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The antioxidant function of the p53 tumor suppressor
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“Another protective, pro-survival mechanism is the capacity of p53 to upregulate the expression of antioxidant genes, such as sestrins 1 and 2 (SESN1 and SESN2, respectively), GPX1 and TIGAR, which suppress the accumulation of reactive oxygen species, thereby maintaining genomic integrity (Liu et al., 2008; Sablina et al., 2005).”
From p53 at a glance (2010) · cites this paper as Sablina et al., 2005
In the citing paper
“ROS act as an upstream signal to trigger the activation of p53, and p53 transcribes the expression of multiple antioxidant genes, such as GPX1 and manganese superoxide dismutase”
From Targeting p53 pathways: mechanisms, structures, and advances in therapy (2023) · cites this paper as [114]
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Metadata
- Authors
- Sablina, A. A., Budanov, A. V., Ilyinskaya, G. V., Agapova, L. S., Kravchenko, J. E., & Chumakov, P. M.
- Venue
- Nature Medicine
- Published
- 2005-11-13
- Volume
- 11
- Issue
- 12
- Pages
- 1306-1313
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W2010077871
- Cited by
- 1,121
- References
- 49
- FWCI
- 18.65
- Type
- journal article
- Language
- en
- Open access
- green
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