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The antioxidant function of the p53 tumor suppressor
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“Another protective, pro-survival mechanism is the capacity of p53 to upregulate the expression of antioxidant genes, such as sestrins 1 and 2 (SESN1 and SESN2, respectively), GPX1 and TIGAR, which suppress the accumulation of reactive oxygen species, thereby maintaining genomic integrity (Liu et al., 2008; Sablina et al., 2005).”
From p53 at a glance (2010) · cites this paper as Sablina et al., 2005
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“ROS act as an upstream signal to trigger the activation of p53, and p53 transcribes the expression of multiple antioxidant genes, such as GPX1 and manganese superoxide dismutase”
From Targeting p53 pathways: mechanisms, structures, and advances in therapy (2023) · cites this paper as [114]
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Metadata
- Authors
- Sablina, A. A., Budanov, A. V., Ilyinskaya, G. V., Agapova, L. S., Kravchenko, J. E., & Chumakov, P. M.
- Venue
- Nature Medicine
- Published
- 2005-11-13
- Volume
- 11
- Issue
- 12
- Pages
- 1306-1313
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W2010077871
- Cited by
- 1,121
- References
- 49
- FWCI
- 18.65
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.