2018) · Molecular Brain · doi:10.1186/s13041-018-0411-6 · Cited by 104 · see citing works
Self-citation
Structure, Dynamics and Function of the 26S Proteasome
Mao, Y. (2020) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-3-030-58971-4_1 · Cited by 105 · see citing works
The Proteasome and Oxidative Stress in Alzheimer's Disease
Bonet-Costa, V., Pomatto, L. C.-D., & Davies, K. J. A. (2016) · Antioxidants & Redox Signaling · doi:10.1089/ars.2016.6802 · Cited by 99 · see citing works
Poly(propylene imine) dendrimers with histidine-maltose shell as novel type of nanoparticles for synapse and memory protection
Aso, E., Martinsson, I., Appelhans, D., Effenberg, C., Benseny‐Cases, N., Cladera, J., Gouras, G. K., Ferrer, I., & Klementieva, O. L. (2019) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2019.01.010 · Cited by 98 · see citing works
Self-citation
Proteasome activation delays aging in vitro and in vivo
Chondrogianni, N., Sakellari, M., Lefaki, M., Papaevgeniou, N., & Gonos, E. S. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.03.031 · Cited by 94 · see citing works
Centella Asiatica Improves Memory and Promotes Antioxidative Signaling in 5XFAD Mice
Matthews, D. G., Caruso, M., Murchison, C. F., Zhu, J. Y., Wright, K. M., Harris, C. J., Gray, N. E., Quinn, J. F., & Soumyanath, A. (2019) · Antioxidants · doi:10.3390/antiox8120630 · Cited by 86 · see citing works
“Elevated SOD expression is indicative of the high levels of oxidative stress associated with Aβ plaques in Alzheimer’s disease brains [21,48,80,104].”
Background
Dysregulation of brain olfactory and taste receptors in AD, PSP and CJD, and AD-related model
Ansoleaga, B., Garcia‐Esparcia, P., Llorens, F., Moreno, J., Aso, E., & Ferrer, I. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.06.034 · Cited by 84 · see citing works
Self-citation
Proteostasis Disturbances and Inflammation in Neurodegenerative Diseases
Sonninen, T.-M., Goldsteins, G., Laham-Karam, N., Koıstınaho, J., & Lehtonen, Š. (2020) · Cells · doi:10.3390/cells9102183 · Cited by 84 · see citing works
Dl-3-n-butylphthalide-induced upregulation of antioxidant defense is involved in the enhancement of cross talk between CREB and Nrf2 in an Alzheimer's disease mouse model
Wang, C., Wang, Z., Xie, J., Wang, T., Wang, X., Xu, Y., & Cai, J. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2015.10.024 · Cited by 80 · see citing works
Overexpression of Mutant Amyloid-β Protein Precursor and Presenilin 1 Modulates Enteric Nervous System
Puig, K. L., Lutz, B. M., Urquhart, S. A., Rebel, A. A., Zhou, X., Manocha, G. D., Sens, M. A., Tuteja, A. K., Foster, N. L., & Combs, C. K. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-142259 · Cited by 77 · see citing works
Biophysical Alterations in Lipid Rafts from Human Cerebral Cortex Associate with Increased BACE1/AβPP Interaction in Early Stages of Alzheimer's Disease
Díaz, M. L., Fabelo, N., Martín, M. V., Ferrer, I., Gómez, T., & Marín, R. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-141146 · Cited by 75 · see citing works
Self-citation
Evidence for Premature Lipid Raft Aging in APP/PS1 Double-Transgenic Mice, a Model of Familial Alzheimer Disease
Fabelo, N., Martín, M. V., Marín, R., Santpere, G., Aso, E., Ferrer, I., & Díaz, M. L. (2012) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e31826be03c · Cited by 75 · see citing works
Self-citation
Effect of Poly(propylene imine) Glycodendrimers on β-Amyloid Aggregation in Vitro and in APP/PS1 Transgenic Mice, as a Model of Brain Amyloid Deposition and Alzheimer’s Disease
Klementieva, O. L., Aso, E., Filippini, D., Benseny‐Cases, N., Carmona, M., Juvés, S., Appelhans, D., Cladera, J., & Ferrer, I. (2013) · Biomacromolecules · doi:10.1021/bm400948z · Cited by 74 · see citing works
Self-citation
A Sentinel in the Crosstalk Between the Nervous and Immune System: The (Immuno)-Proteasome
Limanaqi, F., Biagioni, F., Gaglione, A., Busceti, C. L., & Fornai, F. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00628 · Cited by 69 · see citing works
Docosahexaenoic (DHA) modulates phospholipid-hydroperoxide glutathione peroxidase (Gpx4) gene expression to ensure self-protection from oxidative damage in hippocampal cells
Casañas‐Sánchez, V., Pérez, J. A. P., Fabelo, N., Quinto‐Alemany, D., & Díaz, M. L. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00203 · Cited by 66 · see citing works
Self-citation
Age- and Brain Region-Specific Changes of Glucose Metabolic Disorder, Learning, and Memory Dysfunction in Early Alzheimer’s Disease Assessed in APP/PS1 Transgenic Mice Using 18F-FDG-PET
Li, X., Men, W., Zhu, H., Lei, J., Zuo, F., Wang, Z., Zhu, Z., Bao, X., & Wang, R. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17101707 · Cited by 66 · see citing works
Brain energy metabolism and neuroinflammation in ageing APP/PS1-21 mice using longitudinal 18 F-FDG and 18 F-DPA-714 PET imaging
Helin, J. S., Lopez‐Picon, F. R., Majidi, R. A., Eskola, O., Krzyczmonik, A., Keller, T., Löyttyniemi, E., Solin, O. H., Rinne, J. O., & Haaparanta‐Solin, M. (2016) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x16677990 · Cited by 65 · see citing works
Immunoproteasome deficiency alters microglial cytokine response and improves cognitive deficits in Alzheimer’s disease-like APPPS1 mice
Wagner, L. K., Gilling, K. E., Schormann, E., Kloetzel, P. M., Heppner, F. L., Krüger, E., & Prokop, S. (2017) · Acta Neuropathologica Communications · doi:10.1186/s40478-017-0453-5 · Cited by 66 · see citing works
Upregulation of Proteolytic Pathways and Altered Protein Biosynthesis Underlie Retinal Pathology in a Mouse Model of Alzheimer’s Disease
Mirzaei, M., Pushpitha, K., Deng, L., Chitranshi, N., Gupta, V. B., Rajput, R., Mangani, A. S., Dheer, Y., Godinez, A., McKay, M. J., et al. (2019) · Molecular Neurobiology · doi:10.1007/s12035-019-1479-4 · Cited by 61 · see citing works
An early dysregulation of FAK and MEK/ERK signaling pathways precedes the β-amyloid deposition in the olfactory bulb of APP/PS1 mouse model of Alzheimer's disease
Lachén‐Montes, M., González-Morales, A., de Morentin, X. M., Pérez‐Valderrama, E., Ausín, K., Zelaya, M. V., Serna, A., Aso, E., Ferrer, I., Fernández‐Irigoyen, J., et al. (2016) · Journal of Proteomics · doi:10.1016/j.jprot.2016.07.032 · Cited by 61 · see citing works
Self-citation
Amyloid and tau pathology of familial Alzheimer’s disease APP/PS1 mouse model in a senescence phenotype background (SAMP8)
Porquet, D., Andrés-Benito, P., Griñán-Ferré, C., Camins, A., Ferrer, I., Canudas, A. M., Del Valle, J., & Pallàs, M. (2015) · AGE · doi:10.1007/s11357-015-9747-3 · Cited by 53 · see citing works
Self-citation
Altered mechanisms of protein synthesis in frontal cortex in Alzheimer disease and a mouse model.
Garcia‐Esparcia, P., Sideris-Lampretsas, G., Hernández‐Ortega, K., Grau‐Rivera, O., Sklaviadis, T., Gelpí, E., & Ferrer, I. (2017) · Europe PMC (PubMed Central) · Cited by 53 · see citing works
Self-citation
Methylglyoxal Formation—Metabolic Routes and Consequences
Vašková, J., Sabolová, G., Pudelský, J., Palenčár, D., & Mičková, H. (2025) · Antioxidants · doi:10.3390/antiox14020212 · Cited by 54 · see citing works
Addition of docosahexaenoic acid, but not arachidonic acid, activates glutathione and thioredoxin antioxidant systems in murine hippocampal HT22 cells: potential implications in neuroprotection
Casañas‐Sánchez, V., Pérez, J. A. P., Fabelo, N., Herrera‐Herrera, A. V., Fernández, C., Marín, R., González-Montelongo, M. D. C., & Díaz, M. L. (2014) · Journal of Neurochemistry · doi:10.1111/jnc.12833 · Cited by 48 · see citing works
Self-citation
Glial Activation in AβPP/PS1 Mice is Associated with Infiltration of IFNγ-Producing Cells
Kelly, R. J., Minogue, A. M., Lyons, A., Jones, R. S., Browne, T. C., Costello, D. A., Denieffe, S., O'Sullivan, C., Connor, T. J., & Lynch, M. A. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-130539 · Cited by 48 · see citing works
Oxidative stress regulates the ubiquitin–proteasome system and immunoproteasome functioning in a mouse model of X-adrenoleukodystrophy
Launay, N., Ruíz, M., Fourcade, S., Schlüter, A., Guilera, C., Ferrer, I., Knecht, E., & Pujol, A. (2013) · Brain · doi:10.1093/brain/aws370 · Cited by 48 · see citing works
Self-citation
AβPP/PS1 Transgenic Mice Show Sex Differences in the Cerebellum Associated with Aging
Ordóñez‐Gutiérrez, L., Fernandez-Perez, I., Herrera, J. L., Anton, M., Benito‐Cuesta, I., & Wandosell, F. G. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-160572 · Cited by 45 · see citing works
Aβ promotes VDAC1 channel dephosphorylation in neuronal lipid rafts. Relevance to the mechanisms of neurotoxicity in Alzheimer’s disease
Fernández-Echevarría, C., Díaz, M. L., Ferrer, I., Canerina‐Amaro, A., & Marín, R. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.07.079 · Cited by 45 · see citing works
Self-citation
An integrated proteomics approach shows synaptic plasticity changes in an APP/PS1 Alzheimer's mouse model
Kempf, S. J., Metaxas, A., Ibáñez-Vea, M., Darvesh, S., Finsen, B. R., & Larsen, M. R. (2016) · Oncotarget · doi:10.18632/oncotarget.9092 · Cited by 44 · see citing works
Changes in the brain and plasma Aβ peptide levels with age and its relationship with cognitive impairment in the APPswe/PS1dE9 mouse model of Alzheimer’s disease
Izco, M., Martinez, P. M., Corrales, A., Fandos, N., García-Cerro, S., Insua, D., Montañés, M., Pérez‐Grijalba, V., Rueda, N., Vidal, V., et al. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.01.003 · Cited by 43 · see citing works
Genetic deletion of CB1 cannabinoid receptors exacerbates the Alzheimer-like symptoms in a transgenic animal model
Aso, E., Andrés‐Benito, P., & Ferrer, I. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.08.007 · Cited by 42 · see citing works
Self-citation
Induction of the Immunoproteasome Subunit Lmp7 Links Proteostasis and Immunity in α-Synuclein Aggregation Disorders
Ugras, S. E., Daniels, M. J., Fazelinia, H., Gould, N. S., Yocum, A. K., Luk, K. C., Luna, E., Ding, H., McKennan, C. G., Seeholzer, S. H., et al. (2018) · EBioMedicine · doi:10.1016/j.ebiom.2018.05.007 · Cited by 40 · see citing works
Mid‐life environmental enrichment increases synaptic density in CA1 in a mouse model of Aβ‐associated pathology and positively influences synaptic and cognitive health in healthy ageing
Stuart, K. E., King, A. E., Fernández-Martos, C. M., Dittmann, J., Summers, M. J., & Vickers, J. C. (2016) · The Journal of Comparative Neurology · doi:10.1002/cne.24156 · Cited by 39 · see citing works
Failure of Ubiquitin Proteasome System: Risk for Neurodegenerative Diseases
Chen, Z., Geetha, T., & Babu, J. R. (2014) · Neurodegenerative Diseases · doi:10.1159/000367694 · Cited by 40 · see citing works
Memory Improvement in the AβPP/PS1 Mouse Model of Familial Alzheimer's Disease Induced by Carbamylated-Erythropoietin is Accompanied by Modulation of Synaptic Genes
Armand‐Ugón, M., Aso, E., Moreno, J. R., Riera‐Codina, M., Sánchez‐Pla, Á., Vegas, E., & Ferrer, I. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-141389 · Cited by 38 · see citing works
Self-citation
LMP2 Inhibitors as a Potential Treatment for Alzheimer’s Disease
Bhattarai, D., Lee, M. J., Baek, A., Yeo, I. J., Miller, Z. C., Baek, Y. M., Lee, S., Kim, D., Hong, J. T., & Kim, K. B. (2020) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.0c00416 · Cited by 36 · see citing works
Genotype-induced changes in biophysical properties of frontal cortex lipid raft from APP/PS1 transgenic mice
Díaz, M. L., Fabelo, N., & Marín, R. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00454 · Cited by 34 · see citing works
Self-citation
Intermittent hypoxia treatment alleviates memory impairment in the 6-month-old APPswe/PS1dE9 mice and reduces amyloid beta accumulation and inflammation in the brain
Yue, X., Zhou, Y., Qiao, M., Zhao, X., Huang, X. H., Zhao, T., Cheng, X., Fan, M., Zhao, Y., Chen, R., et al. (2021) · Alzheimer s Research & Therapy · doi:10.1186/s13195-021-00935-z · Cited by 29 · see citing works
A dual inhibitor of the proteasome catalytic subunits LMP2 and Y attenuates disease progression in mouse models of Alzheimer’s disease
Yeo, I. J., Lee, M. J., Baek, A., Miller, Z. C., Bhattarai, D., Baek, Y. M., Jeong, H. J., Kim, Y. K., Kim, D., Hong, J. T., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-54846-z · Cited by 29 · see citing works
Risk of Alzheimer’s Disease in Cancer Patients: Analysis of Mortality Data from the US SEER Population-Based Registries
Mezencev, R., & Chernoff, Y. O. (2020) · Cancers · doi:10.3390/cancers12040796 · Cited by 27 · see citing works
Label-Free High-Resolution Photothermal Optical Infrared Spectroscopy for Spatiotemporal Chemical Analysis in Fresh, Hydrated Living Tissues and Embryos
Gvazava, N., Konings, S. C., Cepeda-Prado, E., Skoryk, V. R., Umeano, C. H., Dong, J., Silva, I. A. N., Ottosson, D. R., Leigh, N. D., Wagner, D. E., et al. (2023) · Journal of the American Chemical Society · doi:10.1021/jacs.3c08854 · Cited by 26 · see citing works
Intravenous ascorbate improves spatial memory in middle-aged APP/PSEN1 and wild type mice
Kennard, J. A., & Harrison, F. E. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.01.044 · Cited by 26 · see citing works
Cerebellar Amyloid-β Plaques: Disturbed Cortical Circuitry in AβPP/PS1 Transgenic Mice as a Model of Familial Alzheimer's Disease
Lomoio, S., López‐González, I., Aso, E., Carmona, M., Torrejón-Escribano, B., Scherini, E., & Ferrer, I. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-112198 · Cited by 26 · see citing works
Self-citation
Lipid Raft Size and Lipid Mobility in Non-raft Domains Increase during Aging and Are Exacerbated in APP/PS1 Mice Model of Alzheimer's Disease. Predictions from an Agent-Based Mathematical Model
Santos, G., Díaz, M. L., & Torres, N. V. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00090 · Cited by 26 · see citing works
Self-citation
Early loss of cerebellar Purkinje cells in human and a transgenic mouse model of Alzheimer's disease
Chaudhari, K., Wang, L., Kruse, J., Winters, A., Sumien, N., Shetty, R. A., Prah, J., Liu, R., Shi, J., Forster, M., et al. (2021) · Neurological Research · doi:10.1080/01616412.2021.1893566 · Cited by 22 · see citing works
Mitochondrial quality control: Epigenetic signatures and therapeutic strategies
Ambekar, T., Pawar, J., Rathod, R., Patel, M., Fernandes, V., Kumar, R., Singh, S. B., & Khatri, D. K. (2021) · Neurochemistry International · doi:10.1016/j.neuint.2021.105095 · Cited by 23 · see citing works
Mechanisms of ubiquitin-independent proteasomal degradation and their roles in age-related neurodegenerative disease
Church, T. R., & Margolis, S. S. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1531797 · Cited by 24 · see citing works
Hippocampal Lipid Homeostasis in APP/PS1 Mice is Modulated by a Complex Interplay Between Dietary DHA and Estrogens: Relevance for Alzheimer’s Disease
Díaz, M. L., Fabelo, N., Casañas‐Sánchez, V., Marín, R., Gómez, T., Quinto‐Alemany, D., & Pérez, J. A. P. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-150470 · Cited by 22 · see citing works
Self-citation
Hypercholesterolemia and neurodegeneration. Comparison of hippocampal phenotypes in LDLr knockout and APPswe/PS1dE9 mice
Ettcheto, M., Petrov, D., Pedrós, I., de Lemos, L., Pallàs, M., Alegret, M., Laguna, J. C., Folch, J., & Camins, A. (2015) · Experimental Gerontology · doi:10.1016/j.exger.2015.03.010 · Cited by 22 · see citing works
Alzheimer’s disease is an inherent, natural part of human brain aging: an integrated perspective
Ferrer, I. (2022) · Free Neuropathology · doi:10.17879/freeneuropathology-2022-3806 · Cited by 21 · see citing works
Self-citation
Immunoproteasome is up-regulated in rotenone-induced Parkinson’s disease rat model
Sun, C., Jia, G., Wang, X., Wang, Y., & Liu, Y. (2020) · Neuroscience Letters · doi:10.1016/j.neulet.2020.135360 · Cited by 20 · see citing works
In situ identification and G4-PPI-His-Mal-dendrimer-induced reduction of early-stage amyloid aggregates in Alzheimer’s disease transgenic mice using synchrotron-based infrared imaging
Benseny‐Cases, N., Álvarez-Marimon, E., Aso, E., Carmona, M., Klementieva, O. L., Appelhans, D., Ferrer, I., & Cladera, J. (2021) · Scientific Reports · doi:10.1038/s41598-021-96379-4 · Cited by 19 · see citing works
Self-citation
Huatuo Zaizao pill ameliorates cognitive impairment of APP/PS1 transgenic mice by improving synaptic plasticity and reducing Aβ deposition
Zhang, J., Yu, L., Yang, H., Hui, Z., Jiang, S., Chen, L., Zhao, Y., Wang, S., Liu, Y., & Xu, Y. (2018) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-018-2237-2 · Cited by 18 · see citing works
Intestinal homeostasis disrupted by Periodontitis exacerbates Alzheimer’s Disease in APP/PS1 mice
Qian, X., Lin, X., Hu, W., Zhang, L., Chen, W., Zhang, S., Ge, S., Xu, X., & Luo, K. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03256-8 · Cited by 17 · see citing works
Targeting immunoproteasome in neurodegeneration: A glance to the future
Tundo, G. R., Cascio, P., Milardi, D., Santoro, A. M., Graziani, G., Lacal, P. M., Bocedi, A., Oddone, F., Parravano, M., Coletta, A., et al. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2022.108329 · Cited by 16 · see citing works
Orthogonal approaches required to measure proteasome composition and activity in mammalian brain tissue
Türker, F., Bharadwaj, R. A., Kleinman, J. E., Weinberger, D. R., Hyde, T. M., White, C. J., Williams, D. W., & Margolis, S. S. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.104811 · Cited by 16 · see citing works
Age-Related Increase of Insulin-Degrading Enzyme Is Inversely Correlated with Cognitive Function in APPswe/PS1dE9 Mice
Zhang, Y., & Wang, P. (2018) · Medical Science Monitor · doi:10.12659/msm.909596 · Cited by 15 · see citing works
The unique neuropathological vulnerability of the human brain to aging
Ferrer, I. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.101916 · Cited by 14 · see citing works
Self-citation
Z-Guggulsterone attenuates cognitive defects and decreases neuroinflammation in APPswe/PS1dE9 mice through inhibiting the TLR4 signaling pathway
Liu, J., Lin, Y., Yang, Y., Guo, Y., Shang, Y., Zhou, B., Liu, T., Fan, J., & Wei, C. (2022) · Biochemical Pharmacology · doi:10.1016/j.bcp.2022.115149 · Cited by 12 · see citing works
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Abad, S., Ramon‐Duaso, C., López‐Arnau, R., Folch, J., Pubill, D., Camarasa, J., Camins, A., & Escubedo, E. (2019) · Journal of Psychopharmacology · doi:10.1177/0269881119855987 · Cited by 12 · see citing works
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Park, J. E., Chaudhary, C. L., Bhattarai, D., & Kim, K. B. (2024) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.3c02488 · Cited by 11 · see citing works
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Ugarte, A., Corbacho, D., Aymerich, M. S., García‐Osta, A., Cuadrado‐Tejedor, M., & Oyarzábal, J. (2018) · Neurotherapeutics · doi:10.1007/s13311-018-0624-5 · Cited by 11 · see citing works
Dopaminergic neurons show increased low-molecular-mass protein 7 activity induced by 6-hydroxydopamine in vitro and in vivo
Mo, M., Li, G.-H., Sun, C., Huang, S., Wei, L., Zhang, L., Zhou, M., Wu, Z., Guo, W., Yang, X., et al. (2018) · Translational Neurodegeneration · doi:10.1186/s40035-018-0125-9 · Cited by 11 · see citing works
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Su, D., Chai, Y.-N., Yang, J., Wang, X., Liu, Y. M., Ma, J., Tang, X., Mishra, C. K., Chandra, S. R., Yue, W., et al. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.633805 · Cited by 11 · see citing works
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Shen, H., Nie, J., Li, G., Tian, H., Zhang, J., Luo, X., Xu, D., Sun, J., Zhang, D., Zhang, H., et al. (2024) · PLoS ONE · doi:10.1371/journal.pone.0310872 · Cited by 9 · see citing works
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Díaz, M. L., & Marín, R. (2021) · IntechOpen eBooks · doi:10.5772/intechopen.94608 · Cited by 9 · see citing works
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Jiang, J., Deng, J., Zhao, Y., Zhao, S., Niazi, N. U. K., Ge, Y., & Yang, Z. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.114591 · Cited by 9 · see citing works
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Milton, N. G. N. (2023) · Frontiers in Dementia · doi:10.3389/frdem.2023.1233340 · Cited by 8 · see citing works
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Guo, Y., Wang, S., Li, L., Zhang, H., Chen, X., Huang, Z., & Liu, Y. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03564-9 · Cited by 8 · see citing works
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Aso, E., Serrano, A. L., Muñoz‐Cánoves, P., & Ferrer, I. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-142928 · Cited by 7 · see citing works
Self-citation
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Olabiyi, B. F., Fleitas, C., Zammou, B., Ferrer, I., Rampon, C., Egea, J., & EspinetMestre, C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910744 · Cited by 7 · see citing works
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Díaz, M. L. (2024) · Genes · doi:10.3390/genes15060810 · Cited by 6 · see citing works
Self-citation
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Benseny‐Cases, N., Álvarez-Marimon, E., Aso, E., Carmona, M., Klementieva, O. L., Appelhans, D., Ferrer, I., & Cladera, J. (2020) · Scientific Reports · doi:10.1038/s41598-020-62708-2 · Cited by 6 · see citing works
Self-citation
Retracted
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Lü, Z., Zhou, H., Tang, H., Luo, S., Wang, J., Zheng, X., Hu, Y., Qin, Q., Yang, Q., Mo, S., et al. (2025) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x251400239 · Cited by 3 · see citing works
Changes in the Activities and Contents of Individual Forms of Proteasomes in Samples of the Cerebral Cortex during Pathology Development in 5xFAD Mice
Morozov, A. V., Burov, A. V., Funikov, S. Y., Teterina, E. V., Astakhova, T. M., Erokhov, P. A., Ustyugov, A. A., & Карпов, В. Л. (2023) · Molecular Biology · doi:10.1134/s0026893323050138 · Cited by 3 · see citing works
Glycodendrimers as Potential Multitalented Therapeutics in Alzheimer’s Disease
Klementieva, O. L. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.88974 · Cited by 3 · see citing works
Time dynamics of protein complexes in the AD11 transgenic mouse model for Alzheimer’s disease like pathology
Arisi, I., D’Onofrio, M., Brandi, R., Cattaneo, A., Bertolazzi, P., Cumbo, F., Felici, G., & Guerra, C. (2015) · BMC Neuroscience · doi:10.1186/s12868-015-0155-5 · Cited by 3 · see citing works
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Santos, G., & Díaz, M. L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222212181 · Cited by 3 · see citing works
Self-citation
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Stecker, M. M. (2022) · Medicina · doi:10.3390/medicina58101368 · Cited by 2 · see citing works
Tauopathy in the APP swe / PS1 ΔE9 mouse model of familial Alzheimer’s diseasePreprint
Metaxas, A., Thygesen, C., Kempf, S. J., Anzalone, M., Vaitheeswaran, R., Petersen, S., Landau, A. M., Audrain, H., Teeling, J. L., Darvesh, S., et al. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/405647 · Cited by 2 · see citing works

Transgenic mice with Alzheimer presenilin 1 mutations show accelerated neurodegeneration without amyloid plaque formation
Chui, D.-H., Tanahashi, H., Ozawa, K., Ikeda, S., Checler, F., Ueda, O., Suzuki, H., Araki, W., Inoue, H., Shirotani, K., et al. (1999) · Nature Medicine · doi:10.1038/8438 · Cited by 364 · see citing works
Intraneuronal β-Amyloid Aggregates, Neurodegeneration, and Neuron Loss in Transgenic Mice with Five Familial Alzheimer's Disease Mutations: Potential Factors in Amyloid Plaque Formation
Oakley, H., Cole, S. L., Logan, S., Maus, E., Shao, P., Craft, J., Guillozet-Bongaarts, A., Ohno, M., Disterhoft, J., Van Eldik, L., et al. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.1202-06.2006 · Cited by 3,530 · see citing works
Accelerated Amyloid Deposition in the Brains of Transgenic Mice Coexpressing Mutant Presenilin 1 and Amyloid Precursor Proteins
Borchelt, D. R., Ratovitski, T., van Lare, J., Lee, M. K., Gonzales, V., Jenkins, N. A., Copeland, N. G., Price, D. L., & Sisodia, S. S. (1997) · Neuron · doi:10.1016/s0896-6273(00)80974-5 · Cited by 1,023 · see citing works
Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes
Holcomb, L., Gordon, M. N., McGowan, E., Yu, X., Benkovic, S., Jantzen, P., Wright, K., Saad, I., Mueller, R., Morgan, D., et al. (1998) · Nature Medicine · doi:10.1038/nm0198-097 · Cited by 1,386 · see citing works
Modeling Alzheimer's disease in transgenic mice: effect of age and of Presenilin1 on amyloid biochemistry and pathology in APP/London mice
Dewachter, I., Dorpe, J. V., Spittaels, K., Tesseur, I. C., den Haute, C. V., Moechars, D., & LEUVEN, F. V. (2000) · Experimental Gerontology · doi:10.1016/s0531-5565(00)00149-2 · Cited by 74 · see citing works

Authors: Aso, E., Lomoio, S., López‐González, I., Joda, L., Carmona, M., Fernández‐Yagüe, N., Moreno, J., Juvés, S., Pujol, A., Pamplona, R., Portero‐Otin, M., Martín, V., Díaz, M., & Ferrer, I.
Affiliations: Bellvitge University Hospital (ES)
University of Pavia (IT)
Institució Catalana de Recerca i Estudis Avançats (ES)
Universitat de Lleida (ES)
Universidad de La Laguna (ES)
ORCID: Aso, Ester
Lomoio, Selene
Carmona, Margarita
Pujol, Aurora
Pamplona, Reinald
Díaz, Mario
Venue: Brain Pathology
Publisher: Wiley
Published: 2012-01-13
Volume: 22
Issue: 5
Pages: 636-653
ISSN: 1015-6305 (ISSN-L)
1750-3639
DOI: 10.1111/j.1750-3639.2011.00560.x
PMC: PMC8057644
OpenAlex: W1869566076
Cited by: 118
References: 73
Citations by year: 2026: 2 · 2025: 5 · 2024: 6 · 2023: 8 · 2022: 4 · 2021: 11 · 2020: 9 · 2019: 10 · 2018: 9 · 2017: 4 · 2016: 11 · 2015: 10 · 2014: 14 · 2013: 9 · 2012: 6
FWCI: 6.33
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Brain Pathology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion, cc-by-nc-nd)
LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by-nc-nd)
Topics: Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: familial Alzheimer's disease, APP/PS1 mice, amyloidogenesis, amyloid plaques, beta-secretase 1, BACE1, Swedish mutation, presenilin 1, proteasome, ubiquitin-proteasome system, mitochondrial dysfunction, oxidative damage, dystrophic neurites, post-translational modification, disease progression, memory impairment
MeSH terms: Superoxide Dismutase-1, Age Factors, Alzheimer Disease, Animals, Avoidance Learning, Brain, Cognition Disorders, Cysteine Endopeptidases, Disease Models, Animal, Gene Expression Regulation, Humans, Mice, Inbred C57BL, Mice, Transgenic, Mutation, Neuropsychological Tests, RNA, Messenger, Superoxide Dismutase, Signal Transduction, Amyloid beta-Peptides, Microscopy, Immunoelectron, Aspartic Acid Endopeptidases, Amyloid beta-Protein Precursor, tau Proteins, Disease Progression, Mitogen-Activated Protein Kinases, Recognition, Psychology, Ubiquitin Thiolesterase, Microscopy, Electron, Transmission, Proteasome Endopeptidase Complex, Mice, alpha-Synuclein, Presenilin-1, Plaque, Amyloid

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Amyloid generation and dysfunctional immunoproteasome activation with disease progression in animal model of familial Alzheimer’s disease

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