The liver X receptor gene team: Potential new players in atherosclerosis

The Metabolic and Molecular Bases of Inherited Disease

Scriver, R. C. (1995) · Medical Entomology and Zoology · Cited by 12,101

The metabolic and molecular bases of inherited disease

Chen, Y.-T. (2001) · Medical Entomology and Zoology · Cited by 6,928

Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells

Plump, A. S., Smith, J. D., Hayek, T., Aalto-Setälä, K., Walsh, A., Verstuyft, J. G., Rubin, E. M., & Breslow, J. L. (1992) · Cell · doi:10.1016/0092-8674(92)90362-g · Cited by 2,263

Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRα and LXRβ

Repa, J. J., Liang, G., Ou, J., Bashmakov, Y., Lobaccaro, J.-M. A., Shimomura, I., Shan, B., Brown, M. S., Goldstein, J. L., & Mangelsdorf, D. J. (2000) · Genes & Development · doi:10.1101/gad.844900 · Cited by 1,692

Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency

Brooks-Wilson, A., Marcil, M., Clee, S. M., Zhang, L.-H., Roomp, K., van Dam, M., Yu, L., Brewer, C., Collins, J. A., Molhuizen, H. O. F., et al. (1999) · Nature Genetics · doi:10.1038/11905 · Cited by 1,687

An oxysterol signalling pathway mediated by the nuclear receptor LXRα

Janowski, B. A., Willy, P. J., Devi, T. R., Falck, J. R., & Mangelsdorf, D. J. (1996) · Nature · doi:10.1038/383728a0 · Cited by 1,591

The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease

Bodzioch, M., Orsó, E., Klucken, J., Langmann, T., Böttcher, A., Diederich, W., Drobnik, W., Barlage, S., Büchler, C., Porsch-Özcürümez, M., et al. (1999) · Nature Genetics · doi:10.1038/11914 · Cited by 1,512

Role of LXRs in control of lipogenesis

Schultz, J. R., Tu, H., Luk, A., Repa, J. J., Medina, J. C., Li, L., Schwendner, S., Wang, S., Thoolen, M., Mangelsdorf, D. J., et al. (2000) · Genes & Development · doi:10.1101/gad.850400 · Cited by 1,499

Cholesterol and Bile Acid Metabolism Are Impaired in Mice Lacking the Nuclear Oxysterol Receptor LXRα

Peet, D. J., Turley, S. D., Ma, W., Janowski, B. A., Lobaccaro, J.-M. A., Hammer, R. E., & Mangelsdorf, D. J. (1998) · Cell · doi:10.1016/s0092-8674(00)81432-4 · Cited by 1,436

Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1

Rust, S., Rosier, M., Funke, H., Real, J., Amoura, Z., Piette, J.-C., Deleuze, J.-F., Brewer, H. B., Duverger, N., Denèfle, P., et al. (1999) · Nature Genetics · doi:10.1038/11921 · Cited by 1,433

A PPARγ-LXR-ABCA1 Pathway in Macrophages Is Involved in Cholesterol Efflux and Atherogenesis

Chawla, A., Boisvert, W. A., Lee, C.-H., Laffitte, B. A., Barak, Y., Joseph, S. B., Liao, D., Nagy, L., Edwards, P. A., Curtiss, L. K., et al. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00164-2 · Cited by 1,347

Regulation of Absorption and ABC1-Mediated Efflux of Cholesterol by RXR Heterodimers

Repa, J. J., Turley, S. D., Lobaccaro, J.-M. A., Medina, J., Li, L., Lustig, K., Shan, B., Heyman, R. A., Dietschy, J. M., & Mangelsdorf, D. J. (2000) · Science · doi:10.1126/science.289.5484.1524 · Cited by 1,301

Effect of Statins on Risk of Coronary Disease: A Meta-analysis of Randomized Controlled Trials

LaRosa, J. C., He, J., & Vupputuri, S. (1999) · JAMA · doi:10.1001/jama.282.24.2340 · Cited by 1,246

PPAR-α and PPAR-γ activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway

Chinetti, G., Lestavel, S., Bocher, V., Remaley, A. T., Neve, B., Torra, I. P., Teissier, E., Minnich, A., Jaye, M., Duverger, N., et al. (2001) · Nature Medicine · doi:10.1038/83348 · Cited by 1,170

Lipoprotein lipase and lipolysis: central roles in lipoprotein metabolism and atherogenesis

Goldberg, I. J. (1996) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)37569-6 · Cited by 1,010

Sterol-dependent Transactivation of theABC1 Promoter by the Liver X Receptor/Retinoid X Receptor

Costet, P., Luo, Y., Wang, N., & Tall, A. R. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m003337200 · Cited by 979

Synthetic LXR ligand inhibits the development of atherosclerosis in mice

Joseph, S. B., McKilligin, E., Pei, L., Watson, M. A., Collins, A. R., Laffitte, B. A., Chen, M., Noh, G., Goodman, J., Hagger, G. N., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.112059299 · Cited by 947

Regulation of ATP-binding Cassette Sterol Transporters ABCG5 and ABCG8 by the Liver X Receptors α and β

Repa, J. J., Berge, K. E., Pomajzl, C., Richardson, J. A., Hobbs, H., & Mangelsdorf, D. J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m109927200 · Cited by 852

Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors

Fahey, J. W., Haristoy, X., Dolan, P. M., Kensler, T. W., Scholtus, I., Stephenson, K. K., Talalay, P., & Lozniewski, A. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.112203099 · Cited by 795

LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes

Laffitte, B. A., Repa, J. J., Joseph, S. B., Wilpitz, D. C., Kast, H. R., Mangelsdorf, D. J., & Tontonoz, P. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.2.507 · Cited by 683

Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol

Yu, L., Li-Hawkins, J., Hammer, R. E., Berge, K. E., Horton, J. D., Cohen, J. C., & Hobbs, H. H. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0216001 · Cited by 596

27-Hydroxycholesterol Is an Endogenous Ligand for Liver X Receptor in Cholesterol-loaded Cells

Fu, X., Menke, J. G., Chen, Y., Zhou, G., MacNaul, K. L., Wright, S. D., Sparrow, C. P., & Lund, E. G. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m105805200 · Cited by 572

ABCG1 (ABC8), the human homolog of the Drosophila white gene, is a regulator of macrophage cholesterol and phospholipid transport

Klucken, J., Büchler, C., Orsó, E., Kaminski, W. E., Porsch-Özcürümez, M., Liebisch, G., Kapinsky, M., Diederich, W., Drobnik, W., Dean, M., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.2.817 · Cited by 543

High density lipoprotein deficiency and foam cell accumulation in mice with targeted disruption of ATP-binding cassette transporter-1

McNeish, J., Aiello, R. J., Guyot, D., Turi, T., Gabel, C., Aldinger, C., Hoppe, K. L., Roach, M. L., Royer, L. J., de Wet, J., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.8.4245 · Cited by 537

ATP-binding Cassette Transporter A1 (ABCA1) Functions as a Cholesterol Efflux Regulatory Protein

Wang, N., Silver, D. L., Thiele, C., & Tall, A. R. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m102348200 · Cited by 482

Prevention of atherosclerosis in apolipoprotein E-deficient mice by bone marrow transplantation

Linton, M. F., Atkinson, J. B., & Fazio, S. (1995) · Science · doi:10.1126/science.7863332 · Cited by 478

Transport of lipids from Golgi to plasma membrane is defective in Tangier disease patients and Abc1-deficient mice

Orsó, E., Broccardo, C., Kaminski, W. E., Böttcher, A., Liebisch, G., Drobnik, W., Götz, A., Chambenoit, O., Diederich, W., Langmann, T., et al. (2000) · Nature Genetics · doi:10.1038/72869 · Cited by 475

Identification of macrophage liver X receptors as inhibitors of atherosclerosis

Tangirala, R. K., Bischoff, E. D., Joseph, S. B., Wagner, B. L., Walczak, R., Laffitte, B. A., Daige, C. L., Thomas, D., Heyman, R. A., Mangelsdorf, D. J., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.182199799 · Cited by 438

Identification of a Nonsteroidal Liver X Receptor Agonist through Parallel Array Synthesis of Tertiary Amines

Collins, J. L., Fivush, A. M., Watson, M. A., Galardi, C. M., Lewis, M. C., Moore, L. B., Parks, D. J., Wilson, J. G., Tippin, T. K., Binz, J. G., et al. (2002) · Journal of Medicinal Chemistry · doi:10.1021/jm0255116 · Cited by 434

Targeted mutation of plasma phospholipid transfer protein gene markedly reduces high-density lipoprotein levels

Jiang, X.-C., Bruce, C., Mar, J., Lin, M., Ji, Y., Francone, O. L., & Tall, A. R. (1999) · Journal of Clinical Investigation · doi:10.1172/jci5578 · Cited by 394

Increased Atherosclerosis in Hyperlipidemic Mice With Inactivation of ABCA1 in Macrophages

Aiello, R. J., Brees, D., Bourassa, P.-A., Royer, L., Lindsey, S., Coskran, T., Haghpassand, M., & Francone, O. L. (2002) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000014804.35824.da · Cited by 390

Human White/Murine ABC8 mRNA Levels Are Highly Induced in Lipid-loaded Macrophages

Venkateswaran, A., Repa, J. J., Lobaccaro, J.-M. A., Bronson, A., Mangelsdorf, D. J., & Edwards, P. A. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.19.14700 · Cited by 386

Sterol upregulation of human CETP expression in vitro and in transgenic mice by an LXR element

Luo, Y., & Tall, A. R. (2000) · Journal of Clinical Investigation · doi:10.1172/jci8573 · Cited by 351

Leukocyte ABCA1 controls susceptibility to atherosclerosis and macrophage recruitment into tissues

Van Eck, M., Bos, I. S. T., Kaminski, W. E., Orsó, E., Rothe, G., Twisk, J., Böttcher, A., Van Amersfoort, E. S., Christiansen-Weber, T. A., Fung-Leung, W.-P., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.092327399 · Cited by 348

Autoregulation of the Human Liver X Receptor α Promoter

Laffitte, B. A., Joseph, S. B., Walczak, R., Pei, L., Wilpitz, D. C., Collins, J. L., & Tontonoz, P. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.22.7558-7568.2001 · Cited by 315

Coexpression of ATP-binding cassette proteins ABCG5 and ABCG8 permits their transport to the apical surface

Graf, G. A., Li, W.-P., Gerard, R. D., Gelissen, I., White, A., Cohen, J. C., & Hobbs, H. H. (2002) · Journal of Clinical Investigation · doi:10.1172/jci16000 · Cited by 305

The Molecular Pharmacology of SERMs

McDonnell, D. P. (1999) · Trends in Endocrinology & Metabolism · doi:10.1016/s1043-2760(99)00177-0 · Cited by 299

ABCA1 mRNA and Protein Distribution Patterns Predict Multiple Different Roles and Levels of Regulation

Wellington, C. L., Walker, E. K. Y., Suarez, A., Kwok, A., Bissada, N., Singaraja, R., Yang, Y.-Z., Zhang, L.-H., James, E., Wilson, J. E., et al. (2002) · Laboratory Investigation · doi:10.1038/labinvest.3780421 · Cited by 297

Increased atherosclerosis in mice reconstituted with apolipoprotein E null macrophages

Fazio, S., Babaev, V. R., Murray, A. B., Hasty, A. H., Carter, K. J., Gleaves, L. A., Atkinson, J. B., & Linton, M. F. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.9.4647 · Cited by 295

Reduction of atherosclerosis in apolipoprotein E knockout mice by activation of the retinoid X receptor

Claudel, T., Leibowitz, M. D., Fiévet, C., Tailleux, A., Wagner, B., Repa, J. J., Torpier, G., Lobaccaro, J.-M., Paterniti, J. R., Mangelsdorf, D. J., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.041609298 · Cited by 292

Regulation of Lipoprotein Lipase by the Oxysterol Receptors, LXRα and LXRβ

Zhang, Y., Repa, J. J., Gauthier, K., & Mangelsdorf, D. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m107823200 · Cited by 284

Pivotal role of ABCA1 in reverse cholesterol transport influencing HDL levels and susceptibility to atherosclerosis

Attie, A. D., Kastelein, J. P., & Hayden, M. R. (2001) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)31498-x · Cited by 284

Coexpression of ATP-binding cassette proteins ABCG5 and ABCG8 permits their transport to the apical surface

Graf, G. A., Li, W.-P., Gerard, R. D., Gelissen, I., White, A., Cohen, J. C., & Hobbs, H. H. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0216000 · Cited by 283

The ATP binding cassette transporter A1 (ABCA1) modulates the development of aortic atherosclerosis in C57BL/6 and apoE-knockout mice

Joyce, C. W., Amar, M. J. A., Lambert, G., Vaisman, B. L., Paigen, B., Najib-Fruchart, J., Hoyt, R. F., Neufeld, E. D., Remaley, A. T., Fredrickson, D. S., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.012587699 · Cited by 269

Control of Cholesterol Turnover in the Mouse

Dietschy, J. M., & Turley, S. D. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.r100057200 · Cited by 265

Homozygous Tangier disease and cardiovascular disease

Serfaty-Lacrosniere, C., Civeira, F., Lanzberg, A., Isaia, P., Berg, J., Janus, E. D., Smith, M. P., Pritchard, P. H., Frohlich, J., Lees, R. S., et al. (1994) · Atherosclerosis · doi:10.1016/0021-9150(94)90144-9 · Cited by 262

Apolipoprotein B secretion and atherosclerosis are decreased in mice with phospholipid-transfer protein deficiency

Jiang, X.-C., Qin, S., Qiao, C., Kawano, K., Lin, M., Skold, A., Xiao, X., & Tall, A. R. (2001) · Nature Medicine · doi:10.1038/89977 · Cited by 256

Apolipoprotein E and atherosclerosis

Curtiss, L. K., & Boisvert, W. A. (2000) · Current Opinion in Lipidology · doi:10.1097/00041433-200006000-00004 · Cited by 251

Increased ABCA1 activity protects against atherosclerosis

Singaraja, R. R., Fievet, C., Castro, G., James, E. R., Hennuyer, N., Clee, S. M., Bissada, N., Choy, J. C., Fruchart, J.-C., McManus, B. M., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15748 · Cited by 250

Regulated Expression of the Apolipoprotein E/C-I/C-IV/C-II Gene Cluster in Murine and Human Macrophages

Mak, P. A., Laffitte, B. A., Desrumaux, C., Joseph, S. B., Curtiss, L. K., Mangelsdorf, D. J., Tontonoz, P., & Edwards, P. A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202993200 · Cited by 244

Increased Atherosclerosis in ApoE and LDL Receptor Gene Knock-Out Mice as a Result of Human Cholesteryl Ester Transfer Protein Transgene Expression

Plump, A. S., Masucci-Magoulas, L., Bruce, C., Bisgaier, C. L., Breslow, J. L., & Tall, A. R. (1999) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.19.4.1105 · Cited by 221

LXR/RXR activation enhances basolateral efflux of cholesterol in CaCo-2 cells

Murthy, S., Born, E., Mathur, S. N., & Field, F. J. (2002) · Journal of Lipid Research · doi:10.1194/jlr.m100358-jlr200 · Cited by 208

Increased Hepatobiliary and Fecal Cholesterol Excretion upon Activation of the Liver X Receptor Is Independent of ABCA1

Plo¨sch, T., Kok, T., Bloks, V. W., Smit, M. J., Havinga, R., Chimini, G., Groen, A. K., & Kuipers, F. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206522200 · Cited by 207

Human Plasma Phospholipid Transfer Protein Increases the Antiatherogenic Potential of High Density Lipoproteins in Transgenic Mice

van Haperen, R., van Tol, A., Vermeulen, P., Jauhiainen, M., van Gent, T., van den Berg, P., Ehnholm, S., Grosveld, F., van der Kamp, A., & de Crom, R. (2000) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.20.4.1082 · Cited by 203

Association between increased arterial-wall thickness and impairment in ABCA1-driven cholesterol efflux: an observational study

van Dam, M. J., de Groot, E., Clee, S. M., Hovingh, G. K., Roelants, R., Brooks-Wilson, A., Zwinderman, A. H., Smit, A. J., Smelt, A. H., Groen, A. K., et al. (2002) · The Lancet · doi:10.1016/s0140-6736(02)07277-x · Cited by 198

Genetic basis of sitosterolemia

Lee, M.-H., Lu, K., & Patel, S. B. (2001) · Current Opinion in Lipidology · doi:10.1097/00041433-200104000-00007 · Cited by 196

Phospholipid Transfer Protein Is Regulated by Liver X Receptors in Vivo

Cao, G., Beyer, T. P., Yang, X. P., Schmidt, R. J., Zhang, Y., Bensch, W. R., Kauffman, R. F., Gao, H., Ryan, T. P., Liang, Y., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m207187200 · Cited by 189

Hepatobiliary cholesterol transport is not impaired in Abca1-null mice lacking HDL

Groen, A. K., Bloks, V. W., Bandsma, R. H. J., Ottenhoff, R., Chimini, G., & Kuipers, F. (2001) · Journal of Clinical Investigation · doi:10.1172/jci12473 · Cited by 162

Liver X Receptor (LXR) Regulation of the LXRα Gene in Human Macrophages

Whitney, K. D., Watson, M. A., Goodwin, B., Galardi, C. M., Maglich, J. M., Wilson, J. G., Willson, T. M., Collins, J. L., & Kliewer, S. A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m106155200 · Cited by 154

Suppression of diet-induced atherosclerosis in low density lipoprotein receptor knockout mice overexpressing lipoprotein lipase.

Shimada, M., Ishibashi, S., Inaba, T., Yagyu, H., Harada, K., Osuga, J.-I., Ohashi, K., Yazaki, Y., & Yamada, N. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.14.7242 · Cited by 153

Macrophage Lipoprotein Lipase Promotes Foam Cell Formation and Atherosclerosis in Low Density Lipoprotein Receptor-deficient Mice

Babaev, V. R., Patel, M., Semenkovich, C. F., Fazio, S., & Linton, M. F. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002423200 · Cited by 151

Plasma Phospholipid Transfer Protein

Föger, B., Santamarina-Fojo, S., Shamburek, R. D., Parrott, C. L., Talley, G. D., & Brewer, H. B. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.43.27393 · Cited by 142

ATP-binding cassette transporter A1 (ABCA1) affects total body sterol metabolism

Drobnik, W., Lindenthal, B., Lieser, B., Ritter, M., Weber, T. C., Liebisch, G., Giesa, U., Igel, M., Borsukova, H., Büchler, C., et al. (2001) · Gastroenterology · doi:10.1053/gast.2001.23250 · Cited by 129

Phospholipid transfer protein

van Tol, A. (2002) · Current Opinion in Lipidology · doi:10.1097/00041433-200204000-00004 · Cited by 128

A Potent Synthetic LXR Agonist Is More Effective than Cholesterol Loading at Inducing ABCA1 mRNA and Stimulating Cholesterol Efflux

Sparrow, C. P., Baffic, J., Lam, M., Lund, E. G., Adams, A. D., Fu, X., Hayes, N. S., Jones, A. B., MacNaul, K. L., Ondeyka, J. G., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m108225200 · Cited by 127

Overexpressed lipoprotein lipase protects against atherosclerosis in apolipoprotein E knockout mice

Yagyu, H., Ishibashi, S., Chen, Z., Osuga, J.-I., Okazaki, M., Perrey, S., Kitamine, T., Shimada, M., Ohashi, K., Harada, K., et al. (1999) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)33414-3 · Cited by 120

Lipoprotein Lipase in the Arterial Wall: Linking LDL to the Arterial Extracellular Matrix and Much More

Pentikäinen, M. O., Oksjoki, R. K., Öörni, K., & Kovanen, P. T. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/hq0102.101551 · Cited by 109

The myotoxicity of statins

Evans, M., & Rees, A. (2002) · Current Opinion in Lipidology · doi:10.1097/00041433-200208000-00009 · Cited by 107

Inactive Lipoprotein Lipase (LPL) Alone Increases Selective Cholesterol Ester Uptake in Vivo, Whereas in the Presence of Active LPL It Also Increases Triglyceride Hydrolysis and Whole Particle Lipoprotein Uptake

Merkel, M., Heeren, J., Dudeck, W., Rinninger, F., Radner, H., Breslow, J. L., Goldberg, I. J., Zechner, R., & Greten, H. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m107914200 · Cited by 105

Overexpression of Lipoprotein Lipase in Transgenic Rabbits Inhibits Diet-induced Hypercholesterolemia and Atherosclerosis

Fan, J., Unoki‐Kubota, H., Kojima, N., Sun, H., Shimoyamada, H., Deng, H., Okazaki, M., Shikama, H., Yamada, N., & Watanabe, T. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m105456200 · Cited by 94

Macrophage-Specific Expression of Human Lipoprotein Lipase Accelerates Atherosclerosis in Transgenic Apolipoprotein E Knockout Mice but Not in C57BL/6 Mice

Wilson, K. M., Fry, G. L., Chappell, D. A., Sigmund, C. D., & Medh, J. D. (2001) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/hq1101.097805 · Cited by 87

Dietary Cholesterol Fails to Stimulate the Human Cholesterol 7α-Hydroxylase Gene (CYP7A1) in Transgenic Mice

Agellon, L. B., Drover, V. A. B., Cheema, S. K., Gbaguidi, F., & Walsh, A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.c200105200 · Cited by 81

Lipoprotein lipase mediates an increase in the selective uptake of high density lipoprotein-associated cholesteryl esters by hepatic cells in culture

Rinninger, F., Kaiser, T., Mann, W. A., Meyer, N., Greten, H., & Beisiegel†, U. (1998) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)32514-1 · Cited by 78

Key regulatory oxysterols in liver: analysis as Δ4-3-ketone derivatives by HPLC and response to physiological perturbations

Zhang, Z., Li, D., Blanchard, D. E., Lear, S. R., Erickson, S. K., & Spencer, T. A. (2001) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)31174-3 · Cited by 76

Mouse models of atherosclerosis

Reardon, C. A., & Getz, G. S. (2001) · Current Opinion in Lipidology · doi:10.1097/00041433-200104000-00010 · Cited by 76

LuXuRies of Lipid Homeostasis: The Unity of Nuclear Hormone Receptors, Transcription Regulation, and Cholesterol Sensing

Zhang, Y., & Mangelsdorf, D. J. (2002) · Molecular Interventions · doi:10.1124/mi.2.2.78 · Cited by 69

Adenovirus-Mediated Gene Transfer of Human Lipoprotein Lipase Ameliorates the Hyperlipidemias Associated with Apolipoprotein E and LDL Receptor Deficiencies in Mice

Zsigmond, E. M., Kobayashi, K., Tzung, K., Li, L., Fuke, Y., & Chan, L. (1997) · Human Gene Therapy · doi:10.1089/hum.1997.8.16-1921 · Cited by 48

Dynamic changes in mouse lipoproteins induced by transiently expressed human phospholipid transfer protein (PLTP): importance of PLTP in preβ-HDL generation

Jaari, S., van Dijk, K. W., Olkkonen, V. M., van der Zee, A., Metso, J., Havekes, L. M., Jauhiainen, M., & Ehnholm, C. (2001) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/s1096-4959(01)00297-4 · Cited by 35

High-density lipoprotein: gene-based approaches to the prevention of atherosclerosis

Rong, J. X., & Fisher, E. A. A. (2000) · Annals of Medicine · doi:10.3109/07853890009002035 · Cited by 14

Reciprocal regulation of inflammation and lipid metabolism by liver X receptors

Joseph, S. B., Castrillo, A., Laffitte, B. A., Mangelsdorf, D. J., & Tontonoz, P. (2003) · Nature Medicine · doi:10.1038/nm820 · Cited by 1,158

Regulation of energy metabolism by long-chain fatty acids

Nakamura, M. T., Yudell, B. E., & Loor, J. J. (2014) · Progress in Lipid Research · doi:10.1016/j.plipres.2013.12.001 · Cited by 818

Apoptotic Cells Promote Their Own Clearance and Immune Tolerance through Activation of the Nuclear Receptor LXR

A-Gonzalez, N., Bensinger, S. J., Hong, C., Beceiro, S., Bradley, M. N., Zelcer, N., Deniz, J., Ramirez, C., Díaz, M., Gallardo, G., et al. (2009) · Immunity · doi:10.1016/j.immuni.2009.06.018 · Cited by 677

Molecular regulation of HDL metabolism and function: implications for novel therapies

Rader, D. J. (2006) · Journal of Clinical Investigation · doi:10.1172/jci30163 · Cited by 599

Transcriptional Repression of Atherogenic Inflammation: Modulation by PPARδ

Lee, C.-H., Chawla, A., Urbiztondo, N., Liao, D., Boisvert, W. A., & Evans, R. M. (2003) · Science · doi:10.1126/science.1087344 · Cited by 580