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A bioinformatic assay for pluripotency in human cells
Open accessAbstract
Pluripotent stem cells (PSCs) are defined by their potential to generate all cell types of an organism. The standard assay for pluripotency of mouse PSCs is cell transmission through the germline, but for human PSCs researchers depend on indirect methods such as differentiation into teratomas in immunodeficient mice. Here we report PluriTest, a robust open-access bioinformatic assay of pluripotency in human cells based on their gene expression profiles.
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“The PluriTest is a bioinformatics assay in which the transcriptome of a test cell line is compared to the transcriptome of a large number of cell lines known to be pluripotent [35].”
MethodChimeric brain models to study human glial-neuronal and macroglial-microglial interactions
Jin, M., Ma, Z., Zhang, H., Dang, R., Papetti, A. V., Stillitano, A. C., Zou, L., Goldman, S. A., & Jiang, P. (2026) · Cell Reports · doi:10.1016/j.celrep.2025.116794 · Cited by 6
Metadata
- Authors
- Müller, F.-J., Schuldt, B. M., Williams, R., Mason, D., Altun, G., Papapetrou, E. P., Danner, S., Goldmann, J. E., Herbst, A., Schmidt, N. O., Aldenhoff, J. B., Laurent, L. C., & Loring, J. F.
- Venue
- Nature Methods
- Published
- 2011-03-06
- Volume
- 8
- Issue
- 4
- Pages
- 315-317
- ISSN
- 1548-7091 (ISSN-L)
- 1548-7105
- OpenAlex
- W1975207448
- Cited by
- 450
- References
- 17
- FWCI
- 13.64
- Type
- journal article
- Language
- en
- Open access
- green
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