Blockade of PI3Kγ suppresses joint inflammation and damage in mouse models of rheumatoid arthritis

Phosphoinositides: Tiny Lipids With Giant Impact on Cell Regulation

Balla, T. (2013) · Physiological Reviews · doi:10.1152/physrev.00028.2012 · Cited by 1,638

A Pharmacological Map of the PI3-K Family Defines a Role for p110α in Insulin Signaling

Knight, Z. A., Gonzalez, B., Feldman, M. E., Zunder, E. R., Goldenberg, D. D., Williams, O., Loewith, R., Stokoe, D., Balla, A., Toth, B., et al. (2006) · Cell · doi:10.1016/j.cell.2006.03.035 · Cited by 1,174

PI3K signalling in inflammation

Hawkins, P. T., & Stephens, L. R. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.12.006 · Cited by 541

Signalling through Class I PI3Ks in mammalian cells

Hawkins, P. T., Anderson, K. E., Davidson, K., & Stephens, L. R. (2006) · Biochemical Society Transactions · doi:10.1042/bst0340647 · Cited by 540

Insulin resistance and atherosclerosis

Semenkovich, C. F. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29024 · Cited by 481

Signaling by the Phosphoinositide 3-Kinase Family in Immune Cells

Okkenhaug, K. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032712-095946 · Cited by 446

Macrophage-secreted granulin supports pancreatic cancer metastasis by inducing liver fibrosis

Nielsen, S. R., Quaranta, V., Linford, A., Emeagi, P., Rainer, C., Santos, A., Ireland, L., Sakai, T., Sakai, K., Kim, Y.-S., et al. (2016) · Nature Cell Biology · doi:10.1038/ncb3340 · Cited by 441

More friend than foe: the emerging role of neutrophils in tissue repair

Peiseler, M., & Kubes, P. (2019) · Journal of Clinical Investigation · doi:10.1172/jci124616 · Cited by 423

PI3Kδ and PI3Kγ: partners in crime in inflammation in rheumatoid arthritis and beyond?

Rommel, C., Camps, M., & Ji, H. (2007) · Nature Reviews Immunology · doi:10.1038/nri2036 · Cited by 398

Receptor Tyrosine Kinases and TLR/IL1Rs Unexpectedly Activate Myeloid Cell PI3Kγ, A Single Convergent Point Promoting Tumor Inflammation and Progression

Schmid, M. C., Avraamides, C. J., Dippold, H. C., Franco, I., Foubert, P., Ellies, L. G., Acevedo, L. M., Manglicmot, J. R. E., Song, X., Wrasidlo, W., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.04.016 · Cited by 378

Phosphoinositide 3-kinase inhibition restores neutrophil accuracy in the elderly: toward targeted treatments for immunosenescence

Sapey, E., Greenwood, H., Walton, G., Mann, E., Love, A., Aaronson, N., Insall, R. H., Stockley, R. A., & Lord, J. M. (2014) · Blood · doi:10.1182/blood-2013-08-519520 · Cited by 358

The PI3K/Akt/mTOR pathway in innate immune cells: emerging therapeutic applications

Weichhart, T., & Säemann, M. D. (2008) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2008.098459 · Cited by 323

Inflammation as a Therapeutic Target in Heart Failure? A Scientific Statement from the Translational Research Committee of the Heart Failure Association of the European Society of Cardiology

Heymans, S., Hirsch, E., Anker, S. D., Aukrust, P., Balligand, J.-L., Cohen-Tervaert, J. W., Drexler, H., Filippatos, G., Felix, S. B., Gullestad, L., et al. (2009) · European Journal of Heart Failure · doi:10.1093/eurjhf/hfn043 · Cited by 323

PI3Kγ inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus

Barber, D. F., Bartolomé, A., Hernandez, C., Flores, J. M., Redondo, C., Fernandez-Arias, C., Camps, M., Rückle, T., Schwarz, M. K., Rodríguez, S., et al. (2005) · Nature Medicine · doi:10.1038/nm1291 · Cited by 310

Understanding Fc Receptor Involvement in Inflammatory Diseases: From Mechanisms to New Therapeutic Tools

Ben Mkaddem, S., Benhamou, M., & Monteiro, R. C. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00811 · Cited by 283

Treatment of arthritis with a selective inhibitor of c-Fos/activator protein-1

Aikawa, Y., Morimoto, K., Yamamoto, T., Chaki, H., Hashiramoto, A., Narita, H., Hirono, S., & Shiozawa, S. (2008) · Nature Biotechnology · doi:10.1038/nbt1412 · Cited by 214

Metformin attenuates experimental autoimmune arthritis through reciprocal regulation of Th17/Treg balance and osteoclastogenesis

Son, H.-J., Lee, J., Lee, S.-Y., Kim, E.-K., Park, M.-J., Kim, K.-W., Park, S.-H., & Cho, M.-L. (2014) · Mediators of Inflammation · doi:10.1155/2014/973986 · Cited by 206

Tyrosine kinase Btk regulates E-selectin–mediated integrin activation and neutrophil recruitment by controlling phospholipase C (PLC) γ2 and PI3Kγ pathways

Mueller, H., Stadtmann, A., Van Aken, H., Hirsch, E., Wang, D., Ley, K., & Zarbock, A. (2010) · Blood · doi:10.1182/blood-2009-11-254185 · Cited by 164

Neuron-specific regulation of class I PI3K catalytic subunits and their dysfunction in brain disorders

Gross, C., & Bassell, G. J. (2014) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2014.00012 · Cited by 63

A PI3K p110β–Rac signalling loop mediates Pten-loss-induced perturbation of haematopoiesis and leukaemogenesis

Yuzugullu, H., Baitsch, L., Von, T., Steiner, A., Tong, H., Ni, J., Clayton, L. K., Bronson, R., Roberts, T. M., Gritsman, K., et al. (2015) · Nature Communications · doi:10.1038/ncomms9501 · Cited by 47

Molecular basis for differential activation of p101 and p84 complexes of PI3Kγ by Ras and GPCRs

Rathinaswamy, M. K., Jenkins, M. L., Duewell, B. R., Zhang, X., Harris, N. J., Evans, J. T., Stariha, J. T. B., Dalwadi, U., Fleming, K. D., Ranga-Prasad, H., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112172 · Cited by 28

Structural framework for the understanding spectroscopic and functional signatures of the cyanobacterial Orange Carotenoid Protein families

Sluchanko, N. N., Maksimov, E. G., Slonimskiy, Y. B., Varfolomeeva, L. A., Bukhanko, A. Y., Egorkin, N. A., Tsoraev, G. V., Khrenova, M. G., Ge, B., Qin, S., et al. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.127874 · Cited by 18

SHIP1 and its role for innate immune regulation—Novel targets for immunotherapy

Yeoh, W. J., & Krebs, P. (2023) · European Journal of Immunology · doi:10.1002/eji.202350446 · Cited by 14