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Bayesian community-wide culture-independent microbial source tracking
Open accessAbstract
Contamination is a critical issue in high-throughput metagenomic studies, yet progress toward a comprehensive solution has been limited. We present SourceTracker, a Bayesian approach to estimate the proportion of contaminants in a given community that come from possible source environments. We applied SourceTracker to microbial surveys from neonatal intensive care units (NICUs), offices and molecular biology laboratories, and provide a database of known contaminants for future testing.
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Metadata
- Authors
- Knights, D., Kuczynski, J., Charlson, E. S., Zaneveld, J., Mozer, M. C., Collman, R. G., Bushman, F. D., Knight, R., & Kelley, S. T.
- Venue
- Nature Methods
- Published
- 2011-07-17
- Volume
- 8
- Issue
- 9
- Pages
- 761-763
- ISSN
- 1548-7091 (ISSN-L)
- 1548-7105
- OpenAlex
- W2054407804
- Cited by
- 1,856
- References
- 6
- FWCI
- 7.52
- Type
- journal article
- Language
- en
- Open access
- green
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