Transcriptional and post‐transcriptional regulation of β‐secretase

β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE

Vassar, R., Bennett, B. D., Babu-Khan, S., Kahn, S., Mendiaz, E. A., Denis, P., Teplow, D. B., Ross, S., Amarante, P., Loeloff, R., et al. (1999) · Science · doi:10.1126/science.286.5440.735 · Cited by 3,876 · see citing works

National Institute on Aging–Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease

Hyman, B. T., Phelps, C. H., Beach, T. G., Bigio, E. H., Cairns, N. J., Carrillo, M. C., Dickson, D. W., Duyckaerts, C., Frosch, M. P., Masliah, E., et al. (2012) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.10.007 · Cited by 3,092 · see citing works

Pathways towards and Away from Alzheimer’s Disease

Mattson, M. P. (2004) · Nature · doi:10.1038/nature02621 · Cited by 3,052 · see citing works

Self-Propagating, Molecular-Level Polymorphism in Alzheimer's ß-Amyloid Fibrils

Petkova, A. T., Leapman, R. D., Guo, Z., Yau, W.-M., Mattson, M. P., & Tycko, R. (2005) · Science · doi:10.1126/science.1105850 · Cited by 1,687 · see citing works

APP Processing and Synaptic Function

Kamenetz, F., Tomita, T., Hsieh, H., Seabrook, G., Borchelt, D., Iwatsubo, T., Sisodia, S., & Malinow, R. (2003) · Neuron · doi:10.1016/s0896-6273(03)00124-7 · Cited by 1,644 · see citing works

Purification and cloning of amyloid precursor protein β-secretase from human brain

Sinha, S., Anderson, J. P., Barbour, R., Basi, G. S., Caccavello, R., Davis, D., Doan, M., Dovey, H. F., Frigon, N., Hong, J., et al. (1999) · Nature · doi:10.1038/990114 · Cited by 1,612 · see citing works

Cellular prion protein mediates impairment of synaptic plasticity by amyloid-β oligomers

Laurén, J., Gimbel, D. A., Nygaard, H. B., Gilbert, J. W., & Strittmatter, S. M. (2009) · Nature · doi:10.1038/nature07761 · Cited by 1,560 · see citing works

Membrane-anchored aspartyl protease with Alzheimer's disease β-secretase activity

Yan, R., Bienkowski, M. J., Shuck, M. E., Miao, H., Tory, M. C., Pauley, A. M., Brashler, J. R., Stratman, N. C., Mathews, W. R., Buhl, A. E., et al. (1999) · Nature · doi:10.1038/990107 · Cited by 1,438 · see citing works

Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of β-secretase

Faghihi, M. A., Modarresi, F., Khalil, A. M., Wood, D. E., Sahagan, B. G., Morgan, T. E., Finch, C. E., St. Laurent III, G., Kenny, P. J., & Wahlestedt, C. (2008) · Nature Medicine · doi:10.1038/nm1784 · Cited by 1,416 · see citing works

Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

Hussain, I., Powell, D., Howlett, D. R., Tew, D. G., Meek, T. D., Chapman, C., Gloger, I. S., Murphy, K. E., Southan, C. D., Ryan, D. M., et al. (1999) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.1999.0811 · Cited by 1,080 · see citing works

Exogenous Induction of Cerebral ß-Amyloidogenesis Is Governed by Agent and Host

Meyer-Luehmann, M., Coomaraswamy, J., Bolmont, T., Kaeser, S., Schaefer, C., Kilger, E., Neuenschwander, A., Abramowski, D., Frey, P., Jaton, A. L., et al. (2006) · Science · doi:10.1126/science.1131864 · Cited by 971 · see citing works

The Neuron-Specific Protein PGP 9.5 Is a Ubiquitin Carboxyl-Terminal Hydrolase

Wilkinson, K. D., Lee, K., Deshpande, S. S., Duerksen-Hughes, P. J., Boss, J. M., & Pohl, J. (1989) · Science · doi:10.1126/science.2530630 · Cited by 871 · see citing works

Autophagy: in sickness and in health

Cuervo, A. M. (2004) · Trends in Cell Biology · doi:10.1016/j.tcb.2003.12.002 · Cited by 816 · see citing works

Human aspartic protease memapsin 2 cleaves the β-secretase site of β-amyloid precursor protein

Lin, X., Koelsch, G., Wu, S., Downs, D., Dashti, A., & Tang, J. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.4.1456 · Cited by 769 · see citing works

Elevated β-secretase expression and enzymatic activity detected in sporadic Alzheimer disease

Yang, L.-B., Lindholm, K., Yan, R., Citron, M., Xia, W., Yang, X.-L., Beach, T., Sue, L., Wong, P., Price, D., et al. (2003) · Nature Medicine · doi:10.1038/nm0103-3 · Cited by 729 · see citing works

Structure of the Protease Domain of Memapsin 2 (β-Secretase) Complexed with Inhibitor

Lin, H., Koelsch, G., Lin, X., Wu, S., Terzyan, S. S., Ghosh, A. K., Zhang, X. C., & Tang, J. (2000) · Science · doi:10.1126/science.290.5489.150 · Cited by 711 · see citing works

β-Secretase Protein and Activity Are Increased in the Neocortex in Alzheimer Disease

Fukumoto, H. (2002) · Archives of Neurology · doi:10.1001/archneur.59.9.1381 · Cited by 695 · see citing works

Transcription factor NF-κB is activated in primary neurons by amyloid β peptides and in neurons surrounding early plaques from patients with Alzheimer disease

Kaltschmidt, B., Uherek, M., Volk, B., Baeuerle, P. A., & Kaltschmidt, C. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.6.2642 · Cited by 611 · see citing works

Hypoxia facilitates Alzheimer's disease pathogenesis by up-regulating <i>BACE1</i> gene expression

Sun, X., He, G., Qing, H., Zhou, W., Dobie, F., Cai, F., Staufenbiel, M., Huang, L. E., & Song, W. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606298103 · Cited by 605 · see citing works

Oxidative Modifications and Down-regulation of Ubiquitin Carboxyl-terminal Hydrolase L1 Associated with Idiopathic Parkinson's and Alzheimer's Diseases

Choi, J., Levey, A. I., Weintraub, S. T., Rees, H. D., Gearing, M., Chin, L.-S., & Li, L. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m314124200 · Cited by 568 · see citing works

Increased expression of the amyloid precursor β‐secretase in Alzheimer's disease

Holsinger, R. M. D., McLean, C. A., Beyreuther, K., Masters, C. L., & Evin, G. (2002) · Annals of Neurology · doi:10.1002/ana.10208 · Cited by 562 · see citing works

Hypoxia-inducible Factor 1α (HIF-1α)-mediated Hypoxia Increases BACE1 Expression and β-Amyloid Generation

Zhang, X., Zhou, K., Wang, R., Cui, J., Lipton, S. A., Liao, F.-F., Xu, H., & Zhang, Y.-W. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m608856200 · Cited by 436 · see citing works

Redox‐Active Metals, Oxidative Stress, and Alzheimer's Disease Pathology

HUANG, X., MOIR, R. D., TANZI, R. E., BUSH, A. I., & ROGERS, J. T. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1306.012 · Cited by 425 · see citing works

Ubiquitin Hydrolase Uch-L1 Rescues β-Amyloid-Induced Decreases in Synaptic Function and Contextual Memory

Gong, B., Cao, Z., Zheng, P., Vitolo, O. V., Liu, S., Staniszewski, A., Moolman, D. L., Zhang, H., Shelanski, M. L., & Arancio, O. (2006) · Cell · doi:10.1016/j.cell.2006.06.046 · Cited by 424 · see citing works

Phosphorylation of the Translation Initiation Factor eIF2α Increases BACE1 Levels and Promotes Amyloidogenesis

O’Connor, T., Sadleir, K. R., Maus, E., Velliquette, R. A., Zhao, J., Cole, S. L., Eimer, W. A., Hitt, B. D., Bembinster, L. A., Lammich, S., et al. (2008) · Neuron · doi:10.1016/j.neuron.2008.10.047 · Cited by 422 · see citing works

Antidiabetic drug metformin (Glucophage ^R ) increases biogenesis of Alzheimer's amyloid peptides via up-regulating <i>BACE1</i> transcription

Chen, Y., Zhou, K., Wang, R., Liu, Y., Kwak, Y.-D., Ma, T., Thompson, R. C., Zhao, Y., Smith, L., Gasparini, L., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0807991106 · Cited by 390 · see citing works

Oxidative stress increases expression and activity of BACE in NT2 neurons

Tamagno, E., Bardini, P., Obbili, A., Vitali, A., Borghi, R., Zaccheo, D., Pronzato, M. A., Danni, O., Smith, M. A., Perry, G., et al. (2002) · Neurobiology of Disease · doi:10.1006/nbdi.2002.0515 · Cited by 385 · see citing works

Nonsteroidal anti-inflammatory drugs repress β-secretase gene promoter activity by the activation of PPARγ

Sastre, M., Dewachter, I., Rossner, S., Bogdanovic, N., Rosen, E., Borghgraef, P., Evert, B. O., Dumitrescu-Ozimek, L., Thal, D. R., Landreth, G., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503839103 · Cited by 373 · see citing works

Progressive age‐related development of Alzheimer‐like pathology in APP/PS1 mice

Trinchese, F., Liu, S., Battaglia, F., Walter, S., Mathews, P. M., & Arancio, O. (2004) · Annals of Neurology · doi:10.1002/ana.20101 · Cited by 369 · see citing works

The Fetal Basis of Amyloidogenesis: Exposure to Lead and Latent Overexpression of Amyloid Precursor Protein and β-Amyloid in the Aging Brain

Basha, R. M., Wei, W., Bakheet, S. A., Benitez, N. B., Siddiqi, H. K., Ge, Y., Lahiri, D. K., & Zawia, N. H. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.4335-04.2005 · Cited by 353 · see citing works

Oxidative stress activates a positive feedback between the γ‐ and β‐secretase cleavages of the β‐amyloid precursor protein

Tamagno, E., Guglielmotto, M., Aragno, M., Borghi, R., Autelli, R., Giliberto, L., Muraca, G., Danni, O., Zhu, X., Smith, M. A., et al. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.05072.x · Cited by 338 · see citing works

Depletion of GGA3 Stabilizes BACE and Enhances β-Secretase Activity

Tesco, G., Koh, Y. H., Kang, E. L., Cameron, A. N., Das, S., Sena-Esteves, M., Hiltunen, M., Yang, S.-H., Zhong, Z., Shen, Y., et al. (2007) · Neuron · doi:10.1016/j.neuron.2007.05.012 · Cited by 337 · see citing works

β‐Site APP cleaving enzyme up‐regulation induced by 4‐hydroxynonenal is mediated by stress‐activated protein kinases pathways

Tamagno, E., Parola, M., Bardini, P., Piccini, A., Borghi, R., Guglielmotto, M., Santoro, G., Davit, A., Danni, O., Smith, M. A., et al. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02895.x · Cited by 324 · see citing works

Evidence that Alzheimer’s disease is a microvascular disorder: the role of constitutive nitric oxide

de la Torre, J. C., & Stefano, G. B. (2000) · Brain Research Reviews · doi:10.1016/s0165-0173(00)00043-6 · Cited by 307 · see citing works

Post-translational Processing of β-Secretase (β-Amyloid-converting Enzyme) and Its Ectodomain Shedding

Benjannet, S., Elagoz, A., Wickham, L., Mamarbachi, M., Munzer, J. S., Basak, A., Lazure, C., Cromlish, J. A., Sisodia, S., Checler, F., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m009899200 · Cited by 301 · see citing works

Inhibition of NF-κB potentiates amyloid β-mediated neuronal apoptosis

Kaltschmidt, B., Uherek, M., Wellmann, H., Volk, B., & Kaltschmidt, C. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.16.9409 · Cited by 280 · see citing works

Oxidative stress and β-amyloid protein in Alzheimer’s disease

Cai, Z., Zhao, B., & Ratka, A. (2011) · NeuroMolecular Medicine · doi:10.1007/s12017-011-8155-9 · Cited by 279 · see citing works

On the Seeding and Oligomerization of pGlu-Amyloid Peptides (<i>in vitro</i>)

Schilling, S., Lauber, T., Schaupp, M., Manhart, S., Scheel, E., Böhm, G., & Demuth, H.-U. (2006) · Biochemistry · doi:10.1021/bi0612667 · Cited by 254 · see citing works

Maturation and Pro-peptide Cleavage of β-Secretase

Capell, A., Steiner, H., Willem, M., Kaiser, H., Meyer, C., Walter, J., Lammich, S., Multhaup, G., & Haass, C. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m003202200 · Cited by 247 · see citing works

The up‐regulation of BACE1 mediated by hypoxia and ischemic injury: role of oxidative stress and HIF1α

Guglielmotto, M., Aragno, M., Autelli, R., Giliberto, L., Novo, E., Colombatto, S., Danni, O., Parola, M., Smith, M. A., Perry, G. L., et al. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05858.x · Cited by 243 · see citing works

Interactions of GGA3 with the ubiquitin sorting machinery

Puertollano, R., & Bonifacino, J. S. (2004) · Nature Cell Biology · doi:10.1038/ncb1106 · Cited by 231 · see citing works

Characterization of Alzheimer's β-Secretase Protein BACE

Haniu, M., Denis, P. E., Young, Y., Mendiaz, E. A., Fuller, J., Hui, J. O., Bennett, B. D., Kahn, S. E., Ross, S. L., Burgess, T. L., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002095200 · Cited by 227 · see citing works

GGA Proteins Mediate the Recycling Pathway of Memapsin 2 (BACE)

He, X., Li, F., Chang, W., & Tang, J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m411296200 · Cited by 225 · see citing works

Lysosomal system pathways: Genes to neurodegeneration in Alzheimer's disease

Nixon, R. A., & Cataldo, A. M. (2006) · Journal of Alzheimer s Disease · doi:10.3233/jad-2006-9s331 · Cited by 222 · see citing works

Transcranial Laser Therapy Attenuates Amyloid-β Peptide Neuropathology in Amyloid-β Protein Precursor Transgenic Mice

Taboada, L. H. D., Yu, J., El‐Amouri, S. S., Gattoni‐Celli, S., Richieri, S., McCarthy, T., Streeter, J., & Kindy, M. S. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-100894 · Cited by 221 · see citing works

Transcriptional Regulation of BACE1, the β-Amyloid Precursor Protein β-Secretase, by Sp1

Christensen, M. A., Zhou, W., Qing, H., Lehman, A., Philipsen, S., & Song, W. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.24.2.865-874.2004 · Cited by 218 · see citing works

β-Amyloid-(1–42) Impairs Activity-dependent cAMP-response Element-binding Protein Signaling in Neurons at Concentrations in Which Cell Survival Is Not Compromised

Tong, L., Thornton, P. L., Balazs, R., & Cotman, C. W. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m010450200 · Cited by 206 · see citing works

β-Amyloid Is Different in Normal Aging and in Alzheimer Disease

Piccini, A., Russo, C., Gliozzi, A., Relini, A., Vitali, A., Borghi, R., Giliberto, L., Armirotti, A., D’Arrigo, C., Bachi, A., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501694200 · Cited by 193 · see citing works

Processing of β-Secretase by Furin and Other Members of the Proprotein Convertase Family

Creemers, J. W. M., Dominguez, D. I., Plets, E., Serneels, L., Taylor, N. A., Multhaup, G., Craessaerts, K., Annaert, W. G., & Strooper, B. D. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m006947200 · Cited by 187 · see citing works

Gene structure and organization of the human β‐secretase ( BACE ) promoter

Sambamurti, K., Kinsey, R., Maloney, B., Ge, Y., & Lahiri, D. K. (2004) · The FASEB Journal · doi:10.1096/fj.03-1378fje · Cited by 179 · see citing works

Inflammation and NF-κB in Alzheimer's Disease and Diabetes

Granic, I., Dolga, A. M., Nijholt, I. M., van Dijk, G., & Eisel, U. L. M. (2009) · Journal of Alzheimer s Disease · doi:10.3233/jad-2009-0976 · Cited by 174 · see citing works

BACE Is Degraded via the Lysosomal Pathway

Koh, Y. H., Arnim, C. A. F. V., Hyman, B. T., Tanzi, R. E., & Tesco, G. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m506199200 · Cited by 166 · see citing works

AGEs/RAGE complex upregulates BACE1 via NF-κB pathway activation

Guglielmotto, M., Aragno, M., Tamagno, E., Vercellinatto, I., Visentin, S., Medana, C., Catalano, M. G., Smith, M. A., Perry, G. L., Danni, O., et al. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.05.026 · Cited by 162 · see citing works

Mitochondrial Alterations, Oxidative Stress and Neuroinflammation in Alzheimer's Disease

Verri, M., Pastoris, O., Dossena, M., Aquilani, R., Guerriero, F., Cuzzoni, G., Venturini, L., Ricevuti, G., & Bongiorno, A. I. (2012) · International Journal of Immunopathology and Pharmacology · doi:10.1177/039463201202500204 · Cited by 144 · see citing works

LRP in Amyloid‐β Production and Metabolism

Bu, G., Cam, J. A., & Zerbinatti, C. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1377.005 · Cited by 133 · see citing works

GGA proteins regulate retrograde transport of BACE1 from endosomes to the trans-Golgi network

Wahle, T., Prager, K., Raffler, N., Haass, C., Famulok, M., & Walter, J. (2005) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2005.03.014 · Cited by 131 · see citing works

Glu11 site cleavage and N-terminally truncated A beta production upon BACE overexpression.

Liu, K., Doms, R., & Lee, V. (2002) · Biochemistry · doi:10.1021/bi015800g · Cited by 128 · see citing works

NFκB-dependent Control of BACE1 Promoter Transactivation by Aβ42

Buggia-Prévot, V., Sévalle, J., Roßner, S., & Checler, F. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m706579200 · Cited by 125 · see citing works

The Role of Ubiquitin C-Terminal Hydrolase L1 in Neurodegenerative Disorders

Gong, B., & Leznik, E. (2007) · Drug News & Perspectives · doi:10.1358/dnp.2007.20.6.1138160 · Cited by 120 · see citing works

Nuclear Factor-κB Regulates βAPP and β- and γ-Secretases Differently at Physiological and Supraphysiological Aβ Concentrations

Chami, L., Buggia-Prévot, V., Duplan, E., Delprete, D., Chami, M., Peyron, J., & Checler, F. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.333054 · Cited by 120 · see citing works

Expression of the Alzheimer protease BACE1 is suppressed via its 5'‐untranslated region

Lammich, S., Schöbel, S., Zimmer, A., Lichtenthaler, S. F., & Haass, C. (2004) · EMBO Reports · doi:10.1038/sj.embor.7400166 · Cited by 118 · see citing works

Use of cDNA microarray in the search for molecular markers involved in the onset of Alzheimer's disease dementia

Pasinetti, G. M. (2001) · Journal of Neuroscience Research · doi:10.1002/jnr.1176 · Cited by 111 · see citing works

Ubiquitin Regulates GGA3-mediated Degradation of BACE1

Kang, E. L., Cameron, A. N., Piazza, F., Walker, K. R., & Tesco, G. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.092742 · Cited by 111 · see citing works

Evidence that γ-secretase mediates oxidative stress-induced β-secretase expression in Alzheimer's disease

Jo, D., Arumugam, T. V., Woo, H., Park, J. S., Tang, S., Mughal, M. R., Hyun, D., Park, J.-H., Choi, Y., Gwon, A., et al. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.07.003 · Cited by 105 · see citing works

Therapeutic effects of remediating autophagy failure in a mouse model of Alzheimer disease by enhancing lysosomal proteolysis

Yang, D., Stavrides, P. H., Mohan, P. S., Kaushik, S., Kumar, A. R., Ohno, M., Schmidt, S. D., Wesson, D. W., Bandyopadhyay, U., Jiang, Y., et al. (2011) · Autophagy · doi:10.4161/auto.7.7.15596 · Cited by 101 · see citing works

Characterization of the Glycosylation Profiles of Alzheimer's β-Secretase Protein Asp-2 Expressed in a Variety of Cell Lines

Charlwood, J., Dingwall, C., Matico, R., Hussain, I., Johanson, K., Moore, S. E., Powell, D. J., Skehel, M. J., Ratcliffe, S., Clarke, B. P., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m009361200 · Cited by 96 · see citing works

Control of BACE1 degradation and APP processing by ubiquitin carboxyl‐terminal hydrolase L1

Zhang, M., Deng, Y., Luo, Y., Zhang, S., Zou, H., Cai, F., Wada, K., & Song, W. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07644.x · Cited by 92 · see citing works

Critical role of PTEN in the coupling between PI3K/Akt and JNK1/2 signaling in ischemic brain injury

Zhang, Q., Dong-na, W. U., Han, D. K., & Zhang, G. (2007) · FEBS Letters · doi:10.1016/j.febslet.2006.12.055 · Cited by 90 · see citing works

Expression of stress‐activated kinases c‐Jun N‐terminal kinase (SAPK/JNK‐P) and p38 kinase (p38‐P), and tau hyperphosphorylation in neurites surrounding βA plaques in APP Tg2576 mice

Puig, B., Gómez‐Isla, T., Ribé, E. M., Cuadrado‐Tejedor, M., Torrejón-Escribano, B., Dalfó, E., & Ferrer, I. (2004) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2004.00569.x · Cited by 85 · see citing works

JNK and ERK1/2 pathways have a dual opposite effect on the expression of BACE1

Tamagno, E., Guglielmotto, M., Giliberto, L., Vitali, A., Borghi, R., Autelli, R., Danni, O., & Tabaton, M. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.12.015 · Cited by 84 · see citing works

Translational regulation of BACE-1 expression in neuronal and non-neuronal cells

Tonelli, D. D. P. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh348 · Cited by 81 · see citing works

Biochemical and Structural Characterization of the Interaction of Memapsin 2 (β-Secretase) Cytosolic Domain with the VHS Domain of GGA Proteins

He, X., Zhu, G., Koelsch, G., Rodgers, K. K., Zhang, X. C., & Tang, J. (2003) · Biochemistry · doi:10.1021/bi035199h · Cited by 80 · see citing works

c‐Jun phosphorylation in Alzheimer disease

Thakur, A., Wang, X., Siedlak, S. L., Perry, G. L., Smith, M. A., & Zhu, X. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21298 · Cited by 80 · see citing works

Autophagy in neurodegeneration: two sides of the same coin

Lee, J. (2009) · BMB Reports · doi:10.5483/bmbrep.2009.42.6.324 · Cited by 73 · see citing works

Aβ42 production in brain capillary endothelial cells after oxygen and glucose deprivation

Bulbarelli, A., Lonati, E., Brambilla, A., Orlando, A., Cazzaniga, E., Piazza, F., Ferrarese, C., Masserini, M., & Sancini, G. (2012) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2012.01.007 · Cited by 71 · see citing works

Axonal degeneration promotes abnormal accumulation of amyloid β-protein in ascending gracile tract of gracile axonal dystrophy (GAD) mouse

Ichihara, N., Wu, J., Hua Chui, D., Yamazaki, K., Wakabayashi, T., & Kikuchi, T. (1995) · Brain Research · doi:10.1016/0006-8993(95)00729-a · Cited by 70 · see citing works

The lipid peroxidation product 4-hydroxy-2,3-nonenal inhibits constitutive and inducible activity of nuclear factor κB in neurons

Camandola, S., Poli, G., & Mattson, M. P. (2000) · Molecular Brain Research · doi:10.1016/s0169-328x(00)00234-5 · Cited by 68 · see citing works

Oxidative Stress and Neuronal Adaptation in Alzheimer Disease: The Role of SAPK Pathways

Zhu, X., Raina, A. K., Lee, H., Chao, M. P., Nunomura, A., Tabaton, M., Petersen, R. B., Perry, G. L., & Smith, M. A. (2003) · Antioxidants and Redox Signaling · doi:10.1089/152308603770310220 · Cited by 67 · see citing works

Aβ1‐42‐mediated down‐regulation of Uch‐L1 is dependent on NF‐κB activation and impaired BACE1 lysosomal degradation

Guglielmotto, M., Monteleone, D., Boido, M., Piras, A., Giliberto, L., Borghi, R., Vercelli, A., Fornaro, M., Tabaton, M., & Tamagno, E. (2012) · Aging Cell · doi:10.1111/j.1474-9726.2012.00854.x · Cited by 66 · see citing works

Anatabine lowers Alzheimer's Aβ production in vitro and in vivo

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Formation of Phospho-SAPK/JNK Granules in the Hippocampus Is an Early Event in Alzheimer Disease

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